Dr Jennifer C Palmer

B.Sc.(Soton.), PhD

  • BS8 2BN


Research output per year

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Personal profile

Research interests

My research is focused on how the endothelin system is disrupted in the brain in Alzheimer’s disease. There are differences in the levels of ECE-2 and ECE-1, the activity of ECE-1 and the level of ET-1 in the brain in Alzheimer’s disease compared to controls, and I am interested in why this is, and what effect this may have in patients. There appears to be a link between disruption of the endothelin system and the reduction of cerebral blood flow in Alzheimer’s disease, and part of my research is to investigate the mechanism of this. A large part of my current work is to investigate whether disruption in the endothelin system plays a role in the recently recognised interrelationship between hypertension, ischaemic brain damage, and Alzheimer’s disease, particularly the potential involvement of Aβ on ECE-mediated regulation of cerebral blood flow. I am currently looking in more detail at the therapeutic potential of these findings for a new treatment of Alzheimer’s disease.

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Research Output

  • 16 Article (Academic Journal)
  • 2 Review article (Academic Journal)
Open Access
  • 53 Downloads (Pure)

    School-based interventions to prevent anxiety and depression in children and young people: a systematic review and network meta-analysis

    Caldwell, D. M., Davies, S. R., Hetrick, S. E., Palmer, J. C., Caro, P., López-López, J. A., Gunnell, D., Kidger, J., Thomas, J., French, C., Stockings, E., Campbell, R. & Welton, N. J., 13 Nov 2019, In : Lancet Psychiatry. 6, 12, p. 1011-1020 10 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 8 Citations (Scopus)
    354 Downloads (Pure)

    Zibotentan, an endothelin AD receptor antagonist, prevents Aβ-induced hypertension and maintains cerebral perfusion

    Tayler, H., Palmer, J., Dyer, L., Kehoe, P., Paton, J. & Love, S., 19 Jun 2019, (Submitted) In : Journal of Alzheimer's Disease.

    Research output: Contribution to journalArticle (Academic Journal)