Projects per year
Personal profile
Research interests
We are interested in how and why proteins, peptides and other macromolecules assemble into condensed phases such as crystals, amorphous aggregates, gels and fibers. We aim to understand how inter-molecular protein-protein interactions relate to the assembly process. We are particularly interested in how anisotropic protein-protein interactions direct protein assembly. We use protein phase diagrams to measure and understand this behaviour. We are also interested in the rational design of protein based materials, in the mechanical properties of protein gels and tissues and in the formulation and stability of proteins.
Current projects include, liquid-liquid phase separation of proteins, membrane protein crystallization, peptide assembly and protein formulation and stability
External positions
Visiting Associate Professor, School of Chemical and Bioprocess Engineering, University College Dublin
1 Sept 2020 → …
Keywords
- Soft Matter
- Biological Physics
- Protein and Peptide Self-Assembly
- Bottom-up Synthetic Biology
- Cavitation Rheology
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Projects
- 2 Finished
Research output
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Assembling membraneless organelles from de novo designed proteins
Hilditch, A., Romanyuk, A., Cross, S., Obexer, R. J., McManus, J. & Woolfson, D. N., 18 Apr 2023, (E-pub ahead of print) In: bioRxiv.Research output: Contribution to journal › Article (Academic Journal)
File36 Downloads (Pure) -
Polymorphic protein phase transitions driven by surface anisotropy
Strofaldi, A., Quinn, M. K., Seddon, A. M. & McManus, J. J., 7 Jan 2023, In: Journal of Chemical Physics. 158, 1, 014905.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Design Rules for Antibody Delivery by Self-Assembled Block-Copolyelectrolyte Nanocapsules
Javan Nikkhah, S., Cazade, P. A., McManus, J. J. & Thompson, D., 12 Apr 2022, In: Macromolecules. 55, 7, p. 2383-2397 15 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
3 Citations (Scopus)