Projects per year
Personal profile
Research interests
We are interested in how and why proteins, peptides and other macromolecules assemble into condensed phases such as crystals, amorphous aggregates, gels and fibers. We aim to understand how inter-molecular protein-protein interactions relate to the assembly process. We are particularly interested in how anisotropic protein-protein interactions direct protein assembly. We use protein phase diagrams to measure and understand this behaviour. We are also interested in the rational design of protein based materials, in the mechanical properties of protein gels and tissues and in the formulation and stability of proteins.
Current projects include, liquid-liquid phase separation of proteins, membrane protein crystallization, peptide assembly and protein formulation and stability
External positions
Visiting Associate Professor, School of Chemical and Bioprocess Engineering, University College Dublin
1 Sep 2020 → …
Keywords
- Soft Matter
- Biological Physics
- Protein and Peptide Self-Assembly
- Bottom-up Synthetic Biology
- Cavitation Rheology
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Network
Projects
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Research output
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Squaramide-Based Self-Associating Amphiphiles for Anion Recognition
McManus, J., 5 Aug 2021, In: Chempluschem. 86, 8, p. 1058-1068Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Surface Exposed Free Cysteine Suppresses Crystallization of Human GammaD-Crystallin
McManus, J., 1 Oct 2021, In: Journal of Molecular Biology. 433, 22, 167252.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Effect of reducing daily herbage allowance during early lactation on composition and processing characteristics of milk from spring-calved herds
Gulati, A., Galvin, N., Kennedy, E., Lewis, E., McManus, J. J., Fenelon, M. A. & Guinee, T. P., May 2020, In: International Dairy Journal. 92, p. 69-76 8 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
5 Citations (Scopus)