Projects per year
Personal profile
Research interests
Understanding the processes that dictate the distribution, maintenance and dynamics of neurotransmitter receptors is of fundamental importance to the molecular basis of fast excitatory transmission, synaptic plasticity and brain function.
The Henley lab is interested in the mechanisms by which neurotransmitter receptors are targeted to, retained at and removed from synapses under normal, stimulated and disease conditions. Receptors share common biosynthetic and endocytic pathways but important specific differences allow selective regulation.
Increased understanding of the mechanisms of these processes will give important insights into synapse formation, stabilisation and plasticity and thus into the cellular mechanisms underlying learning and memory and some neurodegenerative diseases.
In particular we focus on the roles of posttranslational modifications, such as SUMOylation, and protein-protein interactions at AMPA and kainate receptors.
To address these questions we use a wide range of molecular, biochemical, cell biology and imaging techniques including the use of viral transduction and fluorophore protein tagging technology to visualise the dynamics of receptor movement in living neurones in real time.
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Projects
Understanding the roles of SUMO proteases in neuronal function and viability
1/07/18 → 30/06/23
Project: Research
Targets and mechanisms of SUMOylation-mediated cardioprotection during ischemia and reperfusion injury
1/04/15 → 3/10/19
Project: Research
Research Output
Endocytosis, trafficking and exocytosis of intact full-length Botulinum neurotoxin type A in cultured rat neurons
Solabre Valois, L., Wilkinson, K. A., Nakamura, Y. & Henley, J. M., 20 Feb 2020, In : NeuroToxicology. 78 (2020), p. 80-87 8 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Guanosine modulates SUMO2/3-ylation in neurons and astrocytes via adenosine receptors.
Zanella, C. A., Henley, J. M., Wilkinson, K. A., Cimarosti, H. I. & Tasca, C. I., 5 Sep 2020, In : Purinergic Signalling. (2020), 12 p.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia
C. Pereira, G., Lee, L. J., Rawlings, N., Ouwendijk, J., Parker, J. E., Andrienko, T. N., Henley, J. M. & Halestrap, A. P., 24 Jun 2020, In : PLoS ONE. 15, 6, 29 p., e0234653.Research output: Contribution to journal › Article (Academic Journal)
Open Access
File
Supervised Work
Expression, Distribution, and Trafficking of Pore-Forming and Auxiliary Subunits of Kainate Receptors
Author: Al Momany, E., 28 Nov 2019Supervisor: Molnar, E. (Supervisor) & Henley, J. M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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Investigating the role of SUMOylation of Mitochondrial Fission Factor in Mitochondrial Dynamics
Author: Seager, R. A., 23 Jan 2020Supervisor: Henley, J. M. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
File
Kainate Receptors in various forms of plasticity
Author: Gurung, S., 23 Jan 2019Supervisor: Henley, J. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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