Professor Jonathan P Clayden

MA, PhD, CChem, FRSC

  • BS8 1TS

1992 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2008

Stereoselective dearomatizing addition of nucleophiles to uncomplexed benzene rings: A route to carbocyclic sugar analogues

Clayden, J., Parris, S., Cabedo, N. & Payne, A. H., 23 Jun 2008, In : Angewandte Chemie - International Edition. 47, 27, p. 5060-5062 3 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Synthesis of enantiomerically enriched isotopically-labelled anilines by (-)-sparteine directed lithiation

Clayden, J., Lemiègre, L. & Pickworth, M., 22 Sep 2008, In : Tetrahedron: Asymmetry. 19, 18, p. 2218-2221 4 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

α-Pyridylation of chiral amines via urea coupling, lithiation and rearrangement

Clayden, J. & Hennecke, U., 21 Aug 2008, In : Organic Letters. 10, 16, p. 3567-3570 4 p.

Research output: Contribution to journalArticle (Academic Journal)

84 Citations (Scopus)
2007

Achieving conformational control over C-C, C-N and C-O bonds in biaryls, N,N′-diarylureas and diaryl ethers: Advantages of a relay axis

Betson, M. S., Bracegirdle, A., Clayden, J., Helliwell, M., Lund, A., Pickworth, M., Snape, T. J. & Worrall, C. P., 21 Feb 2007, In : Chemical Communications. 7, p. 754-756 3 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Oxidative fragmentation of bicyclic hydroxy silanes and stannanes: a strategy for the stereoselective synthesis of kainoids

Clayden, J., Hebditch, K. R., Read, B. & Helliwell, M., 26 Nov 2007, In : Tetrahedron Letters. 48, 48, p. 8550-8553 4 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Substituted diarylmethylamines by stereospecific intramolecular electrophilic arylation of lithiated ureas

Clayden, J., Dufour, J., Grainger, D. M. & Helliwell, M., 20 Jun 2007, In : Journal of the American Chemical Society. 129, 24, p. 7488-7489 2 p.

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)

Synthesis and stacked conformations of symmetrical and unsymmetrical oligo-ureas of metaphenylenediamine

Clayden, J., Lemiègre, L. & Helliwell, M., 30 Mar 2007, In : Journal of Organic Chemistry. 72, 7, p. 2302-2308 7 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Synthesis of densely functionalised arenes using [2 + 2 + 2] cycloaddition reactions

Clayden, J. & Moran, W. J., 7 Apr 2007, In : Organic and Biomolecular Chemistry. 5, 7, p. 1028-1030 3 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Transmitting information along oligo-para-phenylenes: 1,12-Stereochemical control in a terphenyl tetracarboxamide

Clayden, J., Vallverdú, L. & Helliwell, M., 21 Jun 2007, In : Chemical Communications. 23, p. 2357-2359 3 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)
2006

Addition of lithiated tertiary aromatic amides to epoxides and aziridines: Asymmetric synthesis of (S)-(+)-mellein

Clayden, J., Stimson, C. C., Helliwell, M. & Keenan, M., Apr 2006, In : SYNLETT. 6, p. 873-876 4 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Azabicyclic amino acids by stereoselective dearomatizing cyclization of the enolates of N-nicotinoyl glycine derivatives

Arnott, G., Clayden, J. & Hamilton, S. D., 9 Nov 2006, In : Organic Letters. 8, 23, p. 5325-5328 4 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Conformational arm-wrestling: Battles for stereochemical control in benzamides bearing matched and mismatched chiral 2- and 6-substituents

Clayden, J., Foricher, Y. J. Y., Helliwell, M., Johnson, P., Mitjans, D. & Vinader, V., 7 Feb 2006, In : Organic and Biomolecular Chemistry. 4, 3, p. 444-454 11 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Conformational communication between the Ar-CO and Ar-N axes in 2,2′-disubstituted benzanilides and their derivatives

Clayden, J., Vallverdú, L. & Helliwell, M., 7 Jun 2006, In : Organic and Biomolecular Chemistry. 4, 11, p. 2106-2118 13 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Conformational preference in aromatic amides bearing chiral ortho substituents: Its origin and application to relayed stereocontrol

Betson, M. S., Clayden, J., Helliwell, M., Johnson, P., Lai, L. W., Pink, J. H., Stimson, C. C., Vassiliou, N., Westlund, N., Yasin, S. A. & Youssef, L. H., 7 Feb 2006, In : Organic and Biomolecular Chemistry. 4, 3, p. 424-443 20 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Contra-Friedel-Crafts tert-butylation of substituted aromatic rings via directed metallation and sulfinylation

Clayden, J., Stimson, C. C. & Keenan, M., 7 Apr 2006, In : Chemical Communications. 13, p. 1393-1394 2 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Diastereoselective synthesis of atropisomers containing two non-biaryl stereogenic axes: Stereochemical relay through stereogenic centres in dihydrostilbene-2,2′-dicarboxamides

Clayden, J., Westlund, N., Frampton, C. S. & Helliwell, M., 7 Feb 2006, In : Organic and Biomolecular Chemistry. 4, 3, p. 455-461 7 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Lateral lithiation of N,N′-diaryl ureas

Clayden, J. & Dufour, J., 25 Sep 2006, In : Tetrahedron Letters. 47, 39, p. 6945-6946 2 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Stereochemical relays: Communication via conformation

Clayden, J. & Vassiliou, N., 21 Jul 2006, In : Organic and Biomolecular Chemistry. 4, 14, p. 2667-2678 12 p.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

Synthesis of multiply ortho-substituted diaryl ethers via lithiation and oxidation of a dibenzosiloxane (phenoxasilin)

Betson, M. S. & Clayden, J., 17 Mar 2006, In : SYNLETT. 5, p. 745-746 2 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

The twisted amide 2-quinuclidone: 60 Years in the making

Clayden, J. & Moran, W. J., 6 Nov 2006, In : Angewandte Chemie - International Edition. 45, 43, p. 7118-7120 3 p.

Research output: Contribution to journalArticle (Academic Journal)

60 Citations (Scopus)

Three groups good, four groups bad? Atropisomerism in ortho-substituted diaryl ethers

Betson, M. S., Clayden, J., Worrall, C. P. & Peace, S., 4 Sep 2006, In : Angewandte Chemie - International Edition. 45, 35, p. 5803-5807 5 p.

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)
2005

Asymmetric ortholithiation of amides by conformationally mediated chiral memory: An enantioselective route to naphtho- and benzofuranones

Clayden, J., Stimson, C. C. & Keenan, M., 7 Jul 2005, In : SYNLETT. 11, p. 1716-1720 5 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Beilstein Journal of Organic Chemistry

Clayden, J., 26 Aug 2005, In : Beilstein Journal of Organic Chemistry. 1, 2 p., 1.

Research output: Contribution to journalEditorial (Academic Journal)

1 Citation (Scopus)

Can relief of ring-strain in a cyclopropylmethyllithium drive the Brook rearrangement?

Clayden, J., Watson, D. W. & Chambers, M., 28 Mar 2005, In : Tetrahedron. 61, 13, p. 3195-3203 9 p.

Research output: Contribution to journalArticle (Academic Journal)

32 Citations (Scopus)

Chemistry of domoic acid, isodomoic acids, and their analogues

Clayden, J., Read, B. & Hebditch, K. R., 13 Jun 2005, In : Tetrahedron. 61, 24, p. 5713-5724 12 p.

Research output: Contribution to journalArticle (Academic Journal)

76 Citations (Scopus)

Cyclization of lithiated pyridine and quinoline carboxamides: Synthesis of partially saturated pyrrolopyridines and spirocyclic β-lactams

Clayden, J., Hamilton, S. D. & Mohammed, R. T., 18 Aug 2005, In : Organic Letters. 7, 17, p. 3673-3676 4 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

Diastereoselective protonation of extended pyrrol-3-en-2-one enolates: An attempted 'de-epimerisation'

Clayden, J., Turnbull, R. & Pinto, I., 4 Jul 2005, In : Tetrahedron: Asymmetry. 16, 13, p. 2235-2241 7 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)

Kinetic and thermodynamic stereocontrol in the atroposelective formation of sulfoxides by oxidation of 2-sulfanyl-1-naphthamides

Betson, M. S., Clayden, J., Helliwell, M. & Mitjans, D., 7 Nov 2005, In : Organic and Biomolecular Chemistry. 3, 21, p. 3898-3904 7 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Ring-selective functionalization of N,N′-diarylureas by regioselective N-alkylation and directed ortho metalation

Clayden, J., Turner, H., Pickworth, M. & Adler, T., 21 Jul 2005, In : Organic Letters. 7, 15, p. 3147-3150 4 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Slow interconversion of enantiomeric conformers or atropisomers of anilide and urea derivatives of 2-substituted anilines

Adler, T., Bonjoch, J., Clayden, J., Font-Bardía, M., Pickworth, M., Solans, X., Solé, D. & Vallverdú, L., 7 Sep 2005, In : Organic and Biomolecular Chemistry. 3, 17, p. 3173-3183 11 p.

Research output: Contribution to journalArticle (Academic Journal)

57 Citations (Scopus)

The synthesis of (-)-isodomoic acid C

Clayden, J., Knowles, F. E. & Baldwin, I. R., 2 Mar 2005, In : Journal of the American Chemical Society. 127, 8, p. 2412-2413 2 p.

Research output: Contribution to journalArticle (Academic Journal)

73 Citations (Scopus)

Using dipoles to control the directionality of functional groups: Syn- and anti-oriented benzene-1,3-dicarboxamides

Betson, M. S., Clayden, J., Lam, H. K. & Helliwell, M., 11 Feb 2005, In : Angewandte Chemie - International Edition. 44, 8, p. 1241-1244 4 p.

Research output: Contribution to journalArticle (Academic Journal)

20 Citations (Scopus)
2004

Atropisomerism

Clayden, J., 10 May 2004, In : Tetrahedron. 60, 20, p. 4335 1 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Atropisomers and near-atropisomers: achieving stereoselectivity by exploiting the conformational preferences of aromatic amides

Clayden, J., 21 Jan 2004, In : Chemical Communications. 2, p. 127-135 9 p.

Research output: Contribution to journalArticle (Academic Journal)

93 Citations (Scopus)

Chapter 4 Total synthesis of kainoids by dearomatizing anionic cyclization

Clayden, J., 2004, Strategies and Tactics in Organic Synthesis. Harmata, M. (ed.). Amsterdam:Elsevier, Vol. 4. p. 71-96 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

12 Citations (Scopus)

Controlling chemoselectivity in the lithiation of substituted aromatic tertiary amides

Armstrong, D. R., Boss, S. R., Clayden, J., Haigh, R., Kirmani, B. A., Linton, D. J., Schooler, P. & Wheatley, A. E. H., 13 Apr 2004, In : Angewandte Chemie - International Edition. 43, 16, p. 2135-2138 4 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

Cyclisations of organolithiums onto aromatic rings

Clayden, J. & Kenworthy, M. N., 3 Aug 2004, In : Synthesis (Germany). 11, p. 1721-1736 16 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Dearomatising rearrangements of lithiated thiophenecarboxamides

Clayden, J., Turnbull, R., Helliwell, M. & Pinto, I., 7 Nov 2004, In : Chemical Communications. 10, 21, p. 2430-2431 2 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Dynamic resolution of atropisomeric amides using proline-derived imidazolines and ephedrine-derived oxazolidines

Clayden, J., Lai, L. W. & Helliwell, M., 10 May 2004, In : Tetrahedron. 60, 20, p. 4399-4412 14 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

Fast racemisation and slow epimerisation of laterally lithiated amides: Stereochemical evidence for the mechanism of inversion of amide-substituted benzyllithiums

Clayden, J., Stimson, C. C., Keenan, M. & Wheatley, A. E. H., 21 Jan 2004, In : Chemical Communications. 10, 2, p. 228-229 2 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Nucleophilic Addition to Electron-Rich Heteroaromatics: Dearomatizing Anionic Cyclizations of Pyrrolecarboxamides

Clayden, J., Turnbull, R. & Pinto, I., 19 Feb 2004, In : Organic Letters. 6, 4, p. 609-611 3 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Sulfoxides as 'traceless' resolving agents for the synthesis of atropisomers by dynamic or classical resolution

Clayden, J., Kubinski, P. M., Sammiceli, F., Helliwell, M. & Diorazio, L., 10 May 2004, In : Tetrahedron. 60, 20, p. 4387-4397 11 p.

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Ultra-remote stereocontrol by conformational communication of information along a carbon chain

Clayden, J., Lund, A., Vallverdú, L. & Helltwell, M., 21 Oct 2004, In : Nature. 431, 7011, p. 966-971 6 p.

Research output: Contribution to journalArticle (Academic Journal)

165 Citations (Scopus)
2003

2,3-Dihydroisoindolones by cyclisation and rearomatisation of lithiated benzamides

Clayden, J. & Menet, C. J., 7 Apr 2003, In : Tetrahedron Letters. 44, 15, p. 3059-3062 4 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Dearomatizing cyclization of arylsulfonylalkoxymethyl lithiums: A route to the podophyllotoxin skeleton

Clayden, J., Kenworthy, M. N. & Helliwell, M., 20 Mar 2003, In : Organic Letters. 5, 6, p. 831-834 4 p.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)

Stereospecific dearomatising cyclisation of tertiary α -amidoorganolithiums

Clayden, J., Knowles, F. E. & Menet, C. J., Sep 2003, In : SYNLETT. 11, p. 1701-1703 3 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Stereospecific photochemical ring expansion of lithiated benzamides

Clayden, J., Knowles, F. E. & Menet, C. J., 6 Aug 2003, In : Journal of the American Chemical Society. 125, 31, p. 9278-9279 2 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Synthesis of α-methyl kainic acid by stereospecific lithiation-dearomatizing cyclization of a chiral benzamide

Clayden, J., Knowles, F. E. & Menet, C. J., 14 Apr 2003, In : Tetrahedron Letters. 44, 16, p. 3397-3400 4 p.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Variations in the solid-state, solution and theoretical structures of a laterally deprotonated aromatic tertiary amide

Armstrong, D. R., Clayden, J., Haigh, R., Linton, D. J., Schooler, P. & Wheatley, A. E. H., 21 Jul 2003, In : Chemical Communications. 9, 14, p. 1694-1695 2 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

β-Lactams or γ-lactams by 4-exo-trig or 5-endo-trig anionic cyclisation of lithiated acrylamide derivatives

Clayden, J., Watson, D. W., Helliwell, M. & Chambers, M., 21 Oct 2003, In : Chemical Communications. 9, 20, p. 2582-2583 2 p.

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)