Professor Jonathan P Clayden

MA, PhD, CChem, FRSC

  • BS8 1TS

1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

(-)-Ephedrine as an auxiliary for the asymmetric synthesis of atropisomeric amides by dynamic resolution under thermodynamic control

Clayden, J. & Lai, L. W., 30 Apr 2001, In : Tetrahedron Letters. 42, 18, p. 3163-3166 4 p.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

(S)-2-(Dibenzylamino)-3-phenylpropanal as a chiral auxiliary: A new strategy for the asymmetric synthesis of 2-substituted alcohols

Clayden, J., McCarthy, C. & Cumming, J. G., 24 Apr 1998, In : Tetrahedron: Asymmetry. 9, 8, p. 1427-1440 14 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

1,3,4,5-Tetrahydroazepin-2-ones by dearomatising anionic cyclisation of N-allyl-1-naphthamides

Ahmed, A., Clayden, J. & Rowley, M., 1999, In : SYNLETT. 12, p. 1954-1956 3 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

2,2- and 2,6-diarylpiperidines by aryl migration within lithiated urea derivatives of tetrahydropyridines

Tait, M. B., Butterworth, S. & Clayden, J., 6 Mar 2015, In : Organic Letters. 17, 5, p. 1236-1239 4 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

2,3-Dihydroisoindolones by cyclisation and rearomatisation of lithiated benzamides

Clayden, J. & Menet, C. J., 7 Apr 2003, In : Tetrahedron Letters. 44, 15, p. 3059-3062 4 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N′-diarylureas and diaryl ethers: Advantages of a relay axis

Betson, M. S., Bracegirdle, A., Clayden, J., Helliwell, M., Lund, A., Pickworth, M., Snape, T. J. & Worrall, C. P., 21 Feb 2007, In : Chemical Communications. 7, p. 754-756 3 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Addition of lithiated tertiary aromatic amides to epoxides and aziridines: Asymmetric synthesis of (S)-(+)-mellein

Clayden, J., Stimson, C. C., Helliwell, M. & Keenan, M., Apr 2006, In : SYNLETT. 6, p. 873-876 4 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

A general synthetic approach to the amnesic shellfish toxins: Total synthesis of (-)-isodomoic acid B, (-)-isodomoic acid E and (-)-isodomoic acid F

Lemière, G., Sedehizadeh, S., Toueg, J., Fleary-Roberts, N. & Clayden, J., 7 Apr 2011, In : Chemical Communications. 47, 13, p. 3745-3747 3 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Alkenyl Oxazolidinones by Stereoselective Epoxidation of Delta-Hydroxy Allylic Phosphine Oxides - Synthesis of Any Isomer (Rr, Rs, Sr or Ss, E or Z) Bearing 1,4-Related Chiral Centers Across a Double-Bond

Clayden, J., COLLINGTON, E. W., LAMONT, R. B. & WARREN, S., 1993, In : Tetrahedron Letters. 34, 13, p. 2203-2206 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Alkenyl oxazolidinones by stereoselective epoxidation of δ-hydroxy allylic phosphine oxides: Synthesis of any isomer (RR, RS, SR or SS; E or Z) bearing 1,4-related chiral centres across a double bond

Clayden, J., Collington, E. W., Lamount, R. B. & Warren, S., 26 Mar 1993, In : Tetrahedron Letters. 34, 13, p. 2203-2206 4 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)
26 Citations (Scopus)

Amines bearing tertiary substituents by tandem enantioselective carbolithiation-rearrangement of vinylureas

Tait, M., Donnard, M., Minassi, A., Lefranc, J., Bechi, B., Carbone, G., O'Brien, P. & Clayden, J., 4 Jan 2013, In : Organic Letters. 15, 1, p. 34-37 4 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Amino Acid-Derived trans-N-Chloroformylimidazolidinones: Scalable, Stereoselective Synthesis, Structure, and Utility

Amer, M. M., Abas, H., Leonard, D. J., Ward, J. W. & Clayden, J., 7 Jun 2019, In : Journal of Organic Chemistry. 84, p. 7199-7206 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
30 Downloads (Pure)

An Aliphatic Bischler–Napieralski Reaction: Dihydropyridones by Cyclocarbonylation of 3-Allylimidazolidin-4-ones

Amer, M. M., Olaizola, O., Carter, J., Abas, H. & Clayden, J., 3 Jan 2020, In : Organic Letters. p. 253-256 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Anionic cyclisations of an N-benzyl naphthamide: A route to benzo[e]isoindolones

Ahmed, A., Clayden, J. & Rowley, M., 7 Feb 1998, In : Chemical Communications. 3, p. 297-298 2 p.

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)

Anion translocation in organolithiums: A mechanism for the lithiation and cyclisation of tertiary naphthamides

Ahmed, A., Clayden, J. & Rowley, M., 20 Aug 1998, In : Tetrahedron Letters. 39, 34, p. 6103-6106 4 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

A one-pot synthesis of 2-Aryl-4,5-anti-diphenyloxazolines

Clayden, J., Clayton, J., Harvey, R. A. & KarlubÍková, OG., 24 Sep 2009, In : SYNLETT. 17, p. 2836-2838 3 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Asymmetric and Geometry-Selective α-Alkenylation of α-Amino Acids

Abas, H., Mas-Roselló, J., Amer, M. M., Durand, D. J., Groleau, R. R., Fey, N. & Clayden, J., 18 Feb 2019, In : Angewandte Chemie - International Edition. 58, 8, p. 2418-2422 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
208 Downloads (Pure)

Asymmetric deprotonation and dearomatising cyclisation of N-benzyl benzamides using chiral lithium amides: Formal synthesis of (-)-kainic acid

Clayden, J., Menet, C. J. & Mansfield, D. J., 7 Jan 2002, In : Chemical Communications. 1, p. 38-39 2 p.

Research output: Contribution to journalArticle (Academic Journal)

55 Citations (Scopus)

Asymmetric epoxidation and kinetic resolution of allylic phosphine oxides

Clayden, J. & Warren, S., 1994, In : Journal of the Chemical Society, Perkin Transactions 1. 19, p. 2811-2823 13 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

Asymmetric epoxidations and kinetic resolutions of $-hydroxy allylic phosphine oxides

Clayden, J., Collington, E. W. & Warren, S., 1 Nov 1992, In : Tetrahedron Letters. 33, 46, p. 7043-7046 4 p.

Research output: Contribution to journalArticle (Academic Journal)

Asymmetric epoxidations and kinetic resolutions of δ-hydroxy allylic phosphine oxides

Clayden, J., Collington, E. W. & Warren, S., 10 Nov 1992, In : Tetrahedron Letters. 33, 46, p. 7043-7046 4 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Asymmetric induction using atropisomers: Diastereoselective additions to 2-acyl-1-naphthamides

Clayden, J., Westlund, N. & Wilson, F. X., 29 Jul 1996, In : Tetrahedron Letters. 37, 31, p. 5577-5580 4 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)

Asymmetric ortholithiation of amides by conformationally mediated chiral memory: An enantioselective route to naphtho- and benzofuranones

Clayden, J., Stimson, C. C. & Keenan, M., 7 Jul 2005, In : SYNLETT. 11, p. 1716-1720 5 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
10 Citations (Scopus)

Asymmetric synthesis of enantiomerically enriched atropisomeric amides by desymmetrisation of N,N-dialkylmesitamides

Clayden, J., Johnson, P. & Pink, J. H., 21 Feb 2001, In : Perkin 1. 4, p. 371-375 5 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Asymmetric synthesis of tertiary thiols and thioethers

Clayden, J. & MacLellan, P., 10 May 2011, In : Beilstein Journal of Organic Chemistry. 7, p. 582-595 14 p., A68.

Research output: Contribution to journalArticle (Academic Journal)

130 Citations (Scopus)

Asymmetric α-Arylation of Amino Acids

Leonard, D. J., Ward, J. W. & Clayden, J., 4 Oct 2018, In : Nature. 562, 7725, p. 105-109 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
23 Citations (Scopus)
336 Downloads (Pure)

A tendril perversion in a helical oligomer: trapping and characterizing a mobile screw-sense reversal

Tomsett, M., Maffucci, I., Le Bailly, B. A. F., Byrne, L., Bijvoets, S. M., Lizio, M. G., Raftery, J., Butts, C. P., Webb, S. J., Contini, A. & Clayden, J., 1 Apr 2017, In : Chemical Science. 8, 4, p. 3007-3018 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
407 Downloads (Pure)

Atropisomeric amides as chiral, ligands: Using (-)-sparteine-directed enantioselective silylation to control the conformation of a stereogenic axis

Clayden, J., Johnson, P., Pink, J. H. & Helliwell, M., 20 Oct 2000, In : Journal of Organic Chemistry. 65, 21, p. 7033-7040 8 p.

Research output: Contribution to journalArticle (Academic Journal)

125 Citations (Scopus)

Atropisomeric benzamides and naphthamides as chiral auxiliaries

Clayden, J., Helliwell, M., McCarthy, C. & Westlund, N., 14 Sep 2000, In : Perkin 1. 19, p. 3232-3249 18 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Atropisomeric diastereoisomers from nucleophilic attack on 8-acyl-1-naphthamides

Clayden, J., Westlund, N. & Frampton, C. S., 18 Apr 2000, In : Perkin 1. 9, p. 1379-1385 7 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Atropisomerism

Clayden, J., 10 May 2004, In : Tetrahedron. 60, 20, p. 4335 1 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Atropisomerism about aryl-csp3 bonds: The electronic and steric influence of ortho -substituents on conformational exchange in cannabidiol and linderatin derivatives

Berber, H., Lameiras, P., Denhez, C., Antheaume, C. & Clayden, J., 3 Jul 2014, In : Journal of Organic Chemistry. 79, 13, p. 6015-6027 13 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Atropisomerism at C - S bonds: Asymmetric synthesis of diaryl sulfones by dynamic resolution under thermodynamic control

Clayden, J., Senior, J. & Helliwell, M., 10 Aug 2009, In : Angewandte Chemie - International Edition. 48, 34, p. 6270-6273 4 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Atropisomers and near-atropisomers: achieving stereoselectivity by exploiting the conformational preferences of aromatic amides

Clayden, J., 21 Jan 2004, In : Chemical Communications. 2, p. 127-135 9 p.

Research output: Contribution to journalArticle (Academic Journal)

93 Citations (Scopus)

Atroposelective attack of nucleophiles and electrophiles on 2-acyI-l-naphthamides and their enolates

Clayden, J., Westlund, N., Beddocs, R. L. & Helliwell, M., 18 Apr 2000, In : Perkin 1. 9, p. 1351-1361 11 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Atroposelective attack of nucleophiles on 2-formyl-1-naphthamides and their derivatives: Chelation and non-chelation control

Clayden, J., McCarthy, C., Westlund, N. & Frampton, C. S., 18 Apr 2000, In : Perkin 1. 9, p. 1363-1378 16 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Atroposelectivity in the electrophilic substitution reactions of laterally lithiated and silylated tertiary amides

Clayden, J., Pink, J. H., Westlund, N. & Frampton, C. S., 6 Mar 2002, In : Perkin 1. 7, p. 901-917 17 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Atroposelectivity in the reactions of laterally lithiated tertiary amides

Clayden, J. & Pink, J. H., 7 Apr 1997, In : Tetrahedron Letters. 38, 14, p. 2561-2564 4 p.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)

Atroposelectivity in the reactions of ortholithiated aromatic tertiary amides with aldehydes

Bowles, P., Clayden, J., Helliwell, M., McCarthy, C., Tomkinson, M. & Westlund, N., 7 Sep 1997, In : Journal of the Chemical Society, Perkin Transactions 1. 17, p. 2607-2616 10 p.

Research output: Contribution to journalArticle (Academic Journal)

81 Citations (Scopus)

Attack on fluorinated 2-aryloxazolines by organolithiums: Dearomatisation, lithiation or substitution

Clayton, J. & Clayden, J., 11 May 2011, In : Tetrahedron Letters. 52, 19, p. 2436-2439 4 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)
Open Access
File
29 Downloads (Pure)

Axial chirality in xanthene-4,5-dicarboxamides: 1,9-stereocontrol mediated by remote interactions between conformationally constrained amide groups

Clayden, J., Kenworthy, M. N., Youssef, L. H. & Helliwell, M., 1 Jul 2000, In : Tetrahedron Letters. 41, 27, p. 5171-5175 5 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Azabicyclic amino acids by stereoselective dearomatizing cyclization of the enolates of N-nicotinoyl glycine derivatives

Arnott, G., Clayden, J. & Hamilton, S. D., 9 Nov 2006, In : Organic Letters. 8, 23, p. 5325-5328 4 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Barriers to rotation about the chiral axis of tertiary aromatic amides

Ahmed, A., Bragg, R. A., Clayden, J., Lai, L. W., McCarthy, C., Pink, J. H., Westlund, N. & Yasin, S. A., 22 Oct 1998, In : Tetrahedron. 54, 43, p. 13277-13294 18 p.

Research output: Contribution to journalArticle (Academic Journal)

171 Citations (Scopus)

Beilstein Journal of Organic Chemistry

Clayden, J., 26 Aug 2005, In : Beilstein Journal of Organic Chemistry. 1, 2 p., 1.

Research output: Contribution to journalEditorial (Academic Journal)

1 Citation (Scopus)

Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases

Yuan, B., Page, A., Worrall, C. P., Escalettes, F., Willies, S. C., McDouall, J. J. W., Turner, N. J. & Clayden, J., 17 Sep 2010, In : Angewandte Chemie - International Edition. 49, 39, p. 7010-7013 4 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)