20132020

Research output per year

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Research Output

  • 34 Article (Academic Journal)
  • 1 Conference Abstract
  • 1 Letter (Academic Journal)
2020
Open Access
File
72 Downloads (Pure)

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

Cho, Y., Haycock, P. C., Sanderson, E., Gaunt, T. R., Zheng, J., Morris, A. P., Davey Smith, G. & Hemani, G., 21 Feb 2020, In : Nature Communications. 11, 13 p., 1010 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
64 Downloads (Pure)

Introducing M-GCTA a Software Package to Estimate Maternal (or Paternal) Genetic Effects on Offspring Phenotypes

Qiao, Z., Zheng, J., Helgeland, Ø., Vaudel, M., Johansson, S., Njølstad, P. R., Smith, G. D., Warrington, N. M. & Evans, D. M., 1 Jan 2020, In : Behavior Genetics. 50, p. 51-66 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
40 Downloads (Pure)
Open Access
File
41 Downloads (Pure)

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases

Zheng, J., Haberland, V., Baird, D. A., Walker, V. M., Haycock, P. C., Hurle, M. R., Gutteridge, A., Erola, P., Liu, Y., Luo, S., Robinson, J. W., Richardson, T. G., Staley, J. R., Elsworth, B. L., Burgess, S., Sun, B. B., Danesh, J., Runz, H., Maranville, J. C., Martin, H. M. & 14 others, Yarmolinsky, J., Laurin, C. A., Holmes, M. V., Liu, J. Z., Estrada, K., Santos, R., McCarthy, L., Waterworth, D., Nelson, M. R., Davey Smith, G., Butterworth, A. S., Hemani, G., Scott, R. A. & Gaunt, T. R., 7 Sep 2020, In : Nature Genetics.

Research output: Contribution to journalArticle (Academic Journal)

Testing for causality between systematically identified risk factors and glioma: A Mendelian randomization study

Howell, A. E., Robinson, J. W., Wootton, R. E., McAleenan, A., Tsavachidis, S., Ostrom, Q. T., Bondy, M., Armstrong, G., Relton, C., Haycock, P., Martin, R. M., Zheng, J. & Kurian, K. M., 3 Jun 2020, In : BMC Cancer. (2020) 20, 508, 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
24 Downloads (Pure)

The effect of plasma lipids and lipid lowering interventions on bone mineral density: a Mendelian randomization study

Zheng, J., Brion, M-J. A., Kemp, J. P., Warrington, N. M., Borges, M. C., Hemani, G., Richardson, T. G., Rasheed, H., Qiao, Z., Haycock, P. C., Ala-Korpela, M. J., Davey Smith, G., Tobias, J. H. & Evans, D. M., 12 Mar 2020, In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle (Academic Journal)

2019
Open Access
File
5 Citations (Scopus)
46 Downloads (Pure)

Appraising the role of previously reported risk factors in epithelial ovarian cancer risk: A Mendelian randomization analysis

Yarmolinsky, J., Relton, C. L., Lophatananon, A., Muir, K., Menon, U., Gentry-Maharaj, A., Walther, A., Zheng, J., Fasching, P., Zheng, W., Yin Ling, W., Park, S. K., Kim, B-G., Choi, J-Y., Park, B., Davey Smith, G., Martin, R. M. & Lewis, S. J., 7 Aug 2019, In : PLoS Medicine. 16, 8, 22 p., e1002893.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
10 Citations (Scopus)
141 Downloads (Pure)

Association of Maternal Neurodevelopmental Risk Alleles With Early-Life Exposures

Leppert, B., Havdahl, K. A., Riglin, L., Jones, H., Zheng, J., Davey Smith, G., Tilling, K., Thapar, A., Reichborn-Kjennerud, T. & Stergiakouli, E., 1 May 2019, In : JAMA Psychiatry. 76, 8, p. 834-842 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
340 Downloads (Pure)

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

Adams, C., Richmond, R. C., Santos Ferreira, D. L. D., Spiller, W., Tan, V. Y., Zheng, J., Wurtz, P., Donovan, J. L., Hamdy, F. C., Neal, D. E., Lane, J. A., Davey Smith, G., Relton, C. L., Eeles, R. A., Henderson, B. E., Haiman, C. A., Kote-Jarai, Z., Schumacher, F. R., Amin Al Olama, A., Benlloch, S. & 57 others, Muir, K., Berndt, S. I., Conti, D. V., Wiklund, F., Chanock, S. J., Gapstur, S. M., Stevens, V. L., Tangen, C. M., Batra, J., Clements, J. A., Grönberg, H., Pashayan, N., Schleutker, J., Albanes, D., Wolk, A., West, C. M. L., Mucci, L. A., Cancel-Tassin, G., Koutros, S., Sørensen, K. D., Maehle, L., Travis, R. C., Hamilton, R., Ingles, S. A., Rosenstein, B. S., Lu, Y-J., Giles, G. G., Kibel, A. S., Vega, A., Kogevinas, M., Penney, K. L., Park, J. Y., Stanford, J. L., Cybulski, C., Nordestgaard, B. G., Brenner, H., Maier, C., Kim, J., John, E. M., Teixeira, M. R., Neuhausen, S. L., DeRuyck, K., Razack, A., Newcomb, L. F., Lessel, D., Kaneva, R. P., Usmani, N., Claessens, F., Townsend, P., Gago Dominguez, M., Roobol, M. J., Menegaux, F., Khaw, K-T., Cannon-Albright, L. A., Pandha, H., Thibodeau, S. N. & Martin, R. M., Jan 2019, In : Cancer Epidemiology, Biomarkers and Prevention. 28, 1, p. 208-216 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
248 Downloads (Pure)

Genome-wide analyses using UK biobank data povide new therapeutic targets for osteoarthritis

Hatzikotoulas, K., Tachmazidou, I., Southam, L., Esparza-Gordillo, J., Haberland, V., Zheng, J., Johnson, T., Koprulu, M., Zengini, E., Steinberg, J., Wilkinson, J., Bhatnagar, S., Hoffman, J. D., Buchan, N., Suveges, D., Yerges-Armstrong, L. M., Davey Smith, G., Gaunt, T., Scott, R., McCarthy, L. C. & 1 others, Zeggini, E., Apr 2019.

Research output: Contribution to conferenceConference Abstract

Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data

arcOGEN Consortium, 1 Feb 2019, In : Nature Genetics. 51, 2, p. 230-236 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
48 Citations (Scopus)
154 Downloads (Pure)

Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures

Zheng, J., Maerz, W., Gergei, I., Kleber, M., Drechsler, C., Wanner, C., Brandenburg, V., Reppe, S., Gautvik, K. M., Medina-Gomez, C., Shevroja, E., Gilly, A., Park, Y-C., Dedoussis, G. V., Zeggini, E., Lorentzon, M., Henning, P., Lerner, U. H., Nilsson, K., Moverare-Skrtic, S. & 10 others, Baird, D. A., Elsworth, B. L., Falk, L., Groom, A., Capellini, T. D., Grundberg, E., Nethander, M., Ohlsson, C., Davey Smith, G. & Tobias, J. H., 2 Aug 2019, In : Journal of Bone and Mineral Research. 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
171 Downloads (Pure)

Mendelian Randomization for Nutritional Psychiatry

Carnegie, R., Zheng, J., Sallis, H. M., Jones, H. J., Wade, K. H., Zammit, S., Evans, J., Zammit, S., Munafò, M. R. & Martin, R. M., 20 Nov 2019, In : Lancet Psychiatry. 7, 2, p. 208-216 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
20 Downloads (Pure)

MR-TRYX: Exploiting horizontal pleiotropy to infer novel causal pathways

Cho, Y., Haycock, P., Gaunt, T., Zheng, J., Morris, A. P., Davey Smith, G. & Hemani, G., 2019, (Submitted) In : Nature Communications.

Research output: Contribution to journalArticle (Academic Journal)

Use of Mendelian Randomization to examine causal inference in osteoporosis

Zheng, J., Frysz, M., Kemp, J. P., Evans, D., Davey Smith, G. & Tobias, J. H., 21 Nov 2019, In : Frontiers in Endocrinology. 10, 15 p., 807.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
151 Downloads (Pure)
Open Access
File
3 Citations (Scopus)
192 Downloads (Pure)
Open Access
File
1 Citation (Scopus)
229 Downloads (Pure)
2018

PhenoSpD: an integrated toolkit for phenotypic correlation estimation and multiple testing correction using GWAS summary statistics

Zheng, J., Richardson, T., Millard, L., Hemani, G., Elsworth, B., Raistrick, C., Vilhjalmsson, B., Neale, B. M., Haycock, P., Davey Smith, G. & Gaunt, T., Aug 2018, In : GigaScience. 7, 8, 10 p., giy090.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
225 Downloads (Pure)
Open Access
File
19 Citations (Scopus)
196 Downloads (Pure)

The MR-Base platform supports systematic causal inference across the human phenome

Hemani, G., Zheng, J., Elsworth, B., Wade, K., Haberland, V., Baird, D., Laurin, C., Burgess, S., Bowden, J., Langdon, R., Tan, V., Yarmolinsky, J., Shihab, H., Timpson, N., Evans, D., Relton, C., Martin, R., Davey Smith, G., Gaunt, T. & Haycock, P., 30 May 2018, In : eLife. 7, 29 p., e34408.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
321 Citations (Scopus)
340 Downloads (Pure)

Use of Mendelian Randomization for Identifying Risk Factors for Brain Tumors

Howell, A., Zheng, J., Haycock, P., McAleenan, A., Relton, C., Martin, R. & Kurian, K., 12 Nov 2018, In : Frontiers in Genetics. 9, 13 p., 525.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
211 Downloads (Pure)
2017

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study

Haycock, P. C., Burgess, S., Nounu, A., Zheng, J., Okoli, G. N., Bowden, J., Wade, K. H., Timpson, N. J., Evans, D. M., Willeit, P., Aviv, A., Gaunt, T. R., Hemani, G., Mangino, M., Ellis, H. P., Kurian, K. M., Pooley, K. A., Eeles, R. A., Lee, J. E., Fang, S. & 31 others, Chen, W. V., Law, M. H., Bowdler, L. M., Iles, M. M., Yang, Q., Worrall, B. B., Markus, H. S., Hung, R. J., Amos, C. I., Spurdle, A. B., Thompson, D. J., O'Mara, T. A., Wolpin, B., Amundadottir, L., Stolzenberg-Solomon, R., Trichopoulou, A., Onland-Moret, N. C., Lund, E., Duell, E. J., Canzian, F., Severi, G., Overvad, K., Gunter, M. J., Tumino, R., Brennan, P., Paternoster, L., Soranzo, N., Relton, C. L., Martin, R. M., Davey Smith, G. & Telomeres Mendelian Randomization Collaboration, May 2017, In : JAMA Oncology. 3, 5, p. 636-651 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
150 Citations (Scopus)
213 Downloads (Pure)

Epigenome-wide Association of DNA Methylation in Whole Blood With Bone Mineral Density

Morris, J. A., Tsai, P-C., Joehanes, R., Zheng, J., Trajanoska, K., Soerensen, M., Forgetta, V., Castillo-Fernandez, J. E., Frost, M., Spector, T. D., Christensen, K., Christiansen, L., Rivadeneira, F., Tobias, J. H., Evans, D. M., Kiel, D. P., Hsu, Y-H., Richards, J. B. & Bell, J. T., 9 Aug 2017, In : Journal of Bone and Mineral Research. 32, 8, p. 1644-1650 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
20 Citations (Scopus)
219 Downloads (Pure)

HAPRAP: a haplotype-based iterative method for statistical fine mapping using GWAS summary statistics

Zheng, J., Rodriguez, S., Laurin, C., Baird, D., Trela-Larsen, L., Erzurumluoglu, M., Zheng, Y., White, J., Giambartolomei, C., Zabaneh, D., Morris, R., Kumari, M., Casas, J-P., Hingorani, A. D., Evans, D., Gaunt, T. & Day, I., Jan 2017, In : Bioinformatics. 33, 1, p. 79-86 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
243 Downloads (Pure)

Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis

Kemp, J. P., Medina-Gomez, C., Forgetta, V., Warrington, N. M., Youlten, S. E., Zheng, J., Gregson, C. L., Grundberg, E., Trajanoska, K., Logan, J. G., Pollard, A. S., Sparkes, P. C., Ghirardello, E. J., Leitch, V. D., Butterfield, N. C., Komla-Ebri, D., Adoum, A-T., Curry, K. F., White, J. K., Kussy, F. & 14 others, Greenlaw, K. M., Xu, C., Harvey, N. C., Cooper, C., Greenwood, C. M. T., Maurano, M. T., Kaptoge, S., Rivadeneira, F., Tobias, J. H., Croucher, P. I., Ackert-Bicknell, C. L., Bassett, J. H. D., Richards, J. B. & Evans, D. M., 1 Oct 2017, In : Nature Genetics. 49, p. 1468–1475 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
124 Citations (Scopus)
942 Downloads (Pure)

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

Zheng, J., Erzurumluoglu, M., Elsworth, B., Howe, L., Haycock, P., Hemani, G., Tansey, K., Laurin, C., St Pourcain, B., Warrington, N. M., Finucane, H., Price, A. L., Bulik-Sullivan, B., Anttila, V., Paternoster, L., Gaunt, T., Evans, D. & Neale, B. M., 15 Jan 2017, In : Bioinformatics. 33, 2, p. 272-279 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
323 Downloads (Pure)
Open Access
File
26 Citations (Scopus)
199 Downloads (Pure)

Recent developments in mendelian randomization studies

Zheng, J., Baird, D., Borges, C., Bowden, J., Hemani, G., Haycock, P., Evans, D. M. & Davey Smith, G., 22 Nov 2017, In : Current Epidemiology Reports. 4, 4, p. 330–345 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
262 Downloads (Pure)

Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology

Ferreira, M. A., Vonk, J. M., Baurecht, H., Marenholz, I., Tian, C., Hoffman, J. D., Helmer, Q., Tillander, A., Ullemar, V., van Dongen, J., Lu, Y., Rüschendorf, F., Esparza-Gordillo, J., Medway, C. W., Mountjoy, E., Burrows, K., Hummel, O., Grosche, S., Brumpton, B. M., Witte, J. S. & 31 others, Hottenga, J-J., Willemsen, G., Zheng, J., Rodríguez, E., Hotze, M., Franke, A., Revez, J. A., Beesley, J., Matheson, M. C., Dharmage, S. C., Bain, L. M., Fritsche, L. G., Gabrielsen, M. E., Balliu, B., Nielsen, J. B., Zhou, W., Hveem, K., Langhammer, A., Holmen, O. L., Løset, M., Abecasis, G. R., Willer, C. J., Arnold, A., Homuth, G., Schmidt, C. O., Thompson, P. J., Martin, N. G., Duffy, D. L., Lee, Y-A., Paternoster, L. & the 23 and Me Research Team, 30 Oct 2017, In : Nature Genetics. 49, 12, p. 1752-1757 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
127 Citations (Scopus)
488 Downloads (Pure)
2016

Collapsed Methylation Quantitative Trait Loci analysis for Low Frequency and Rare variants

Richardson, T., Shihab, H., Hemani, G., Zheng, J., Hannon, E., Mill, J., Carnero-Montoro, E., Bell, J. T., Lyttleton, O., McArdle, W., Ring, S., Rodriguez, S., Campbell, C., Davey Smith, G., Relton, C., Timpson, N. & Gaunt, T., 1 Oct 2016, In : Human Molecular Genetics. 25, 19, p. 4339-4349 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
363 Downloads (Pure)

Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array

Rodriguez, S., Gaunt, T. R., Guo, Y., Zheng, J., Barnes, M. R., Tang, W., Danish, F., Johnson, A., Castillo, B. A., Li, Y. R., Hakonarson, H., Buxbaum, S. G., Palmer, T., Tsai, M. Y., Lange, L. A., Ebrahim, S., Davey Smith, G., Lawlor, D. A., Folsom, A. R., Hoogeveen, R. & 3 others, Reiner, A., Keating, B. & Day, I. N., Jan 2016, In : European Journal of Human Genetics. 24, 1, p. 106-112 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Citations (Scopus)
416 Downloads (Pure)

Systematic identification of genetic influences on methylation across the human life course

Gaunt, T., Shihab, H., Hemani, G., Min, J., Woodward, G., Lyttleton, O., Zheng, J., Duggirala, A., McArdle, W., Ho, K., Ring, S., Evans, D., Davey Smith, G. & Relton, C., 31 Mar 2016, In : Genome Biology. 17, 14 p., 61.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
255 Downloads (Pure)
2015

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C., Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., Marenholz, I. & 31 others, Kalb, B., Pino-Yanes, M., Xu, C-J., Carstensen, L., Groen-Blokhuis, M. M., Venturini, C., Pennell, C. E., Barton, S. J., Levin, A. M., Curjuric, I., Bustamante, M., Kreiner-Møller, E., Lockett, G. A., Bacelis, J., Bunyavanich, S., Myers, R. A., Matanovic, A., Kumar, A., Tung, J. Y., Hirota, T., Kubo, M., McArdle, W. L., Henderson, A. J., Kemp, J. P., Zheng, J., Smith, G. D., Relton, C. L., Duijts, L., Lee, Y-A., Evans, D. M. & Australian Asthma Genetics Consortium (AAGC), Dec 2015, In : Nature Genetics. 47, 12, p. 1449-1456 8 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
File
223 Citations (Scopus)
343 Downloads (Pure)
2013
4 Citations (Scopus)