Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

2020

An update on the structure of hERG

Butler, A., Helliwell, M. V., Zhang, Y., Hancox, J. C. & Dempsey, C. E., 24 Jan 2020, In : Frontiers in Pharmacology. 10, 13 p., 1572.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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34 Downloads (Pure)
Open Access
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91 Downloads (Pure)

Complementarity between Arrhythmia Mechanisms Found in Silico and in Genetic Models of N588K-hERG Linked Short QT Syndrome

Hancox, J. C., Zhang, Y., Du, C. & Zhang, H., 30 Mar 2020, In : Journal of Integrative Cardiology Open Access. 3, 1, 4 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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28 Downloads (Pure)

Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes

Caves, R. E., Carpenter, A., Choisy, S. C. M., Clennell, B., Cheng, H., McNiff, C., Mann, B., Milnes, J. T., Hancox, J. C. & James, A. F., 19 May 2020, (Accepted/In press) In : Heart Rhythm O2.

Research output: Contribution to journalArticle (Academic Journal)

Ion currents, action potentials and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes

Bond, R. C., Choisy, S. C., Bryant, S. M., Hancox, J. C. & James, A. F., 13 May 2020, In : Physiological Reports. 8, 9, 16 p., e14432.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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21 Downloads (Pure)

Polyaromatic hydrocarbons in pollution: a heart-breaking matter

Marris, C. R., Kompella, S. N., Miller, M. R., Incardona, J. P., Brette, F., Hancox, J. C., Sørhus, E. & Shiels, H. A., 15 Jan 2020, In : Journal of Physiology. 598, 2, p. 227-247 21 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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3 Citations (Scopus)
87 Downloads (Pure)
Open Access
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39 Downloads (Pure)

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide

Dawidowski, M., Król, M., Szulczyk, B., Chodkowski, A., Podsadni, P., Konopelski, P., Ufnal, M., Szuberski, P., Wróbel, M. Z., Zhang, Y., El Harchi, A., Hancox, J. C., Jarkovska, D., Mistrova, E., Sviglerova, J., Štengl, M., Popowicz, G. M. & Turło, J., 1 May 2020, In : Bioorganic chemistry. 98, 14 p., 103717.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Downloads (Pure)

Synthetic cannabinoids and potential cardiac arrhythmia risk: an important message for drug users

Hancox, J. C., Kalk, N. J. & Henderson, G., 24 Mar 2020, In : Therapeutic Advances in Drug Safety. 11, 4 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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27 Downloads (Pure)

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

El Harchi, A., Butler, A. S., Zhang, Y., Dempsey, C. E. & Hancox, J. C., 8 Mar 2020, In : Physiological Reports. 8, 5, 14 p., e14385.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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40 Downloads (Pure)
2019

Comment: postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2

Hancox, J. C. & James, A. F., 10 Jul 2019, In : EP-Europace. 21, 7, p. 1141 1 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

Butler, A., Zhang, Y., Stuart, A. G., Dempsey, C. E. & Hancox, J. C., 20 Apr 2019, In : Heliyon. 5, 4, p. e01429 29 p., e01429.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
169 Downloads (Pure)

Identification of a proton sensor that regulates conductance and open time of single hERG channels

Wilson, S. L., Dempsey, C. E., Hancox, J. C. & Marrion, N. V., 27 Dec 2019, In : Scientific Reports. 9, 15 p., 19825 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
73 Downloads (Pure)

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

Whittaker, D. G., Hancox, J. C. & Zhang, H., 11 Jan 2019, In : Frontiers in Physiology. 9, 16 p., 1888.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
178 Downloads (Pure)

Learning from studying very rare cardiac conditions: the example of short QT syndrome

Hancox, J. C., Whittaker, D. G., Zhang, H. & Stuart, G., 17 Apr 2019, In : Journal of Congenital Cardiology. 3, 15 p., 3 (2019).

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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24 Downloads (Pure)

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

Cheng, H., Du, C., Zhang, Y., James, A., Dempsey, C., Abdala, A. P. & Hancox, J., 1 Oct 2019, In : Journal of Molecular and Cellular Cardiology. 135, p. 22-30 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
156 Downloads (Pure)

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

Lei, C. L., Clerx, M., Beattie, K. A., Melgari, D., Hancox, J. C., Gavaghan, D. J., Polonchuk, L., Wang, K. & Mirams, G. R., 24 Dec 2019, In : Biophysical Journal. 117, 12, p. 2455-2470 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
34 Downloads (Pure)
Open Access
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1 Citation (Scopus)
54 Downloads (Pure)
2018

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

Butler, A., Zhang, Y., Stuart, A. G., Dempsey, C. E. & Hancox, J. C., Sep 2018, In : Physiological Reports. 6, 17, 14 p., e13845.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
206 Downloads (Pure)

A hERG mutation E1039X produced a synergistic lesion on I Ks together with KCNQ1-R174C mutation in a LQTS family with three compound mutations

Wu, J., Mizusawa, Y., Ohno, S., Ding, W. G., Higaki, T., Wang, Q., Kohjitani, H., Makiyama, T., Itoh, H., Toyoda, F., James, A. F., Hancox, J. C., Matsuura, H. & Horie, M., 15 Feb 2018, In : Scientific Reports. 8, 1, 12 p., 3129.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
244 Downloads (Pure)

A multicentre study of patients with Timothy syndrome

Walsh, M. A., Turner, C., Timothy, K. W., Seller, N., Hares, D. L., James, A. F., Hancox, J. C., Uzun, O., Boyce, D., Stuart, A. G., Brennan, P., Sarton, C., McGuire, K., Newbury-Ecob, R. A. & Mcleod, K., 1 Feb 2018, In : EP-Europace. 20, 2, p. 377-385 9 p., euw433.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
258 Downloads (Pure)
Open Access
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243 Downloads (Pure)

Emerging therapeutic targets in the short QT syndrome

Hancox, J. C., Whittaker, D. G., Du, C., Stuart, A. G. & Zhang, H., May 2018, In : Expert Opinion on Therapeutic Targets. 22, 5, p. 439-451 13 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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15 Citations (Scopus)
191 Downloads (Pure)

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Whittaker, D. G., Colman, M. A., Ni, H., Hancox, J. C. & Zhang, H., 4 Oct 2018, In : Frontiers in Physiology. 9, 15 p., 1402.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
210 Downloads (Pure)

Investigation of hERG1b influence on hERG channel pharmacology at physiological temperature

Hancox, J., El Harchi, A., Melgari, D. & Zhang, H., 2018, In : Journal of Pharmacology and Pharmacotherapeutics. 9, 2, p. 92-103 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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203 Downloads (Pure)

Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells

Fowler, E., Kong, C., Hancox, J. & Cannell, M., 2018, In : Circulation Research. 122, p. 473-478 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
161 Downloads (Pure)

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study

Wang, W., Zhang, S., Ni, H., Garratt, C. J., Boyett, M. R., Hancox, J. C. & Zhang, H., 30 Nov 2018, In : PLoS Computational Biology. 14, 11, 27 p., e1006594.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
220 Downloads (Pure)

Primary carnitine deficiency as a potential cause of short QT syndrome

Hancox, J., 27 Jul 2018, In : Cardiovascular Research and Medicine. 2, 1, p. 10-12 3 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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94 Downloads (Pure)

Rational prediction of pharmacological treatment options for a novel KCNH2-linked variant of the Short QT Syndrome

Hancox, J. & Stuart, G., Mar 2018, In : Annals of Circulation . 3, 1, p. 008-009 2 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
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173 Downloads (Pure)

Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623

Lainez Vicente, S., Doray, A., Hancox, J. & Cannell, M., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 120-130 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
315 Downloads (Pure)

Structural implications of hERG K+ channel block by a high affinity minimally-structured blocker

Helliwell, M. V., Zhang, Y., El Harchi, A., Du, C., Hancox, J. C. & Dempsey, C. E., 4 May 2018, In : Journal of Biological Chemistry. 293, 18, p. 7040-7057 38 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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13 Citations (Scopus)
200 Downloads (Pure)
2017

A basis for human QT interval prolongation and arrhythmia risk in type 2 diabetes?

Hancox, J. C., 2 Sep 2017, In : Experimental Physiology. 102, 11, p. 1395-1396 2 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
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1 Citation (Scopus)
200 Downloads (Pure)

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Whittaker, D. G., Ni, H., Harchi, A. E., Hancox, J. C. & Zhang, H., 13 Jun 2017, In : PLoS Computational Biology. 13, 6, 29 p., e1005593.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Citations (Scopus)
223 Downloads (Pure)

Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: basis for atrial-selective block by ranolazine

Caves, R., Cheng, H., Choisy, S., Gadeberg, H., Bryant, S., Hancox, J. & James, A., 1 Nov 2017, In : Heart Rhythm. 14, 11, p. 1657-1664 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
243 Downloads (Pure)

Atrial-Ventricular Differences in Voltage-Gated Na+ Currents of Rabbit Cardiomyocytes

Caves, R. E., Cheng, H., Choisy, S. C., Gadeberg, H. C., Bryant, S. M., Hancox, J. C. & James, A. F., 3 Feb 2017, p. 243a. 1 p.

Research output: Contribution to conferenceConference Abstract

Open Access
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271 Downloads (Pure)

Cardiac background sodium current: Elusive but important

Cheng, H., James, A. F., Boyett, M. R. & Hancox, J. C., 2 Jan 2017, In : Channels. 11, 1, p. 3-4 2 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
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228 Downloads (Pure)

Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles

Whittaker, D. G., Ni, H., Benson, A. P., Hancox, J. C. & Zhang, H., 4 Oct 2017, In : Frontiers in Physiology. 8, 15 p., 759.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
214 Downloads (Pure)

Could ivabradine be a new treatment for the short QT syndrome?

Hancox, J. C., Sep 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, 9, p. 907-908 2 p.

Research output: Contribution to journalEditorial (Academic Journal)

Open Access
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1 Citation (Scopus)
179 Downloads (Pure)

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Batson, J., Toop, H. D., Redondo, C., Babaei-Jadidi, R., Chaikuad, A., Wearmouth, S. F., Gibbons, B., Allen, C., Tallant, C., Zhang, J., Du, C., Hancox, J. C., Hawtrey, T., Da Rocha, J., Griffith, R., Knapp, S., Bates, D. O. & Morris, J. C., 17 Mar 2017, In : ACS Chemical Biology. 12, 3, p. 825-832 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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28 Citations (Scopus)
395 Downloads (Pure)

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

Cheng, H., Cannell, M. B. & Hancox, J. C., 7 Mar 2017, In : Physiological Reports. 5, 5, 16 p., e13172.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
181 Downloads (Pure)

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Adeniran, I., Whittaker, D. G., El Harchi, A., Hancox, J. C. & Zhang, H., 16 Aug 2017, In : Scientific Reports. 7, 14 p., 8469.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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13 Citations (Scopus)
225 Downloads (Pure)

Long QT syndrome and left ventricular noncompaction in 4 family members across 2 generations with KCNQ1 mutation

Kharbanda, M., Hunter, A., Tennant, S., Curtis, S. L., Hancox, J. C. & Murday, V., 1 May 2017, In : European Journal of Medical Genetics. 60, 5, p. 233-238 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
246 Downloads (Pure)

Measuring kinetics and potency of hERG block for CiPA

Windley, M. J., Abi-Gerges, N., Fermini, B., Hancox, J. C., Vandenberg, J. I. & Hill, A. P., Sep 2017, In : Journal of Pharmacological and Toxicological Methods. 87, p. 99-107 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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22 Citations (Scopus)
249 Downloads (Pure)

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study

Bai, X., Wang, K., Yuan, Y., Li, Q., Dobrzynski, H., Boyett, M. R., Hancox, J. C. & Zhang, H., Sep 2017, In : Chaos. 27, 9, 10 p., 093934.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
218 Downloads (Pure)

Modulation of hERG potassium channels by a novel small molecule activator

Mitcheson, J. S. & Hancox, J. C., 22 Sep 2017, In : British Journal of Pharmacology. 174, 20, p. 3669-3671 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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170 Downloads (Pure)

Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure

Bond, R., Bryant, S., Watson, J., Hancox, J., Orchard, C. & James, A., Mar 2017, In : AJP - Heart and Circulatory Physiology. 312, 3, p. H384-H391 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
183 Downloads (Pure)

Solifenacin linked QT interval prolongation and torsades de pointes

Bray, J. & Hancox, J., 10 Apr 2017, In : Therapeutic Advances in Drug Safety. 3 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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1 Citation (Scopus)
261 Downloads (Pure)

The basis for low-affinity hERG potassium channel block by sotalol

Zhang, Y., Dempsey, C. & Hancox, J., 27 Sep 2017, In : Journal of Pharmacology and Pharmacotherapeutics. 8, 3, p. 130-131 2 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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1 Citation (Scopus)
55 Downloads (Pure)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K. & 31 others, Arumugam, T. V., Attali, B., Bäck, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M., Birdsall, N. J., Blaho, V., Boison, D., Bräuner-osborne, H., Bröer, S., Bryant, C., Burnstock, G., Calo, G., Catterall, W. A., Ceruti, S., Chan, S. L., Chandy, K. G., Chazot, P., Chiang, N., Chun, J. J., Chung, J. J., Clapham, D. E., Connor, M. A., Hancox, J. C., Lolait, S. J., Mcardle, C. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, p. S1-S16 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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157 Citations (Scopus)
240 Downloads (Pure)

The Effects of Extracellular Protons on the hERG Potassium Channel

Wilson, S. L., Marrion, N. V. & Hancox, J. C., 3 Feb 2017, p. 410a. 1 p.

Research output: Contribution to conferenceConference Abstract

Open Access
File
240 Downloads (Pure)