Personal profile
Research interests
We are interested in how and why proteins, peptides and other macromolecules assemble into condensed phases such as crystals, amorphous aggregates, gels and fibers. We aim to understand how inter-molecular protein-protein interactions relate to the assembly process. We are particularly interested in how anisotropic protein-protein interactions direct protein assembly. We use protein phase diagrams to measure and understand this behaviour. We are also interested in the rational design of protein based materials, in the mechanical properties of protein gels and tissues and in the formulation and stability of proteins.
Current projects include, liquid-liquid phase separation of proteins, membrane protein crystallization, peptide assembly and protein formulation and stability
External positions
Visiting Associate Professor, School of Chemical and Bioprocess Engineering, University College Dublin
1 Sept 2020 → …
Research Groups and Themes
- Quantum & Soft Matter
Keywords
- Soft Matter
- Biological Physics
- Protein and Peptide Self-Assembly
- Bottom-up Synthetic Biology
- Cavitation Rheology
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Research output
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Correction to “Synthetic T-Cell Receptor-like Protein Behaves as a Janus Particle in Solution”
Sakamoto-Rablah, E., Bye, J., Modak, A., Hooker, A., Uddin, S. & McManus, J. J., 25 Feb 2026, In: Journal of the American Chemical Society. 148, 7, p. 8019–8020 2 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access -
Engineering the ADDomer Nanoparticle Vaccine Scaffold for Improved Assembly and Enhanced Stability
Balchin, G., Kabasakal, B. V., Strofaldi, A., Hall, S., Fletcher, C., Buzas, D., Bufton, J. C., Yadav, S. K. N., Shen, D., Garzoni, F., Bunzel, H. A., McManus, J. J., Schaffitzel, C. & Berger, I., 16 Mar 2026, In: ACS Synthetic Biology. 15, 4, p. 1340-1352 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Assembling membraneless organelles from de novo designed proteins
Hilditch, A. T., Romanyuk, A., Cross, S. J., Obexer, R., McManus, J. J. & Woolfson, D. N., 1 Jan 2024, In: Nature Chemistry. 16, 1, p. 89-97 9 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access51 Citations (Scopus)56 Downloads (Pure)
Projects
- 2 Finished
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BBSRC International Institutional Award 2022 _ McManus
McManus, J. (Principal Investigator)
1/11/22 → 31/03/23
Project: Research
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Datasets
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Data associated with the publication "Assembling membraneless organelles from de novo designed proteins", v3
Hilditch, A. T. (Creator), Romanyuk, A. (Creator), Cross, S. J. (Creator), Obexer, R. (Creator), McManus, J. J. (Creator) & Woolfson, D. N. (Creator), Zenodo, 15 Oct 2022
DOI: 10.5281/zenodo.7878607, https://zenodo.org/record/7878607
Dataset
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Data associated with the publication "Assembling membraneless organelles from de novo designed proteins", v2
Hilditch, A. T. (Creator), Romanyuk, A. (Creator), Cross, S. J. (Creator), Obexer, R. (Creator), McManus, J. J. (Creator) & Woolfson, D. N. (Creator), Zenodo, 15 Oct 2022
DOI: 10.5281/zenodo.7688563, https://zenodo.org/record/7688563
Dataset
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Data associated with the publication "Assembling membraneless organelles from de novo designed proteins", v1
Hilditch, A. T. (Creator), Romanyuk, A. (Creator), Cross, S. J. (Creator), Obexer, R. (Creator), McManus, J. J. (Creator) & Woolfson, D. N. (Creator), Zenodo, 15 Oct 2022
DOI: 10.5281/zenodo.7199036, https://zenodo.org/record/7199036
Dataset