Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

2001

Anti-adrenergic effect of adenosine on Na+-Ca2+ exchange current recorded from guinea-pig ventricular myocytes

Zhang, YH., Hinde, AK. & Hancox, JC., May 2001, In : Cell Calcium. 29 (5), p. 347 - 358 12 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)
2003

A novel, voltage-dependent nonselective cation current activated by insulin in guinea pig isolated ventricular myocytes

Zhang, YH. & Hancox, JC., Apr 2003, In : Circulation Research. 92 (7), p. 765 - 768 4 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

Milnes, JT., Crociani, O., Arcangeli, A., Hancox, JC. & Witchel, HJ., Jul 2003, In : British Journal of Pharmacology. 139 (5), p. 887 - 898 12 p.

Research output: Contribution to journalArticle (Academic Journal)

164 Citations (Scopus)

Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine

Ridley, JM., Milnes, JT., Zhang, YH., Witchel, HJ. & Hancox, JC., Jun 2003, In : Journal of Physiology. 549 (3), p. 667 - 672 6 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

Milnes, JT., Dempsey, CE., Ridley, JM., Crociani, O., Arcangeli, A., Hancox, JC. & Witchel, HJ., Jul 2003, In : FEBS Letters. 547 (1-3), p. 20 - 26 7 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)
2004

Evidence for a novel K+ channel modulated by α1A-adrenoceptors in cardiac myocytes

Choisy, SCM., Hancox, JC., Arberry, LA., Reynolds, AM., Shattock, MJ. & James, AF., Sep 2004, In : Molecular Pharmacology. 66 (3), p. 735 - 748 14 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Gender-related differences in ventricular myocyte repolarization in the guinea pig

James, AF., Arberry, LA. & Hancox, JC., May 2004, In : Basic Research in Cardiology. 99 (3), p. 183 - 192 10 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Moderately elevated plasma homocysteine impairs functional endothelial recovery following denudation of mouse carotid arteries

Miller, AL., Witchel, HJ., Hancox, JC., Jackson, CL. & Jeremy, JY., 2004, In : Metabolism. p. 760 - 765

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Paradoxical effects of insulin on cardiac L-type calcium current and on contraction at physiological temperature

Pabbathi, VK., Suleiman, M-S. & Hancox, JC., Apr 2004, In : Diabetologia. 47 (4), p. 748 - 752 5 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

The low-potency, voltage-dependent HERG blocker propafenone-molecular determinants and drug trapping

Witchel, HJ., Dempsey, CE., Sessions, RB., Perry, M., Milnes, JT., Hancox, JC. & Mitcheson, JS., Nov 2004, In : Molecular Pharmacology. 66 (5), p. 1201 - 1212 12 p.

Research output: Contribution to journalArticle (Academic Journal)

103 Citations (Scopus)
2006

A TRPC-like non-selective cation current activated by α1-adrenoceptors in rat mesenteric artery smooth muscle cells

Hill, AJ., Hinton, JM., Cheng, H., Gao, Z., Bates, DO., Hancox, JC., Langton, PD. & James, AF., Jul 2006, In : Cell Calcium. 40 (1), p. 29 - 40 12 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel

Ridley, JM., Milnes, JT., Hancox, JC. & Witchel, HJ., Jan 2006, In : Journal of Molecular and Cellular Cardiology. 40 (1), p. 107 - 118 12 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome

McPate, MJW., Duncan, RS., Witchel, HJ. & Hancox, JC., Sep 2006, In : Journal of Molecular and Cellular Cardiology. 41 (3), p. 563 - 566 4 p.

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Erythromycin block of the HERG K,sup>+ channel: Accessability to F656 and Y652

Duncan, RS., Ridley, JM., Dempsey, CE., Leishman, DJ., Leaney, JL., Hancox, JC. & Witchel, HJ., 2006, In : Biochemical and Biophysical Research Communications. 341, p. 500 - 506 7 p.

Research output: Contribution to journalArticle (Academic Journal)

VEGF activates receptor-operated cation channels in human microvascular endothelial cells

Cheng, H., James, AF., Foster, RR., Hancox, JC. & Bates, DO., Aug 2006, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (8), p. 1768 - 1776 9 p.

Research output: Contribution to journalArticle (Academic Journal)

91 Citations (Scopus)
2007

Increased Susceptibility to Atrial Tachyarrhythmia in Spontaneously Hypertensive Rat Hearts

Choisy, SCM., Arberry, LA., Hancox, JC. & James, AF., Mar 2007, In : Hypertension. 49 (3), p. 498 - 505 8 p., HYP.0000257123.95372.ab.

Research output: Contribution to journalArticle (Academic Journal)

70 Citations (Scopus)

Recent advances in understanding sex differences in cardiac repolarization

James, AF., Choisy, SCM. & Hancox, JC., Jul 2007, In : Progress in Biophysics and Molecular Biology. 94 (3), p. 265 - 319 55 p.

Research output: Contribution to journalArticle (Academic Journal)

122 Citations (Scopus)
27 Citations (Scopus)
2008

Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study

Kharche, S., Garratt, CJ., Boyett, M. R., Inada, S., Holden, AV., Hancox, JC. & Zhang, H., 2008, In : Progress in Biophysics and Molecular Biology. 98, p. 186 - 197

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Computer three-dimensional reconstruction of the atrioventricular node

Li, J., Greener, I. D., Inada, S., Nikolski, V. P., Yamamoto, M., Hancox, JC., Zhang, H., Billeter, R., Efimov, I., Dobryznksi, H. & Boyett, M. R., 2008, In : Circulation Research. 102, p. 975 - 985

Research output: Contribution to journalArticle (Academic Journal)

74 Citations (Scopus)

Modulation by testosterone of an endogenous hERG potassium channel current

Ridley, JM., Shuba, YM., James, AF. & Hancox, JC., 2008, In : Journal of Physiology and Pharmacology. 59, p. 395 - 407

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Perception of validity of clinical and preclinical methods for assessment of torsades de pointes liability

Pugsley, MK., Hancox, JC. & Curtis, MJ., 2008, In : Pharmacology and Therapeutics. p. 115 - 117

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

McPate, MJW., Duncan, RS., Hancox, JC. & Witchel, HJ., 2008, In : British Journal of Pharmacology. 155, p. 957 - 966

Research output: Contribution to journalArticle (Academic Journal)

67 Citations (Scopus)

Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel

Hancox, JC. & James, AF., 2008, In : Molecular Pharmacology. 73, p. 1592 - 1595

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Regulation of cardiac Na+-Ca2+ exchanger activity by protein kinase phosphorylation--still a paradox?

Zhang, YH. & Hancox, JC., 2008, In : Cell Calcium. 45, p. 1 - 10

Research output: Contribution to journalArticle (Academic Journal)

Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study

Zhang, H., Kharche, S., Holden, AV. & Hancox, JC., 2008, In : Progress in Biophysics and Molecular Biology. 96, p. 112 - 132

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Spontaneous frequency of rabbit atrioventricular node myocytes depends on SR function

Ridley, JM., Cheng, H., Harrison, OJ., Jones, SK., Smith, GL., Hancox, JC. & Orchard, CH., 2008, In : Cell Calcium. 44, p. 580 - 591

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

Hancox, JC., McPate, MJW., El Harchi, A. & Zhang, YH., Aug 2008, In : Pharmacology and Therapeutics. 119, 2, p. 118 - 132 15 p.

Research output: Contribution to journalArticle (Academic Journal)

186 Citations (Scopus)

VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6

Hamdollah-Zadeh, AM., Glass, CA., Magnussen, AL., Hancox, JC. & Bates, DO., 2008, In : Mircrocirculation. 15, p. 605 - 614

Research output: Contribution to journalArticle (Academic Journal)

114 Citations (Scopus)
2009

Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular node

Cheng, H., Smith, GL., Orchard, CH. & Hancox, JC., Jan 2009, In : Journal of Molecular and Cellular Cardiology. 46, 1, p. 75 - 85

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome

El Harchi, A., McPate, MJW., Zhang, YH., Zhang, H. & Hancox, JC., 2009, In : Journal of Molecular and Cellular Cardiology. 47, p. 743 - 747

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Comparative effects of the short QT N588K mutation at 37 degrees C on hERG K+ channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study

McPate, MJW., Zhang, H., Adeniran, I., Cordeiro, JM., Witchel, HJ. & Hancox, JC., 2009, In : Journal of Physiology and Pharmacology. 60, p. 23 - 41

Research output: Contribution to journalArticle (Academic Journal)

hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome

Mcpate, MJ., Zhang, H., Cordeiro, JM., Dempsey, CE., Witchel, HJ. & Hancox, JC., Aug 2009, In : Biochemical and Biophysical Research Communications. 386 (1), p. 111 - 117 7 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells

Inada, S., Hancox, JC., Zhang, H. & Boyett, M. R., 2009, In : Biophysical Journal. 97, p. 2117 - 2127

Research output: Contribution to journalArticle (Academic Journal)

55 Citations (Scopus)

Short QT interval linked to androgen misuse: wider significance and possible basis

Hancox, JC., Choisy, SCM. & James, AF., 2009, In : Annals of Noninvasive Electrocardiology. 14, p. 311 - 312

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)
2010

Acidosis Impairs the Protective Role of hERG K(+) Channels Against Premature Stimulation

Du, C., Adeniran, I., Cheng, H., Zhang, YH., El Harchi, A., McPate, MJW., Zhang, H., Orchard, CH. & Hancox, JC., 2010, In : Journal of Cardiovascular Electrophysiology. 21, p. 1160 - 1169

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation

El Harchi, A., McPate, MJW., Zhang, YH. & Hancox, JC., 2010, In : Journal of Physiology and Pharmacology. 61, p. 123 - 131

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone

Zhang, YH., Cheng, H., Alexeenko, VA., Dempsey, CE. & Hancox, JC., 2010, In : Journal of Electrocardiology. 43, p. 440 - 448

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide

Milnes, JT., Witchel, HJ., Leaney, JL., Leishman, DJ. & Hancox, JC., Mar 2010, In : Journal of Pharmacological and Toxicological Methods. 61, 2, p. 178 - 191 14 p.

Research output: Contribution to journalArticle (Academic Journal)

54 Citations (Scopus)

Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells

Aslanidi, OV., Sleiman, RN., Boyett, M. R., Hancox, JC. & Zhang, H., 2010, In : Biophysical Journal. 98, p. 2420 - 2431

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome

Butters, TD., Aslanidi, OV., Inada, S., Boyett, M. R., Hancox, JC., Lei, M. & Zhang, H., 9 Jul 2010, In : Circulation Research. 107, 1, p. 126 - 137

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Perspective: does ranolazine have potential for the treatment of atrial fibrillation?

Hancox, JC. & Doggrell, SA., 2010, In : Expert Opinion on Investigational Drugs. 19, p. 1465 - 1474

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias

O'Leary, ME. & Hancox, JC., 2010, In : British Journal of Clinical Pharmacology. 69, p. 427 - 442

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

Streptozotocin-induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node

Yuill, KH., Tosh, D. & Hancox, JC., 2010, In : Experimental Physiology. 95, p. 508 - 517

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
2011

Atrial Remodeling and the Substrate for Atrial Fibrillation in Rat Hearts with Elevated Afterload

Kim, SJ., Choisy, SCM., Barman, P., Zhang, H., Hancox, JC., Jones, SA. & James, AF., Oct 2011, In : Circulation: Arrhythmia and Electrophysiology. 4, 5, p. 761 - 769 9 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101

Barman, P., Choisy, SCM., Gadeberg, HC., Hancox, JC. & James, AF., 2011, In : Biochemical and Biophysical Research Communications. 408, p. 12 - 17

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone

Hancox, JC., 2011, In : British Journal of Pharmacology. 163, p. 496 - 498

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform

Du, C., El Harchi, A., McPate, MJW., Orchard, CH. & Hancox, JC., 2011, In : Biochemical and Biophysical Research Communications. 405, p. 222 - 227

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome

Adeniran, I., McPate, MJW., Witchel, HJ., Hancox, JC. & Zhang, H., Dec 2011, In : PLoS Computational Biology. 12, 7, p. e1002313

Research output: Contribution to journalArticle (Academic Journal)

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46 Citations (Scopus)
248 Downloads (Pure)

Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca2+ ATPase

Cheng, H., Smith, GL., Hancox, JC. & Orchard, CH., Jan 2011, In : Cell Calcium. 49, 1, p. 56 - 65

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)