Dr Jennifer C Palmer

B.Sc.(Soton.), PhD

  • BS8 2PS

Personal profile

Research interests

My research is focused on how the endothelin system is disrupted in the brain in Alzheimer’s disease. There are differences in the levels of ECE-2 and ECE-1, the activity of ECE-1 and the level of ET-1 in the brain in Alzheimer’s disease compared to controls, and I am interested in why this is, and what effect this may have in patients. There appears to be a link between disruption of the endothelin system and the reduction of cerebral blood flow in Alzheimer’s disease, and part of my research is to investigate the mechanism of this. A large part of my current work is to investigate whether disruption in the endothelin system plays a role in the recently recognised interrelationship between hypertension, ischaemic brain damage, and Alzheimer’s disease, particularly the potential involvement of Aβ on ECE-mediated regulation of cerebral blood flow. I am currently looking in more detail at the therapeutic potential of these findings for a new treatment of Alzheimer’s disease.


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