Professor Jonathan P Clayden

MA, PhD, CChem, FRSC

  • BS8 1TS

1992 …2020

Research output per year

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Personal profile

Research interests

Jonathan Clayden and his research group work on the construction of molecules with defined shapes, and are particular interested in exploring and exploiting molecular conformation.

The shape of a molecule dictates its function, and understanding conformational effects allows us to make molecules that behave in specific ways. We use the understanding we gain from conformational studies to design and synthesise molecular communication devices that transmit information to remote reactive sites, and to make conformationally-defined molecules (foldamers) that mimic biological function.  We also explore new classes of atropisomers for potential use as chiral ligands.

We have also discovered that the restricted conformation of planar functional groups such as amides and ureas endue them, and their anionic (especially organolithium) derivatives, with remarkable new reactive properties which we make use of in the synthesis of valuable, potentially bioactive, target molecules.

Jonathan Clayden is the author of the widely-used textbook Organic Chemistry (Clayden, Greeves and Warren, 2nd edn. published OUP 2012)


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Molecular Robotics

Clayden, J. P.


Project: Research

Fellowship - Quentin Lefebvre

Clayden, J. P.

1/08/16 → …

Project: Research

REFOLDAMER: Fellowship - David Tilly

Clayden, J. P.


Project: Research

Research Output

An Aliphatic Bischler–Napieralski Reaction: Dihydropyridones by Cyclocarbonylation of 3-Allylimidazolidin-4-ones

Amer, M. M., Olaizola, O., Carter, J., Abas, H. & Clayden, J., 3 Jan 2020, In : Organic Letters. p. 253-256 4 p.

Research output: Contribution to journalArticle (Academic Journal)

  • Open Access
  • 33 Downloads (Pure)

    Molecular Recognition by Zn(II)-Capped Dynamic Foldamers

    Eccles, N., della Sala, F., Le Bailly, B. A. F., Whitehead, G. F. S., Clayden, J. & Webb, S. J., 1 Mar 2020, In : ChemistryOpen. 9, 3, p. 338-345 8 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
  • 23 Downloads (Pure)