If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Research in our group involves the use of a broad range of techniques including protein expression and purification, enzyme kinetics, and the accurate mass analysis of these large biomolecules by electrospray mass spectrometry. By isolating individual enzymes and establishing structural details, enzyme specificities, and kinetic characteristics we hope to understand fully how biosynthetic pathways are controlled.

Enzymology of Polyketide Biosynthesis

Many biologically active compounds are synthesised in nature via the polyketide pathway. The core of all polyketide structures is similar, and is assembled by a multicomponent enzyme system, the polyketide synthase (PKS). The synthase controls a series of cycles of reactions in which simple building blocks (usually acetate) are linked via carbon bond formation, followed by a highly specific sequence of modifying reactions. We aim to understand how the PKS controls the exact sequence of chemical steps involved in the biosynthesis of antibiotics.

Fingerprint

Dive into the research topics where John Crosby is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 7 Similar Profiles

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or
If you made any changes in Pure these will be visible here soon.