Projects per year
Personal profile
Research interests
I am the lead analyst and study coordinator for The Genetics of DNA Methylation Consortium (GoDMC, www.godmc.org.uk), an international collaboration of 55 human epidemiological studies comprising >45,000 study participants with genetic, phenotypic and DNAm data. It is the largest effort to date to identify cis and trans mQTL analysis by conducting GWAS meta-analyses of 450k DNAm levels, to develop new network approaches to understand interaction between cis- and trans acting variants and DNAm sites, to map the causal relationships of DNAm with 116 complex traits and diseases in a bi-directional manner. All code and results is freely available through github (https://github.com/mrcieu/godmc) and http://mqtldb.godmc.org.uk.
Research interests
I co-developed a Rpackage meffil to analyse and process large DNA methylation datasets (https://github.com/perishky/meffil)
Research interests
The Biomarkers in Atopic Dermatitis and Psoriasis (BIOMAP, https://www.biomap-imi.eu/) project addresses key unmet needs in chronic inflammatory skin diseases, with a broad impact on disease understanding, patient care and future therapies. The collaborative team involves 26 universities, including the University of Bristol, five industry partners as well as five patient organisations. In Bristol we provide statistical expertise and analysts to conduct genetic and molecular epidemiological analysis and causal inference.
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Collaborations and top research areas from the last five years
Projects
- 3 Active
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Making sense of the varying methylome and varying disease patterns
Li, Y. (Student), Min, J. L. (Principal Investigator) & Hemani, G. (Principal Investigator)
4/10/23 → …
Project: Research
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DEEP study: Harnessing DNA methylation variation between populations to understand disease discordance across ancestries
Elliott, H. R. (Principal Investigator) & Min, J. L. (Principal Investigator)
1/10/23 → 30/09/28
Project: Research
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Harnessing DNA methylation variation between populations to understand disease discordance across ancestries
1/10/23 → 30/09/28
Project: Research
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European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Budu-Aggrey, A., Kilanowski, A., Sobczyk-Barad, M. K., Mitchell, R. E., Min, J. L., Paternoster, L. & al, E., 4 Oct 2023, In: Nature Communications. 14, 1, 6172 .Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access22 Citations (Scopus) -
Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans
Elliott, H. R., Burrows, K., Min, J. L., Tillin, T., Mason, D., Wright, J., Santorelli, G., Davey Smith, G., Lawlor, D. A., Hughes, A. D., Chaturvedi, N. & Relton, C. L., 15 Oct 2022, In: Clinical Epigenetics. 14, 1, 130.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile14 Citations (Scopus)83 Downloads (Pure) -
Complex trait methylation scores in the prediction of major depressive disorder
Min, J. L. & Relton, C. L., 28 Apr 2022, In: EBioMedicine. 79, 104000.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile2 Citations (Scopus)58 Downloads (Pure)
Datasets
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Additional file 2 of DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses
Shen, X. (Creator), Caramaschi, D. (Creator), Adams, M. J. (Creator), Walker, R. M. (Creator), Min, J. L. (Creator), Kwong, A. (Creator), Hemani, G. (Creator), Barbu, M. C. (Creator), Whalley, H. C. (Creator), Harris, S. E. (Creator), Deary, I. J. (Creator), Morris, S. W. (Creator), Cox, S. R. (Creator), Relton, C. L. (Creator), Marioni, R. E. (Creator), Evans, K. L. (Creator) & McIntosh, A. M. (Creator), figshare, 31 Mar 2022
DOI: 10.6084/m9.figshare.19470512.v1, https://springernature.figshare.com/articles/dataset/Additional_file_2_of_DNA_methylome-wide_association_study_of_genetic_risk_for_depression_implicates_antigen_processing_and_immune_responses/19470512/1
Dataset
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Additional file 3 of DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses
Shen, X. (Creator), Caramaschi, D. (Creator), Adams, M. J. (Creator), Walker, R. M. (Creator), Min, J. L. (Creator), Kwong, A. (Creator), Hemani, G. (Creator), Barbu, M. C. (Creator), Whalley, H. C. (Creator), Harris, S. E. (Creator), Deary, I. J. (Creator), Morris, S. W. (Creator), Cox, S. R. (Creator), Relton, C. L. (Creator), Marioni, R. E. (Creator), Evans, K. L. (Creator) & McIntosh, A. M. (Creator), figshare, 31 Mar 2022
DOI: 10.6084/m9.figshare.19470515.v1, https://springernature.figshare.com/articles/dataset/Additional_file_3_of_DNA_methylome-wide_association_study_of_genetic_risk_for_depression_implicates_antigen_processing_and_immune_responses/19470515/1
Dataset
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Additional file 4 of Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans
Elliott, H. R. (Creator), Burrows, K. (Creator), Min, J. L. (Creator), Tillin, T. (Creator), Mason, D. (Creator), Wright, J. (Creator), Santorelli, G. (Creator), Davey Smith, G. (Creator), Lawlor, D. A. (Creator), Hughes, A. D. (Creator), Chaturvedi, N. (Creator) & Relton, C. L. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.21343091.v1, https://springernature.figshare.com/articles/dataset/Additional_file_4_of_Characterisation_of_ethnic_differences_in_DNA_methylation_between_UK-resident_South_Asians_and_Europeans/21343091/1
Dataset
Activities
- 2 Participation in conference
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Epigenomics of Common Diseases
Josine L Min (Speaker)
2016Activity: Participating in or organising an event types › Participation in conference
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Genomics of Common Diseases
Josine L Min (Speaker)
2013Activity: Participating in or organising an event types › Participation in conference