Professor Jonathan P Clayden

MA, PhD, CChem, FRSC

  • BS8 1TS

1992 …2020

Research output per year

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Research Output

2015

Helical peptaibol mimics are better ionophores when racemic than when enantiopure

Pike, S. J., Jones, J. E., Raftery, J., Clayden, J. & Webb, S. J., 21 Aug 2015, In : Organic and Biomolecular Chemistry. 13, 37, p. 9580-9584 5 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Lithium choreography determines contrasting stereochemical outcomes of aryl migrations in benzylic carbamates, ureas and thiocarbamates

Vincent, M. A., Maury, J., Hillier, I. H. & Clayden, J., 9 Feb 2015, In : European Journal of Organic Chemistry. 2015, 5, p. 953-959 7 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Mechanism of stabilization of helix secondary structure by constrained Cα-tetrasubstituted α-amino acids

Maffucci, I., Pellegrino, S., Clayden, J. & Contini, A., 29 Jan 2015, In : Journal of Physical Chemistry B. 119, 4, p. 1350-1361 12 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Origin of Helical Screw Sense Selectivity Induced by Chiral Constrained Cα-Tetrasubstituted α-Amino Acids in Aib-based Peptides

Maffucci, I., Clayden, J. & Contini, A., 12 Oct 2015, In : Journal of Physical Chemistry B. 119, 44, p. 14003-14013 11 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Palladium Catalyzed C-Arylation of Amino Acid Derived Hydantoins

Fernández-Nieto, F., Mas Roselló, J., Lenoir, S., Hardy, S. & Clayden, J., 7 Aug 2015, In : Organic Letters. 17, 15, p. 3838-3841 4 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Participation of non-aminoisobutyric acid (Aib) residues in the 3<inf>10</inf> helical conformation of Aib-rich foldamers: A solid state study

Pike, S. J., Boddaert, T., Raftery, J., Webb, S. J. & Clayden, J., 1 May 2015, In : New Journal of Chemistry. 39, 5, p. 3288-3294 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Pseudoephedrine-Directed Asymmetric α-Arylation of α-Amino Acid Derivatives

Atkinson, R. C., Fernández-Nieto, F., Mas Rosellõ, J. & Clayden, J., 27 Jul 2015, In : Angewandte Chemie - International Edition. 54, 31, p. 8961-8965 5 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Screw sense alone can govern enantioselective extension of a helical peptide by kinetic resolution of a racemic amino acid

Byrne, L., Solà, J. & Clayden, J., 11 Jul 2015, In : Chemical Communications. 51, 54, p. 10965-10968 4 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

α-Quaternary Proline Derivatives by Intramolecular Diastereoselective Arylation of N-Carboxamido Proline Ester Enolates

Maury, J. & Clayden, J., 6 Nov 2015, In : Journal of Organic Chemistry. 80, 21, p. 10757-10768 12 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)
2014

Atropisomerism about aryl-csp3 bonds: The electronic and steric influence of ortho -substituents on conformational exchange in cannabidiol and linderatin derivatives

Berber, H., Lameiras, P., Denhez, C., Antheaume, C. & Clayden, J., 3 Jul 2014, In : Journal of Organic Chemistry. 79, 13, p. 6015-6027 13 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Conformational analysis of helical aminoisobutyric acid (Aib) oligomers bearing C-terminal ester Schellman motifs

Pike, S. J., Raftery, J., Webb, S. J. & Clayden, J., 28 Jun 2014, In : Organic and Biomolecular Chemistry. 12, 24, p. 4124-4131 8 p.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Controlling the sign and magnitude of screw-sense preference from the C-terminus of an achiral helical foldamer

Le Bailly, B. A. F. & Clayden, J., 28 Jul 2014, In : Chemical Communications. 50, 59, p. 7949-7952 4 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Dearomatization and Aryl Migration in Organolithium Chemistry

Clayden, J., 19 May 2014, Lithium Compounds in Organic Synthesis: From Fundamentals to Applications. Wiley-Blackwell, p. 375-396 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

1 Citation (Scopus)

Designing foldamer-foldamer interactions in solution: the roles of helix length and terminus functionality in promoting the self-association of aminoisobutyric acid oligomers

Pike, S. J., Diemer, V., Raftery, J., Webb, S. J. & Clayden, J., 24 Nov 2014, In : Chemistry - A European Journal. 20, 48, p. 15981-15990 10 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Diastereomeric ratio determination by high sensitivity band-selective pure shift NMR spectroscopy

Adams, R. W., Byrne, L., Király, P., Foroozandeh, M., Paudel, L., Nilsson, M., Clayden, J. & Morris, G. A., 7 Mar 2014, In : Chemical Communications. 50, 19, p. 2512-2514 3 p.

Research output: Contribution to journalArticle (Academic Journal)

55 Citations (Scopus)

Dihydrothiophenes containing quaternary stereogenic centres by sequential stereospecific rearrangements and ring-closing metathesis

Mingat, G., McDouall, J. J. W. & Clayden, J., 28 Jun 2014, In : Chemical Communications. 50, 51, p. 6754-6757 4 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Engineering the structure of an N-terminal β-turn to maximize screw-sense preference in achiral helical peptide chains

De Poli, M., Byrne, L., Brown, R. A., Solà, J., Castellanos, A., Boddaert, T., Wechsel, R., Beadle, J. D. & Clayden, J., 16 May 2014, In : Journal of Organic Chemistry. 79, 10, p. 4659-4675 17 p.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers

Staniland, S., Yuan, B., Giménez-Agullõ, N., Marcelli, T., Willies, S. C., Grainger, D. M., Turner, N. J. & Clayden, J., 6 Oct 2014, In : Chemistry - A European Journal. 20, 41, p. 13084-13088 5 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Foldamer-mediated remote stereocontrol: >1,60 asymmetric induction

Byrne, L., Solà, J., Boddaert, T., Marcelli, T., Adams, R. W., Morris, G. A. & Clayden, J., 3 Jan 2014, In : Angewandte Chemie - International Edition. 53, 1, p. 151-155 5 p.

Research output: Contribution to journalArticle (Academic Journal)

70 Citations (Scopus)

Inducing achiral aliphatic oligoureas to fold into helical conformations

Wechsel, R., Maury, J., Fremaux, J., France, S. P., Guichard, G. & Clayden, J., 11 Dec 2014, In : Chemical Communications. 50, 95, p. 15006-15009 4 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Introduction to Volume 8: Reduction

Clayden, J., Feb 2014, Comprehensive Organic Synthesis (Second Edition): Volume 8: Reduction. Vol. 8. p. xiii 1 p.

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Synthesis of 1-arylcycloalkenamines by intramolecular arylation of lithiated ureas

Tait, M. B., Ottersbach, P. A., Tetlow, D. J. & Clayden, J., 17 Oct 2014, In : Organic Process Research & Development. 18, 10, p. 1245-1252 8 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Tertiary thiols from allylic thiocarbamates by tandem enantioselective [3,3]-sigmatropic rearrangement and stereospecific arylation

Mingat, G., Maclellan, P., Laars, M. & Clayden, J., 21 Feb 2014, In : Organic Letters. 16, 4, p. 1252-1255 4 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Thionoglycine as a multifunctional spectroscopic reporter of screw-sense preference in helical foldamers

De Poli, M. & Clayden, J., 7 Feb 2014, In : Organic and Biomolecular Chemistry. 12, 5, p. 836-843 8 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)
2013

Amines bearing tertiary substituents by tandem enantioselective carbolithiation-rearrangement of vinylureas

Tait, M., Donnard, M., Minassi, A., Lefranc, J., Bechi, B., Carbone, G., O'Brien, P. & Clayden, J., 4 Jan 2013, In : Organic Letters. 15, 1, p. 34-37 4 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates

Lefranc, J., Minassi, A. & Clayden, J., 28 Mar 2013, In : Beilstein Journal of Organic Chemistry. 9, p. 628-632 5 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Carbolithiation of S-alkenyl-N-aryl thiocarbamates: Carbanion arylation in a connective route to tertiary thiols

Castagnolo, D., Foley, D. J., Berber, H., Luisi, R. & Clayden, J., 3 May 2013, In : Organic Letters. 15, 9, p. 2116-2119 4 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Dearomatising cyclisation of lithiated allyl phenyl ethers: The role of an oxazoline substituent

Harvey, R. A., Karlubíková, OG., Parris, S. & Clayden, J., 31 Jul 2013, In : Tetrahedron Letters. 54, 31, p. 4064-4066 3 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Diastereotopic fluorine substituents as 19F NMR probes of screw-sense preference in helical foldamers

Pike, S. J., De Poli, M., Zawodny, W., Raftery, J., Webb, S. J. & Clayden, J., 21 May 2013, In : Organic and Biomolecular Chemistry. 11, 19, p. 3168-3176 9 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

End-to-end conformational communication through a synthetic purinergic receptor by ligand-induced helicity switching

Brown, R. A., Diemer, V., Webb, S. J. & Clayden, J., Oct 2013, In : Nature Chemistry. 5, 10, p. 853-860 8 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)

Erratum: Amines bearing tertiary substituents by tandem enantioselective carbolithiation - Rearrangement of vinylureas (Organic Letters (2013) 15 (34-37))

Tait, M., Donnard, M., Minassi, A., Lefranc, J., Bechi, B., Carbone, G., O'Brien, P. & Clayden, J., 15 Feb 2013, In : Organic Letters. 15, 4, p. 974-976 3 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Influence of achiral units with gem-dimethyl substituents on the helical character of aliphatic oligourea foldamers

Fremaux, J., Dolain, C., Kauffmann, B., Clayden, J. & Guichard, G., 28 Aug 2013, In : Chemical Communications. 49, 67, p. 7415-7417 3 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Intramolecular arylation of amino acid enolates

Atkinson, R. C., Leonard, D. J., Maury, J., Castagnolo, D., Volz, N. & Clayden, J., 28 Oct 2013, In : Chemical Communications. 49, 84, p. 9734-9736 3 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Left-handed helical preference in an achiral peptide chain is induced by an l-amino acid in an N-terminal type II β-turn

De Poli, M., De Zotti, M., Raftery, J., Aguilar, J. A., Morris, G. A. & Clayden, J., 15 Mar 2013, In : Journal of Organic Chemistry. 78, 6, p. 2248-2255 8 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

Manipulating the diastereoselectivity of ortholithiation in planar chiral ferrocenes

Herbert, S. A., Castell, D. C., Clayden, J. & Arnott, G. E., 5 Jul 2013, In : Organic Letters. 15, 13, p. 3334-3337 4 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Reversible aryl migrations in metallated ureas: Controlled inversion of configuration at a quaternary carbon atom

Tetlow, D. J., Vincent, M. A., Hillier, I. H. & Clayden, J., 21 Feb 2013, In : Chemical Communications. 49, 15, p. 1548-1550 3 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Spirocyclic dihydropyridines by electrophile-induced dearomatizing cyclization of N-alkenyl pyridinecarboxamides

Senczyszyn, J., Brice, H. & Clayden, J., 19 Apr 2013, In : Organic Letters. 15, 8, p. 1922-1925 4 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Structural influences in lithium pentadienylsilane complexes

Day, B. M., Clayden, J. & Layfield, R. A., 12 Aug 2013, In : Organometallics. 32, 15, p. 4448-4451 4 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

The N-terminal nonapeptide of cephaibols A and C: A naturally occurring example of mismatched helical screw-sense control

Orcel, U., De Poli, M., De Zotti, M. & Clayden, J., 25 Nov 2013, In : Chemistry - A European Journal. 19, 48, p. 16357-16365 9 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)
2012

Chemical communication: Conductors and insulators of screw-sense preference between helical oligo(aminoisobutyric acid) domains

Boddaert, T., Solà, J., Helliwell, M. & Clayden, J., 7 Apr 2012, In : Chemical Communications. 48, 28, p. 3397-3399 3 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

Induction of unexpected left-handed helicity by an N-terminal L -amino acid in an otherwise achiral peptide chain

Brown, R. A., Marcelli, T., Depoli, M., Solà, J. & Clayden, J., 6 Feb 2012, In : Angewandte Chemie - International Edition. 51, 6, p. 1395-1399 5 p.

Research output: Contribution to journalArticle (Academic Journal)

59 Citations (Scopus)

Intramolecular vinylation of secondary and tertiary organolithiums

Lefranc, J., Fournier, A. M., Mingat, G., Herbert, S., Marcelli, T. & Clayden, J., 2 May 2012, In : Journal of the American Chemical Society. 134, 17, p. 7286-7289 4 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Is nevirapine atropisomeric? Experimental and computational evidence for rapid conformational inversion

Burke, E. W. D., Morris, G. A., Vincent, M. A., Hillier, I. H. & Clayden, J., 28 Jan 2012, In : Organic and Biomolecular Chemistry. 10, 4, p. 716-719 4 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Lithiated tertiary carbanions display variable coordination modes: Evidence from DFT and NMR studies

Vincent, M. A., Campbell Smith, A., Donnard, M., Harford, P. J., Haywood, J., Hillier, I. H., Clayden, J. & Wheatley, A. E. H., 27 Aug 2012, In : Chemistry - A European Journal. 18, 35, p. 11036-11045 10 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Lithium choreography: Intramolecular arylations of carbamate-stabilised carbanions and their mechanisms probed by in situ IR spectroscopy and DFT calculations

Fournier, A. M., Nichols, C. J., Vincent, M. A., Hillier, I. H. & Clayden, J., 14 Dec 2012, In : Chemistry - A European Journal. 18, 51, p. 16478-16490 13 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

On the control of secondary carbanion structure utilising ligand effects during directed metallation

Wheatley, A. E. H., Clayden, J., Hillier, I. H., Smith, A. C., Vincent, M. A., Taylor, L. J. & Haywood, J., 9 Jan 2012, In : Beilstein Journal of Organic Chemistry. 8, p. 50-60 11 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Organic chemistry: Stabilizers cause instability

Clayden, J., 19 Jan 2012, In : Nature. 481, 7381, p. 274-275 2 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

S-allyl thiocarbamates from allylic alcohols by in situ [3,3]-sigmatropic rearrangement of a thiocarbonyldiimidazole adduct

Mingat, G. & Clayden, J., 2012, In : Synthesis (Germany). 44, 17, p. 2723-2734 12 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Tertiary alcohols by tandem β-carbolithiation and N→C aryl migration in enol carbamates

Fournier, A. M. & Clayden, J., 6 Jan 2012, In : Organic Letters. 14, 1, p. 142-145 4 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

The mechanism of the stereospecific intramolecular arylation of lithiated ureas: The role of Li + probed by electronic structure calculations, and by NMR and IR spectroscopy

Grainger, D. M., Campbell Smith, A., Vincent, M. A., Hillier, I. H., Wheatley, A. E. H. & Clayden, J., Feb 2012, In : European Journal of Organic Chemistry. 4, p. 731-743 13 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)