20012020

Research output per year

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Research Output

2020

A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

Anton, Z., Betin, V. M. S., Simonetti, B., Traer, C. J., Attar, N., Cullen, P. J. & Lane, J. D., 15 Jul 2020, In : Journal of Cell Science. 133, 14, 38 p., jcs246306.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
33 Downloads (Pure)

A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons

Stathakos, P., Jiménez Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., Kerrigan, T. L., Randall, A. D., Caldwell, M. A. & Lane, J. D., 23 Jan 2020, (Accepted/In press) In : Autophagy.

Research output: Contribution to journalArticle (Academic Journal)

2019

DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation

Mansell, E., Zareian, N., Malouf, C., Kapeni, C., Brown, N., Badie, C., Baird, D., Lane, J. D., Ottersbach, K., Blair, A. & Case, C. P., 13 Mar 2019, In : Scientific Reports. 9, 1, 17 p., 4370.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
177 Downloads (Pure)

Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research

Stathakos, P., Jimenez Moreno, N., Crompton, L., Nistor, P., Caldwell, M. & Lane, J., 5 Jan 2019, Autophagy. Humana Press, p. 257-280 23 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Open Access
File
1 Citation (Scopus)
70 Downloads (Pure)

Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells

Anderson, M. W., Moss, J., Szalai, R. & Lane, J., 22 Feb 2019, In : iScience. 12, p. 182-193 36 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
152 Downloads (Pure)
2018

Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes

Hawkins, S. J., Crompton, L. A., Sood, A., Saunders, M., Boyle, N. T., Buckley, A., Minogue, A. M., McComish, S. F., Jiménez-Moreno, N., Cordero-Llana, O., Stathakos, P., Gilmore, C. E., Kelly, S., Lane, J. D., Case, C. P. & Caldwell, M. A., 2 Apr 2018, In : Nature Nanotechnology. p. 427-433 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
31 Citations (Scopus)
437 Downloads (Pure)

Transautophagy: Research and Translation of Autophagy Knowledge

Lane, J., Albertini, M., Proikas-Cezanne, T., Engedal, N. & Zerovnik, E., 16 May 2018, In : Oxidative medicine and cellular longevity. 2018, 3 p.

Research output: Contribution to journalEditorial (Academic Journal)

2017

Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease

Jimenez Moreno, N., Stathakos, P., Caldwell, M. A. & Lane, J., Sep 2017, In : Cells. 6, 3, 27 p., 24.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
296 Downloads (Pure)

Self-eating on demand: autophagy in cancer and cancer therapy

Lane, J. D. & Agostinis, P., 7 Dec 2017, In : Frontiers in Oncology. 7, DEC, 3 p., 302.

Research output: Contribution to journalEditorial (Academic Journal)

Open Access
File
218 Downloads (Pure)

Signalling mechanisms in autophagy: an introduction to the issue

Lane, J., 12 Dec 2017, In : Essays in Biochemistry.

Research output: Contribution to journalEditorial (Academic Journal)

Open Access
1 Citation (Scopus)
2015
Open Access
File
11 Citations (Scopus)
265 Downloads (Pure)

Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells

MacVicar, T., Mannack, L., Lees, R. M. & Lane, J., Jun 2015, In : International Journal of Molecular Sciences. p. 13356-13380 25 p.

Research output: Contribution to journalSpecial issue (Academic Journal)

16 Citations (Scopus)

The autophagosome: current understanding of formation and maturation

Mannack, L. V. J. & Lane, J. D., 16 Feb 2015, In : Research and Reports in Biochemistry. 2015, 5, p. 39-58 20 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
311 Downloads (Pure)

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

Liang, J-R., Lane, J., Mayor, U., Clague, M. & Urbe, S., 4 Mar 2015, In : EMBO Reports. 10 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)
2014

Impaired OMA1 dependent OPA1 cleavage and reduced DRP1 fission activity combine to prevent mitophagy in OXPHOS dependent cells

MacVicar, T. & Lane, J. D., 2014, In : Journal of Cell Science. p. 2313-2325 15.

Research output: Contribution to journalArticle (Academic Journal)

Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions

Curtis, D. J., Sood, A., Phillips, T. E. J., Leinster, V. H. L., Nishiguchi, A., Coyle, C., Lacharme-Lora, L., Beaumont, O., Kemp, H., Goodall, R., Cornes, L., Giugliano, M., Barone, R. A., Matsusaki, M., Akashi, M., Tanaka, H. Y., Kano, M., McGarvey, J., Halemani, N. D., Simon, K. & 17 others, Keehan, R., Ind, W., Masters, T., Grant, S., Athwal, S., Collett, G., Tannetta, D., Sargent, I. L., Scull-Brown, E., Liu, X., Aquilina, K., Cohen, N., Lane, J. D., Thoresen, M., Hanley, J., Randall, A. D. & Case, C. P., 10 May 2014, In : Experimental Neurology.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)
2013

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Petherick, K. J., Williams, A. C., Lane, J. D., Ordóñez-Morán, P., Huelsken, J., Collard, T. J., Smartt, H. J., Batson, J., Malik, K., Paraskeva, C. & Greenhough, A., 4 Jun 2013, In : EMBO Journal. 32, 13, p. 1903 - 1916 14 p.

Research output: Contribution to journalArticle (Academic Journal)

129 Citations (Scopus)

Autophagy facilitates organelle clearance during differentiation of human erythroblasts: Evidence for a role for ATG4 paralogs during autophagosome maturation

Betin, V. M. S., Singleton, B. K., Parsons, S. F., Anstee, D. J. & Lane, J. D., Jun 2013, In : Autophagy. 9, 6, p. 881-893 13 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)

Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity

Raghunathan, V. K., Devey, M., Hawkins, S., Hails, L., Davis, S. A., Mann, S., Chang, I. T., Ingham, E., Malhas, A., Vaux, D. J., Lane, J. D. & Case, C. P., May 2013, In : Biomaterials. 34, 14, p. 3559-3570 12 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)

SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and Disease

Weir, H. J. M., Lane, J. D. & Balthasar, N., 2013, In : Genes & Cancer. 4, 3-4, p. 118-24

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)
2012

A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress

Betin, VMS., MacVicar, TDB., Parsons, SF., Anstee, DJ. & Lane, JD., Apr 2012, In : Autophagy. 8(4), 13 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease

Weir, H. J. M., Murray, T. K., Kehoe, P. G., Love, S., Verdin, E. M., O'Neill, M. J., Lane, J. D. & Balthasar, N., 6 Nov 2012, In : PLoS ONE. 7, 11, p. e48225 7 p., ARTN e48225.

Research output: Contribution to journalArticle (Academic Journal)

69 Citations (Scopus)

Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis

Griffiths, R. E., Kupzig, S., Cogan, N., Mankelow, T. J., Betin, V. M. S., Trakarnsanga, K., Massey, E. J., Lane, J. D., Parsons, S. F. & Anstee, D. J., 28 Jun 2012, In : Blood. 119, 26, p. 6296-6306 11 p.

Research output: Contribution to journalArticle (Academic Journal)

80 Citations (Scopus)

The ins and outs of human reticulocyte maturation Autophagy and the endosome/exosome pathway

Griffiths, R. E., Kupzig, S., Cogan, N., Mankelow, T. J., Betin, V. M. S., Trakarnsanga, K., Massey, E. J., Parsons, S. F., Anstee, D. J. & Lane, J. D., Jul 2012, In : Autophagy. 8, 7, p. 1150-1151 2 p.

Research output: Contribution to journalEditorial (Academic Journal)

34 Citations (Scopus)
2010

Alternative macroautophagy

Klionsky, DJ. & Lane, JD., Feb 2010, In : Autophagy. 6, 2, p. 201 - 201 1 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis

Cheng, JPX., Betin, VMS., Weir, H., Shelmani, GMA., Moss, DK. & Lane, JD., 2010, In : Nature. 1

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Organelle dynamics and membrane trafficking in apoptosis and autophagy

Cheng, JPX. & Lane, JD., Nov 2010, In : Histology and Histopathology. 25 (11), p. 1457 - 1472 17 p.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

Patsos, HA., Greenhough, A., Hicks, DJ., Al kharusi, M., Collard, TJ., Lane, JD., Paraskeva, C. & Williams, AC., Jul 2010, In : International Journal of Oncology. 37 (5), p. 187 - 193 7 p.

Research output: Contribution to journalArticle (Academic Journal)

54 Citations (Scopus)
2009

Alternative macroauotophagy

Klionsky, DJ. & Lane, JD., Feb 2009, In : Autophagy. 6 (2), p. 201 - 201 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Atg4D at the interface between autophagy and apoptosis

Betin, VMS. & Lane, JD., Oct 2009, In : Autophagy. 5 (7), p. 1057 - 1059 3 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondiral targetting and apoptosis

Betin, V. M. S. & Lane, J. D., Jul 2009, In : Journal of Cell Science. 122 , 14, p. 2554 - 2566 13 p.

Research output: Contribution to journalArticle (Academic Journal)

174 Citations (Scopus)

Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase

Moss, DK., Wilde, A. & Lane, JD., Mar 2009, In : Journal of Cell Science. 122 (5), p. 644 - 655 12 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Nanoparticles can cause DNA damage across a cellular barrier

Bhabra, G., Sood, A., Fisher, B., Cartwright, L., Saunders, M. W., Evans, W. H., Surprenant, A., Lopez-Castejon, G., Mann, S., Davis, S. A., Hails, L. A., Ingham, E., Verkade, P., Lane, J., Heesom, K., Newson, R. & Case, C. P., Dec 2009, In : Nature Nanotechnology. 4, 12, p. 876 - 883 8 p.

Research output: Contribution to journalArticle (Academic Journal)

261 Citations (Scopus)
2008

The cytoskeleton and the control of organelle dynamics in the apoptotic execution phase

Betin, VMS. & Lane, JD., 2008, The Eukaryotic Cell Cycle (SEB Experimental Biology Series, 59). Bryant, JA. & Francis, D. (eds.). Taylor & Francis Group, p. 267 - 283 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

1 Citation (Scopus)
2006

A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation

Moss, DK., Betin, VM., Malesinski, SD. & Lane, JD., Jun 2006, In : Journal of Cell Science. 119 (11), p. 2362 - 2374 13 p.

Research output: Contribution to journalArticle (Academic Journal)

83 Citations (Scopus)

Microtubules: forgotten players in the apoptotic execution phase

Moss, DK. & Lane, JD., Jul 2006, In : Trends in Cell Biology. 16(7), p. 330 - 338 9 p.

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Transmitted light imaging

Lane, JD. & Stebbings, H., 2006, Methods Express: Cell Imaging. Stephens, D. (ed.). Chapter 4 ed. Scion Publishing Limited, p. 73 - 93 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

2005

Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptic cells

Lane, JD., Allen, VJ. & Woodman, PG., Sep 2005, In : Journal of Cell Science. 118 (17), p. 4059 - 4071 13 p.

Research output: Contribution to journalArticle (Academic Journal)

105 Citations (Scopus)

The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2

Patsos, HA., Hicks, DJ., Dobson, RRH., Greenhough, A., Woodman, N., Lane, JD., Williams, AC. & Paraskeva, C., Dec 2005, In : Gut. 54 (12), p. 1741 - 1750 10 p.

Research output: Contribution to journalArticle (Academic Journal)

87 Citations (Scopus)
2004

Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis

Lowe, M., Lane, JD., Woodman, PG. & Allan, VJ., 2004, In : Journal of Cell Science. 117, p. 1139 - 1150

Research output: Contribution to journalArticle (Academic Journal)

60 Citations (Scopus)
2002

Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis

Lane, JD., Lucocq, J., Pryde, J., Barr, FA., Woodman, PG., Allan, VJ. & Lowe, M., Feb 2002, In : Journal of Cell Biology. 156 (3), p. 495 - 509 15 p.

Research output: Contribution to journalArticle (Academic Journal)

159 Citations (Scopus)
2001

Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150Glued stops dynein-dependent membrane motility

Lane, JD., Maïlys, AS., Vergnolle, MAS., Woodman, PG. & Allan, VJ., Jun 2001, In : Journal of Cell Biology. 153 (7), p. 1415 - 1426 12 p.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)