Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Personal profile

Research interests

I am interested in elucidating the function of small membrane proteins (ion channels and exchangers) responsible for generating electrical activity of cells in the heart. I have a long-standing interest is the basis of the activity of a key part of the heart's electrical conducting system called the atrioventricular (AV) node, which co-ordinates the normal sequence of beating of the heart's upper and lower chambers (the atria and ventricles). We study single AV node cells using electrophysiological and imaging techniques. Recent work in collaboration with Clive Orchard , Andrew James and Prof Godfrey Smith (Glasgow) has been focused on the effects of acidosis, endothelin-1 and calcium-cycling on AV node cellular electrophysiology. Collaborative work with colleagues in Manchester (Prof Mark Boyett, Prof Henggui Zhang) and Kings College London (Dr Oleg Aslanidi) is focused on producing biophysically accurate models of the AV node and atrium.

I also have a long-standing interest in the electrophysiology and pharmacology of the hERG potassium channel, which plays an important role in drug-induced arrhythmias and in the congenital 'Short QT syndrome'. Using a combination of molecular and electrophysiological methods, we have studied mechanisms of hERG blockade by a range of drugs and identified in vitro the antiarrhythmic disopyramide as an effective inhibitor of the hERG mutant K+ channel responsible for one form of Short QT syndrome. We are also investigating different K+ channel mutations involved in other forms of this syndrome and are focused both on identifying pharmacological agents that can inhibit Short QT mutant channels and on identifying arrhythmia substrates in the syndrome (in collaboration with Prof Henggui Zhang and colleagues, Manchester).

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Projects

Research Output

An update on the structure of hERG

Butler, A., Helliwell, M. V., Zhang, Y., Hancox, J. C. & Dempsey, C. E., 24 Jan 2020, In : Frontiers in Pharmacology. 10, 13 p., 1572.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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  • 28 Downloads (Pure)
    Open Access
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  • 86 Downloads (Pure)

    Complementarity between Arrhythmia Mechanisms Found in Silico and in Genetic Models of N588K-hERG Linked Short QT Syndrome

    Hancox, J. C., Zhang, Y., Du, C. & Zhang, H., 30 Mar 2020, In : Journal of Integrative Cardiology Open Access. 3, 1, 4 p.

    Research output: Contribution to journalReview article (Academic Journal)

    Open Access
    File
  • 25 Downloads (Pure)

    Supervised Work

    Characterisation of two short QT syndrome potassium channel mutations

    Author: Butler, A., 23 Jan 2019

    Supervisor: Hancox, J. (Supervisor) & Dempsey, C. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

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    Modulation of the herg potassium channel function by extracellular acidosis: single channel effects and underlying basis

    Author: Wilson, S., 20 Mar 2018

    Supervisor: Hancox, J. (Supervisor) & Marrion, N. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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    Structural requirements for high-affinity block of hERG K⁺ channels using electrophysiology and mutagenesis with simplified blockers

    Author: Helliwell, M., 7 May 2019

    Supervisor: Hancox, J. (Supervisor) & Dempsey, C. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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