Projects per year
Understanding the processes that dictate the distribution, maintenance and dynamics of neurotransmitter receptors is of fundamental importance to the molecular basis of fast excitatory transmission, synaptic plasticity and brain function.
The Henley lab is interested in the mechanisms by which neurotransmitter receptors are targeted to, retained at and removed from synapses under normal, stimulated and disease conditions. Receptors share common biosynthetic and endocytic pathways but important specific differences allow selective regulation.
Increased understanding of the mechanisms of these processes will give important insights into synapse formation, stabilisation and plasticity and thus into the cellular mechanisms underlying learning and memory and some neurodegenerative diseases.
In particular we focus on the roles of posttranslational modifications, such as SUMOylation, and protein-protein interactions at AMPA and kainate receptors.
To address these questions we use a wide range of molecular, biochemical, cell biology and imaging techniques including the use of viral transduction and fluorophore protein tagging technology to visualise the dynamics of receptor movement in living neurones in real time.
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1/07/18 → 30/06/23
30/06/22 → 29/06/26
2/07/18 → 31/01/20
AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic ToneWalz, R. & et al., 6 Jan 2021, In: Molecular Neurobiology. 58, 4, p. 1859-1870 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review1 Citation (Scopus)
Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and DegenerationNeeds, H. I. I., Protasoni, M., Henley, J. M., Prudent, J., Collinson, I. R. & C. Pereira, G., 11 May 2021, In: Life. 11, 5, 44 p., 432.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile2 Citations (Scopus)32 Downloads (Pure)
Henley, J. M., Nair, J. D., Seager, R., Yucel, B. P., Woodhall, G., Henley, B. S., Talandyte, K., Needs, H. I. & Wilkinson, K. A., 3 Jul 2021, In: Neuropharmacology. 195, 108569.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile3 Downloads (Pure)