Professor John P Iredale

B.M. (Hons), D.M.(Soton.), F.Med.Sci, FRSE, FRCP (Lond and Ed)

  • BS8 1QU


Research output per year

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Personal profile

Research interests

John Iredale is Pro Vice Chancellor Health at the University of Bristol. He holds the chair of Experimental Medicine, and his areas of leadership and responsibility are for the research, teaching and management strategy for the Schools of Medicine, Veterinary Medicine, Dentistry and Biomedical Sciences across the relevant Faculties at the University of Bristol. He also holds Honorary Consultant contracts with the North Bristol NHS Trust and the University Hospitals Bristol Foundation Trust. Previously Professor Iredale was the Regius Chair of Medical Science, Dean of Clinical Medicine and Vice Principal Health Services at the University of Edinburgh where he led the Medical School. He has previously held the Chair of Medicine in Edinburgh (2006-2013), the chair of Medicine at the University of Southampton (2004-2006) and a Personal Chair in Hepatology (2000-2004).

Professor Iredale graduated from the University of Southampton with honours in Clinical Distinction in 1985 and was awarded a DM in 1995. He was made a Fellow of the Royal College of Physicians of London in 1999 and The Royal College of Physicians of Edinburgh in 2007. He was made a Fellow of the Academy of Medical Sciences in 2003 and Fellow of the Royal Society of Edinburgh in 2011.

Iredale's research interests are focused on tissue scarring and regeneration and he has published extensively on these subjects including key contributions in manuscripts published in Science, The Journal of Clinical Investigation, PNAS, Nature Medicine and Nature Cell Biology in addition to other specialist journals. Between 2010 and 2016, Iredale was Non-Executive Director of NHS Lothian, one of the UK's largest territorial health boards with 23 000 employees and an annual turnover of £1.5 billion. At Lothian Health Board Iredale played a lead role in aligning University and NHS activities and in-service redesign as chair of the Lothian Health Board service redesign committee.

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Research Output

  • 14 Article (Academic Journal)
  • 1 Comment/debate (Academic Journal)

Embryonic mesothelial-derived hepatic lineage of quiescent and heterogenous scar-orchestrating cells defined but suppressed by WT1

Kendall, T. J., Duff, C. M., Boulter, L., Wilson, D. H., Freyer, E., Aitken, S., Forbes, S. J., Iredale, J. P. & Hastie, N. D., 1 Dec 2019, In : Nature Communications. 10, 1, 18 p., 4688.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
  • 1 Citation (Scopus)
    112 Downloads (Pure)

    Loss of Integrin αvβ8 in Murine Hepatocytes Accelerates Liver Regeneration

    Greenhalgh, S. N., Matchett, K. P., Taylor, R. S., Huang, K., Li, J. T., Saeteurn, K., Donnelly, M. C., Simpson, E. E. M., Pollack, J. L., Atakilit, A., Simpson, K. J., Maher, J. J., Iredale, J. P., Sheppard, D. & Henderson, N. C., Feb 2019, In : American Journal of Pathology. 189, 2, p. 258-271 14 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 1 Citation (Scopus)
    206 Downloads (Pure)

    Resolving the fibrotic niche of human liver cirrhosis at single-cell level

    Ramachandran, P., Dobie, R., Wilson-Kanamori, J. R., Dora, E. F., Henderson, B. E. P., Luu, N. T., Portman, J. R., Matchett, K. P., Brice, M., Marwick, J. A., Taylor, R. S., Efremova, M., Vento-Tormo, R., Carragher, N. O., Kendall, T. J., Fallowfield, J. A., Harrison, E. M., Mole, D. J., Wigmore, S. J., Newsome, P. N. & 8 others, Weston, C. J., Iredale, J. P., Tacke, F., Pollard, J. W., Ponting, C. P., Marioni, J. C., Teichmann, S. A. & Henderson, N. C., 9 Oct 2019, In : Nature. 575, 7783, p. 512-518 7 p.

    Research output: Contribution to journalArticle (Academic Journal)