Dr Jon D Lane

Search results

• 2020

  A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

  Anton, Z., Betin, V. M. S., Simonetti, B., Traer, C. J., Attar, N., Cullen, P. J. & Lane, J. D., 15 Jul 2020, In: Journal of Cell Science. 133, 14, 38 p., jcs246306.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Sorting Nexins
  • Autophagosomes
  • Autophagy
  • Membranes
  • Clustered Regularly Interspaced Short Palindromic Repeats
  57 Downloads (Pure)

• A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons

  Stathakos, P., Jiménez Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., Kerrigan, T. L., Randall, A. D., Caldwell, M. A. & Lane, J. D., 14 Apr 2020, In: Autophagy. 17 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Mitochondrial Degradation
  • Induced Pluripotent Stem Cells
  • Dopaminergic Neurons
  • Autophagy
  • Cell Culture Techniques
  58 Downloads (Pure)

• Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

  Jimenez Moreno, N. & Lane, J. D., 10 Nov 2020, In: Oxidative medicine and cellular longevity. 38 p., 8865611 .

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Reactive Nitrogen Species
  • Oxidation-Reduction
  • Autophagy
  • Neurons
  • Reactive Oxygen Species
  36 Downloads (Pure)

• Efficient and scalable generation of human midbrain astrocytes from hiPSCs

  Crompton, L. A., McComish, S. F., Stathakos, P., Cordero Llana, O., Lane, J. D. & Caldwell, M. A., 24 Sep 2020, (Submitted) In: Journal of visualized experiments : JoVE.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Astrocytes
  • Mesencephalon
  • Induced Pluripotent Stem Cells
  • Dopamine
  • Preclinical Drug Evaluations

• LIR-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

  Jimenez Moreno, N., Stathakos, P., Anton, Z., Shoemark, D. K., Sessions, R. B., Witzgall, R., Caldwell, M. A. & Lane, J. D., 2020, (Submitted) In: The Journal of cell biology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Mesencephalon
  • Autophagy
  • Rotenone
  • Autophagy-Related Protein 8 Family
  • Nutrients

• Mitochondrial import, health and mtDNA copy number variability using Type II and Type V CRISPR effectors

  Anton, Z., Mullally, G. E. L., Ford, H. C., Van Der Kamp, M. W., Szczelkun, M. D. & Lane, J. D., 16 Sep 2020, In: Journal of Cell Science. 133, jcs248468.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Mitochondrial DNA
  • Guide RNA
  • Mitochondrial Genome
  • Health

• Zebrafish as a Model to Study Autophagy and its Role in Skeletal Development and Disease

  Moss, J. J., Hammond, C. & Lane, J. D., 11 Sep 2020, In: Histochemistry and Cell Biology. 16 p.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Zebrafish
  • Autophagy
  • Genetic Phenomena
  • Fertility
  • Proteolysis
  31 Downloads (Pure)
• 2019

  DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation

  Mansell, E., Zareian, N., Malouf, C., Kapeni, C., Brown, N., Badie, C., Baird, D., Lane, J. D., Ottersbach, K., Blair, A. & Case, C. P., 13 Mar 2019, In: Scientific Reports. 9, 1, 17 p., 4370.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Fetal Blood
  • Placenta
  • DNA Damage
  • Leukemia
  • Bone Marrow Cells
  4 Citations (Scopus)

  224 Downloads (Pure)

• Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research

  Stathakos, P., Jimenez Moreno, N., Crompton, L., Nistor, P., Caldwell, M. & Lane, J., 5 Jan 2019, Autophagy. Humana Press, p. 257-280 24 p. (Methods in Molecular Biology).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

  Open Access

  File

  • Induced Pluripotent Stem Cells
  • Mesencephalon
  • Autophagy
  • Parkinson Disease
  • Neurons
  1 Citation (Scopus)

  114 Downloads (Pure)

• Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells

  Anderson, M. W., Moss, J., Szalai, R. & Lane, J., 22 Feb 2019, In: iScience. 12, p. 182-193 36 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Colorectal Neoplasms
  • Apoptosis
  • Proteins
  • Cell Death
  • Proto-Oncogene Proteins c-akt
  4 Citations (Scopus)

  202 Downloads (Pure)
• 2018

  Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes

  Hawkins, S. J., Crompton, L. A., Sood, A., Saunders, M., Boyle, N. T., Buckley, A., Minogue, A. M., McComish, S. F., Jiménez-Moreno, N., Cordero-Llana, O., Stathakos, P., Gilmore, C. E., Kelly, S., Lane, J. D., Case, C. P. & Caldwell, M. A., 2 Apr 2018, In: Nature Nanotechnology. 13, p. 427-433 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Astrocytes
  • toxicity
  • Toxicity
  • DNA
  • Nanoparticles
  56 Citations (Scopus)

  569 Downloads (Pure)

• Transautophagy: Research and Translation of Autophagy Knowledge

  Lane, J., Albertini, M., Proikas-Cezanne, T., Engedal, N. & Zerovnik, E., 16 May 2018, In: Oxidative medicine and cellular longevity. 2018, 3 p.

  Research output: Contribution to journal › Editorial (Academic Journal)

  • Translational Medical Research
  • Autophagy
  • Health
  • Pathology
  • Medicine
• 2017

  Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease

  Jimenez Moreno, N., Stathakos, P., Caldwell, M. A. & Lane, J., Sep 2017, In: Cells. 6, 3, 27 p., 24.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Neurodegenerative diseases
  • Stem cells
  • Induced Pluripotent Stem Cells
  • Autophagy
  • Neurons
  361 Downloads (Pure)

• Self-eating on demand: autophagy in cancer and cancer therapy

  Lane, J. D. & Agostinis, P., 7 Dec 2017, In: Frontiers in Oncology. 7, DEC, 3 p., 302.

  Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

  Open Access

  File

  • Autophagy
  • Eating
  • Neoplasms
  • Therapeutics
  268 Downloads (Pure)

• Signalling mechanisms in autophagy: an introduction to the issue

  Lane, J., 12 Dec 2017, In: Essays in Biochemistry.

  Research output: Contribution to journal › Editorial (Academic Journal)

  Open Access
  1 Citation (Scopus)
• 2015

  Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells

  Morgan, R. G., Molnar, E., Jones, R. F., Collard, T. J., Lane, J. D., Greenhough, A., Paraskeva, C. & Williams, A. C., 17 Feb 2015, In: British Journal of Cancer. 112, 4, p. 714-719 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Protein Stability
  • Neoplastic Stem Cells
  • Glycosylation
  • Nutrients
  • Colorectal Neoplasms
  12 Citations (Scopus)

  316 Downloads (Pure)

• Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells

  MacVicar, T., Mannack, L., Lees, R. M. & Lane, J., Jun 2015, In: International Journal of Molecular Sciences. p. 13356-13380 25 p.

  Research output: Contribution to journal › Special issue (Academic Journal) › peer-review

  • Mitochondrial Degradation
  • Autophagy
  • Endoplasmic Reticulum
  • Small Interfering RNA
  • Calcium
  19 Citations (Scopus)

• The autophagosome: current understanding of formation and maturation

  Mannack, L. V. J. & Lane, J. D., 16 Feb 2015, In: Research and Reports in Biochemistry. 2015, 5, p. 39-58 20 p.

  Research output: Contribution to journal › Review article (Academic Journal) › peer-review

  Open Access

  File

  • Autophagosomes
  • Autophagy
  • Membranes
  • Lysosomes
  • Organelles
  371 Downloads (Pure)

• USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

  Liang, J-R., Lane, J., Mayor, U., Clague, M. & Urbe, S., 4 Mar 2015, In: EMBO Reports. 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cell death
  • Mitochondria
  • Cell Death
  • Substrates
  • Ubiquitination
  64 Citations (Scopus)
• 2014

  Impaired OMA1 dependent OPA1 cleavage and reduced DRP1 fission activity combine to prevent mitophagy in OXPHOS dependent cells

  MacVicar, T. & Lane, J. D., 2014, In: Journal of Cell Science. p. 2313-2325 15.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Mitochondrial Degradation
  • Mitochondrial Dynamics
  • Mitochondria
  • Quality Control
  • Carbonyl Cyanide m-Chlorophenyl Hydrazone

• Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions

  Curtis, D. J., Sood, A., Phillips, T. E. J., Leinster, V. H. L., Nishiguchi, A., Coyle, C., Lacharme-Lora, L., Beaumont, O., Kemp, H., Goodall, R., Cornes, L., Giugliano, M., Barone, R. A., Matsusaki, M., Akashi, M., Tanaka, H. Y., Kano, M., McGarvey, J., Halemani, N. D., Simon, K. & 17 others, Keehan, R., Ind, W., Masters, T., Grant, S., Athwal, S., Collett, G., Tannetta, D., Sargent, I. L., Scull-Brown, E., Liu, X., Aquilina, K., Cohen, N., Lane, J. D., Thoresen, M., Hanley, J., Randall, A. D. & Case, C. P., 10 May 2014, In: Experimental Neurology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Placenta
  • Hypoxia
  • Neurons
  • Conditioned Culture Medium
  • Brain
  20 Citations (Scopus)
• 2013

  Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

  Petherick, K. J., Williams, A. C., Lane, J. D., Ordóñez-Morán, P., Huelsken, J., Collard, T. J., Smartt, H. J., Batson, J., Malik, K., Paraskeva, C. & Greenhough, A., 4 Jun 2013, In: EMBO Journal. 32, 13, p. 1903 - 1916 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Catenins
  • Autophagy
  • Autophagosomes
  • Physiological Stress
  • Wnt Signaling Pathway
  156 Citations (Scopus)

• Autophagy facilitates organelle clearance during differentiation of human erythroblasts: Evidence for a role for ATG4 paralogs during autophagosome maturation

  Betin, V. M. S., Singleton, B. K., Parsons, S. F., Anstee, D. J. & Lane, J. D., Jun 2013, In: Autophagy. 9, 6, p. 881-893 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Erythroblasts
  • Autophagosomes
  • Autophagy
  • Organelles
  • Erythroid Cells
  57 Citations (Scopus)

• Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity

  Raghunathan, V. K., Devey, M., Hawkins, S., Hails, L., Davis, S. A., Mann, S., Chang, I. T., Ingham, E., Malhas, A., Vaux, D. J., Lane, J. D. & Case, C. P., May 2013, In: Biomaterials. 34, 14, p. 3559-3570 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Cobalt
  • Particle Size
  • Nanoparticles
  • Particle size
  • Reactive Oxygen Species
  57 Citations (Scopus)

• SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and Disease

  Weir, H. J. M., Lane, J. D. & Balthasar, N., 2013, In: Genes & Cancer. 4, 3-4, p. 118-24

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  37 Citations (Scopus)
• 2012

  A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress

  Betin, VMS., MacVicar, TDB., Parsons, SF., Anstee, DJ. & Lane, JD., Apr 2012, In: Autophagy. 8(4), 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Caspases
  • Oxidative Stress
  • Reactive Oxygen Species
  • Carbonyl Cyanide m-Chlorophenyl Hydrazone
  • Mitochondrial Degradation
  29 Citations (Scopus)

• CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease

  Weir, H. J. M., Murray, T. K., Kehoe, P. G., Love, S., Verdin, E. M., O'Neill, M. J., Lane, J. D. & Balthasar, N., 6 Nov 2012, In: PLoS ONE. 7, 11, p. e48225 7 p., ARTN e48225.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Sirtuin 3
  • Alzheimer disease
  • reactive oxygen species
  • Reactive Oxygen Species
  • Alzheimer Disease
  74 Citations (Scopus)

• Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis

  Griffiths, R. E., Kupzig, S., Cogan, N., Mankelow, T. J., Betin, V. M. S., Trakarnsanga, K., Massey, E. J., Lane, J. D., Parsons, S. F. & Anstee, D. J., 28 Jun 2012, In: Blood. 119, 26, p. 6296-6306 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  88 Citations (Scopus)

• The ins and outs of human reticulocyte maturation Autophagy and the endosome/exosome pathway

  Griffiths, R. E., Kupzig, S., Cogan, N., Mankelow, T. J., Betin, V. M. S., Trakarnsanga, K., Massey, E. J., Parsons, S. F., Anstee, D. J. & Lane, J. D., Jul 2012, In: Autophagy. 8, 7, p. 1150-1151 2 p.

  Research output: Contribution to journal › Editorial (Academic Journal) › peer-review
  36 Citations (Scopus)
• 2010

  Alternative macroautophagy

  Klionsky, DJ. & Lane, JD., Feb 2010, In: Autophagy. 6, 2, p. 201 - 201 1 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  9 Citations (Scopus)

• Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis

  Cheng, JPX., Betin, VMS., Weir, H., Shelmani, GMA., Moss, DK. & Lane, JD., 2010, In: Nature. 1

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Golgi Matrix Proteins
  • Caspases
  • Apoptosis
  • Mitochondria
  • Cell Membrane Structures
  32 Citations (Scopus)

• Organelle dynamics and membrane trafficking in apoptosis and autophagy

  Cheng, JPX. & Lane, JD., Nov 2010, In: Histology and Histopathology. 25 (11), p. 1457 - 1472 17 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Autophagy
  • Organelles
  • Cell Death
  • Apoptosis
  • Membranes
  10 Citations (Scopus)

• The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

  Patsos, HA., Greenhough, A., Hicks, DJ., Al kharusi, M., Collard, TJ., Lane, JD., Paraskeva, C. & Williams, AC., Jul 2010, In: International Journal of Oncology. 37 (5), p. 187 - 193 7 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • anandamide
  • Cannabinoids
  • Colonic Neoplasms
  • Colorectal Neoplasms
  • Cell Death
  57 Citations (Scopus)
• 2009

  Alternative macroauotophagy

  Klionsky, DJ. & Lane, JD., Feb 2009, In: Autophagy. 6 (2), p. 201 - 201 1 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

• Atg4D at the interface between autophagy and apoptosis

  Betin, VMS. & Lane, JD., Oct 2009, In: Autophagy. 5 (7), p. 1057 - 1059 3 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Caspases
  • Autophagy
  • Endopeptidases
  • Autophagosomes
  • Apoptosis
  39 Citations (Scopus)

• Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondiral targetting and apoptosis

  Betin, V. M. S. & Lane, J. D., Jul 2009, In: Journal of Cell Science. 122 , 14, p. 2554 - 2566 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Autophagosomes
  • Caspases
  • Apoptosis
  • Autophagy
  • Mitochondria
  186 Citations (Scopus)

• Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase

  Moss, DK., Wilde, A. & Lane, JD., Mar 2009, In: Journal of Cell Science. 122 (5), p. 644 - 655 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  28 Citations (Scopus)

• Nanoparticles can cause DNA damage across a cellular barrier

  Bhabra, G., Sood, A., Fisher, B., Cartwright, L., Saunders, M. W., Evans, W. H., Surprenant, A., Lopez-Castejon, G., Mann, S., Davis, S. A., Hails, L. A., Ingham, E., Verkade, P., Lane, J., Heesom, K., Newson, R. & Case, C. P., Dec 2009, In: Nature Nanotechnology. 4, 12, p. 876 - 883 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • DNA
  • Nanoparticles
  • deoxyribonucleic acid
  • damage
  • nanoparticles
  281 Citations (Scopus)
• 2008

  The cytoskeleton and the control of organelle dynamics in the apoptotic execution phase

  Betin, VMS. & Lane, JD., 2008, The Eukaryotic Cell Cycle (SEB Experimental Biology Series, 59). Bryant, JA. & Francis, D. (eds.). Taylor & Francis Group, p. 267 - 283 17 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

  1 Citation (Scopus)
• 2006

  A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation

  Moss, DK., Betin, VM., Malesinski, SD. & Lane, JD., Jun 2006, In: Journal of Cell Science. 119 (11), p. 2362 - 2374 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  88 Citations (Scopus)

• Microtubules: forgotten players in the apoptotic execution phase

  Moss, DK. & Lane, JD., Jul 2006, In: Trends in Cell Biology. 16(7), p. 330 - 338 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  43 Citations (Scopus)

• Transmitted light imaging

  Lane, JD. & Stebbings, H., 2006, Methods Express: Cell Imaging. Stephens, D. (ed.). Chapter 4 ed. Scion Publishing Limited, p. 73 - 93 11 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
• 2005

  Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptic cells

  Lane, JD., Allen, VJ. & Woodman, PG., Sep 2005, In: Journal of Cell Science. 118 (17), p. 4059 - 4071 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  106 Citations (Scopus)

• The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2

  Patsos, HA., Hicks, DJ., Dobson, RRH., Greenhough, A., Woodman, N., Lane, JD., Williams, AC. & Paraskeva, C., Dec 2005, In: Gut. 54 (12), p. 1741 - 1750 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  88 Citations (Scopus)
• 2004

  Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis

  Lowe, M., Lane, JD., Woodman, PG. & Allan, VJ., 2004, In: Journal of Cell Science. 117, p. 1139 - 1150

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  62 Citations (Scopus)
• 2002

  Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis

  Lane, JD., Lucocq, J., Pryde, J., Barr, FA., Woodman, PG., Allan, VJ. & Lowe, M., Feb 2002, In: Journal of Cell Biology. 156 (3), p. 495 - 509 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  166 Citations (Scopus)
• 2001

  Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150^Glued stops dynein-dependent membrane motility

  Lane, JD., Maïlys, AS., Vergnolle, MAS., Woodman, PG. & Allan, VJ., Jun 2001, In: Journal of Cell Biology. 153 (7), p. 1415 - 1426 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  42 Citations (Scopus)