Jules C Hancox

2018

Primary carnitine deficiency as a potential cause of short QT syndrome

Hancox, J., 27 Jul 2018, In: Cardiovascular Research and Medicine. 2, 1, p. 10-12 3 p.

Research output: Contribution to journal › Review article (Academic Journal)

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182 Downloads (Pure)

Rational prediction of pharmacological treatment options for a novel KCNH2-linked variant of the Short QT Syndrome

Hancox, J. & Stuart, G., Mar 2018, In: Annals of Circulation . 3, 1, p. 008-009 2 p.

Research output: Contribution to journal › Comment/debate (Academic Journal) › peer-review

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252 Downloads (Pure)

Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K⁺ channel activator NS3623

Lainez Vicente, S., Doray, A., Hancox, J. & Cannell, M., 1 Apr 2018, In: Biochemical Pharmacology. 150, p. 120-130 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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8 Citations (Scopus)

459 Downloads (Pure)

Structural implications of hERG K+ channel block by a high affinity minimally-structured blocker

Helliwell, M. V., Zhang, Y., El Harchi, A., Du, C., Hancox, J. C. & Dempsey, C. E., 4 May 2018, In: Journal of Biological Chemistry. 293, 18, p. 7040-7057 38 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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38 Citations (Scopus)

326 Downloads (Pure)

2017

A basis for human QT interval prolongation and arrhythmia risk in type 2 diabetes?

Hancox, J. C., 2 Sept 2017, In: Experimental Physiology. 102, 11, p. 1395-1396 2 p.

Research output: Contribution to journal › Comment/debate (Academic Journal)

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3 Citations (Scopus)

268 Downloads (Pure)

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Whittaker, D. G., Ni, H., Harchi, A. E., Hancox, J. C. & Zhang, H., 13 Jun 2017, In: PLoS Computational Biology. 13, 6, 29 p., e1005593.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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28 Citations (Scopus)

328 Downloads (Pure)

Atrial-ventricular differences in rabbit cardiac voltage-gated Na⁺ currents: basis for atrial-selective block by ranolazine

Caves, R., Cheng, H., Choisy, S., Gadeberg, H., Bryant, S., Hancox, J. & James, A., 1 Nov 2017, In: Heart Rhythm. 14, 11, p. 1657-1664 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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12 Citations (Scopus)

317 Downloads (Pure)

Atrial-Ventricular Differences in Voltage-Gated Na⁺ Currents of Rabbit Cardiomyocytes

Caves, R. E., Cheng, H., Choisy, S. C., Gadeberg, H. C., Bryant, S. M., Hancox, J. C. & James, A. F., 3 Feb 2017, p. 243a. 1 p.

Research output: Contribution to conference › Conference Abstract

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323 Downloads (Pure)

Cardiac background sodium current: Elusive but important

Cheng, H., James, A. F., Boyett, M. R. & Hancox, J. C., 2 Jan 2017, In: Channels. 11, 1, p. 3-4 2 p.

Research output: Contribution to journal › Comment/debate (Academic Journal)

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1 Citation (Scopus)

305 Downloads (Pure)

Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles

Whittaker, D. G., Ni, H., Benson, A. P., Hancox, J. C. & Zhang, H., 4 Oct 2017, In: Frontiers in Physiology. 8, 15 p., 759.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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27 Citations (Scopus)

295 Downloads (Pure)

Could ivabradine be a new treatment for the short QT syndrome?

Hancox, J. C., Sept 2017, In: Clinical and Experimental Pharmacology and Physiology. 44, 9, p. 907-908 2 p.

Research output: Contribution to journal › Editorial (Academic Journal)

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2 Citations (Scopus)

306 Downloads (Pure)

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Batson, J., Toop, H. D., Redondo, C., Babaei-Jadidi, R., Chaikuad, A., Wearmouth, S. F., Gibbons, B., Allen, C., Tallant, C., Zhang, J., Du, C., Hancox, J. C., Hawtrey, T., Da Rocha, J., Griffith, R., Knapp, S., Bates, D. O. & Morris, J. C., 17 Mar 2017, In: ACS Chemical Biology. 12, 3, p. 825-832 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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72 Citations (Scopus)

650 Downloads (Pure)

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

Cheng, H., Cannell, M. B. & Hancox, J. C., 7 Mar 2017, In: Physiological Reports. 5, 5, 16 p., e13172.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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16 Citations (Scopus)

311 Downloads (Pure)

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Adeniran, I., Whittaker, D. G., El Harchi, A., Hancox, J. C. & Zhang, H., 16 Aug 2017, In: Scientific Reports. 7, 14 p., 8469.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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20 Citations (Scopus)

307 Downloads (Pure)

Long QT syndrome and left ventricular noncompaction in 4 family members across 2 generations with KCNQ1 mutation

Kharbanda, M., Hunter, A., Tennant, S., Curtis, S. L., Hancox, J. C. & Murday, V., 1 May 2017, In: European Journal of Medical Genetics. 60, 5, p. 233-238 6 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

525 Downloads (Pure)

Measuring kinetics and potency of hERG block for CiPA

Windley, M. J., Abi-Gerges, N., Fermini, B., Hancox, J. C., Vandenberg, J. I. & Hill, A. P., Sept 2017, In: Journal of Pharmacological and Toxicological Methods. 87, p. 99-107 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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34 Citations (Scopus)

393 Downloads (Pure)

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study

Bai, X., Wang, K., Yuan, Y., Li, Q., Dobrzynski, H., Boyett, M. R., Hancox, J. C. & Zhang, H., Sept 2017, In: Chaos. 27, 9, 10 p., 093934.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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8 Citations (Scopus)

309 Downloads (Pure)

Modulation of hERG potassium channels by a novel small molecule activator

Mitcheson, J. S. & Hancox, J. C., 22 Sept 2017, (E-pub ahead of print) In: British Journal of Pharmacology. 174, 20, p. 3669-3671 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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1 Citation (Scopus)

244 Downloads (Pure)

Reduced density and altered regulation of rat atrial L-type Ca²⁺ current in heart failure

Bond, R., Bryant, S., Watson, J., Hancox, J., Orchard, C. & James, A., Mar 2017, In: AJP - Heart and Circulatory Physiology. 312, 3, p. H384-H391 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

278 Downloads (Pure)

Solifenacin linked QT interval prolongation and torsades de pointes

Bray, J. & Hancox, J., 10 Apr 2017, (E-pub ahead of print) In: Therapeutic Advances in Drug Safety. 3 p.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

Open Access

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2 Citations (Scopus)

533 Downloads (Pure)

The basis for low-affinity hERG potassium channel block by sotalol

Zhang, Y., Dempsey, C. & Hancox, J., 27 Sept 2017, In: Journal of Pharmacology and Pharmacotherapeutics. 8, 3, p. 130-131 2 p.

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

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10 Citations (Scopus)

125 Downloads (Pure)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K., & 31 othersArumugam, T. V., Attali, B., Bäck, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M., Birdsall, N. J., Blaho, V., Boison, D., Bräuner-osborne, H., Bröer, S., Bryant, C., Burnstock, G., Calo, G., Catterall, W. A., Ceruti, S., Chan, S. L., Chandy, K. G., Chazot, P., Chiang, N., Chun, J. J., Chung, J. J., Clapham, D. E., Connor, M. A., Hancox, J. C., Lolait, S. J., Mcardle, C. A. & CGTP Collaborators, 1 Dec 2017, In: British Journal of Pharmacology. 174, p. S1-S16 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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229 Citations (Scopus)

360 Downloads (Pure)

The Effects of Extracellular Protons on the hERG Potassium Channel

Wilson, S. L., Marrion, N. V. & Hancox, J. C., 3 Feb 2017, p. 410a. 1 p.

Research output: Contribution to conference › Conference Abstract

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289 Downloads (Pure)

2016

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., Gintant, G., Imredy, J., Koerner, J., Kramer, J., Levesque, P., Li, Z., Lindqvist, A., Obejero-Paz, C. A., Rampe, D., Sawada, K., & 2 othersStrauss, D. G. & Vandenberg, J. I., Jan 2016, In: Journal of Biomolecular Screening. 21, 1, p. 1-11 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

235 Citations (Scopus)

Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

Varela, M., Colman, M. A., Hancox, J. C. & Aslanidi, O. V., 16 Dec 2016, In: PLoS Computational Biology. 12, 12, 22 p., e1005245.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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44 Citations (Scopus)

367 Downloads (Pure)

Characterization and influence of cardiac background sodium current in the atrioventricular node

Cheng, H., Li, J., James, A. F., Inada, S., Choisy, S. C. M., Orchard, C. H., Zhang, H., Boyett, M. R. & Hancox, J. C., 1 Aug 2016, In: Journal of Molecular and Cellular Cardiology. 97, p. 114-124 11 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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9 Citations (Scopus)

357 Downloads (Pure)

Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings

Walsh, M. A., Stuart, A. G., Schlecht, H., James, A. F., Hancox, J. C. & Newbury-Ecob, R. A., May 2016, In: Pacing and Clinical Electrophysiology. 39, 5, p. 497-501 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

17 Citations (Scopus)

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

Hill, A. P., Perry, M. D., Abi-Gerges, N., Couderc, J-P., Fermini, B., Hancox, J. C., Knollmann, B. C., Mirams, G. R., Skinner, J., Zareba, W. & Vandenberg, J. I., 1 Dec 2016, In: Journal of Physiology. 594, 23, p. 6893-6908 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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12 Citations (Scopus)

330 Downloads (Pure)

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

Zhang, Y. H., Colenso, C. K., Harchi, A. E., Cheng, H., Witchel, H. J., Dempsey, C. E. & Hancox, J. C., 1 Aug 2016, In: Biochemical Pharmacology. 113, p. 24-35 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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37 Citations (Scopus)

485 Downloads (Pure)

Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node

Cheng, H., Curtis, A. E., Fellingham, C. & Hancox, J. C., 10 Jun 2016, In: Physiological Reports. 4, 11, 10 p., e12819.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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3 Citations (Scopus)

333 Downloads (Pure)

Novel ion channel targets in atrial fibrillation

Hancox, J. C., James, A. F., Marrion, N. V., Zhang, H. & Thomas, D., Aug 2016, In: Expert Opinion on Therapeutic Targets. 20, 8, p. 947-958 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

29 Citations (Scopus)

2015

Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an electromechanically detailed biophysical modeling study

Adeniran, I., MacIver, D. H., Hancox, J. C. & Zhang, H., 2015, In: Frontiers in Physiology. 6, p. 78

Research output: Contribution to journal › Article (Academic Journal) › peer-review

48 Citations (Scopus)

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems--insights from 3D virtual human atria and torso

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., Hancox, J. C. & Zhang, H., Jan 2015, In: PLoS Computational Biology. 11, 1, p. e1004026

Research output: Contribution to journal › Article (Academic Journal) › peer-review

20 Citations (Scopus)

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

Choisy, S. C., Kim, S-J., Hancox, J. C., Jones, S. A. & James, A. F., 1 Jan 2015, In: Physiological Reports. 3, 1

Research output: Contribution to journal › Article (Academic Journal) › peer-review

6 Citations (Scopus)

Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria

Adeniran, I., MacIver, D. H., Garratt, C. J., Ye, J., Hancox, J. C. & Zhang, H., 2015, In: PLoS ONE. 10, 11, p. e0142397

Research output: Contribution to journal › Article (Academic Journal) › peer-review

23 Citations (Scopus)

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange

Choisy, S. C., Cheng, H., Orchard, C. H., James, A. F. & Hancox, J. C., Nov 2015, In: Physiological Reports. 3, 11, 18 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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9 Citations (Scopus)

321 Downloads (Pure)

Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease

Avolio, E., Rodriguez-Arabaolaza, I., Spencer, H. L., Riu, F., Mangialardi, G., Slater, S. C., Rowlinson, J., Alvino, V. V., Idowu, O. O., Soyombo, S., Oikawa, A., Swim, M. M., Kong, C. H. T., Cheng, H., Jia, H., Ghorbel, M. T., Hancox, J. C., Orchard, C. H., Angelini, G., Emanueli, C., & 2 othersCaputo, M. & Madeddu, P., 2015, In: Journal of the American Heart Association. 4, 6

Research output: Contribution to journal › Article (Academic Journal) › peer-review

61 Citations (Scopus)

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

Melgari, D., Brack, K. E., Zhang, C., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., 24 Apr 2015, In: Journal of the American Heart Association. 4, 4, p. 1-13

Research output: Contribution to journal › Article (Academic Journal) › peer-review

70 Citations (Scopus)

26 Downloads (Pure)

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes

Hancox, J. C., Melgari, D., Dempsey, C. E., Brack, K. E., Mitcheson, J. & Ng, G. A., Aug 2015, In: Therapeutic Advances in Drug Safety. 6, 4, p. 177-9 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

10 Citations (Scopus)

hERG potassium channel inhibition by ivabradine requires channel gating

Melgari, D., Brack, K. E., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., Oct 2015, In: Journal of Molecular and Cellular Cardiology. 87, p. 126-8 3 p.

Research output: Contribution to journal › Article (Academic Journal)

2 Citations (Scopus)

Initiation and sustenance of reentry are promoted by two different mechanisms

Aslanidi, O. V. & Hancox, J. C., Jan 2015, In: Heart Rhythm. 12, 1, p. e2

Research output: Contribution to journal › Article (Academic Journal) › peer-review

4 Citations (Scopus)

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Melgari, D., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sept 2015, In: Journal of Molecular and Cellular Cardiology. 86, p. 42-53 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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48 Citations (Scopus)

347 Downloads (Pure)

Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes

Hancock, J. M., Weatherall, K. L., Choisy, S. C., James, A. F., Hancox, J. C. & Marrion, N. V., 1 May 2015, In: Heart Rhythm. 12, 5, p. 1003-15 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

26 Citations (Scopus)

To the Editor--Altered in vivo systolic function in the short QT syndrome anticipated in silico

Hancox, J. C., Adeniran, I., Whittaker, D. G. & Zhang, H., Sept 2015, In: Heart Rhythm. 12, 9, p. e115

Research output: Contribution to journal › Article (Academic Journal)

2 Citations (Scopus)

2014

Acidosis slows electrical conduction through the atrio-ventricular node

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. & Smith, G. L., 2014, In: Frontiers in Physiology. 5, p. 233

Research output: Contribution to journal › Article (Academic Journal) › peer-review

14 Citations (Scopus)

A novel genetic modifier for clarithromycin-related cardiac arrhythmia risk?

Hancox, J. C., Du, C., Harchi, A. E., Baranchuk, A. & Zhang, H., Apr 2014, In: Therapeutic advances in infectious disease. 2, 2, p. 71-2 2 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

2 Citations (Scopus)

Assessing hERG pore models as templates for drug docking using published experimental constraints: The inactivated state in the context of drug block.

Dempsey, C. E., Wright, D., Colenso, C. K., Sessions, R. B. & Hancox, J. C., 2014, In: Journal of Chemical Information and Modeling. 54, p. 601-612 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

50 Citations (Scopus)

Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine

Doggrell, S. A. & Hancox, J. C., Jan 2014, In: Expert opinion on drug safety. 13, 1, p. 131-8 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

55 Citations (Scopus)

Erythromycin, QTc interval prolongation, and torsade de pointes: Case reports, major risk factors and illness severity

Hancox, J. C., Hasnain, M., Vieweg, W. V. R., Gysel, M., Methot, M. & Baranchuk, A., Apr 2014, In: Therapeutic advances in infectious disease. 2, 2, p. 47-59 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

20 Citations (Scopus)

Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model

Colman, M. A., Varela, M., Hancox, J. C., Zhang, H. & Aslanidi, O. V., Mar 2014, In: EP-Europace. 16, 3, p. 416-23 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

38 Citations (Scopus)

Professor Jules C Hancox

Research output

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