Dr Jennifer C Palmer

B.Sc.(Soton.), PhD

  • BS8 2BN

20082020

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

My research is focused on how the endothelin system is disrupted in the brain in Alzheimer’s disease. There are differences in the levels of ECE-2 and ECE-1, the activity of ECE-1 and the level of ET-1 in the brain in Alzheimer’s disease compared to controls, and I am interested in why this is, and what effect this may have in patients. There appears to be a link between disruption of the endothelin system and the reduction of cerebral blood flow in Alzheimer’s disease, and part of my research is to investigate the mechanism of this. A large part of my current work is to investigate whether disruption in the endothelin system plays a role in the recently recognised interrelationship between hypertension, ischaemic brain damage, and Alzheimer’s disease, particularly the potential involvement of Aβ on ECE-mediated regulation of cerebral blood flow. I am currently looking in more detail at the therapeutic potential of these findings for a new treatment of Alzheimer’s disease.

Fingerprint Dive into the research topics where Jennifer C Palmer is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

  • 16 Article (Academic Journal)
  • 2 Review article (Academic Journal)
Open Access
File
  • 42 Downloads (Pure)

    School-based interventions to prevent anxiety and depression in children and young people: a systematic review and network meta-analysis

    Caldwell, D. M., Davies, S. R., Hetrick, S. E., Palmer, J. C., Caro, P., López-López, J. A., Gunnell, D., Kidger, J., Thomas, J., French, C., Stockings, E., Campbell, R. & Welton, N. J., 13 Nov 2019, In : Lancet Psychiatry. 6, 12, p. 1011-1020 10 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 5 Citations (Scopus)
    185 Downloads (Pure)