1991 …2020

Research output per year

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Article (Academic Journal)
2020

TBC1D1 INTERACTING PROTEINS, VPS13A AND VPS13C, REGULATE GLUT4 HOMEOSTASIS IN C2C12 MYOTUBES

Hook, S. C., Chadt, A., Heesom, K. J., Kishida, S., Al-Hasani, H., Tavare, J. M. & Thomas, E. C., 7 Sep 2020, (Accepted/In press) In : Scientific Reports.

Research output: Contribution to journalArticle (Academic Journal)

2019

Tumor growth suppression using a combination of taxol-based therapy and GSK3 inhibition in non-small cell lung cancer

O'Flaherty, L., Shnyder, S. D., Cooper, P. A., Cross, S. J., Wakefield, J., Pardo, O. E., Seckl, M. J. & Tavare, J., 10 Apr 2019, In : PLoS ONE. 14, 4, p. e0214610 7 p., e0214610.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
193 Downloads (Pure)
2018

Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

Thomas, E., Hook, S. C., Grey, A., Chadt, A., Carling, D., Al-Hasani, H., Heesom, K. J., Hardie, G. & Tavare, J., Sep 2018, In : Biochemical Journal. 475, 18, p. 2969-2983 15 p., 475.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
256 Downloads (Pure)
2016

Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event

Boal, F., Hodgson, L. R., Reed, S. E., Yarwood, S. E., Just, V. J., Stephens, D. J., McCaffrey, M. W. & Tavaré, J. M., Jan 2016, In : Cellular Signalling. 28, 1, p. 74-82 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
235 Downloads (Pure)
2015

Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal

Chen, M. Z., Hudson, C. A., Vincent, E. E., De Berker, D. A. R., May, M. T., Hers, I., Dayan, C. M., Andrews, R. C. & Tavare, J. M., 13 Apr 2015, In : PLoS ONE. 10, 4, e0120084.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

Vincent, E. E., Sergushichev, A., Griss, T., Gingras, M. C., Samborska, B., Ntimbane, T., Coelho, P. P., Blagih, J., Raissi, T. C., Choinière, L., Bridon, G., Loginicheva, E., Flynn, B. R., Thomas, E. C., Tavaré, J. M., Avizonis, D., Pause, A., Elder, D. J. E., Artyomov, M. N. & Jones, R. G., 15 Oct 2015, In : Molecular Cell. 60, 2, p. 195-207 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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98 Citations (Scopus)
340 Downloads (Pure)
2014
11 Citations (Scopus)

Evaluating the role of a galanin enhancer genotype on a range of metabolic, depressive and additive phenotypes

Richardson, T. G., Minica, C., Heron, J., Tavare, J., MacKenzie, A., Day, I., Lewis, G., Hickman, M., Vink, J. M., Gelernter, J., Kranzler, H. R., Farrer, L. A., Munafò, M. & Wynick, D., 16 Sep 2014, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3

Stergiakouli, E., Gaillard, R., Tavaré, J. M., Balthasar, N., Loos, R. J., Taal, H. R., Evans, D. M., Rivadeneira, F., St Pourcain, B., Uitterlinden, A. G., Kemp, J. P., Hofman, A., Ring, S. M., Cole, T. J., Jaddoe, V. W. V., Davey Smith, G. & Timpson, N. J., 21 Jul 2014, In : Obesity.

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Glycogen synthase kinase 3 protein kinase activity is frequently elevated in human non-small cell lung carcinoma and supports tumour cell proliferation

Vincent, E. E., Elder, D. J. E., O Flaherty, L., Pardo, O. E., Dzien, P., Phillips, L., Morgan, C., Pawade, J., May, M. T., Sohail, M., Hetzel, M. R., Seckl, M. J. & Tavaré, J. M., 8 Dec 2014, In : PLoS ONE. 9, 12, p. e114725

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)
2013

A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.

Steinberg, F., Gallon, M. J., Winfield, M. O., Thomas, E. C., Bell, A. J., Heesom, K. J., Tavare, J. M. & Cullen, P. J., May 2013, In : Nature Cell Biology. 15, 5, p. 461-471 11 p.

Research output: Contribution to journalArticle (Academic Journal)

239 Citations (Scopus)

A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes

Reed, S. E., Hodgson, L. R., Song, S., May, M. T., Kelly, E. E., McCaffrey, M. W., Mastick, C. C., Verkade, P. & Tavaré, J. M., 1 May 2013, In : Journal of Cell Science. 126, 9, p. 1931-1941 11 p.

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle

Liu, Y., Lai, Y-C., Hill, E. V., Tyteca, D., Carpentier, S., Ingvaldsen, A., Vertommen, D., Lantier, L., Foretz, M., Dequiedt, F., Courtoy, P. J., Erneux, C., Viollet, B., Shepherd, P. R., Tavare, J. M., Jensen, J. & Rider, M. H., 1 Aug 2013, In : Biochemical Journal.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Structural and population-based evaluations of TBC1D1 p.Arg125Trp

Richardson, T. G., Thomas, E. C., Sessions, R. B., Lawlor, D. A., Tavaré, J. M. & Day, I. N. M., 2013, In : PLoS ONE. 8, 5, p. e63897

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Targeting non-small cell lung cancer cells by dual inhibition of the insulin receptor and the insulin-like growth factor-1 receptor

Vincent, E. E., Elder, D. J. E., Curwen, J., Kilgour, E., Hers, I. & Tavaré, J. M., 2013, In : PLoS ONE. 8, 6, p. e66963

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)
2012

Altered stress stimulation of inward rectifier potassium channels in Andersen-Tawil syndrome

Seebohm, G., Strutz-Seebohm, N., Ursu, O. N., Preisig-Müller, R., Zuzarte, M., Hill, E. V., Kienitz, M-C., Bendahhou, S., Fauler, M., Tapken, D., Decher, N., Collins, A., Jurkat-Rott, K., Steinmeyer, K., Lehmann-Horn, F., Daut, J., Tavaré, J. M., Pott, L., Bloch, W. & Lang, F., Feb 2012, In : FASEB Journal. 26, 2, p. 513 - 522 10 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Bariatric surgery in morbidly-obese insulin resistant humans normalizes insulin signaling but not insulin-stimulated glucose disposal

Chen, MZ., Hudson, CA., Vincent, EE., de Berker, D., May, M., Hers, I., Dayan, CM., Andrews, RC. & Tavaré, JM., 2012, (In preparation) In : Diabetes.

Research output: Contribution to journalArticle (Academic Journal)

Identification of a novel signaling pathway and its relevance for GluA1 recycling

Seebohm, G., Neumann, S., Theiss, C., Novkovic, T., Hill, E. V., Tavaré, J. M., Lang, F., Hollmann, M., Manahan-Vaughan, D. & Strutz-Seebohm, N., 2012, In : PLoS ONE. 7, 3, p. e33889

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
2011

Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

Vincent, E. E., Elder, D. J. E., Thomas, E. C., Phillips, L., Morgan, C., Pawade, J., Sohail, M., May, M. T., Hetzel, M. R. & Tavaré, J. M., 19 Apr 2011, In : British Journal of Cancer. 104 , 11, p. 1755 - 1761 7 p.

Research output: Contribution to journalArticle (Academic Journal)

109 Citations (Scopus)

Akt signalling in health and disease

Hers, I., Vincent, EE. & Tavaré, JM., Oct 2011, In : Cellular Signalling. 23 (10), p. 1515 - 1527 13 p.

Research output: Contribution to journalArticle (Academic Journal)

631 Citations (Scopus)

Nucleo-cytosolic shuttling of Fox01 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6)

Meur, G., Qian, Q., da Silva Xavier, G., Pullen, TJ., Tsuboi, T., McKinnon, CM., Fletcher, L., Tavaré, JM., Hughes, S., Johnson, P. & Rutter, GA., Apr 2011, In : Journal of Biological Chemistry. 286 (15), p. 13647 - 13657 10 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Overexpression of the TXNDC5 protein in non-small cell lung carcinoma

Vincent, E. E., Elder, D. J. E., Phillips, L., Heesom, K. J., Pawade, J., Luckett, M., Sohail, M., May, M. T., Hetzel, M. R. & Tavaré, J. M., May 2011, In : Anticancer Research. 31, 5, p. 1577 - 1582 6 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)
2010

Insulin signaling to the glomerular podocyte is critical for normal kidney function

Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M., Maezawa, Y., Lennon, R., Pons, D. A., Owen, R. J., Satchell, S. C., Miles, M. J., Caunt, C. J., McArdle, C. A., Pavenstädt, H., Tavaré, J. M., Herzenberg, A. M., Kahn, C. R., Mathieson, P. W., Quaggin, S. E., Saleem, M. A. & Coward, R. J. M., 6 Oct 2010, In : Cell Metabolism. 12, 4, p. 329 - 340 12 p.

Research output: Contribution to journalArticle (Academic Journal)

264 Citations (Scopus)

Regulation of PIKfyve phosphorylation by insulin and osmotic stress

Hill, EV., Hudson, CA., Vertommen, D., Rider, MH. & Tavaré, JM., Jul 2010, In : Biochemical and Biophysical Research Communications. 397 (4), p. 650 - 655 6 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Regulation of the glutamate transporter EAAT4 by PIkfyve

Alesutan, IS., Ureche, ON., Laufer, J., Klaus, F., Zürn, A., Lindner, R., Strutz-Seebohm, N., Tavaré, JM., Boehmer, C., Palmada, M., Lang, UE., Seebohm, G. & Lang, F., Mar 2010, In : Cellular Physiology and Biochemistry. 25 (2-3), p. 187 - 194 8 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)
2009

PIKfyve upregulates CFTR activity

Gehring, E-M., Lam, RS., Siraskar, G., Koutsouki, E., Seebohm, G., Ureche, ON., Ureche, L., Baltaev, R., Tavaré, JM. & Lang, F., Dec 2009, In : Biochemical and Biophysical Research Communications. 390 (3), p. 952 - 957 6 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Regulation of the glutamate transporter EAAT2 by PIKfyve

Gehring, E-M., Zürn, A., Klaus, F., Laufer, J., Sopjani, M., Lindner, R., Strutz-Seebohm, N., Tavaré, JM., Boehmer, C., Palmada, M., Lang, UE., Seebohm, G. & Lang, F., 2009, In : Cellular Physiology and Biochemistry. 24 (5-6), p. 361 - 368 8 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)

Regulation of the Na+-coupled glutamate transporter EAAT3 by PIKfyve

Klaus, F., Gehring, E-M., Zürn, A., Laufer, J., Lindner, R., Strutz-Seebohm, N., Tavaré, JM., Rothstein, JD., Boehmer, C., Palmada, M., Gruner, I., Lang, UE., Seebohm, G. & Lang, F., Jun 2009, In : Neurochemistry International. 54 (5-6), p. 372 - 377 6 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1

Lennon, R., Welsh, G. I., Singh, A., Satchell, S. C., Coward, R. J., Tavaré, J. M., Mathieson, P. W. & Saleem, M. A., Sep 2009, In : Diabetologia. 52, 9, p. 1944 - 1952 9 p.

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy

Lennon, R., Pons, D., Sabin, M. A., Wei, C., Hamilton-Shield, J. P., Coward, R. J., Tavaré, J. M., Mathieson, P. W., Saleem, M. A. & Welsh, G. I., Nov 2009, In : Nephrology Dialysis Transplantation. 24, 11, p. 3288 - 3296 9 p.

Research output: Contribution to journalArticle (Academic Journal)

102 Citations (Scopus)

The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets

Leney, SE. & Tavaré, JM., Oct 2009, In : Journal of Endocrinology. 203 (1), p. 1 - 18 18 p.

Research output: Contribution to journalArticle (Academic Journal)

107 Citations (Scopus)
2008

Long QT syndrome - associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channels

Seebohm, G., Strutz-Seebohm, N., Ureche, O. N., Henrion, U., Baltaev, R., Mack, A. F., Korniychuk, G., Steinke, K., Tapken, D., Pfeufer, A., Kääb, S., Bucci, C., Attali, B., Merot, J., Tavaré, J. M., Hoppe, U. C., Sanguinetti, M. C. & Lang, F., Dec 2008, In : Circulation Research. 103 , 12, p. 1451 - 1457 7 p.

Research output: Contribution to journalArticle (Academic Journal)

64 Citations (Scopus)
2007

Nephrin is critical for the action of insulin on human glomerular podocytes

Coward, R. J. M., Welsh, G. I., Koziell, A., Hussain, S., Lennon, R., Ni, L., Tavaré, J. M., Mathieson, P. W. & Saleem, M. A., Apr 2007, In : Diabetes. 56, 4, p. 1127 - 1135 9 p.

Research output: Contribution to journalArticle (Academic Journal)

113 Citations (Scopus)

Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels

Seebohm, G., Strutz-Seebohm, N., Birkin, R., Dell, G., Bucci, C., Spinosa, MR., Baltaev, R., Mack, AF., Korniychuk, G., Choudhury, A., Marks, D., Pagano, RE., Attali, B., Pfeufer, A., Kass, RS., Sanguinetti, MC., Tavaré, JM. & Lang, F., Mar 2007, In : Circulation Research. 100 (5), p. 686 - 692 7 p.

Research output: Contribution to journalArticle (Academic Journal)

120 Citations (Scopus)

Regulation of Na+, glucose cotransporter by PIKfyve and the serum and glucocorticoid inducible kinase SGK1

Shojaiefard, M., Strutz-Seebohm, N., Tavaré, JM., Seebohm, G. & Lang, F., Aug 2007, In : Biochemical and Biophysical Research Communications. 359 (4), p. 843 - 847 5 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes

Welsh, GI., Leney, SE., Lloyd-Lewis, B., Wherlock, M., Lindsay, AJ., McCaffrey, MW. & Tavaré, JM., Dec 2007, In : Journal of Cell Science. 120 (23), p. 4197 - 4208 12 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)
2006

Identification of p122RhoGAP (deleted in liver cancer-1) serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells

Hers, I., Wherlock, M., Homma, Y., Yagisawa, H. & Tavaré, JM., Feb 2006, In : Journal of Biological Chemistry. 281 (8), p. 4762 - 4770 9 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Imaging of insulin signaling in skeletal muscle of living mice shows major role of t-tubules

Lauritzen, HPMM., Ploug, T., Prats, C., Tavaré, JM. & Galbo, H., May 2006, In : Diabetes. 55, p. 1300 - 1306 5 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)

Insulin, calcium and the control of mammalian metabolism: Regulation of small GTP-binding proteins by insulin

Welsh, GI., Hers, I., Wherlock, M. & Tavaré, JM., Apr 2006, In : Biochemical Society Transactions. 34 (2), p. 209 - 212 4 p.

Research output: Contribution to journalArticle (Academic Journal)

2005

A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'

Gunn-Moore, FJ., Welsh, GI., Herron, LR., Brannigan, F., Venkateswarlu, K., Gillespie, S., Brandwein-Gensler, M., Madan, R., Tavaré, JM., Brophy, PJ., Prystowsky, MB. & Guild, S., 12 Sep 2005, In : FEBS Letters. 579 (22), p. 5089 - 5094 6 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Mechanism of feedback regulation of insulin receptor substrate-1 phosphorylation in primary adipocytes

Hers, I. & Tavaré, JM., Jun 2005, In : Biochemical Journal. 388 (2), p. 713 - 720 8 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Role of protein kinase B in insulin-regulated glucose uptake

Welsh, GI., Hers, I., Berwick, DC., Dell, G., Wherlock, M., Birkin, R., Leney, S. & Tavaré, JM., 2005, In : Biochemical Society Transactions. 33(2), p. 346 - 349 4 p.

Research output: Contribution to journalArticle (Academic Journal)

102 Citations (Scopus)

Site-specific differences of insulin action in adipose tissue derived from normal prepubertal children

Grohmann, M., Stewart, CE., Welsh, G., Hunt, L. P., Tavare, J. M., Holly, JMP., Hamilton-Shield, J. P., Sabin, M. A. & Crowne, E. C., 15 Aug 2005, In : Experimental Cell Research. 308, 2, p. 469 - 478 10 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

The human glomerular podocyte is a novel target for insulin action

Coward, R. J. M., Welsh, G. I., Yang, J., Tasman, C., Lennon, R., Koziell, A., Satchell, S., Holman, G. D., Kerjaschki, D., Tavaré, J. M., Mathieson, P. W. & Saleem, M. A., Nov 2005, In : Diabetes. 54, 11, p. 3095 - 3102 8 p.

Research output: Contribution to journalArticle (Academic Journal)

193 Citations (Scopus)
2004

Identifying protein kinase substrates: hunting for the organ-grinder's monkeys

Berwick, DC. & Tavaré, JM., 2004, In : Trends in Biochemical Sciences. 29(5), p. 227 - 232 6 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles

Berwick, DC., Dell, GC., Welsh, GI., Heesom, KJ., Hers, I., Fletcher, LM., Cooke, FT. & Tavaré, JM., Dec 2004, In : Journal of Cell Science. 117 (25), p. 5985 - 5993 9 p.

Research output: Contribution to journalArticle (Academic Journal)

111 Citations (Scopus)

Proteome analysis of adipogenesis

Welsh, GI., Griffiths, MR., Webster, KJ., Page, MJ. & Tavaré, JM., Apr 2004, In : Proteomics. 4 (4), p. 1042 - 1051 10 p.

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)
2003

A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

Wakefield, JG., Stephens, DJ. & Tavaré, JM., Feb 2003, In : Journal of Cell Science. 116 (4), p. 637 - 646 10 p.

Research output: Contribution to journalArticle (Academic Journal)

125 Citations (Scopus)
2002

Dual role for mitogen-activated protein kinase (Erk) in insulin-dependent regulation of Fra-1 (fos-related antigen-1) transcription and phosphorylation

Hurd, TW., Culbert, AA., Webster, KJ. & Tavaré, JM., 2002, In : Biochemical Journal. 368, p. 573 - 580

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Functional consequences of targeting protein kinase B/Akt to GLUT4 vesicles

Ducluzeau, P-H., Fletcher, LM., Welsh, GI. & Tavaré, JM., Jul 2002, In : Journal of Cell Science. 115 (14), p. 2857 - 2866 10 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)