Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

2016

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., Gintant, G., Imredy, J., Koerner, J., Kramer, J., Levesque, P., Li, Z., Lindqvist, A., Obejero-Paz, C. A., Rampe, D., Sawada, K. & 2 others, Strauss, D. G. & Vandenberg, J. I., Jan 2016, In : Journal of Biomolecular Screening. 21, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle (Academic Journal)

151 Citations (Scopus)

Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

Varela, M., Colman, M. A., Hancox, J. C. & Aslanidi, O. V., 16 Dec 2016, In : PLoS Computational Biology. 12, 12, 22 p., e1005245.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
23 Citations (Scopus)
256 Downloads (Pure)

Characterization and influence of cardiac background sodium current in the atrioventricular node

Cheng, H., Li, J., James, A. F., Inada, S., Choisy, S. C. M., Orchard, C. H., Zhang, H., Boyett, M. R. & Hancox, J. C., Aug 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 114-124 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
269 Downloads (Pure)

Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings

Walsh, M. A., Stuart, A. G., Schlecht, H., James, A. F., Hancox, J. C. & Newbury-Ecob, R. A., May 2016, In : Pacing and Clinical Electrophysiology. 39, 5, p. 497-501 5 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

Hill, A. P., Perry, M. D., Abi-Gerges, N., Couderc, J-P., Fermini, B., Hancox, J. C., Knollmann, B. C., Mirams, G. R., Skinner, J., Zareba, W. & Vandenberg, J. I., 1 Dec 2016, In : Journal of Physiology. 594, 23, p. 6893-6908 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
9 Citations (Scopus)
266 Downloads (Pure)

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

Zhang, Y. H., Colenso, C. K., Harchi, A. E., Cheng, H., Witchel, H. J., Dempsey, C. E. & Hancox, J. C., 1 Aug 2016, In : Biochemical Pharmacology. 113, p. 24-35 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
19 Citations (Scopus)
354 Downloads (Pure)

Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node

Cheng, H., Curtis, A. E., Fellingham, C. & Hancox, J. C., 10 Jun 2016, In : Physiological Reports. 4, 11, 10 p., e12819.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
262 Downloads (Pure)

Novel ion channel targets in atrial fibrillation

Hancox, J. C., James, A. F., Marrion, N. V., Zhang, H. & Thomas, D., Aug 2016, In : Expert Opinion on Therapeutic Targets. 20, 8, p. 947-958 12 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)
2015
28 Citations (Scopus)

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems--insights from 3D virtual human atria and torso

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., Hancox, J. C. & Zhang, H., Jan 2015, In : PLoS Computational Biology. 11, 1, p. e1004026

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

Choisy, S. C., Kim, S-J., Hancox, J. C., Jones, S. A. & James, A. F., 1 Jan 2015, In : Physiological Reports. 3, 1

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria

Adeniran, I., MacIver, D. H., Garratt, C. J., Ye, J., Hancox, J. C. & Zhang, H., 2015, In : PLoS ONE. 10, 11, p. e0142397

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange

Choisy, S. C., Cheng, H., Orchard, C. H., James, A. F. & Hancox, J. C., Nov 2015, In : Physiological Reports. 3, 11, 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
248 Downloads (Pure)

Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease

Avolio, E., Rodriguez-Arabaolaza, I., Spencer, H. L., Riu, F., Mangialardi, G., Slater, S. C., Rowlinson, J., Alvino, V. V., Idowu, O. O., Soyombo, S., Oikawa, A., Swim, M. M., Kong, C. H. T., Cheng, H., Jia, H., Ghorbel, M. T., Hancox, J. C., Orchard, C. H., Angelini, G., Emanueli, C. & 2 others, Caputo, M. & Madeddu, P., 2015, In : Journal of the American Heart Association. 4, 6

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

Melgari, D., Brack, K. E., Zhang, C., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., 2015, In : Journal of the American Heart Association. 4, 4

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)
26 Downloads (Pure)

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes

Hancox, J. C., Melgari, D., Dempsey, C. E., Brack, K. E., Mitcheson, J. & Ng, G. A., Aug 2015, In : Therapeutic Advances in Drug Safety. 6, 4, p. 177-9 3 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

hERG potassium channel inhibition by ivabradine requires channel gating

Melgari, D., Brack, K. E., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., Oct 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 126-8 3 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Initiation and sustenance of reentry are promoted by two different mechanisms

Aslanidi, O. V. & Hancox, J. C., Jan 2015, In : Heart Rhythm. 12, 1, p. e2

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Melgari, D., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sep 2015, In : Journal of Molecular and Cellular Cardiology. 86, p. 42-53 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
26 Citations (Scopus)
260 Downloads (Pure)

Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes

Hancock, J. M., Weatherall, K. L., Choisy, S. C., James, A. F., Hancox, J. C. & Marrion, N. V., May 2015, In : Heart Rhythm. 12, 5, p. 1003-15 13 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

To the Editor--Altered in vivo systolic function in the short QT syndrome anticipated in silico

Hancox, J. C., Adeniran, I., Whittaker, D. G. & Zhang, H., Sep 2015, In : Heart Rhythm. 12, 9, p. e115

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
2014

Acidosis slows electrical conduction through the atrio-ventricular node

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. & Smith, G. L., 2014, In : Frontiers in Physiology. 5, p. 233

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

A novel genetic modifier for clarithromycin-related cardiac arrhythmia risk?

Hancox, J. C., Du, C., Harchi, A. E., Baranchuk, A. & Zhang, H., Apr 2014, In : Therapeutic advances in infectious disease. 2, 2, p. 71-2 2 p.

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)

Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine

Doggrell, S. A. & Hancox, J. C., Jan 2014, In : Expert opinion on drug safety. 13, 1, p. 131-8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Erythromycin, QTc interval prolongation, and torsade de pointes: Case reports, major risk factors and illness severity

Hancox, J. C., Hasnain, M., Vieweg, W. V. R., Gysel, M., Methot, M. & Baranchuk, A., Apr 2014, In : Therapeutic advances in infectious disease. 2, 2, p. 47-59 13 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model

Colman, M. A., Varela, M., Hancox, J. C., Zhang, H. & Aslanidi, O. V., Mar 2014, In : EP-Europace. 16, 3, p. 416-23 8 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes

Bond, R. C., Choisy, S. C. M., Bryant, S. M., Hancox, J. C. & James, A. F., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 206-15 10 p.

Research output: Contribution to journalArticle (Academic Journal)

File
8 Citations (Scopus)
322 Downloads (Pure)

In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation

Hancox, J. C., Kharche, S., El Harchi, A., Stott, J., Law, P. & Zhang, H., 15 Jan 2014, In : Journal of Electrocardiology. 47, 2, p. 158-165 8 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Inverstigating Stereoselectivity of Pharmacological Inhibition of Herg Channels

Zhang, Y. H., Harchi, A. E. I., Dempsey, C. E. & Hancox, J. C., 28 Jan 2014, In : Biophysical Journal. 106, 2, p. 139A-139A 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Modification of KCNH2-encoded cardiac potassium channels by KCNE1 polymorphism

Hancox, J. C., Du, C., El Harchi, A. & Zhang, H., 2014, In : Circulation Research. 78, 9, p. 2330

Research output: Contribution to journalArticle (Academic Journal)

Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy

Gysel, M., Crystal, A., Hancox, J. C., Methot, M. & Baranchuk, A., 2014, In : Case Reports in Cardiology. 2014, p. 213842

Research output: Contribution to journalArticle (Academic Journal)

Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports

Hasnain, M., Vieweg, W. V. R., Howland, R. H., Kogut, C., Breden Crouse, E. L., Koneru, J. N., Hancox, J. C., Digby, G. C., Baranchuk, A., Deshmukh, A. & Pandurangi, A. K., Jun 2014, In : Therapeutic Advances in Psychopharmacology. 4, 3, p. 130-8 9 p.

Research output: Contribution to journalArticle (Academic Journal)

23 Citations (Scopus)

Quetiapine and the need for a thorough QT/QTc study

Hasnain, M., Vieweg, W. V. R., Howland, R. H., Kogut, C., Breden Crouse, E. L., Koneru, J. N., Hancox, J. C., Digby, G. C., Baranchuk, A., Deshmukh, A. & Pandurangi, A. K., Feb 2014, In : Journal of Clinical Psychopharmacology. 34, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)
Open Access
File
28 Citations (Scopus)
424 Downloads (Pure)

Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration

Melgari, D., Du, C., El Harchi, A., Zhang, Y. & Hancox, J. C., 1 Oct 2014, In : Physiological Reports. 2, 10

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
31 Downloads (Pure)

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues

Alexandrou, A. J., Milnes, J. T., Sun, S. Z., Fermini, B., Kim, S. C., Jenkinson, S., Leishman, D. J., Witchel, H. J., Hancox, J. C. & Leaney, J. L., Aug 2014, In : Journal of Physiology and Pharmacology. 65, 4, p. 511-523 13 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Towards limiting QT interval prolongation and arrhythmia risk in citalopram use

Zhang, Y., Baranchuk, A. & Hancox, J. C., 2014, In : Cardiol Young. 21, 5, p. 454-457 4 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Voltage sensor gating charge transfer in a HERG potassium channel model

Colenso, C. K., Cao, Y., Sessions, R. B., Hancox, J. C. & Dempsey, C. E., 18 Nov 2014, In : Biophysical Journal. 107, 10, p. L25-8

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
2013

Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development

Aslanidi, O. V., Nikolaidou, T., Zhao, J., Smaill, B. H., Gilbert, S. H., Holden, A. V., Lowe, T., Withers, P. J., Stephenson, R. S., Jarvis, J. C., Hancox, J. C., Boyett, M. R. & Zhang, H., Jan 2013, In : IEEE Transactions on Medical Imaging. 32, 1, p. 8-17 10 p.

Research output: Contribution to journalArticle (Academic Journal)

75 Citations (Scopus)

Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins

Aslanidi, O. V., Colman, M. A., Zhao, J., Smaill, B. H., Gilbert, S. H., Hancox, J. C., Boyett, M. R. & Zhang, H., Jan 2013, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA. Institute of Electrical and Electronics Engineers (IEEE), p. 203-206 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: A narrative review based on the study of case reports

Hancox, J. C., Hasnain, M., Vieweg, W. V. R., Crouse, E. L. B. & Baranchuk, A., Oct 2013, In : Therapeutic advances in infectious disease. 1, 5, p. 155-65 11 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia

Doggrell, S. A. & Hancox, J. C., May 2013, In : Expert opinion on drug safety. 12, 3, p. 421-31 11 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Clarithromycin, QTc interval prolongation and torsades de pointes: the need to study case reports

Vieweg, W. V. R., Hancox, J. C., Hasnain, M., Koneru, J. N., Gysel, M. & Baranchuk, A., Aug 2013, In : Therapeutic advances in infectious disease. 1, 4, p. 121-38 18 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation

Aslanidi, O. V., Colman, M. A., Varela, M., Zhao, J., Smaill, B. H., Hancox, J. C., Boyett, M. R. & Zhang, H., 6 Apr 2013, In : Interface Focus. 3, 2, p. 20120069

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling

Adeniran, I., Hancox, J. C. & Zhang, H., 2013, In : Frontiers in Physiology. 4, p. 166

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)
14 Citations (Scopus)

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem

Vieweg, W. V. R., Hasnain, M., Howland, R. H., Clausen, T., Koneru, J. N., Kogut, C., Crouse, E. L. B., Hancox, J. C., Fernandez, A. & Pandurangi, A. K., Aug 2013, In : Therapeutic Advances in Psychopharmacology. 3, 4, p. 219-32 14 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Methadone and torsade de pointes: how can we better understand the association?

Hasnain, M., Vieweg, W. V. R., Breden Crouse, E. L. & Hancox, J. C., Sep 2013, In : American Journal of Medicine. 126, 9, p. 757-8 2 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition

Du, C., El Harchi, A., Zhang, H. & Hancox, J. C., Nov 2013, In : Physiological Reports. 1, 6, p. e00175

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)