1993 …2019

Research output per year

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Personal profile

Research interests

My research reflects my clinical practice as a consultant in general hospital psychiatry at the Bristol Royal Infirmary. Mood disorders are much more prevalent in this population for a range of reasons. We are interested in all patients who have conditions that bring them into contact with hospital and where mood is a significant co-morbidity and have active research in Inflammatory Bowel Disease, Diabetes, and Self-Harm (with Professor David Gunnell). An intriguing example of the mind/brain/body interface is hepatitis c, which is frequently acquired through intravenous drug use. In some cases this behaviour (drug taking) is initiated in an attempt to damp down overwhelming emotional symptoms that reflect early adversity. The virus itself can be associated with negative mood symptoms, but this is greatly magnified by the treatment given for the condition - interferon. This pro-inflamatory cytokine effects serotonin function, and we know from ours and others work that this neurotransmitter is important in maintaining therapeutic response to ssri antidepressants - perturbing it can lead to relapse acutely; further patients with hep C who develop these mood symptoms (sickness behaviour or depression) respond to antidepressants. We are actively exploring this fascinating area, which encompasses neurosciences, psychopharmacology, psychology, and even anthropology; ultimately I hope it will provide insights that will not only help our patients who suffer, but also help elucidate the mechanisms behind and reasons underpinning the behavioural responses we call depression.

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Research Output

  • 54 Article (Academic Journal)
  • 9 Conference Contribution (Conference Proceeding)

Advance decisions to refuse treatment and suicidal behaviour in emergency care: “It’s very much a step into the unknown”

Quinlivan, L., Nowland, R., Steeg, S., Cooper, J., Meehan, D., Godfrey, J., Robertson, D., Longson, D., Potokar, J., Davies, R., Allen, N., Huxtable, R., Mackway-Jones, K., Hawton, K., Gunnell, D. & Kapur, N., 1 Jul 2019, In : BJPsych Open. 5, 4, 8 p., e50.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 1 Citation (Scopus)
    137 Downloads (Pure)
    Open Access
    File
  • 241 Downloads (Pure)

    The Help for People with Money, Employment or Housing Problems (HOPE) Intervention: pilot randomised trial with mixed methods feasibility research

    Barnes, M., Haase, A., Scott, L., Linton, M-J., Bard, A., Donovan, J., Davies, R., Dursley, S., Williams, S., Elliott, D., Potokar, J., Kapur, N., Hawton, K., O'Connor, R. C., Hollingworth, W., Metcalfe, C. & Gunnell, D., 13 Nov 2018, In : Pilot and Feasibility Studies. 4, 18 p., 172.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 214 Downloads (Pure)