Professor Jonathan P Clayden

MA, PhD, CChem, FRSC

  • BS8 1TS

1992 …2020

Research output per year

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Research Output

2020

An Aliphatic Bischler–Napieralski Reaction: Dihydropyridones by Cyclocarbonylation of 3-Allylimidazolidin-4-ones

Amer, M. M., Olaizola, O., Carter, J., Abas, H. & Clayden, J., 3 Jan 2020, In : Organic Letters. p. 253-256 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Molecular Recognition by Zn(II)-Capped Dynamic Foldamers

Eccles, N., della Sala, F., Le Bailly, B. A. F., Whitehead, G. F. S., Clayden, J. & Webb, S. J., 1 Mar 2020, In : ChemistryOpen. 9, 3, p. 338-345 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
20 Downloads (Pure)

Switchable foldamer ion channels with antibacterial activity

Peters, A. D., Clayden, J. & al., E., 4 Jun 2020, In : Chemical Science. 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Downloads (Pure)
2019

Amino Acid-Derived trans-N-Chloroformylimidazolidinones: Scalable, Stereoselective Synthesis, Structure, and Utility

Amer, M. M., Abas, H., Leonard, D. J., Ward, J. W. & Clayden, J., 7 Jun 2019, In : Journal of Organic Chemistry. 84, p. 7199-7206 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
21 Downloads (Pure)

Asymmetric and Geometry-Selective α-Alkenylation of α-Amino Acids

Abas, H., Mas-Roselló, J., Amer, M. M., Durand, D. J., Groleau, R. R., Fey, N. & Clayden, J., 18 Feb 2019, In : Angewandte Chemie - International Edition. 58, 8, p. 2418-2422 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
193 Downloads (Pure)

Connective synthesis of 5,5-disubstituted hydantoins by tandem α-amination and α-arylation of silyl ketene acetals

Saunthwal, R. K., Cornall, M. T., Abrams, R., Ward, J. W. & Clayden, J., 21 Mar 2019, In : Chemical Science. 10, 11, p. 3408-3412 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
237 Downloads (Pure)

Extended Diethylglycine Homopeptides Formed by Desulfurization of Their Tetrahydrothiopyran Analogues

De Zotti, M. & Clayden, J., 5 Apr 2019, In : Organic Letters. 21, 7, p. 2209-2212 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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38 Downloads (Pure)

N-Chloroformylimidazolidinone Enolates as 1,3-Dipolar Reagents for the Stereoselective Synthesis of 3,4-Dihydroisoquinolones

Abas, H., Amer, M. M., Olaizola, O. & Clayden, J., 15 Mar 2019, In : Organic Letters. 21, 6, p. 1908-1911 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
46 Downloads (Pure)

Remote conformational responses to enantiomeric excess in carboxylate-binding dynamic foldamers

Eccles, N., Le Bailly, B. A. F., Della Sala, F., Vitórica-Yrezábal, I. J., Clayden, J. & Webb, S. J., 14 Aug 2019, In : Chemical communications (Cambridge, England). 55, 63, p. 9331-9334 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
8 Downloads (Pure)
2018

Asymmetric α-Arylation of Amino Acids

Leonard, D. J., Ward, J. W. & Clayden, J., 4 Oct 2018, In : Nature. 562, 7725, p. 105-109 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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22 Citations (Scopus)
303 Downloads (Pure)

Bis-pyrene probes of foldamer conformation in solution and in phospholipid bilayers

Lister, F. G. A., Eccles, N., Pike, S. J., Brown, R. A., Whitehead, G. F. S., Raftery, J., Webb, S. J. & Clayden, J., 7 Sep 2018, In : Chemical Science. 9, 33, p. 6860-6870 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
221 Downloads (Pure)

Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement

Zawodny, W., Montgomery, S. L., Marshall, J. R., Finnigan, J. D., Turner, N. J. & Clayden, J., 26 Dec 2018, In : Journal of the American Chemical Society. 140, 51, p. 17872–17877 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
99 Downloads (Pure)

Competing Hydrogen-Bond Polarities in a Dynamic Oligourea Foldamer: A Molecular Spring Torsion Balance

Wechsel, R., Žabka, M., Ward, J. W. & Clayden, J., 14 Mar 2018, In : Journal of the American Chemical Society. 140, 10, p. 3528-3531 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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16 Citations (Scopus)
217 Downloads (Pure)

Consecutive Ring Expansion and Contraction for the Synthesis of 1-Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines from Readily Available Heterocyclic Precursors

Hill, J. E., Matlock, J. V., Lefebvre, Q., Cooper, K. G. & Clayden, J., 14 May 2018, In : Angewandte Chemie - International Edition. 57, 20, p. 5788-5791 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
144 Downloads (Pure)

Enantioselectively functionalised phenytoin derivatives by auxiliary-directed N to C aryl migration in lithiated α-amino nitriles

Mas-Roselló, J., Okoh, M. & Clayden, J., 7 Oct 2018, In : Chemical Communications. 54, 78, p. 10985-10988 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
73 Downloads (Pure)

Optically Active Vibrational Spectroscopy of α-Aminoisobutyric Acid Foldamers in Organic Solvents and Phospholipid Bilayers

Lizio, M. G., Andrushchenko, V., Pike, S. J., Peters, A. D., Whitehead, G. F. S., Vitórica-Yrezábal, I. J., Mutter, S. T., Clayden, J., Bouř, P., Blanch, E. W. & Webb, S. J., 2 Jul 2018, In : Chemistry - A European Journal. 24, 37, p. 9399-9408 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
156 Downloads (Pure)

Polycyclic Indoline Derivatives by Dearomatizing Anionic Cyclization of Indole and Tryptamine-Derived Ureas

Hill, J. E., Lefebvre, Q., Fraser, L. A. & Clayden, J., 21 Sep 2018, In : Organic Letters. 20, 18, p. 5770-5773 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
196 Downloads (Pure)

Substituted Dihydroisoquinolinones by Iodide-Promoted Cyclocarbonylation of Aromatic α-Amino Acids

Amer, M. M., Carrasco, A. C., Leonard, D. J., Ward, J. W. & Clayden, J., 21 Dec 2018, In : Organic Letters. 20, 24, p. 7977-7981 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
90 Downloads (Pure)

The Role of Terminal Functionality in the Membrane and Antibacterial Activity of Peptaibol-Mimetic Aib Foldamers

Adam, C., Peters, A. D., Lizio, M. G., Whitehead, G. F. S., Diemer, V., Cooper, J. A., Cockroft, S. L., Clayden, J. & Webb, S. J., 9 Feb 2018, In : Chemistry - A European Journal. p. 2249-2256 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
211 Downloads (Pure)

Transition Metal Free Cycloamination of Prenyl Carbamates and Ureas Promoted by Aryldiazonium Salts

Abrams, R., Lefebvre, Q. & Clayden, J., 8 Oct 2018, In : Angewandte Chemie - International Edition. 57, 41, p. 13587-13591 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
130 Downloads (Pure)

α-Methyl phenylglycines by asymmetric α-arylation of alanine and their effect on the conformational preference of helical Aib foldamers

Costil, R., Fernández-Nieto, F., Atkinson, R. C. & Clayden, J., 21 Apr 2018, In : Organic and Biomolecular Chemistry. 16, 15, p. 2757-2761 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
182 Downloads (Pure)
2017

A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversal

Tomsett, M., Maffucci, I., Le Bailly, B. A. F., Byrne, L., Bijvoets, S. M., Lizio, M. G., Raftery, J., Butts, C. P., Webb, S. J., Contini, A. & Clayden, J., 1 Apr 2017, In : Chemical Science. 8, 4, p. 3007-3018 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Citations (Scopus)
378 Downloads (Pure)

Dibenzazepinyl ureas as dual NMR and CD probes of helical screw-sense preference in conformationally equilibrating dynamic foldamers

Diemer, V., Maury, J., Le Bailly, B. A. F., Webb, S. J. & Clayden, J., 7 Oct 2017, In : Chemical Communications. 53, 78, p. 10768-10771 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
220 Downloads (Pure)

Geometry-Retentive C-Alkenylation of Lithiated α-Aminonitriles: Quaternary α-Alkenyl Amino Acids and Hydantoins

Mas-Roselló, J., Hachisu, S. & Clayden, J., 28 Aug 2017, In : Angewandte Chemie - International Edition. 56, 36, p. 10750-10754 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
224 Downloads (Pure)

Heavily Substituted Atropisomeric Diarylamines by Unactivated Smiles Rearrangement of N-Aryl Anthranilamides

Costil, R., Dale, H. J. A., Fey, N., Whitcombe, G., Matlock, J. V. & Clayden, J., 6 Sep 2017, In : Angewandte Chemie - International Edition. 56, 41, p. 12533-12537 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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20 Citations (Scopus)
277 Downloads (Pure)

Intramolecular vinylation of carbanions using N-acyl benzomorpholines as masked vinylureas and vinylcarbamates

Corbet, B., Matlock, J., Mas Rosello, J. & Clayden, J., 1 Jun 2017, In : Comptes Rendus Chimie. 20, 6, p. 634-642 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
218 Downloads (Pure)

Ligand-modulated conformational switching in a fully synthetic membrane-bound receptor

Lister, F., Le Bailly, B., Webb, S. J. & Clayden, J., May 2017, In : Nature Chemistry. 9, 5, p. 420–425 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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41 Citations (Scopus)
366 Downloads (Pure)

Medium-Sized-Ring Analogues of Dibenzodiazepines by a Conformationally Induced Smiles Ring Expansion

Costil, R., Lefebvre, Q. & Clayden, J., 16 Oct 2017, In : Angewandte Chemie - International Edition. 56, 46, p. 14602-14606

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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23 Citations (Scopus)
245 Downloads (Pure)

Signal transduction in oligoamide foldamers by selective non-covalent binding of chiral phosphates at a urea binding site

Gratzer, K., Diemer, V. & Clayden, J., Sep 2017, In : Organic and Biomolecular Chemistry. 15, 17, p. 3585-3589 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
405 Downloads (Pure)

Stereospecific Intramolecular Arylation of 2- and 3-Pyridyl Substituted Alkylamines via Configurationally Stable α-Pyridyl Organolithiums

Maury, J., Zawodny, W. & Clayden, J., 3 Feb 2017, In : Organic Letters. 19, 3, p. 472-475 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
227 Downloads (Pure)

Supramolecular chemistry: Host in translation

Clayden, J., May 2017, In : Nature Nanotechnology. 12, 5, p. 403-404 2 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
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3 Citations (Scopus)
125 Downloads (Pure)
2016

Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts

Staniland, S., Adams, R. W., McDouall, J. J. W., Maffucci, I., Contini, A., Grainger, D. M., Turner, N. J. & Clayden, J., 26 Aug 2016, In : Angewandte Chemie - International Edition. 55, 36, p. 10755-10759 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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29 Citations (Scopus)
260 Downloads (Pure)

Chemistry: No turning back for motorized molecules

Clayden, J., 9 Jun 2016, In : Nature. 534, 7606, p. 187-188 2 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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5 Citations (Scopus)
239 Downloads (Pure)

Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer

De Poli, M., Zawodny, W., Quinonero, O., Lorch, M., Webb, S. J. & Clayden, J., 29 Apr 2016, In : Science. 352, 6285, p. 575-580 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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65 Citations (Scopus)
366 Downloads (Pure)

Dynamic foldamer chemistry

Le Bailly, B. A. F. & Clayden, J., 7 Apr 2016, In : Chemical Communications. 52, 27, p. 4852-4863 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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60 Citations (Scopus)
351 Downloads (Pure)

Helical foldamers incorporating photoswitchable residues for light-mediated modulation of conformational preference

Mazzier, D., Crisma, M., De Poli, M., Marafon, G., Peggion, C., Clayden, J. & Moretto, A., 29 Jun 2016, In : Journal of the American Chemical Society. 138, 25, p. 8007-8018 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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26 Citations (Scopus)
266 Downloads (Pure)

Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers

Jones, J. E., Diemer, V., Adam, C., Raftery, J., Ruscoe, R. E., Sengel, J. T., Wallace, M. I., Bader, A., Cockroft, S. L., Clayden, J. & Webb, S. J., 20 Jan 2016, In : Journal of the American Chemical Society. 138, 2, p. 688-695 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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37 Citations (Scopus)
265 Downloads (Pure)

Medium-Ring Nitrogen Heterocycles through Migratory Ring Expansion of Metalated Ureas

Hall, J., Matlock, J., Ward, J., Gray, K. V. & Clayden, J., 5 Sep 2016, In : Angewandte Chemie - International Edition. 55, 37, p. 11153-11157 5 p.

Research output: Contribution to journalSpecial issue (Academic Journal)

Open Access
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46 Citations (Scopus)
302 Downloads (Pure)

Refoldable Foldamers: Global Conformational Switching by Deletion or Insertion of a Single Hydrogen Bond

Le Bailly, B. A. F., Byrne, L. & Clayden, J., 5 Feb 2016, In : Angewandte Chemie - International Edition. 55, 6, p. 2132–2136 5 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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39 Citations (Scopus)
288 Downloads (Pure)

Substituent effects on axial chirality in 1-aryl-3,4-dihydroisoquinolines: controlling the rate of bond rotation

Roselló, J. M., Staniland, S., Turner, N. J. & Clayden, J., 25 Aug 2016, In : Tetrahedron. 72, 34, p. 5172-5177 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
239 Downloads (Pure)

The meso Helix: Symmetry and Symmetry-Breaking in Dynamic Oligourea Foldamers with Reversible Hydrogen-Bond Polarity

Wechsel, R., Raftery, J., Cavagnat, D., Guichard, G. & Clayden, J., 8 Aug 2016, In : Angewandte Chemie - International Edition. 55, 33, p. 9657-9661 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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19 Citations (Scopus)
200 Downloads (Pure)
2015

2,2- and 2,6-diarylpiperidines by aryl migration within lithiated urea derivatives of tetrahydropyridines

Tait, M. B., Butterworth, S. & Clayden, J., 6 Mar 2015, In : Organic Letters. 17, 5, p. 1236-1239 4 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras

Maury, J., Le Bailly, B. A. F., Raftery, J. & Clayden, J., 28 Jul 2015, In : Chemical Communications. 51, 59, p. 11802-11805 4 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Conformational Switching of a Foldamer in a Multicomponent System by pH-Filtered Selection between Competing Noncovalent Interactions

Brioche, J., Pike, S. J., Tshepelevitsh, S., Leito, I., Morris, G. A., Webb, S. J. & Clayden, J., 27 May 2015, In : Journal of the American Chemical Society. 137, 20, p. 6680-6691 12 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

Directed Lithiation of Pentadienylsilanes

Day, B. M., McDouall, J. J. W., Clayden, J. & Layfield, R. A., 8 Jun 2015, In : Organometallics. 34, 11, p. 2348-2355 8 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Enantioselective carbolithiation of S-alkenyl-N-aryl thiocarbamates: Kinetic and thermodynamic control

Castagnolo, D., Degennaro, L., Luisi, R. & Clayden, J., 28 Feb 2015, In : Organic and Biomolecular Chemistry. 13, 8, p. 2330-2340 11 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Flaws in foldamers: Conformational uniformity and signal decay in achiral helical peptide oligomers

Le Bailly, B. A. F., Byrne, L., Diemer, V., Foroozandeh, M., Morris, G. A. & Clayden, J., 1 Apr 2015, In : Chemical Science. 6, 4, p. 2313-2322 10 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Geometry-selective synthesis of the unsaturated side chains of the isodomoic acids

Fleary-Roberts, N., Lemière, G. & Clayden, J., 30 Sep 2015, In : Tetrahedron. 71, 39, p. 7204-7208 5 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Pike, S. J., Jones, J. E., Raftery, J., Clayden, J. & Webb, S. J., 21 Aug 2015, In : Organic and Biomolecular Chemistry. 13, 37, p. 9580-9584 5 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)