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Jonathan Clayden and his research group work on the construction of molecules with defined shapes, and are particular interested in exploring and exploiting molecular conformation.
The shape of a molecule dictates its function, and understanding conformational effects allows us to make molecules that behave in specific ways. We use the understanding we gain from conformational studies to design and synthesise molecular communication devices that transmit information to remote reactive sites, and to make conformationally-defined molecules (foldamers) that mimic biological function. We also explore new classes of atropisomers for potential use as chiral ligands.
We have also discovered that the restricted conformation of planar functional groups such as amides and ureas endue them, and their anionic (especially organolithium) derivatives, with remarkable new reactive properties which we make use of in the synthesis of valuable, potentially bioactive, target molecules.
Jonathan Clayden is the author of the widely-used textbook Organic Chemistry (Clayden, Greeves and Warren, 2nd edn. published OUP 2012)
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Enantioselective one-carbon expansion of aromatic rings by simultaneous formation and chromoselective irradiation of a transient coloured enolateSaunthwal, R. K., Mortimer, J., Orr-Ewing, A. J. & Clayden, J., 25 Jan 2022, (E-pub ahead of print) In: Chemical Science. 13, 7, p. 2079-2085 7 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile10 Downloads (Pure)
Inducing a pH-dependent conformational response by competitive binding to Zn2+ of a series of chiral ligands of disparate basicityWootten, M. M., Bailly, B. A. F. L., Tshepelevitsh, S., Leito, I. & Clayden, J., 17 Jan 2022, In: Chemical Science. 13, 8, p. 2258-2269 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile6 Downloads (Pure)
Reversible Capture and Release of a Ligand Mediated by a Long-Range Relayed Polarity Switch in a Urea OligomerWales, S. M., Morris, D. T. J. & Clayden, J., 10 Feb 2022, In: Journal of the American Chemical Society. 144, 7, p. 2841-2846 6 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile5 Downloads (Pure)