Professor Jonathan P Clayden

MA, PhD, CChem, FRSC

  • BS8 1TS

1992 …2020

Research output per year

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Research Output

2002

Asymmetric deprotonation and dearomatising cyclisation of N-benzyl benzamides using chiral lithium amides: Formal synthesis of (-)-kainic acid

Clayden, J., Menet, C. J. & Mansfield, D. J., 7 Jan 2002, In : Chemical Communications. 1, p. 38-39 2 p.

Research output: Contribution to journalArticle (Academic Journal)

55 Citations (Scopus)

Atroposelectivity in the electrophilic substitution reactions of laterally lithiated and silylated tertiary amides

Clayden, J., Pink, J. H., Westlund, N. & Frampton, C. S., 6 Mar 2002, In : Perkin 1. 7, p. 901-917 17 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Carbolithiation of aromatic rings: Cyclohexadienes from N-aroyl-2,2,6,6-tetramethylpiperidines

Clayden, J., Foricher, Y. J. Y. & Lam, H. K., 22 Aug 2002, In : Chemical Communications. 18, p. 2138-2139 2 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Dearomatizing disrotatory electrocyclic ring closure of lithiated N-benzoyloxazolidines

Clayden, J., Purewal, S., Helliwell, M. & Mantell, S. J., 15 Mar 2002, In : Angewandte Chemie - International Edition. 41, 6, p. 1049-1051 3 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

Foreword

Clayden, J., 2002, Tetrahedron Organic Chemistry Series: Organolithiums: Selectivity for Synthesis. Vol. 23. p. xi (Tetrahedron Organic Chemistry Series).

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Intermolecular dearomatising addition of organolithium compounds to N-benzoylamides of 2,2,6,6-tetramethylpiperidine

Clayden, J., Foricher, Y. J. Y. & Lam, H. K., Nov 2002, In : European Journal of Organic Chemistry. 21, p. 3558-3565 8 p.

Research output: Contribution to journalArticle (Academic Journal)

27 Citations (Scopus)

Lithiation and stereoselective transformations of 3-aroyl-2,2,4,4tetramethyloxazolidines (TMO amides), a new class of acid-labile atropisomeric amides

Anstiss, M., Clayden, J., Grube, A. & Youssef, L. H., Feb 2002, In : SYNLETT. 2, p. 290-294 5 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Lithium-sulfoxide-lithium exchange for the asymmetric synthesis of atropisomers under thermodynamic control

Clayden, J., Mitjans, D. & Youssef, L. H., 15 May 2002, In : Journal of the American Chemical Society. 124, 19, p. 5266-5267 2 p.

Research output: Contribution to journalArticle (Academic Journal)

88 Citations (Scopus)

'meso-Selective' functionalisation of N-benzyl-α-methylbenzylamine derivatives by α-lithiation and alkylation

Bragg, R. A., Clayden, J. & Menet, C. J., 11 Mar 2002, In : Tetrahedron Letters. 43, 11, p. 1955-1959 5 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Pathways for decomposition of THF by organolithiums: The role of HMPA

Clayden, J. & Yasin, S. A., 2002, In : New Journal of Chemistry. 26, 2, p. 191-192 2 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)

Stereodynamics of bond rotation in tertiary aromatic amides

Bragg, R. A., Clayden, J., Morris, G. A. & Pink, J. H., 15 Mar 2002, In : Chemistry - A European Journal. 8, 6, p. 1279-1289 11 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)

Synthesis of (-)-kainic acid using chiral lithium amides in an asymmetric dearomatizing cyclization

Clayden, J., Menet, C. J. & Tchabanenko, K., 3 Jun 2002, In : Tetrahedron. 58, 23, p. 4727-4733 7 p.

Research output: Contribution to journalArticle (Academic Journal)

73 Citations (Scopus)
2001

(-)-Ephedrine as an auxiliary for the asymmetric synthesis of atropisomeric amides by dynamic resolution under thermodynamic control

Clayden, J. & Lai, L. W., 30 Apr 2001, In : Tetrahedron Letters. 42, 18, p. 3163-3166 4 p.

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

Asymmetric synthesis of enantiomerically enriched atropisomeric amides by desymmetrisation of N,N-dialkylmesitamides

Clayden, J., Johnson, P. & Pink, J. H., 21 Feb 2001, In : Perkin 1. 4, p. 371-375 5 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Conformational preference and remote (1,10) stereocontrol in biphenyl-2,2′-dicarboxamides

Clayden, J., Lund, A. & Youssef, L. H., 27 Dec 2001, In : Organic Letters. 3, 26, p. 4133-4136 4 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Dearomatising cyclisation of lithiated 1-naphthamides with a phenylglycinol-derived chiral auxiliary: Asymmetric synthesis of an arylkainoid and a kainoid-like pyroglutamate

Bragg, R. A., Clayden, J., Bladon, M. & Ichihara, O., 14 May 2001, In : Tetrahedron Letters. 42, 20, p. 3411-3414 4 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Pyrrolidinone-fused cyclohexenones by regioselective dearomatising anionic cyclisation of 2-, 3- or 4-methoxybenzamides

Clayden, J., Tchabanenko, K., Yasin, S. A. & Turnbull, M. D., 2001, In : SYNLETT. 2, p. 302-304 3 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)
43 Citations (Scopus)

Synthesis of a potent (±)-4-(2-hydroxyphenyl) analogue of the acromelic acids by dearomatising cyclisation of a lithiated N-p-methoxybenzyl-4-methoxy-1-naphthamide

Ahmed, A., Bragg, R. A., Clayden, J. & Tchabanenko, K., 14 May 2001, In : Tetrahedron Letters. 42, 20, p. 3407-3410 4 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

The first crystallographic evidence for the structures of ortho-lithiated aromatic tertiary amides

Clayden, J., Davies, R. P., Hendy, M. A., Snaith, R. & Wheatley, A. E. H., 1 Apr 2001, In : Angewandte Chemie - International Edition. 40, 7, p. 1238-1240 3 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Using amide conformation to 'project' the stereochemistry of an (-)-ephedrine-derived oxazolidine: A pair of pseudoenantiomeric chiral amido-phosphine ligands

Clayden, J., Lai, L. W. & Helliwell, M., 2 Apr 2001, In : Tetrahedron: Asymmetry. 12, 5, p. 695-698 4 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)
2000

Atropisomeric amides as chiral, ligands: Using (-)-sparteine-directed enantioselective silylation to control the conformation of a stereogenic axis

Clayden, J., Johnson, P., Pink, J. H. & Helliwell, M., 20 Oct 2000, In : Journal of Organic Chemistry. 65, 21, p. 7033-7040 8 p.

Research output: Contribution to journalArticle (Academic Journal)

125 Citations (Scopus)

Atropisomeric benzamides and naphthamides as chiral auxiliaries

Clayden, J., Helliwell, M., McCarthy, C. & Westlund, N., 14 Sep 2000, In : Perkin 1. 19, p. 3232-3249 18 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Atropisomeric diastereoisomers from nucleophilic attack on 8-acyl-1-naphthamides

Clayden, J., Westlund, N. & Frampton, C. S., 18 Apr 2000, In : Perkin 1. 9, p. 1379-1385 7 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Atroposelective attack of nucleophiles and electrophiles on 2-acyI-l-naphthamides and their enolates

Clayden, J., Westlund, N., Beddocs, R. L. & Helliwell, M., 18 Apr 2000, In : Perkin 1. 9, p. 1351-1361 11 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Atroposelective attack of nucleophiles on 2-formyl-1-naphthamides and their derivatives: Chelation and non-chelation control

Clayden, J., McCarthy, C., Westlund, N. & Frampton, C. S., 18 Apr 2000, In : Perkin 1. 9, p. 1363-1378 16 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Axial chirality in xanthene-4,5-dicarboxamides: 1,9-stereocontrol mediated by remote interactions between conformationally constrained amide groups

Clayden, J., Kenworthy, M. N., Youssef, L. H. & Helliwell, M., 1 Jul 2000, In : Tetrahedron Letters. 41, 27, p. 5171-5175 5 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Dynamically resolved peri-substituted 2-formyl naphthamides: A new class of atropisomeric chiral auxiliary

Clayden, J., McCarthy, C. & Cumming, J. G., 29 Apr 2000, In : Tetrahedron Letters. 41, 18, p. 3279-3283 5 p.

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

Synthesis of (±)-kainic acid by dearomatising cyclisation of a lithiated N-benzyl p-anisamide

Clayden, J. & Tchabanenko, K., 21 Feb 2000, In : Chemical Communications. 4, p. 317-318 2 p.

Research output: Contribution to journalArticle (Academic Journal)

59 Citations (Scopus)

Using symmetry to monitor geared bond rotation in aromatic amides by dynamic NMR

Bragg, R. A. & Clayden, J., 19 Oct 2000, In : Organic Letters. 2, 21, p. 3351-3354 4 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)
1999

1,3,4,5-Tetrahydroazepin-2-ones by dearomatising anionic cyclisation of N-allyl-1-naphthamides

Ahmed, A., Clayden, J. & Rowley, M., 1999, In : SYNLETT. 12, p. 1954-1956 3 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Bonded peri-interactions govern the rate of racemisation of atropisomeric 8-substituted 1-naphthamides

Clayden, J., McCarthy, C. & Helliwell, M., 21 Oct 1999, In : Chemical Communications. 20, p. 2059-2060 2 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)

Dearomatising cyclisations of lithiated N-benzylbenzamides

Ahmed, A., Clayden, J. & Yasin, S. A., 7 Feb 1999, In : Chemical Communications. 3, p. 231-232 2 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)

Diastereoisomeric atropisomers of peri-substituted naphthamides: Synthesis, stereoselectivity and stability

Clayden, J., Westlund, N. & Wilson, F. X., 5 Nov 1999, In : Tetrahedron Letters. 40, 45, p. 7883-7887 5 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Diastereoselective ortholithiation and conformational control in stereospecific dearomatising anionic cyclisations

Bragg, R. A. & Clayden, J., 26 Nov 1999, In : Tetrahedron Letters. 40, 48, p. 8327-8331 5 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
87 Citations (Scopus)

Perilithiation and the synthesis of 8-substituted-1-naphthamides

Clayden, J., Frampton, C. S., McCarthy, C. & Westlund, N., 3 Dec 1999, In : Tetrahedron. 55, 49, p. 14161-14184 24 p.

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Stereospecific formation of tetrasubstituted centres from trisubstituted centres during dearomatising anionic cyclisations

Bragg, R. A. & Clayden, J., 26 Nov 1999, In : Tetrahedron Letters. 40, 48, p. 8323-8326 4 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Synthesis of atropisomeric 2-(1-aminoalkyl)-1-naphthamides by stereoselective addition of organolithiums to a 2-imino-1-naphthamide

Clayden, J., Westlund, N. & Wilson, F. X., 23 Apr 1999, In : Tetrahedron Letters. 40, 17, p. 3329-3330 2 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Synthesis of atropisomeric diamides with remotely related stereogenic axes by stereoselective additions to imines

Clayden, J., Westlund, N. & Wilson, F. X., 23 Apr 1999, In : Tetrahedron Letters. 40, 17, p. 3331-3334 4 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
1998

(S)-2-(Dibenzylamino)-3-phenylpropanal as a chiral auxiliary: A new strategy for the asymmetric synthesis of 2-substituted alcohols

Clayden, J., McCarthy, C. & Cumming, J. G., 24 Apr 1998, In : Tetrahedron: Asymmetry. 9, 8, p. 1427-1440 14 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

Anionic cyclisations of an N-benzyl naphthamide: A route to benzo[e]isoindolones

Ahmed, A., Clayden, J. & Rowley, M., 7 Feb 1998, In : Chemical Communications. 3, p. 297-298 2 p.

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)

Anion translocation in organolithiums: A mechanism for the lithiation and cyclisation of tertiary naphthamides

Ahmed, A., Clayden, J. & Rowley, M., 20 Aug 1998, In : Tetrahedron Letters. 39, 34, p. 6103-6106 4 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Barriers to rotation about the chiral axis of tertiary aromatic amides

Ahmed, A., Bragg, R. A., Clayden, J., Lai, L. W., McCarthy, C., Pink, J. H., Westlund, N. & Yasin, S. A., 22 Oct 1998, In : Tetrahedron. 54, 43, p. 13277-13294 18 p.

Research output: Contribution to journalArticle (Academic Journal)

171 Citations (Scopus)

Concerted rotation in a tertiary aromatic amide: Towards a simple molecular gear

Clayden, J. & Pink, J. H., 3 Aug 1998, In : Angewandte Chemie - International Edition. 37, 13-14, p. 1937-1939 3 p.

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)

Conformationally interlocked amides: Remote asymmetric induction by mechanical transfer of stereochemical information

Clayden, J., Pink, J. H. & Yasin, S. A., 1 Jan 1998, In : Tetrahedron Letters. 39, 1-2, p. 105-108 4 p.

Research output: Contribution to journalArticle (Academic Journal)

64 Citations (Scopus)

Controlling the regioselectivity of lithiation using kinetic isotope effects: Deuterium as a protecting group for carbon

Clayden, J., Pink, J. H., Westlund, N. & Wilson, F. X., 12 Nov 1998, In : Tetrahedron Letters. 39, 46, p. 8377-8380 4 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)
5 Citations (Scopus)

Stereocontrol with rotationally restricted amides

Clayden, J., Aug 1998, In : SYNLETT. 8, p. 810-816 7 p.

Research output: Contribution to journalArticle (Academic Journal)

92 Citations (Scopus)
1997

Atroposelectivity in the reactions of laterally lithiated tertiary amides

Clayden, J. & Pink, J. H., 7 Apr 1997, In : Tetrahedron Letters. 38, 14, p. 2561-2564 4 p.

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)