Projects per year
Biochemistry and biomechanics of skeletal disease
My overall research theme is in the physiology, pathology, regeneration and repair of musculoskeletal and connective tissues. This includes research in:
- Regenerative medicine, tissue engineering and stem cell biology
- Diet and health
- Bone and joint disease
- Mechanisms of discogenic back pain
- Tissue repair
- Collagen biochemistry
- Animal health and welfare
Bone and joint disease: In a recent study we have found that omega-3 fatty acid substantially and significantly reduced the severity of osteoarthritis in a spontaneous disease model, as well as reducing biochemical and metabolic indicators of disease. This was the first (and remains the only) report of any drug or nutraceutical shown to prevent osteoarthritis by influencing the pathological process in spontaneous disease (as against merely affecting symptoms) . Properly followed up, these findings are likely to represent an intervention that could substantially lower the incidence and severity of new cases of human osteoarthritis.
Regenerative medicine: We have recently developed the first ever "stem cell bandage" shown to improve articular cartilage and meniscus repair in the laboratory. This is currently in phase1/2 human clinical trial.
Diet, animal welfare and health: More than three out of five of the EUs 200 million free range laying hens suffer keel bone breakage during their lives. We have recently shown that omega-3 fatty acid supplemented diets can reduce this rate by over 40%, which would potentially represent 80 million fewer hens in the EU suffering this painful condition, with clear welfare and economic benefits.
Mechanisms of pain in intervertebral discs: Back pain is a major health problem in the UK, affecting over two thirds of the population at some stage in their lives. In a recent published study, we have demonstrated how a combination of reduced pressure within the disc, and a change in the extracellular matrix composition is linked to the in-growth of nerves into degenerate discs, which is the cause of the most severe and chronic forms of backpain.
Tissue repair and wound healing: With around 6 million sufferers in the US and 500,000 in the UK, chronic wounds is one of the major health problems affecting the ageing population. One of the principle mechanisms of impaired healing in chronic wounds is the presence of excesive tissue degrading enzymes. In studies performed using surrogate wound fluids, we were able to demonstrate that technologically advanced superabsorbant gel based wound dressings were able to deplete tissue degrading enzymes, and prevent their ability to degrade extracellular matix components.
Colitis: Fibrosis is a serious consequence of Crohn’s disease, which without surgical resection may be life threatening. In a recently published paper, we have revealed a previously unidentified mechanism which drives fibrosis in this disease.
Tissue repair and wound healing: It has long been believed that there is a strong relationship between disease susceptibility and state of mind. Diebetes effect nearly 300 million adults worldwide, and up to 15% of these will develop foot ulcers. In recent studies we have demonstrated that depression and the ability to cope are linked to the rate of healing in diabetic foot ulcers, revealing a novel disease mechanism and the potential for therapy.
Further information about Dr John Tarlton can be found here.
External Examiner, Univ Liverpool, Dept Musculoskeletal Biol, Inst Ageing & Chron Dis1 Apr 2015 → 31 Mar 2020
Pool Committee panel member, BBSRC1 Jan 2014 → 31 Dec 2019
Panel Member Fellowship Committee, Versus Arthritis1 Sep 2013 → 31 Jan 2017
Structured keywords and research groupings
A Mathematical Modelling approach to defining factors which influence keel fractures in free range laying hens
Toscano, M. J., Tsaneva-Atanasova, K. T. & Tarlton, J. F.
1/01/13 → 31/12/16
1/10/20 → 30/09/21
Omega-3 (n3) fatty acid supplemented diets reduces bone breakage and increases bone strength in free range laying hensTarlton, JF., Avery, NC., Wilkins, LJ. & Knott, L., Aug 2011, In : British Poultry Abstracts. 7, p. 72 - 73 2 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Stiffness-matched biomaterial implants for cell delivery: clinical, intraoperative ultrasound elastography provides a 'target' stiffness for hydrogel synthesis in spinal cord injuryPrager, J., Adams, C. F., Delaney, A. M., Chanoit, G., Tarlton, J. F., Wong, L-F., Chari, D. M. & Granger, N., 17 Jul 2020, In : Journal of Tissue Engineering. 11, p. 2041731420934806
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile25 Downloads (Pure)
Mullan, S., Bunglavan, S. J., Rowe, E., Barrett, D. C., Lee, M. R. F., Ananth, D. & Tarlton, J., 31 Mar 2020, In : Animals. 10, 4, 13 p., 586.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile46 Downloads (Pure)