Research output per year
Research output per year
Personal profile
Research interests
Professional Focus
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Biomedical scientist specializing in immune and metabolic mechanisms underlying age-related degenerative eye diseases.
Key Discoveries & Innovations
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Led the discovery of IRAK-M as a gene therapy target for atrophic macular degeneration, opening new avenues for treatment.
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Pioneered the therapeutic use of topical trehalose to non-invasively enhance autophagy and preserve retinal health.
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Research published in leading journals, including Science Translational Medicine and Aging Cell.
Research Approach
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Bridge fundamental biology with translational medicine.
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Integrate expertise in immunoaging and therapeutic development.
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Reveal molecular pathways critical to retinal degeneration and propose novel strategies to slow or prevent disease progression.
Service
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PhD student supervisor.
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Grant reviewer for major funding bodies including the MRC and BBSRC.
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Peer reviewer for high-impact journals such as: Signal Transduction & Targeted Therapy, Science Advances, Autophagy, Aging Cell, Molecular Therapy, etc.
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Associate editor with Frontiers in Immunology and Topic editor with Cells.
Keywords
- ageing
- innate immunity
- chronic inflammation
- autophagy
- cellular senescence
- induced pluripotent stem cells
- metabolism
- mitochondria
- macular degeneration
- diabetic retinopathy
- uveitis
- gene therapy
- small molecule therapy
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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Age-Associated Decline in Autophagy Pathways in Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-induced Outer Retinal Degeneration in Mice
Cox, K., Shi, G., Read, N., Ou, K., Liu, Z., Wu, J., Cendanawati, S., Powell, J. L. B., Nicholson, L., Dick, A. D. & Liu, J., 18 Jan 2025Research output: Other contribution
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Age-Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light-Induced Outer Retinal Degeneration in Mice
Cox, K., Shi, G., Read, N., Patel, M. T., Ou, K., Liu, Z., Wu, J., Cendanawati, S., Le Brun Powell, J., Oppenheimer, P. G., Hill, L. J., Nicholson, L. B., Dick, A. D. & Liu, J., 28 Apr 2025, (E-pub ahead of print) In: Aging Cell. 24, 7, 16 p., e70081.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access -
Marine bromophenols suppressed choroidal neovascularization by targeting HUWE1 through NF-κb signaling pathway
Ou, K., Li, Y., Wang, Y., Liu, J., Luo, Y., Jiang, J., Dan, J., Tang, D., Chen, Z. & Wu, J., 1 Feb 2024, In: International Journal of Biological Macromolecules. 257, Part 1, 128620.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access2 Citations (Scopus)
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Combination therapy for dry AMD: targeting systemic and local inflammation synergistically with oral metformin and subretinal IRAK3 gene delivery
Liu, J. (Principal Investigator)
6/01/25 → 5/01/26
Project: Research
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Regulating systemic and local inflammation to shape high-fat diet-altered neuroretinal immune privilege
Liu, J. (Principal Investigator)
5/02/24 → 4/02/28
Project: Research
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A novel dual-target gene therapy for safe and efficacious treatment of chronic non-infectious uveitis
Liu, J. (Co-Investigator)
1/02/24 → 1/02/26
Project: Research
Datasets
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Data from: Fossil embryos from the Middle and Late Cambrian period of Hunan, south China
Dong, X.-P. (Contributor), Donoghue, P. C. J. (Contributor), Cheng, H. (Contributor) & Liu, J.-B. (Contributor), Dryad, 30 Oct 2012
DOI: 10.5061/dryad.f3050, http://datadryad.org/stash/dataset/doi:10.5061/dryad.f3050
Dataset
Activities
- 1 Participation in workshop, seminar, course
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Global Sustainable Farming Systems Workshop
Liu, J. (Participant)
28 May 2013 → 29 May 2013Activity: Participating in or organising an event types › Participation in workshop, seminar, course