Personal profile
Research interests
John Iredale is Pro Vice Chancellor Health at the University of Bristol. He holds the chair of Experimental Medicine, and his areas of leadership and responsibility are for the research, teaching and management strategy for the Schools of Medicine, Veterinary Medicine, Dentistry and Biomedical Sciences across the relevant Faculties at the University of Bristol. He also holds Honorary Consultant contracts with the North Bristol NHS Trust and the University Hospitals Bristol Foundation Trust. Previously Professor Iredale was the Regius Chair of Medical Science, Dean of Clinical Medicine and Vice Principal Health Services at the University of Edinburgh where he led the Medical School. He has previously held the Chair of Medicine in Edinburgh (2006-2013), the chair of Medicine at the University of Southampton (2004-2006) and a Personal Chair in Hepatology (2000-2004).
Professor Iredale graduated from the University of Southampton with honours in Clinical Distinction in 1985 and was awarded a DM in 1995. He was made a Fellow of the Royal College of Physicians of London in 1999 and The Royal College of Physicians of Edinburgh in 2007. He was made a Fellow of the Academy of Medical Sciences in 2003 and Fellow of the Royal Society of Edinburgh in 2011.
Iredale's research interests are focused on tissue scarring and regeneration and he has published extensively on these subjects including key contributions in manuscripts published in Science, The Journal of Clinical Investigation, PNAS, Nature Medicine and Nature Cell Biology in addition to other specialist journals. Between 2010 and 2016, Iredale was Non-Executive Director of NHS Lothian, one of the UK's largest territorial health boards with 23 000 employees and an annual turnover of £1.5 billion. At Lothian Health Board Iredale played a lead role in aligning University and NHS activities and in-service redesign as chair of the Lothian Health Board service redesign committee.
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Collaborations and top research areas from the last five years
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Linking epidemiology and genomics of maternal smoking during pregnancy in utero and in ageing: a population-based study using human foetuses and the UK Biobank cohort
Mihov, M., Shoctor, H., Douglas, A., Hay, D. C., O'Shaughnessy, P. J., Iredale, J. P., Shaw, S., Fowler, P. A. & Grassmann, F., 1 Apr 2025, In: eBioMedicine. 114, 18 p., 105590.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access2 Citations (Scopus) -
In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study
Hyötyläinen, T., McGlinchey, A., Salihovic, S., Schubert, A., Douglas, A., Hay, D. C., O'Shaughnessy, P. J., Iredale, J. P., Shaw, S., Fowler, P. A. & Orešič, M., 1 Jan 2024, In: Lancet Planetary Health. 8, 1, p. e5-e17 13 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access24 Citations (Scopus) -
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis
Hayes, A. J., Zheng, X., O'Kelly, J., Neyton, L. P. A., Bochkina, N. A., Uings, I., Liddle, J., Baillie, J. K., Just, G., Binnie, M., Homer, N. Z. M., Murray, T. B. J., Baily, J., McGuire, K., Skouras, C., Garden, O. J., Webster, S. P., Iredale, J. P., Howie, S. E. M. & Mole, D. J., 29 Aug 2023, In: Cell Reports. 42, 8, 24 p., 112763.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access17 Citations (Scopus)
Projects
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NIHR Bristol Biomedical Research Centre
Iredale, J. P. (Principal Investigator)
Project: Research, Parent