Projects per year
Personal profile
Research interests
Understanding the processes that dictate the distribution, maintenance and dynamics of neurotransmitter receptors is of fundamental importance to the molecular basis of fast excitatory transmission, synaptic plasticity and brain function.
The Henley lab is interested in the mechanisms by which neurotransmitter receptors are targeted to, retained at and removed from synapses under normal, stimulated and disease conditions. Receptors share common biosynthetic and endocytic pathways but important specific differences allow selective regulation.
Increased understanding of the mechanisms of these processes will give important insights into synapse formation, stabilisation and plasticity and thus into the cellular mechanisms underlying learning and memory and some neurodegenerative diseases.
In particular we focus on the roles of posttranslational modifications, such as SUMOylation, and protein-protein interactions at AMPA and kainate receptors.
To address these questions we use a wide range of molecular, biochemical, cell biology and imaging techniques including the use of viral transduction and fluorophore protein tagging technology to visualise the dynamics of receptor movement in living neurones in real time.
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Network
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Understanding the roles of SUMO proteases in neuronal function and viability
1/07/18 → 30/06/23
Project: Research
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FRANCE: Molecular and cellular regulation of the endocannabinoid system
30/06/22 → 29/06/26
Project: Research
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Research output
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AMPAr GluA1 Phosphorylation at Serine 845 in Limbic System Is Associated with Cardiac Autonomic Tone
Walz, R. & et al., 6 Jan 2021, In: Molecular Neurobiology. 58, 4, p. 1859-1870 12 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
1 Citation (Scopus) -
Interplay between Mitochondrial Protein Import and Respiratory Complexes Assembly in Neuronal Health and Degeneration
Needs, H. I. I., Protasoni, M., Henley, J. M., Prudent, J., Collinson, I. R. & C. Pereira, G., 11 May 2021, In: Life. 11, 5, 44 p., 432.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile2 Citations (Scopus)32 Downloads (Pure) -
Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk
Henley, J. M., Nair, J. D., Seager, R., Yucel, B. P., Woodhall, G., Henley, B. S., Talandyte, K., Needs, H. I. & Wilkinson, K. A., 3 Jul 2021, In: Neuropharmacology. 195, 108569.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile3 Downloads (Pure)