Dr Jim Spencer

B.A.(Cantab.), Ph.D.(Bristol)

  • BS8 1TD

19952020

Research output per year

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Research Output

  • 69 Article (Academic Journal)
  • 1 Conference Contribution (Conference Proceeding)
  • 1 Editorial (Academic Journal)
  • 1 Review article (Academic Journal)
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Article (Academic Journal)
2020

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

Tooke, C. L., Hinchliffe, P., Kranjnc, A., Mulholland, A. J., Brem, J., Schofield, C. J. & Spencer, J., 10 Jan 2020, In : Medicinal Chemistry. 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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72 Downloads (Pure)

Discovery of New and Potent InhA Inhibitors as Anti-tuberculosis Agents: Structure Based Virtual Screening Validated by Biological Assays and X-ray Crystallography

Kamsri, P., Hanwarinroj, C., Phusi, N., Pornprom, T., Chayajarus, K., Punkvang, A., Suttipanta, N., Srimanote, P., Suttisintong, K., Songsiriritthigul, C., Saparpakorn, P., Hannongbua, S., Rattanabunyong, S., Seetaha, S., Choowongkomon, K., Sureram, S., Kittakoop, P., Hongmanee, P., Santanirand, P., Chen, Z. & 7 others, Zhu, W., Blood, R. A., Takebayashi, Y., Hinchliffe, P., Mulholland, A. J., Spencer, J. & Pungpo, P., 27 Jan 2020, In : Journal of Chemical Information and Modeling. 60 (2020), 1, p. 226-234 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Mixing and Matching Genes of Marine and Terrestrial Origin in the Biosynthesis of the Mupirocin Antibiotics

Wang, L., Song, Z., Race, P. R., Spencer, J., Simpson, T. J., Crump, M. P. & Willis, C. L., 9 May 2020, In : Chemical Science. 11, p. 5221-5226 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Downloads (Pure)

Resistance to the “Last Resort” Antibiotic Colistin: A Single-Zinc Mechanism for Phosphointermediate Formation in MCR Enzymes

Lythell, E., Suardiaz Del Rio, R., Hinchliffe, P., Hanpaibool, C., Visitsatthawong, S., Oliveira, A. S. F., Lang, E. J. M., Surawatanawong, P., Sanghiran Lee, V., Rungrotmongkol, T., Fey, N., Spencer, J. & Mulholland, A. J., 25 Jun 2020, In : Chemical Communications. 50, p. 6874-6877 4 p.

Research output: Contribution to journalArticle (Academic Journal)

2019

An Efficient Computational Assay for β-Lactam Antibiotic Breakdown by Class A β-Lactamases

Hirvonen, V., Hammond, K., Chudyk, E., Limb, M., Spencer, J., Mulholland, A. & Van der Kamp, M., 30 Jul 2019, In : Journal of Chemical Information and Modeling. 59, 8, p. 3365-3369 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
14 Downloads (Pure)

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

Krajnc, A., Brem, J., Hinchliffe, P., Calvopina, K. A., Panduwawala, T. D., Lang, P., Kamps, J. J. A. G., Tyrrell, J. M., Widlake, E., Saward, B. G., Walsh, T. R., Spencer, J. & Schofield, C. J., 27 Aug 2019, In : Journal of Medicinal Chemistry. 62, 18, p. 8544-8556 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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28 Citations (Scopus)
171 Downloads (Pure)

Crystal structures of VIM-1 complexes explain active site heterogeneity in VIM-class metallo-β-lactamases

Salimraj, R., Hinchliffe, P., Kosmopoulou, M., Tyrrell, J. M., Brem, J., van Berkel, S. S., Verma, A., Owens, R. J., McDonough, M. A., Walsh, T. R., Schofield, C. J. & Spencer, J., Jan 2019, In : FEBS Journal. 286, 1, p. 169-183 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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8 Citations (Scopus)
210 Downloads (Pure)

Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug

Evans, L. E., Krishna, A., Ma, Y., Webb, T. E., Marshall, D. C., Tooke, C. L., Spencer, J., Clarke, T. B., Armstrong, A. & Edwards, A. M., 9 May 2019, In : Journal of Medicinal Chemistry. 62, 9, p. 4411-4425 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
236 Downloads (Pure)

In silico study directed towards identification of the key structural features of GyrB inhibitors targeting MTB DNA gyrase: HQSAR, CoMSIA and molecular dynamics simulations

Kamsri, P., Punkvang, A., Hannongbua, S., Suttisintong, K., Kittakoop, P., Spencer, J., Mulholland, A. J. & Pungpo, P., 2 Nov 2019, In : SAR and QSAR in Environmental Research. 30, 11, p. 775-800 27 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

Lohans, C. T., Freeman, E. I., Groesen, E. V., Tooke, C. L., Hinchliffe, P., Spencer, J., Brem, J. & Schofield, C. J., 20 Sep 2019, In : Scientific Reports. 9, 9 p., 13608.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
114 Downloads (Pure)

Molecular Basis of Class A β-lactamase Inhibition by Relebactam

Tooke, C., Hinchliffe, P., Pauline, L., Mulholland, A., Brem, J., Schofield, C. J. & Spencer, J., 5 Aug 2019, In : Antimicrobial Agents and Chemotherapy. 49 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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140 Downloads (Pure)

Non-Hydrolytic β-Lactam Antibiotic Fragmentation by l,d-Transpeptidases and Serine β-Lactamase Cysteine Variants

Lohans, C. T., Chan, H. T. H., Malla, T. R., Kumar, K., Kamps, J. J. A. G., McArdle, D. J. B., van Groesen, E., de Munnik, M., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. & Schofield, C. J., 11 Feb 2019, In : Angewandte Chemie - International Edition. 58, 7, p. 1990-1994 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
206 Downloads (Pure)

Profiling interactions of vaborbactam with metallo-β-lactamases

Langley, G. W., Cain, R., Tyrrell, J. M., Hinchliffe, P., Calvopiña, K., Tooke, C. L., Widlake, E., Dowson, C. G., Spencer, J., Walsh, T. R., Schofield, C. J. & Brem, J., 1 Aug 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 15, p. 1981-1984 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
169 Downloads (Pure)

Simulations of Shikimate Dehydrogenase from Mycobacterium tuberculosis in Complex with 3-Dehydroshikimate and NADPH Suggest Strategies for MtbSDH Inhibition

Punkvang, A., Kamsri, P., Mulholland, A., Spencer, J., Hannongbua, S. & Pungpo, P., 22 Apr 2019, In : Journal of Chemical Information and Modeling. 59, 4, p. 1422-1433 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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42 Downloads (Pure)
2018

A New Mechanism for β-Lactamases: Class D Enzymes Degrade 1β-Methyl Carbapenems through Lactone Formation

Lohans, C. T., van Groesen, E., Kumar, K., Tooke, C. L., Spencer, J., Paton, R. S., Brem, J. & Schofield, C. J., Jan 2018, In : Angewandte Chemie - International Edition. 57, 5, p. 1282-1285 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
162 Downloads (Pure)

Detecting RNA base methylations in single cells by in situ hybridization

Ranasinghe, R. T., Challand, M. R., Ganzinger, K. A., Lewis, B. W., Softley, C., Schmied, W. H., Horrocks, M. H., Shivji, N., Chin, J. W., Spencer, J. & Klenerman, D., 13 Mar 2018, In : Nature Communications. 9, 1, 10 p., 655.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
231 Downloads (Pure)

In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-β-lactamase Inhibitors

Cain, R., Brem, J., Zollman, D., McDonough, M. A., Johnson, R. M., Spencer, J., Makena, A., Abboud, M. I., Cahill, S., Lee, S. Y., McHugh, P. J., Schofield, C. J. & Fishwick, C. W. G., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1255-1260 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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20 Citations (Scopus)
213 Downloads (Pure)

Multiscale simulations of clavulanate inhibition identify the reactive complex in class A β-lactamases and predict efficiency of inhibition

Fritz, R., Alzate-Morales, J. H., Spencer, J., Mulholland, A. J. & Van Der Kamp, M. W., 29 May 2018, In : Biochemistry. 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
169 Downloads (Pure)

Structural and Kinetic Studies of the Potent Inhibition of Metallo-β-lactamases by 6-Phosphonomethylpyridine-2-carboxylates

Hinchliffe, P., Tanner, C. A., Krismanich, A. P., Labbé, G., Goodfellow, V. J., Marrone, L., Desoky, A. Y., Calvopiña, K., Whittle, E. E., Zeng, F., Avison, M. B., Bols, N. C., Siemann, S., Spencer, J. & Dmitrienko, G. I., 27 Mar 2018, In : Biochemistry. 57, 12, p. 1880-1892 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Citations (Scopus)
237 Downloads (Pure)
2017
Open Access
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16 Citations (Scopus)
269 Downloads (Pure)

13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions

Lohans, C. T., Wang, D. Y., Jorgensan, C., Cahill, S. T., Clifton, I. J., McDonough, M. A., Oswin, H., Spencer, J., Domene, C., Claridge, T. D. W., Brem, J. & Schofield, C. J., 28 Jul 2017, In : Organic and Biomolecular Chemistry. 15, 28, p. 6024-6032 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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8 Citations (Scopus)
343 Downloads (Pure)

19F-NMR Reveals the Role of Mobile Loops in Product and Inhibitor Binding by the São Paulo Metallo-β-Lactamase

Abboud, M. I., Hinchliffe, P., Brem, J., Macsics, R., Pfeffer, I., Makena, A., Umland, K-D., Rydzik, A. M., Li, G-B., Spencer, J., Claridge, T. D. W. & Schofield, C. J., 22 Mar 2017, In : Angewandte Chemie - International Edition. 56, 14, p. 3862–3866 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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14 Citations (Scopus)
239 Downloads (Pure)

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

Lisa, M. N., Palacios, A. R., Aitha, M., González, M. M., Moreno, DI. M., Crowder, M. W., Bonomo, R. A., Spencer, J., Tierney, D. L., Llarrull, L. I. & Vila, A. J., 14 Sep 2017, In : Nature Communications. 8, 538.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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38 Citations (Scopus)
218 Downloads (Pure)

Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms

Yang, Q., Li, M., Spiller, O. B., Andrey, D. O., Hinchliffe, P., Li, H., MacLean, C., Niumsup, P., Powell, L., Pritchard, M., Papkou, A., Shen, Y., Portal, E., Sands, K., Spencer, J., Tansawai, U., Thomas, D., Wang, S., Wang, Y., Shen, J. & 1 others, Walsh, T., Dec 2017, In : Nature Communications. 8, 12 p., 2054.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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36 Citations (Scopus)
261 Downloads (Pure)

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition

Li, G-B., Brem, J., Abboud, M. I., Lohans, C. T., Clifton, I. J., Jiménez-Castellanos, J-C., Avison, M. B., Spencer, J., McDonough, M. A. & Schofield, C. J., 30 May 2017, In : Chemical Communications. 53, 43, p. 5806-5809 4 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Cyclic Boronates Inhibit All Classes of β-Lactamases

Cahill, S. T., Cain, R., Wang, D. Y., Lohans, C. T., Wareham, D. W., Oswin, H. P., Mohammed, J., Spencer, J., Fishwick, C. W. G., McDonough, M. A., Schofield, C. J. & Brem, J., Apr 2017, In : Antimicrobial Agents and Chemotherapy. 61, 4, 13 p., e02260-16.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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52 Citations (Scopus)
559 Downloads (Pure)

Cyclobutanone Mimics of Intermediates in Metallo-β-Lactamase Catalysis

Abboud, M. I., Kosmopoulou, M., Krismanich, A. P., Johnson, J. W., Hinchliffe, P., Brem, J., Claridge, T. D. W., Spencer, J., Schofield, C. J. & Dmitrienko, G. I., 17 Dec 2017, In : Chemistry - A European Journal. 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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12 Citations (Scopus)
216 Downloads (Pure)

Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from the Crystal Structure of the Catalytic Domain of MCR-1

Hinchliffe, P., Yang, Q., Portal, E., Young, T., Li, H., Tooke, C., Mendes de Carvalho, M., Paterson, N., Brem, J., Ritivirool, P., Tansawai, U., Lei, L., Li, M., Shen, Z., Wang, Y., Schofield, C., Mulholland, A., Shen, J., Walsh, T., Fey, N. & 1 others, Spencer, J., 6 Jan 2017, In : Scientific Reports. 7, 10 p., 39392 .

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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54 Citations (Scopus)
218 Downloads (Pure)

NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors

Li, G-B., Abboud, M. I., Brem, J., Someya, H., Lohans, C. T., Yang, S-Y., Spencer, J., Wareham, D. W., McDonough, M. A. & Schofield, C. J., 1 Feb 2017, In : Chemical Science. 8, 2, p. 928-937 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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37 Citations (Scopus)
115 Downloads (Pure)

Structural/mechanistic insights into the efficacy of nonclassical β-lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates

Calvopina Tapia, K., Hinchliffe, P., Brem, J., Heesom, K. J., Johnson, S., Cain, R., Lohans, C. T., Fishwick, C. W. G., Schofield, C. J., Spencer, J. & Avison, M. B., 23 Oct 2017, In : Molecular Microbiology. 106, 3, p. 492–504 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Citations (Scopus)
263 Downloads (Pure)
2016
Open Access
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2 Citations (Scopus)
279 Downloads (Pure)

Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes

Hinchliffe, P., Gonzalez, M. M., Mojica, M. F., Gonzalez, J. M., Castillo, V., Saiz, C., Kosmopoulou, M., Tooke, C., Llarrull, L., Mahler, G., Bonomo, R. A., Villa, A. J. & Spencer, J., 28 Jun 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. E3745-E3754 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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51 Citations (Scopus)
284 Downloads (Pure)

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

Liu, Y-Y., Wang, Y., Walsh, T. R., Yi, L-X., Zhang, R., Spencer, J., Doi, Y., Tian, G., Dong, B., Huang, X., Yu, L-F., Gu, D., Ren, H., Chen, X., Lv, L., He, D., Zhou, H., Liang, Z., Liu, J-H. & Shen, J., 1 Feb 2016, In : Lancet Infectious Diseases. 16, 2, p. 161-168 8 p.

Research output: Contribution to journalArticle (Academic Journal)

1989 Citations (Scopus)

Role of Residues W228 and Y233 in the Structure and Activity of Metallo-β-Lactamase GIM-1

Skagseth, S., Carlsen, T. J., Bjerga, G. E. K., Spencer, J., Samuelsen, Ø. & Leiros, H-K. S., Feb 2016, In : Antimicrobial Agents and Chemotherapy. 60, 2, p. 990-1002 13 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Sideromimic Modification of Lactivicin Dramatically Increases Potency against Extensively Drug-Resistant Stenotrophomonas maltophilia Clinical Isolates

Calvopiña, K., Umland, K-D., Rydzik, A. M., Hinchliffe, P., Brem, J., Spencer, J., Schofield, C. J. & Avison, M. B., Jul 2016, In : Antimicrobial Agents and Chemotherapy. 60, 7, p. 4170-4175 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
135 Downloads (Pure)

Structural and Biochemical Characterization of Rm3, a SubClass B3 Metallo- β-Lactamase Identified from a Functional Metagenomic Study

Salimraj, R., Zhang, L., Hinchliffe, P., Wellington, E. M. H., Brem, J., Schofield, C. J., Gaze, W. & Spencer, J., Oct 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5828-5840 13 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
338 Downloads (Pure)

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates

Brem, J., Cain, R., Cahill, S., McDonough, M. A., Clifton, I. J., Jiménez-Castellanos, J-C., Avison, M. B., Spencer, J., Fishwick, C. W. G. & Schofield, C. J., 8 Aug 2016, In : Nature Communications. 7, 8 p., 12406.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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107 Citations (Scopus)
341 Downloads (Pure)
2015

Arginine-containing peptides as potent inhibitors of VIM-2 metallo-β-lactamase

Rotondo, C. M., Marrone, L., Goodfellow, V. J., Ghavami, A., Labbé, G., Spencer, J., Dmitrienko, G. I. & Siemann, S., Nov 2015, In : Biochimica et Biophysica Acta (BBA) - General Subjects. 1850, 11, p. 2228-38 11 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Assay for drug discovery: Synthesis and testing of nitrocefin analogues for use as β-lactamase substrates

Ghavami, A., Labbé, G., Brem, J., Goodfellow, V. J., Marrone, L., Tanner, C. A., King, D. T., Lam, M., Strynadka, N. C. J., Pillai, D. R., Siemann, S., Spencer, J., Schofield, C. J. & Dmitrienko, G. I., 1 Oct 2015, In : Analytical Biochemistry. 486, p. 75-7 3 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase

González, M. M., Kosmopoulou, M., Mojica, M. F., Castillo, V., Hinchliffe, P., Pettinati, I., Brem, J., Schofield, C. J., Mahler, G., Bonomo, R. A., Llarrull, L. I., Spencer, J. & Vila, A. J., 13 Nov 2015, In : ACS Infectious Diseases. 1, 11, p. 544-54 11 p.

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)

Crystal Structure of DIM-1, an Acquired Subclass B1 Metallo-β-Lactamase from Pseudomonas stutzeri

Booth, M. P. S., Kosmopoulou, M., Poirel, L., Nordmann, P. & Spencer, J., 2015, In : PLoS ONE. 10, 10, p. e0140059

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-β-lactamases

Mojica, M. F., Mahler, S. G., Bethel, C. R., Taracila, M. A., Kosmopoulou, M., Papp-Wallace, K. M., Llarrull, L. I., Wilson, B. M., Marshall, S. H., Wallace, C. J., Villegas, M. V., Harris, M. E., Vila, A. J., Spencer, J. & Bonomo, R. A., 26 May 2015, In : Biochemistry. 54, 20, p. 3183-96 14 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1

Brem, J., Struwe, W. B., Rydzik, A. M., Tarhonskaya, H., Pfeffer, I., Flashman, E., van Berkel, S. S., Spencer, J., Claridge, T. D. W., McDonough, M. A., Benesch, J. L. P. & Schofield, C. J., 19 Feb 2015, In : Chemical Science. 6, 2, p. 956-963 8 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
2014

Molecular basis of non-mutational derepression of ramA in Klebsiella pneumoniae

De Majumdar, S., Yu, J., Spencer, J., Tikhonova, I. G. & Schneiders, T., Oct 2014, In : Journal of Antimicrobial Chemotherapy. 69, 10, p. 2681-9 9 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

QM/MM simulations as an assay for carbapenemase activity in class A β-lactamases

Chudyk, E. I., Limb, M. A. L., Jones, C., Spencer, J., van der Kamp, M. W. & Mulholland, A. J., 7 Dec 2014, In : Chemical Communications. 50, 94, p. 14736-14739 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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21 Citations (Scopus)
258 Downloads (Pure)

Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition

Brem, J., van Berkel, S. S., Aik, W., Rydzik, A. M., Avison, M. B., Pettinati, I., Umland, K-D., Kawamura, A., Spencer, J., Claridge, T. D. W., McDonough, M. A. & Schofield, C. J., Dec 2014, In : Nature Chemistry. 6, 12, p. 1084-90 7 p.

Research output: Contribution to journalArticle (Academic Journal)

67 Citations (Scopus)
2012

The Basis for Carbapenem Hydrolysis by Class A β-Lactamases: A Combined Investigation using Crystallography and Simulations.

Fonseca, M. F., Chudyk, E. I., Van der Kamp, M. W., Correia, A., Mulholland, A. J. & Spencer, J., 7 Nov 2012, In : Journal of the American Chemical Society. 134, 44, p. 18275-18285 11 p.

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)
2011

Biochemical characterization of Sfh-I, the subclass B2 metallo-{beta}-lactamase from Serratia fonticola UTAD54

Fonseca, MF., Arthur, CJ., Bromley, EHC., Samyn, B., Moerman, P., Saavedra, MJ., Correia, A. & Spencer, J., Nov 2011, In : Antimicrobial Agents and Chemotherapy. 55, p. 5392 - 5395 4 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Crystal structure of Serratia fonticola Sfh-I: activation of the nucleophile in mono-zinc metallo-β-lactamases

Fonseca, MF., Bromley, EHC., Saavedra, MJ., Correia, A. & Spencer, J., Jul 2011, In : Journal of Molecular Biology. 411, p. 951 - 959 9 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)