Jon D Lane

2024

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis

Chen, X., Tsvetkov, A. S., Shen, H.-M., Isidoro, C., Ktistakis, N. T., Linkermann, A., Koopman, W. J. H., Simon, H.-U., Galluzzi, L., Luo, S., Xu, D., Gu, W., Peulen, O., Cai, Q., Rubinsztein, D. C., Chi, J.-T., Zhang, D. D., Li, C., Toyokuni, S. & Liu, J. & 49 others, Roh, J.-L., Dai, E., Juhasz, G., Liu, W., Zhang, J., Yang, M., Liu, J., Zhu, L.-Q., Zou, W., Piacentini, M., Ding, W.-X., Yue, Z., Xie, Y., Petersen, M., Gewirtz, D. A., Mandell, M. A., Chu, C. T., Sinha, D., Eftekharpour, E., Zhivotovsky, B., Besteiro, S., Gabrilovich, D. I., Kim, D.-H., Kagan, V. E., Bayir, H., Chen, G.-C., Ayton, S., Lünemann, J. D., Komatsu, M., Krautwald, S., Loos, B., Baehrecke, E. H., Wang, J., Lane, J. D., Sadoshima, J., Yang, W. S., Gao, M., Münz, C., Thumm, M., Kampmann, M., Yu, D., Lipinski, M. M., Jones, J. W., Jiang, X., Zeh, H. J., Kang, R., Klionsky, D. J., Kroemer, G. & Tang, D., 2 Jun 2024, In: Autophagy. 20, 6, p. 1213-1246 34 p.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

67 Citations (Scopus)

Reactive astrocytes generated from human iPSC are pro-inflammatory and display altered metabolism

McComish, S. F., O'Sullivan, J., Copas, A. M. M., Imiolek, M., Boyle, N. T., Crompton, L. A., Lane, J. D. & Caldwell, M. A., 1 Dec 2024, In: Experimental Neurology. 382, p. 114979 114979.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1 Citation (Scopus)

2023

ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience

Jimenez Moreno, N., Kollareddy, M., Stathakos, P., Moss, J. J., Anton, Z., Shoemark, D. K., Sessions, R. B., Witzgall, R., Caldwell, M. & Lane, J. D., 4 Apr 2023, In: Journal of Cell Biology. 222, 5

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

9 Citations (Scopus)

ATG8 proteins are co-factors for human dopaminergic neuronal transcriptional control: implications for neuronal resilience in Parkinson disease

Jimenez Moreno, N. & Lane, J. D., 20 Jun 2023, In: Autophagy.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

Human stem cell-derived ventral midbrain astrocytes exhibit a region-specific secretory profile

Crompton, L. A., McComish, S. F., Steward, T. G. J., Whitcomb, D., Lane, J. D. & Caldwell, M. A., 17 Apr 2023, In: Brain Communications. 5, 2, p. 1-6 6 p., fcad114.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

2022

Autophagy tunes chondrocyte differentiation and joint developmental precision in zebrafish

Moss, J. J., Wirth, M., Tooze, S. A., Hammond, C. & Lane, J. D., 31 Dec 2022, In: Autophagy Reports. 1, 1, p. 214-218 5 p.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery

Baines, K., Yoshioka, K., Takuwa, Y. & Lane, J. D., 7 Apr 2022, In: Autophagy Reports. 1, 1, p. 88-118 31 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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6 Citations (Scopus)

72 Downloads (Pure)

2021

Autophagy coordinates chondrocyte development and early joint formation in zebrafish

Moss, J. J., Wirth, M., Tooze, S. A., Lane, J. D. & Hammond, C., 28 Oct 2021, In: FASEB Journal. 35, 11, p. 1-34 34 p., e22002.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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17 Citations (Scopus)

126 Downloads (Pure)

Efficient and Scalable Generation of Human Ventral Midbrain Astrocytes from Human-Induced Pluripotent Stem Cells

Crompton, L. A., McComish, S. F., Stathakos, P., Cordero Llana, O., Lane, J. D. & Caldwell, M. A., 2 Oct 2021, In: Journal of Visualized Experiments. 176, e62095.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

294 Downloads (Pure)

L-Arginine Ameliorates Defective Autophagy in GM2 Gangliosidoses by mTOR Modulation

Castejon Vega, B., Rubio, A., Perez-Pulido, A., Quiles, J., Lane, J. D., Fernandez-Dominguez, B., Cachon-Gonzales, M., Martin-Ruiz, C., Sanz, A., Cox, T., Alcocer-Gomez, E. & Cordero, M., 11 Nov 2021, In: Cells. 10, 11, 21 p., 3122.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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6 Citations (Scopus)

61 Downloads (Pure)

Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study

COVIDSurg Collaborative, 30 Nov 2021, In: BMJ Open. 11, 11, 10 p., e050830.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

2020

A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

Anton, Z., Betin, V. M. S., Simonetti, B., Traer, C. J., Attar, N., Cullen, P. J. & Lane, J. D., 15 Jul 2020, In: Journal of Cell Science. 133, 14, 38 p., jcs246306.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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33 Citations (Scopus)

134 Downloads (Pure)

A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons

Stathakos, P., Jiménez Moreno, N., Crompton, L. A., Nistor, P. A., Badger, J. L., Barbuti, P. A., Kerrigan, T. L., Randall, A. D., Caldwell, M. A. & Lane, J. D., 14 Apr 2020, In: Autophagy. 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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22 Citations (Scopus)

175 Downloads (Pure)

Autophagy and Redox Homeostasis in Parkinson’s: A Crucial Balancing Act

Moreno, N. J. & Lane, J., 10 Nov 2020, In: Oxidative medicine and cellular longevity. 2020, 1, 38 p., 8865611 .

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

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21 Citations (Scopus)

183 Downloads (Pure)

Efficient and scalable generation of human midbrain astrocytes from hiPSCs

Crompton, L. A., McComish, S. F., Stathakos, P., Cordero Llana, O., Lane, J. D. & Caldwell, M. A., 24 Sept 2020, (Submitted) In: Journal of visualized experiments : JoVE.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Mitochondrial import, health and mtDNA copy number variability using Type II and Type V CRISPR effectors

Anton, Z., Mullally, G. E. L., Ford, H. C., Van Der Kamp, M. W., Szczelkun, M. D. & Lane, J. D., 16 Sept 2020, In: Journal of Cell Science. 133, jcs248468.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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23 Citations (Scopus)

79 Downloads (Pure)

Zebrafish as a Model to Study Autophagy and its Role in Skeletal Development and Disease

Moss, J. J., Hammond, C. & Lane, J. D., 11 Sept 2020, In: Histochemistry and Cell Biology. 16 p.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

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20 Citations (Scopus)

110 Downloads (Pure)

2019

DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation

Mansell, E., Zareian, N., Malouf, C., Kapeni, C., Brown, N., Badie, C., Baird, D., Lane, J. D., Ottersbach, K., Blair, A. & Case, C. P., 13 Mar 2019, In: Scientific Reports. 9, 1, 17 p., 4370.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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11 Citations (Scopus)

281 Downloads (Pure)

Imaging Autophagy in hiPSC-Derived Midbrain Dopaminergic Neuronal Cultures for Parkinson’s Disease Research

Stathakos, P., Jimenez Moreno, N., Crompton, L., Nistor, P., Caldwell, M. & Lane, J., 5 Jan 2019, Autophagy. Humana Press, p. 257-280 24 p. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

Open Access

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4 Citations (Scopus)

330 Downloads (Pure)

Mathematical Modeling Highlights the Complex Role of AKT in TRAIL-Induced Apoptosis of Colorectal Carcinoma Cells

Anderson, M. W., Moss, J., Szalai, R. & Lane, J., 22 Feb 2019, In: iScience. 12, p. 182-193 36 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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18 Citations (Scopus)

307 Downloads (Pure)

2018

Nanoparticle-induced neuronal toxicity across placental barriers is mediated by autophagy and dependent on astrocytes

Hawkins, S. J., Crompton, L. A., Sood, A., Saunders, M., Boyle, N. T., Buckley, A., Minogue, A. M., McComish, S. F., Jiménez-Moreno, N., Cordero-Llana, O., Stathakos, P., Gilmore, C. E., Kelly, S., Lane, J. D., Case, C. P. & Caldwell, M. A., 2 Apr 2018, In: Nature Nanotechnology. 13, p. 427-433 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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117 Citations (Scopus)

1042 Downloads (Pure)

Transautophagy: Research and Translation of Autophagy Knowledge

Lane, J., Albertini, M., Proikas-Cezanne, T., Engedal, N. & Zerovnik, E., 16 May 2018, In: Oxidative medicine and cellular longevity. 2018, 3 p.

Research output: Contribution to journal › Editorial (Academic Journal)

2 Citations (Scopus)

2017

Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease

Jimenez Moreno, N., Stathakos, P., Caldwell, M. A. & Lane, J., Sept 2017, In: Cells. 6, 3, 27 p., 24.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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19 Citations (Scopus)

427 Downloads (Pure)

Self-eating on demand: autophagy in cancer and cancer therapy

Lane, J. D. & Agostinis, P., 7 Dec 2017, In: Frontiers in Oncology. 7, DEC, 3 p., 302.

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

Open Access

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1 Citation (Scopus)

359 Downloads (Pure)

Signalling mechanisms in autophagy: an introduction to the issue

Lane, J., 12 Dec 2017, In: Essays in Biochemistry.

Research output: Contribution to journal › Editorial (Academic Journal)

Open Access

5 Citations (Scopus)

2015

Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells

Morgan, R. G., Molnar, E., Jones, R. F., Collard, T. J., Lane, J. D., Greenhough, A., Paraskeva, C. & Williams, A. C., 17 Feb 2015, In: British Journal of Cancer. 112, 4, p. 714-719 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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14 Citations (Scopus)

360 Downloads (Pure)

Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells

MacVicar, T., Mannack, L., Lees, R. M. & Lane, J., Jun 2015, In: International Journal of Molecular Sciences. p. 13356-13380 25 p.

Research output: Contribution to journal › Special issue (Academic Journal) › peer-review

46 Citations (Scopus)

The autophagosome: current understanding of formation and maturation

Mannack, L. V. J. & Lane, J. D., 16 Feb 2015, In: Research and Reports in Biochemistry. 2015, 5, p. 39-58 20 p.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

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403 Downloads (Pure)

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

Liang, J.-R., Lane, J., Mayor, U., Clague, M. & Urbe, S., 4 Mar 2015, In: EMBO Reports. 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

140 Citations (Scopus)

2014

Impaired OMA1 dependent OPA1 cleavage and reduced DRP1 fission activity combine to prevent mitophagy in OXPHOS dependent cells

MacVicar, T. & Lane, J. D., 2014, In: Journal of Cell Science. p. 2313-2325 15.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

93 Citations (Scopus)

Secretions from placenta, after hypoxia/reoxygenation, can damage developing neurones of brain under experimental conditions

Curtis, D. J., Sood, A., Phillips, T. E. J., Leinster, V. H. L., Nishiguchi, A., Coyle, C., Lacharme-Lora, L., Beaumont, O., Kemp, H., Goodall, R., Cornes, L., Giugliano, M., Barone, R. A., Matsusaki, M., Akashi, M., Tanaka, H. Y., Kano, M., McGarvey, J., Halemani, N. D. & Simon, K. & 17 others, Keehan, R., Ind, W., Masters, T., Grant, S., Athwal, S., Collett, G., Tannetta, D., Sargent, I. L., Scull-Brown, E., Liu, X., Aquilina, K., Cohen, N., Lane, J. D., Thoresen, M., Hanley, J., Randall, A. D. & Case, C. P., 10 May 2014, In: Experimental Neurology.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

32 Citations (Scopus)

2013

Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

Petherick, K. J., Williams, A. C., Lane, J. D., Ordóñez-Morán, P., Huelsken, J., Collard, T. J., Smartt, H. J., Batson, J., Malik, K., Paraskeva, C. & Greenhough, A., 4 Jun 2013, In: EMBO Journal. 32, 13, p. 1903 - 1916 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

269 Citations (Scopus)

Autophagy facilitates organelle clearance during differentiation of human erythroblasts: Evidence for a role for ATG4 paralogs during autophagosome maturation

Betin, V. M. S., Singleton, B. K., Parsons, S. F., Anstee, D. J. & Lane, J. D., Jun 2013, In: Autophagy. 9, 6, p. 881-893 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

87 Citations (Scopus)

Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity

Raghunathan, V. K., Devey, M., Hawkins, S., Hails, L., Davis, S. A., Mann, S., Chang, I. T., Ingham, E., Malhas, A., Vaux, D. J., Lane, J. D. & Case, C. P., May 2013, In: Biomaterials. 34, 14, p. 3559-3570 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

75 Citations (Scopus)

SIRT3: A Central Regulator of Mitochondrial Adaptation in Health and Disease

Weir, H. J. M., Lane, J. D. & Balthasar, N., 2013, In: Genes & Cancer. 4, 3-4, p. 118-24

Research output: Contribution to journal › Article (Academic Journal) › peer-review

58 Citations (Scopus)

2012

A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress

Betin, V., MacVicar, T., Parsons, S., Anstee, D. & Lane, J., Apr 2012, In: Autophagy. 8(4), 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

47 Citations (Scopus)

CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease

Weir, H. J. M., Murray, T. K., Kehoe, P. G., Love, S., Verdin, E. M., O'Neill, M. J., Lane, J. D. & Balthasar, N., 6 Nov 2012, In: PLoS ONE. 7, 11, p. e48225 7 p., ARTN e48225.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

111 Citations (Scopus)

Maturing reticulocytes internalize plasma membrane in glycophorin A-containing vesicles that fuse with autophagosomes before exocytosis

Griffiths, R. E., Kupzig, S., Cogan, N., Mankelow, T. J., Betin, V. M. S., Trakarnsanga, K., Massey, E. J., Lane, J. D., Parsons, S. F. & Anstee, D. J., 28 Jun 2012, In: Blood. 119, 26, p. 6296-6306 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

147 Citations (Scopus)

The ins and outs of human reticulocyte maturation Autophagy and the endosome/exosome pathway

Griffiths, R. E., Kupzig, S., Cogan, N., Mankelow, T. J., Betin, V. M. S., Trakarnsanga, K., Massey, E. J., Parsons, S. F., Anstee, D. J. & Lane, J. D., Jul 2012, In: Autophagy. 8, 7, p. 1150-1151 2 p.

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

47 Citations (Scopus)

2010

Alternative macroautophagy

Klionsky, D. & Lane, J., Feb 2010, In: Autophagy. 6, 2, p. 201 - 201 1 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

Caspase cleavage of the Golgi stacking factor GRASP65 is required for Fas/CD95-mediated apoptosis

Cheng, J., Betin, V., Weir, H., Shelmani, G., Moss, D. & Lane, J., 2010, In: Nature. 1

Research output: Contribution to journal › Article (Academic Journal) › peer-review

41 Citations (Scopus)

Organelle dynamics and membrane trafficking in apoptosis and autophagy

Cheng, J. & Lane, J., Nov 2010, In: Histology and Histopathology. 25 (11), p. 1457 - 1472 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

Patsos, H., Greenhough, A., Hicks, D., Al kharusi, M., Collard, T., Lane, J., Paraskeva, C. & Williams, A., Jul 2010, In: International Journal of Oncology. 37 (5), p. 187 - 193 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

73 Citations (Scopus)

2009

Alternative macroauotophagy

Klionsky, D. & Lane, J., Feb 2009, In: Autophagy. 6 (2), p. 201 - 201 1 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Atg4D at the interface between autophagy and apoptosis

Betin, V. & Lane, J., Oct 2009, In: Autophagy. 5 (7), p. 1057 - 1059 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

65 Citations (Scopus)

Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondiral targetting and apoptosis

Betin, V. M. S. & Lane, J. D., Jul 2009, In: Journal of Cell Science. 122 , 14, p. 2554 - 2566 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

238 Citations (Scopus)

Dynamic release of nuclear RanGTP triggers TPX2-dependent microtubule assembly during the apoptotic execution phase

Moss, D., Wilde, A. & Lane, J., Mar 2009, In: Journal of Cell Science. 122 (5), p. 644 - 655 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

37 Citations (Scopus)

Nanoparticles can cause DNA damage across a cellular barrier

Bhabra, G., Sood, A., Fisher, B., Cartwright, L., Saunders, M. W., Evans, W. H., Surprenant, A., Lopez-Castejon, G., Mann, S., Davis, S. A., Hails, L. A., Ingham, E., Verkade, P., Lane, J., Heesom, K., Newson, R. & Case, C. P., Dec 2009, In: Nature Nanotechnology. 4, 12, p. 876 - 883 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

345 Citations (Scopus)

2008

The cytoskeleton and the control of organelle dynamics in the apoptotic execution phase

Betin, V. & Lane, J., 2008, The Eukaryotic Cell Cycle (SEB Experimental Biology Series, 59). Bryant, J. & Francis, D. (eds.). Taylor & Francis Group, p. 267 - 283 17 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book

2 Citations (Scopus)

2006

A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation

Moss, D., Betin, V., Malesinski, S. & Lane, J., Jun 2006, In: Journal of Cell Science. 119 (11), p. 2362 - 2374 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

119 Citations (Scopus)

Professor Jon D Lane

Research output

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