Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

Article (Academic Journal)
28 Citations (Scopus)

Acidosis Impairs the Protective Role of hERG K(+) Channels Against Premature Stimulation

Du, C., Adeniran, I., Cheng, H., Zhang, YH., El Harchi, A., McPate, MJW., Zhang, H., Orchard, CH. & Hancox, JC., 2010, In : Journal of Cardiovascular Electrophysiology. 21, p. 1160 - 1169

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular node

Cheng, H., Smith, GL., Orchard, CH. & Hancox, JC., Jan 2009, In : Journal of Molecular and Cellular Cardiology. 46, 1, p. 75 - 85

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Acidosis slows electrical conduction through the atrio-ventricular node

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. & Smith, G. L., 2014, In : Frontiers in Physiology. 5, p. 233

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome

El Harchi, A., McPate, MJW., Zhang, YH., Zhang, H. & Hancox, JC., 2009, In : Journal of Molecular and Cellular Cardiology. 47, p. 743 - 747

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation

El Harchi, A., McPate, MJW., Zhang, YH. & Hancox, JC., 2010, In : Journal of Physiology and Pharmacology. 61, p. 123 - 131

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel

El Harchi, A., Melgari, D., Zhang, Y. H., Zhang, H. & Hancox, J. C., 2012, In : PLoS ONE. 7, 12, p. e52451

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

Butler, A., Zhang, Y., Stuart, A. G., Dempsey, C. E. & Hancox, J. C., Sep 2018, In : Physiological Reports. 6, 17, 14 p., e13845.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
206 Downloads (Pure)

Activation of Glibenclamide-Sensitive ATP-Sensitive K+ Channels During β-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia

Kim, S. J., Zhang, H., Khaliulin, I., Choisy, S. C. M., Bond, R. C., Lin, H., El Haou, S., Milnes, J. T., Hancox, J. C., Suleiman, M. S. & James, A. F., 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 6, p. 1184-1192

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

A hERG mutation E1039X produced a synergistic lesion on I Ks together with KCNQ1-R174C mutation in a LQTS family with three compound mutations

Wu, J., Mizusawa, Y., Ohno, S., Ding, W. G., Higaki, T., Wang, Q., Kohjitani, H., Makiyama, T., Itoh, H., Toyoda, F., James, A. F., Hancox, J. C., Matsuura, H. & Horie, M., 15 Feb 2018, In : Scientific Reports. 8, 1, 12 p., 3129.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
244 Downloads (Pure)

A multicentre study of patients with Timothy syndrome

Walsh, M. A., Turner, C., Timothy, K. W., Seller, N., Hares, D. L., James, A. F., Hancox, J. C., Uzun, O., Boyce, D., Stuart, A. G., Brennan, P., Sarton, C., McGuire, K., Newbury-Ecob, R. A. & Mcleod, K., 1 Feb 2018, In : EP-Europace. 20, 2, p. 377-385 9 p., euw433.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
258 Downloads (Pure)

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems--insights from 3D virtual human atria and torso

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., Hancox, J. C. & Zhang, H., Jan 2015, In : PLoS Computational Biology. 11, 1, p. e1004026

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., Gintant, G., Imredy, J., Koerner, J., Kramer, J., Levesque, P., Li, Z., Lindqvist, A., Obejero-Paz, C. A., Rampe, D., Sawada, K. & 2 others, Strauss, D. G. & Vandenberg, J. I., Jan 2016, In : Journal of Biomolecular Screening. 21, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle (Academic Journal)

151 Citations (Scopus)
Open Access
File
243 Downloads (Pure)

A novel, voltage-dependent nonselective cation current activated by insulin in guinea pig isolated ventricular myocytes

Zhang, YH. & Hancox, JC., Apr 2003, In : Circulation Research. 92 (7), p. 765 - 768 4 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

A novel genetic modifier for clarithromycin-related cardiac arrhythmia risk?

Hancox, J. C., Du, C., Harchi, A. E., Baranchuk, A. & Zhang, H., Apr 2014, In : Therapeutic advances in infectious disease. 2, 2, p. 71-2 2 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Anti-adrenergic effect of adenosine on Na+-Ca2+ exchange current recorded from guinea-pig ventricular myocytes

Zhang, YH., Hinde, AK. & Hancox, JC., May 2001, In : Cell Calcium. 29 (5), p. 347 - 358 12 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

An update on the structure of hERG

Butler, A., Helliwell, M. V., Zhang, Y., Hancox, J. C. & Dempsey, C. E., 24 Jan 2020, In : Frontiers in Pharmacology. 10, 13 p., 1572.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
34 Downloads (Pure)

Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development

Aslanidi, O. V., Nikolaidou, T., Zhao, J., Smaill, B. H., Gilbert, S. H., Holden, A. V., Lowe, T., Withers, P. J., Stephenson, R. S., Jarvis, J. C., Hancox, J. C., Boyett, M. R. & Zhang, H., Jan 2013, In : IEEE Transactions on Medical Imaging. 32, 1, p. 8-17 10 p.

Research output: Contribution to journalArticle (Academic Journal)

75 Citations (Scopus)
Open Access
File
91 Downloads (Pure)

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Whittaker, D. G., Ni, H., Harchi, A. E., Hancox, J. C. & Zhang, H., 13 Jun 2017, In : PLoS Computational Biology. 13, 6, 29 p., e1005593.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
17 Citations (Scopus)
222 Downloads (Pure)

Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

Varela, M., Colman, M. A., Hancox, J. C. & Aslanidi, O. V., 16 Dec 2016, In : PLoS Computational Biology. 12, 12, 22 p., e1005245.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
23 Citations (Scopus)
257 Downloads (Pure)

Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study

Kharche, S., Garratt, CJ., Boyett, M. R., Inada, S., Holden, AV., Hancox, JC. & Zhang, H., 2008, In : Progress in Biophysics and Molecular Biology. 98, p. 186 - 197

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Atrial Remodeling and the Substrate for Atrial Fibrillation in Rat Hearts with Elevated Afterload

Kim, SJ., Choisy, SCM., Barman, P., Zhang, H., Hancox, JC., Jones, SA. & James, AF., Oct 2011, In : Circulation: Arrhythmia and Electrophysiology. 4, 5, p. 761 - 769 9 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: basis for atrial-selective block by ranolazine

Caves, R., Cheng, H., Choisy, S., Gadeberg, H., Bryant, S., Hancox, J. & James, A., 1 Nov 2017, In : Heart Rhythm. 14, 11, p. 1657-1664 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
3 Citations (Scopus)
242 Downloads (Pure)

A TRPC-like non-selective cation current activated by α1-adrenoceptors in rat mesenteric artery smooth muscle cells

Hill, AJ., Hinton, JM., Cheng, H., Gao, Z., Bates, DO., Hancox, JC., Langton, PD. & James, AF., Jul 2006, In : Cell Calcium. 40 (1), p. 29 - 40 12 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: A narrative review based on the study of case reports

Hancox, J. C., Hasnain, M., Vieweg, W. V. R., Crouse, E. L. B. & Baranchuk, A., Oct 2013, In : Therapeutic advances in infectious disease. 1, 5, p. 155-65 11 p.

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

Milnes, JT., Crociani, O., Arcangeli, A., Hancox, JC. & Witchel, HJ., Jul 2003, In : British Journal of Pharmacology. 139 (5), p. 887 - 898 12 p.

Research output: Contribution to journalArticle (Academic Journal)

164 Citations (Scopus)

Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101

Barman, P., Choisy, SCM., Gadeberg, HC., Hancox, JC. & James, AF., 2011, In : Biochemical and Biophysical Research Communications. 408, p. 12 - 17

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone

Hancox, JC., 2011, In : British Journal of Pharmacology. 163, p. 496 - 498

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine

Doggrell, S. A. & Hancox, J. C., Jan 2014, In : Expert opinion on drug safety. 13, 1, p. 131-8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia

Doggrell, S. A. & Hancox, J. C., May 2013, In : Expert opinion on drug safety. 12, 3, p. 421-31 11 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Characterization and influence of cardiac background sodium current in the atrioventricular node

Cheng, H., Li, J., James, A. F., Inada, S., Choisy, S. C. M., Orchard, C. H., Zhang, H., Boyett, M. R. & Hancox, J. C., Aug 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 114-124 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
271 Downloads (Pure)

Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone

Zhang, YH., Cheng, H., Alexeenko, VA., Dempsey, CE. & Hancox, JC., 2010, In : Journal of Electrocardiology. 43, p. 440 - 448

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Clarithromycin, QTc interval prolongation and torsades de pointes: the need to study case reports

Vieweg, W. V. R., Hancox, J. C., Hasnain, M., Koneru, J. N., Gysel, M. & Baranchuk, A., Aug 2013, In : Therapeutic advances in infectious disease. 1, 4, p. 121-38 18 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel

Ridley, JM., Milnes, JT., Hancox, JC. & Witchel, HJ., Jan 2006, In : Journal of Molecular and Cellular Cardiology. 40 (1), p. 107 - 118 12 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Comparative effects of the short QT N588K mutation at 37 degrees C on hERG K+ channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study

McPate, MJW., Zhang, H., Adeniran, I., Cordeiro, JM., Witchel, HJ. & Hancox, JC., 2009, In : Journal of Physiology and Pharmacology. 60, p. 23 - 41

Research output: Contribution to journalArticle (Academic Journal)

Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings

Walsh, M. A., Stuart, A. G., Schlecht, H., James, A. F., Hancox, J. C. & Newbury-Ecob, R. A., May 2016, In : Pacing and Clinical Electrophysiology. 39, 5, p. 497-501 5 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles

Whittaker, D. G., Ni, H., Benson, A. P., Hancox, J. C. & Zhang, H., 4 Oct 2017, In : Frontiers in Physiology. 8, 15 p., 759.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
213 Downloads (Pure)

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

Hill, A. P., Perry, M. D., Abi-Gerges, N., Couderc, J-P., Fermini, B., Hancox, J. C., Knollmann, B. C., Mirams, G. R., Skinner, J., Zareba, W. & Vandenberg, J. I., 1 Dec 2016, In : Journal of Physiology. 594, 23, p. 6893-6908 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
267 Downloads (Pure)

Computer three-dimensional reconstruction of the atrioventricular node

Li, J., Greener, I. D., Inada, S., Nikolski, V. P., Yamamoto, M., Hancox, JC., Zhang, H., Billeter, R., Efimov, I., Dobryznksi, H. & Boyett, M. R., 2008, In : Circulation Research. 102, p. 975 - 985

Research output: Contribution to journalArticle (Academic Journal)

74 Citations (Scopus)

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Batson, J., Toop, H. D., Redondo, C., Babaei-Jadidi, R., Chaikuad, A., Wearmouth, S. F., Gibbons, B., Allen, C., Tallant, C., Zhang, J., Du, C., Hancox, J. C., Hawtrey, T., Da Rocha, J., Griffith, R., Knapp, S., Bates, D. O. & Morris, J. C., 17 Mar 2017, In : ACS Chemical Biology. 12, 3, p. 825-832 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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28 Citations (Scopus)
395 Downloads (Pure)

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

Cheng, H., Cannell, M. B. & Hancox, J. C., 7 Mar 2017, In : Physiological Reports. 5, 5, 16 p., e13172.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
181 Downloads (Pure)

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome

McPate, MJW., Duncan, RS., Witchel, HJ. & Hancox, JC., Sep 2006, In : Journal of Molecular and Cellular Cardiology. 41 (3), p. 563 - 566 4 p.

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

Choisy, S. C., Kim, S-J., Hancox, J. C., Jones, S. A. & James, A. F., 1 Jan 2015, In : Physiological Reports. 3, 1

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria

Adeniran, I., MacIver, D. H., Garratt, C. J., Ye, J., Hancox, J. C. & Zhang, H., 2015, In : PLoS ONE. 10, 11, p. e0142397

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange

Choisy, S. C., Cheng, H., Orchard, C. H., James, A. F. & Hancox, J. C., Nov 2015, In : Physiological Reports. 3, 11, 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
248 Downloads (Pure)

Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform

Du, C., El Harchi, A., McPate, MJW., Orchard, CH. & Hancox, JC., 2011, In : Biochemical and Biophysical Research Communications. 405, p. 222 - 227

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)