Dr John Crosby

B.Sc.(Hull), Ph.D.(Edin.)

  • BS8 1TS

1993 …2019

Research output per year

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Research Output

  • 69 Article (Academic Journal)
  • 1 Conference Abstract
  • 1 Review article (Academic Journal)
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Article (Academic Journal)
1993

Action spectra for the trans to cis photoisomerisation of urocanic acid invitro and in mouse skin

Gibbs, NK., Norval, M., Traynor, NJ., Crosby, J., Johnson, BE. & Wolf, MW., 1993, In : Photochemistry and Photobiology. 57

Research output: Contribution to journalArticle (Academic Journal)

Action spectra for the trans to cis photoisomerisation of urocanic acid in vitro and in mouse skin

Gibbs, NK., Norval, M., Traynor, NJ., Wolf, MW., Johnson, BE. & Crosby, J., 1993, In : Photochemistry and Photobiology. 57, p. 584 - 590 6 p.

Research output: Contribution to journalArticle (Academic Journal)

72 Citations (Scopus)

Comparative potency of broad-band and narrow-band phototherapy sources to induce edema, sunburn cells and urocanic acid photoisomerisation in hairless mouse skin

Gibbs, NK., Norval, M., Traynor, NJ., Crosby, J., Lowe, G. & Johnson, BE., 1993, In : Photochemistry and Photobiology. 58, p. 643 - 647 4 p.

Research output: Contribution to journalArticle (Academic Journal)

1995

Polyketide synthase acyl carrier proteins from Streptomyces:expression in Escherischia coli, purification and partial characterisation

Crosby, J., Sherman, DH., Bibb, M., Simpson, TJ. & Hopwood, DA., 1995, In : Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1251, p. 32 - 40 8 p.

Research output: Contribution to journalArticle (Academic Journal)

56 Citations (Scopus)

The effect of chronic low-dose UV-B radiation on Langerhans cells, sunburn cells, urocanic acid isomers, contact hypersensitivity and serum immunoglobulins in mice

El-Ghorr, AA., Norval, M., Lappin, MB. & Crosby, J., 1995, In : Photchem. Photobiol. 62, p. 326 - 332

Research output: Contribution to journalArticle (Academic Journal)

Urocanic acid isomers in human skin: analysis of site variation

Kavanagh, G., Crosby, J. & Norval, M., 1995, In : British Journal of Dermatology. 133, p. 728 - 731

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)
1996

The sunscreening effect of urocanic acid

Olivarus, FD., Wulf, HC., Crosby, J. & Norval, M., 1996, In : Photodermatology, Photoimmunology and Photomedicine. 12, p. 95 - 99

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
1997

Seasonal variation in urocanic acid isomers in human skin

Olivarius, FD., Wulf, HC., Crosby, J. & Norval, M., 1997, In : Photochem. Photobiol. 66, p. 119 - 123

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2)

Crump, MP., Crosby, J., Dempsey, CE., Parkinson, JA., Murray, M., Hopwood, DA. & Simpson, TJ., 1997, In : Biochemistry. 36, p. 6000 - 6008

Research output: Contribution to journalArticle (Academic Journal)

136 Citations (Scopus)

Urocanic acid isomers: relation to body site, pigmentation, stratum corneum thickness and photosensitivity

Olivarius, FD., Wulf, HC., Therkildsen, P., Pulsen, T., Crosby, J. & Norval, M., 1997, In : Archives of Dermatological Research. 289, p. 501 - 505

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)
1998

Acylation of Streptomyces type II polyketide synthase acyl carrier proteins

Crosby, J., Byrom, KJ., Hitchman, TS., Cox, RJ., Crump, MP., Findlow, ISC., Bibb, M. & Simpson, TJ., 1998, In : FEBS Letters. 433, p. 132 - 138

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Catalytic self-acylation of type II polyketide synthase acyl carrier proteins

Hitchman, TS., Crosby, J., Byrom, KJ., Cox, RJ. & Simpson, TJ., 1998, In : Chemistry and Biology. 5, p. 35 - 47

Research output: Contribution to journalArticle (Academic Journal)

66 Citations (Scopus)

Chemometric analysis of high performance liquid chromatography - diode array detector electrospray mass spectrometry of 2-and 3-hydroxypyridine

Dunkerley, S., Crosby, J., Brereton, RG., Zissis, K. & Escott, REA., Oct 1998, In : Analyst. 123(10), p. 2021 - 2034 12 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Urocanic acid isomers and photosensitivity in healthy children

Olivarius, FD., Wulf, HC., Crosby, J. & Norval, M., 1998, In : British Journal of Dermatology. 139, p. 605 - 609

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Urocanic acid isomers in patients with basal cell carcinoma and cutaneous malignant melanoma

Olivarius, FDF., Lock-Andersen, J., Larsen, FG., Wulf, HC., Crosby, J. & Norval, M., 1998, In : British Journal of Dermatology. 138, p. 986 - 992

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
1999

A chain initiation factor common to both modular and aromatic polyketide synthases

Bisang, C., Long, PF., Cortés, J., Westcott, J., Crosby, J., Matharu, A-L., Cox, RJ., Simpson, TJ., Staunton, J. & Leadlay, PF., 1999, In : Nature. 401, p. 502 - 505

Research output: Contribution to journalArticle (Academic Journal)

219 Citations (Scopus)

Isomerization of urocanic acid after ultraviolet radiation is influenced by skin pigmentation

Olivarius, FD., Wulf, HC., Crosby, J. & Norval, M., 1999, In : Journal of Photochemistry and Photobiology B: Biology. 48, p. 42 - 47

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Robust and catalytically active mono- and bis-palladium complexes of the 'Trost modular ligand'

Butts, CP., Crosby, J., Lloyd-Jones, GC. & Stephen, SC., 1999, In : Chemical Communications. 1999, p. 1707 - 1708

Research output: Contribution to journalArticle (Academic Journal)

Sunscreen protection against cis-urocanic acid production in human skin

Olivarius, FD., Wulf, HC., Crosby, J. & Norval, M., 1999, In : Acta Dermato-Venereologica. 79, p. 426 - 430

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

The role of urocanic acid in UVB-induced suppression of immunity to Trichinella spiralis infection in the rat

Garssen, J., Norval, M., Crosby, J., Dortant, P. & Van Loveren, H., 1999, In : Immunology. 96, p. 298 - 306

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
2001

High performance liquid chromatography/electrospray tandem mass spectrometry of polycyclic aromatic hydrocarbons

Crosby, J., Brereton, RG. & Airiau, C., Jan 2001, In : Rapid Communications in Mass Spectrometry. 15(2), p. 135 - 140 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Solid Phase Synthesis of 4-Hydroxycinnamic Acid and its Derivatives for Potential Use in Combinatorial Chemistry: A Novel Route for the Synthesis of 4-Hydroxycinnamoyl Coenzyme A and NMDA Receptor Antagonists

Mcintyre, BG., Martinez Bermejo, F., Srivastava, SK., Husbands, SM., Simpson, TJ., Crosby, J. & Lewis, JW., 2001, In : Combinatorial Chemistry and High Throughput Screening. 4, p. 111 - 114

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
2002

Kinetic and Mechanistic Analysis of the Malonyl CoA:ACP Transacylase from Streptomyces coelicolor Indicates a Single Catalytically Competent Serine Nucleophile at the Active Site

Szafranska, AE., Hitchman, TS., Cox, RJ., Crosby, J. & Simpson, TJ., Feb 2002, In : Biochemistry. 41 (5), p. 1421 - 1427 7 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Streptomyces coelicolor phosphopantetheinyl transferase: a promiscuous activator of polyketide and fatty acid synthase acyl carrier proteins

Cox, RJ., Crosby, J., Daltrop, O., Glod, F., Jarzabek, ME., Nicholson, TP., Reed, MAC., Simpson, TJ., Smith, LH., Soulas, F., Szafranska, AE. & Westcott, J., Jun 2002, In : Perkin 1. 14, p. 1644 - 1649 6 p.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide Analogues

Winfield, CJ., Simpson, TJ., Crosby, J., Cox, RJ., Szafranska, AE., Westcott, J., Arthur, CJ., Rahman, M., Soulas, F. & Spogli, R., 2002, In : ChemBioChem. p. 253 - 257

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)
2003

Endogenous β-carbolines as clonidine displacing substances

Robinson, ESJ., Anderson, NJ., Crosby, J., Nutt, DJ. & Hudson, AL., 2003, In : Annals of the New York Academy of Sciences. 1099, p. 157 - 166 15 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determination

Nicholson, TP., Winfield, CJ., Westcott, J., Crosby, J., Simpson, TJ. & Cox, RJ., Mar 2003, In : Chemical Communications. 6, p. 686 - 687 2 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

Solution structure and dynamics of Oxytetracycline polyketide synthase ACP from S. rimosus

Simpson, TJ., Crosby, J., Crump, MP., Findlow, IS. & Winsor, C., May 2003, In : Biochemistry. 42, p. 8423 - 8433 11 p.

Research output: Contribution to journalArticle (Academic Journal)

The isolated Acyl Carrier Protein Domain from the Type I Rat Fatty Acid Synthase Shows Considerable Homology and Analogous Biochemical Properties to Type II Acyl Carrier Proteins

Simpson, TJ., Crosby, J., Cox, RJ., Arthur, CJ., Nicholson, TP., Szafranska, AE., Reed, MAC., Crump, MP. & Schweizer, M., 2003, In : Organic and Biomolecular Chemistry. 1, p. 463 - 471

Research output: Contribution to journalArticle (Academic Journal)

2005

Bulgecin A: a novel inhibitor of binuclear metallo-beta-lactamases

Simm, AM., Loveridge, EJ., Crosby, J., Avison, MB., Walsh, TR. & Bennett, PM., May 2005, In : Biochemical Journal. 387, p. 585 - 590 6 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Exploring protein interactions on a minimal type II polyketide synthase using a yeast two-hybrid system

Castaldo, G., Crosby, J. & Long, PF., 28 Feb 2005, In : Food Technology & Biotechnology. 43(2), p. 109 - 112 4 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Cooper, SM., Cox, RJ., Crosby, J., Crump, MP., Hothersall, J., Laosripaiboon, W., Simpson, TJ. & Thomas, CM., Mar 2005, In : Chemical Communications. (9), p. 1179 - 1181 3 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Self-malonylation is an intrinsic property of a chemically synthesized type II polyketide synthase acyl carrier protein

Arthur, CJ., Szafranska, A., Evans, SE., Findlow, SC., Burston, SG., Owen, P., Clark-Lewis, I., Simpson, TJ., Crosby, J. & Crump, MP., Nov 2005, In : Biochemistry. 44 (46), p. 15414 - 15421 8 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Shift to Pseudomonic Acid B Production in Pseudomonas fluorescens NCIMB10586 by Mutation of Mupirocin Tailoring Genes mupO, mupU, mupV and macpE

Cooper, SM., Laosripaiboon, W., Rahman, AS., Hothersall, J., El-Sayed, AK., Winfield, CJ., Crosby, J., Cox, RJ., Simpson, TJ. & Thomas, CM., Jul 2005, In : Chem. Biol. 12(7), p. 825 - 833 8 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Tandemly Duplicated Acyl Carrier Proteins Which Increase Polyketide Antibiotic Production can Apparently Function Either in Parallel or in Series

Simpson, TJ., Crosby, J., Thomas, CM., Rahman, AS. & Hothersall, J., 25 Feb 2005, In : Journal of Biological Chemistry. 280(8), p. 6399 - 6408 10 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)
2006

The malonyl transferase activity of type II polyketide synthase acyl carrier proteins

Arthur, CJ., Szafranska, A., Long, J., Mills, J., Cox, RJ., Findlow, SC., Simpson, TJ., Crump, MP. & Crosby, J., 23 Jun 2006, In : Chemistry and Biology. 13 (6), p. 587 - 596 10 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)
2007

Dissecting the Component Reactions Catalysed by the Actinorhodin Minimal Polyketide Synthase

Beltran-Alvarez, P., Cox, RJ., Crosby, J. & Simpson, TJ., Nov 2007, In : Biochemistry. 46(50), p. 14672 - 14681 9 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Mupirocin H, a novel metabolite isolated from mutation of the HMG-GoA synthase analogue, mupH in Pseudomonas fluorescens

Wu, J., Cooper, SM., Cox, RJ., Crosby, J., Crump, MP., Hothersall, J., Simpson, TJ., Thomas, CM. & Willis, CL., Feb 2007, In : Chemical Communications. 20, p. 2040 - 2042 3 p.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Mutational analysis reveals that all tailoring region genes are required for production of polyketide antibiotic mupirocin by Pseudomonas fluorescens: Pseudomic acid B biosynthesis precedes pseudomonic acid A

Hothersall, J., Wu, J., Rahman, AS., Shields, JA., Haddock, J., Johnson, N., Cooper, SM., Stephens, ER., Cox, RJ., Crosby, J., Willis, CL., Simpson, TJ. & Thomas, CM., May 2007, In : Journal of Biological Chemistry. 282, 21, p. 15451 - 15461 11 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Structural Insights into the Interaction of Insulin-like Growth Factor 2 with IGF2R Domain 11

Williams, C., Rezgui, D., Prince, SN., Zaccheo, OJ., Foulstone, EJ., Forbes, BE., Norton, RS., Crosby, J., Hassan, AB. & Crump, MP., Sep 2007, In : Structure. 15 (9), p. 1065 - 1078 14 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)
2008

Accumulation of Mupirocin H and Mupiric Acid During In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the "Leaky Hosepipe" Mechanism

O'Connell, Y., Shields, JA., Cox, RJ., Crosby, J., Hothersall, J., Simpson, TJ., Thomas, CM. & Willis, CL., 2008, In : ChemBioChem. 9, p. 1500 - 1508 9 p.

Research output: Contribution to journalArticle (Academic Journal)

A Mammalian Type I Fatty Acid Synthase Acyl Carrier Protein Domain Does Not Sequester Acyl Chains

Ploskon, EA., Arthur, CJ., Evans, SE., Williams, C., Crosby, J., Simpson, TJ. & Crump, MP., 2008, In : Journal of Biological Chemistry. 283 (1), p. 518 - 528 11 p.

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)

An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein

Evans, SE., Williams, C., Arthur, CJ., Burston, SG., Simpson, TJ., Crosby, J. & Crump, MP., Oct 2008, In : ChemBioChem. 9, p. 2424 - 2432 9 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the 'Leaky Hosepipe' Mechanism

Wu, J., Hothersall, J., Mazzetti, C., O'Connell, Y., Shields, J. A., Rahman, A. S., Cox, R. J., Crosby, J., Simpson, T. J., Thomas, C. M. & Willis, C. L., Jun 2008, In : ChemBioChem. 9 , 9, p. 1500 - 1508 9 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Proposed Arrangement of Proteins Forming a Bacterial Type II Polyketide Synthase

Castaldo, G., Zucko, J., Heidelberger, S., Vujaklija, D., Hranueli, D., Cullum, J., Wattana-Amorn, P., Crump, MP., Crosby, J. & Long, PF., 2008, In : Chemistry & Biology. 15, p. 1156 - 1165

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)
2009

Preliminary kinetic analysis of acyl carrier protein-ketoacylsynthase interactions in the actinorhodin minimal polyketide synthase

Beltran-Alvarez, P., Arthur, C. J., Cox, R. J., Crosby, J., Crump, M. P. & Simpson, T. J., 2009, In : Molecular bioSystems. 5, 5, p. 511-518 8 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Probing the interactions of early polyketide intermediates with the actinorhodin ACP from S. coelicolor A3(2)

Evans, SE., Williams, C., Arthur, CJ., Ploskon, E., Crosby, J., Cox, RJ., Willis, CL., Simpson, TJ. & Crump, MP., 2009, In : Journal of Molecular Biology. 389, p. 511 - 528

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Structure and malonyl CoA-ACP transacylase binding of Streptomyces coelicolor fatty acid synthase acyl carrier protein

Arthur, C. J., Williams, C., Pottage, K., Płoskoń, E., Findlow, S. C., Burston, S. G., Simpson, T. J., Crump, M. P. & Crosby, J., Aug 2009, In : ACS Chemical Biology. 4 , 8, p. 625 - 636 12 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)