Research output per year
Research output per year
Personal profile
Research interests
My research is focused on how the endothelin system is disrupted in the brain in Alzheimer’s disease. There are differences in the levels of ECE-2 and ECE-1, the activity of ECE-1 and the level of ET-1 in the brain in Alzheimer’s disease compared to controls, and I am interested in why this is, and what effect this may have in patients. There appears to be a link between disruption of the endothelin system and the reduction of cerebral blood flow in Alzheimer’s disease, and part of my research is to investigate the mechanism of this. A large part of my current work is to investigate whether disruption in the endothelin system plays a role in the recently recognised interrelationship between hypertension, ischaemic brain damage, and Alzheimer’s disease, particularly the potential involvement of Aβ on ECE-mediated regulation of cerebral blood flow. I am currently looking in more detail at the therapeutic potential of these findings for a new treatment of Alzheimer’s disease.
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Collaborations and top research areas from the last five years
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Research output
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Do the effects of interventions aimed at the prevention of childhood obesity reduce inequities? A re-analysis of randomized trial data from two Cochrane reviews
Palmer, J. C., Davies, A. L., Spiga, F., Heitmann, B., Jago, R., Summerbell, C. & Higgins, J. P. T., 4 Mar 2025, In: EClinicalMedicine. 81, 103130.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Evaluating liquid biopsy biomarkers for early detection of brain metastasis: a systematic review
Yu, J., Paterson, C., Davies, P., Palmer, J. C., Higgins, J. P. T. & Kurian, K. M., 18 Mar 2025, (E-pub ahead of print) In: Neuro-Oncology Practice. npaf032.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Exploring the moderating effect of control group type on intervention effectiveness in school-based anxiety and depression prevention: findings from a rapid review and network meta-analysis
Caldwell, D. M., Palmer, J. C., Webster, K. E., Davies, S. J., Hughes, H., Rona, J., Churchill, R., Hetrick, S. E. & Welton, N. J., 12 Feb 2025, In: Prevention Science. 26, 2, p. 175–192 18 p., k1079.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access
Projects
- 1 Active
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NIHR Evidence Synthesis Group
Higgins, J. P. T. (Principal Investigator), Caldwell, D. M. (Co-Principal Investigator), Savovic, J. (Co-Investigator), Jones, H. E. (Co-Investigator), Cabral, C. L. (Co-Investigator), Macdonald, G. M. (Co-Investigator), Gibson, A. J. (Co-Investigator), Welton, N. J. (Co-Investigator), Sanghera, S. (Co-Investigator), Whiting, P. F. (Co-Investigator), Webster, K. E. (Researcher), Spiga, F. (Researcher), Dawson, S. (Researcher), Parkhouse, T. L. (Researcher), Halicka, M. (Researcher), Paterson, C. (Researcher) & Palmer, J. C. (Researcher)
1/04/23 → 31/03/28
Project: Research, Parent