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Jonathan Clayden and his research group work on the construction of molecules with defined shapes, and are particular interested in exploring and exploiting molecular conformation.
The shape of a molecule dictates its function, and understanding conformational effects allows us to make molecules that behave in specific ways. We use the understanding we gain from conformational studies to design and synthesise molecular communication devices that transmit information to remote reactive sites, and to make conformationally-defined molecules (foldamers) that mimic biological function. We also explore new classes of atropisomers for potential use as chiral ligands.
We have also discovered that the restricted conformation of planar functional groups such as amides and ureas endue them, and their anionic (especially organolithium) derivatives, with remarkable new reactive properties which we make use of in the synthesis of valuable, potentially bioactive, target molecules.
Jonathan Clayden is the author of the widely-used textbook Organic Chemistry (Clayden, Greeves and Warren, 2nd edn. published OUP 2012)
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A Molecular Communication Channel Consisting of a Single Reversible Chain of Hydrogen Bonds in a Conformationally Flexible OligomerMorris, D. T. J., Wales, S. M., Tilly, D. P., Farrar, E. H. E., Grayson, M. N., Ward, J. W. & Clayden, J. P., 22 Jun 2021, (Accepted/In press) In: Chem.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Hydantoin-bridged medium ring scaffolds by migratory insertion of urea-tethered nitrile anions into aromatic C-N bondsMillward, M. J., Ellis, E., Ward, J. W. & Clayden, J., 14 Feb 2021, In: Chemical Science. 12, 6, p. 2091-2096 6 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile1 Citation (Scopus)14 Downloads (Pure)
Insight into the Mechanism of Action and Peptide-Membrane Interactions of Aib-Rich Peptides: Multitechnique Experimental and Theoretical AnalysisLizio, M. G., Campana, M., De Poli, M., Jefferies, D. F., Cullen, W., Andrushchenko, V., Chmel, N. P., Bouř, P., Khalid, S., Clayden, J., Blanch, E., Rodger, A. & Webb, S. J., 4 May 2021, In: ChemBioChem. 22, 9, p. 1656-1667 12 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile