Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

2011

KCNE5 (KCNE1L) Variants Are Novel Modulator of Brugada Syndrome and Idiopathic Ventricular Fibrillation

Ohno, S., Zankov, DP., Ding, WG., Itoh, H., Makiyama, T., Doi, T., Shizuta, S., Hattori, T., Miyamoto, A., Naiki, N., Hancox, JC., Matsuura, H. & Horie, M., 2011, In : Circulation: Arrhythmia and Electrophysiology. 4, p. 352 - 361

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)
26 Citations (Scopus)

The hERG K(+) channel S4 domain L532P mutation: Characterization at 37°C

Zhang, YH., Colenso, CK., Sessions, RB., Dempsey, CE. & Hancox, JC., Oct 2011, In : Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808 (10), p. 2477 - 2487

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

The short QT syndrome

Hancox, JC., McPate, MJW., El Harchi, A., Duncan, RS., Dempsey, CE., Witchel, HJ., Adeniran, I. & Zhang, H., 2011, Heart Rate and Rhythm. T. (ed.). Springer-Verlag Berlin, p. 431 - 449 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

β-Adrenoceptor/PKA-stimulation, Na(+)-Ca(2+) exchange and PKA-activated Cl(-) currents in rabbit cardiomyocytes: A conundrum

Barman, P., Choisy, SCM., Hancox, JC. & James, AF., 2011, In : Cell Calcium. 49, p. 233 - 239

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
2012

Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel

El Harchi, A., Melgari, D., Zhang, Y. H., Zhang, H. & Hancox, J. C., 2012, In : PLoS ONE. 7, 12, p. e52451

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Activation of Glibenclamide-Sensitive ATP-Sensitive K+ Channels During β-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia

Kim, S. J., Zhang, H., Khaliulin, I., Choisy, S. C. M., Bond, R. C., Lin, H., El Haou, S., Milnes, J. T., Hancox, J. C., Suleiman, M. S. & James, A. F., 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 6, p. 1184-1192

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943

Cheng, H., Zhang, Y., Du, C., Dempsey, CE. & Hancox, JC., Apr 2012, In : British Journal of Pharmacology. 165, 7, p. 2260 - 2273 14 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits.

Cheng, H., Smith, G., Orchard, C. H., Hancox, J. C. & Burton, F., 2012, In : Experimental Physiology. 97, 10, p. 1131-1139

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Integration of Genetics into a Systems Model of Electrocardiographic Traits using HumanCVD BeadChip

Gaunt, T. R., Shah, S., Nelson, C. P., Drenos, F., Braund, P. S., Adeniran, I., Folkersen, L., Lawlor, D. A., Casas, J-P., Amuzu, A., Kivimaki, M., Whittaker, J., Eriksson, P., Zhang, H., Hancox, J. C., Tomaszewski, M., Burton, P. R., Tobin, M. D., Humphries, S. E., Talmud, P. J. & 5 others, Macfarlane, P. W., Hingorani, A. D., Samani, N. J., Kumari, M. & Day, I. N. M., Dec 2012, In : Circulation: Cardiovascular Genetics. 5, 6, p. 630-638

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node

Zhang, H., Butters, T., Adeniran, I., Higham, J., Holden, A., Boyett, M. & Hancox, J. C., 2012, In : Frontiers in Physiology. 241.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart

Choisy, S. C. M., Cheng, H., Smith, G., James, A. F. & Hancox, J. C., 29 Mar 2012, In : PLoS ONE. 7, 3, p. e33448

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Molecular determinants of hERG potassium channel inhibition by disopyramide

El Harchi, A., Zhang, YH., Hussein, LK., Dempsey, CE. & Hancox, JC., Jan 2012, In : Journal of Molecular and Cellular Cardiology. 52, 1, p. 185 - 195 11 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

PALLAS: limiting indications for dronedarone treatment of atrial fibrillation?

Hancox, J. C. & Doggrell, S., 2012, In : Expert Opinion on Pharmacotherapy. 13, 6, p. 867-871

Research output: Contribution to journalReview article (Academic Journal)

1 Citation (Scopus)

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling

Adeniran, I., El Harchi, A., Hancox, J. C. & Zhang, H., 1 Apr 2012, In : Cardiovascular Research. 94, 1, p. 66-76

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling

Karche, S., Adeniran, I., Stott, J., Law, P., Boyett, M., Hancox, J. C. & Zhang, H., 2012, In : Journal of Physiology. 590, 18, p. 4501-4514

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)
2013

Application of micro-computed tomography with iodine staining to cardiac imaging, segmentation, and computational model development

Aslanidi, O. V., Nikolaidou, T., Zhao, J., Smaill, B. H., Gilbert, S. H., Holden, A. V., Lowe, T., Withers, P. J., Stephenson, R. S., Jarvis, J. C., Hancox, J. C., Boyett, M. R. & Zhang, H., Jan 2013, In : IEEE Transactions on Medical Imaging. 32, 1, p. 8-17 10 p.

Research output: Contribution to journalArticle (Academic Journal)

75 Citations (Scopus)

Arrhythmogenic substrate for atrial fibrillation: insights from an integrative computational model of pulmonary veins

Aslanidi, O. V., Colman, M. A., Zhao, J., Smaill, B. H., Gilbert, S. H., Hancox, J. C., Boyett, M. R. & Zhang, H., Jan 2013, 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2012): Proceedings of a meeting held 28 August - 1 September 2012, San Diego, California, USA. Institute of Electrical and Electronics Engineers (IEEE), p. 203-206 4 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Azithromycin, cardiovascular risks, QTc interval prolongation, torsade de pointes, and regulatory issues: A narrative review based on the study of case reports

Hancox, J. C., Hasnain, M., Vieweg, W. V. R., Crouse, E. L. B. & Baranchuk, A., Oct 2013, In : Therapeutic advances in infectious disease. 1, 5, p. 155-65 11 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Cardiac safety concerns for ondansetron, an antiemetic commonly used for nausea linked to cancer treatment and following anaesthesia

Doggrell, S. A. & Hancox, J. C., May 2013, In : Expert opinion on drug safety. 12, 3, p. 421-31 11 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Clarithromycin, QTc interval prolongation and torsades de pointes: the need to study case reports

Vieweg, W. V. R., Hancox, J. C., Hasnain, M., Koneru, J. N., Gysel, M. & Baranchuk, A., Aug 2013, In : Therapeutic advances in infectious disease. 1, 4, p. 121-38 18 p.

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation

Aslanidi, O. V., Colman, M. A., Varela, M., Zhao, J., Smaill, B. H., Hancox, J. C., Boyett, M. R. & Zhang, H., 6 Apr 2013, In : Interface Focus. 3, 2, p. 20120069

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling

Adeniran, I., Hancox, J. C. & Zhang, H., 2013, In : Frontiers in Physiology. 4, p. 166

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)
14 Citations (Scopus)

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem

Vieweg, W. V. R., Hasnain, M., Howland, R. H., Clausen, T., Koneru, J. N., Kogut, C., Crouse, E. L. B., Hancox, J. C., Fernandez, A. & Pandurangi, A. K., Aug 2013, In : Therapeutic Advances in Psychopharmacology. 3, 4, p. 219-32 14 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Methadone and torsade de pointes: how can we better understand the association?

Hasnain, M., Vieweg, W. V. R., Breden Crouse, E. L. & Hancox, J. C., Sep 2013, In : American Journal of Medicine. 126, 9, p. 757-8 2 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)
13 Citations (Scopus)

Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels

Barman, P. P., Cheng, H., Hancox, J. C. & James, A. F., 1 Mar 2013, In : Biochemical and Biophysical Research Communications. 432, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle (Academic Journal)

ORM-10103: a significant advance in sodium-calcium exchanger pharmacology?

Terracciano, C. M. & Hancox, J. C., Oct 2013, In : British Journal of Pharmacology. 170, 4, p. 765-7 3 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Pro-arrhythmogenic Effects of Atrial Fibrillation Induced Electrical Remodelling- Insights from 3D Virtual Human Atria

Colman, M. A., Aslanidi, O. V., Kharche, S., Boyett, M. R., Garratt, C. J., Hancox, J. C. & Zhang, H., 3 Jun 2013, In : Journal of Physiology.

Research output: Contribution to journalArticle (Academic Journal)

84 Citations (Scopus)

Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports

Vieweg, W. V. R., Hasnain, M., Hancox, J. C., Baranchuk, A., Digby, G. C., Kogut, C., Crouse, E. L. B., Koneru, J. N., Deshmukh, A. & Pandurangi, A. K., Aug 2013, In : Psychopharmacology. 228, 4, p. 515-24 10 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Selective serotonin reuptake inhibitors and torsade de pointes: new concepts and new directions derived from a systematic review of case reports

Kogut, C., Crouse, E. B., Vieweg, W. V. R., Hasnain, M., Baranchuk, A., Digby, G. C., Koneru, J. N., Fernandez, A., Deshmukh, A., Hancox, J. C. & Pandurangi, A. K., Oct 2013, In : Therapeutic Advances in Drug Safety. 4, 5, p. 189-98 10 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias

Curtis, M. J., Hancox, J. C., Farkas, A., Wainwright, C. L., Stables, C. L., Saint, D. A., Clements-Jewery, H., Lambiase, P. D., Billman, G. E., Janse, M. J., Pugsley, M. K., Ng, G. A., Roden, D. M., Camm, A. J. & Walker, M. J. A., 12 Apr 2013, In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle (Academic Journal)

167 Citations (Scopus)

Topical anti-angiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative-AMD

Gammons, M. V., Federov, O., Ivison, D., Du, C., Clark, T. L., Hopkins, C., Hagiwara, M., Dick, A. D., Cox, R. J., Harper, S. J., Hancox, J. C., Knapp, S. & Bates, D. O., 25 Jul 2013, In : Investigative Ophthalmology and Visual Science.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Torsades de pointes following clarithromycin treatment

Gysel, M., Vieweg, W. V. R., Hasnain, M., Hancox, J. C., Kunanithy, V. & Baranchuk, A., Nov 2013, In : Expert Review of Cardiovascular Therapy. 11, 11, p. 1485-93 9 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
2014

Acidosis slows electrical conduction through the atrio-ventricular node

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H. & Smith, G. L., 2014, In : Frontiers in Physiology. 5, p. 233

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

A novel genetic modifier for clarithromycin-related cardiac arrhythmia risk?

Hancox, J. C., Du, C., Harchi, A. E., Baranchuk, A. & Zhang, H., Apr 2014, In : Therapeutic advances in infectious disease. 2, 2, p. 71-2 2 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Cardiac safety concerns for domperidone, an antiemetic and prokinetic, and galactogogue medicine

Doggrell, S. A. & Hancox, J. C., Jan 2014, In : Expert opinion on drug safety. 13, 1, p. 131-8 8 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Erythromycin, QTc interval prolongation, and torsade de pointes: Case reports, major risk factors and illness severity

Hancox, J. C., Hasnain, M., Vieweg, W. V. R., Gysel, M., Methot, M. & Baranchuk, A., Apr 2014, In : Therapeutic advances in infectious disease. 2, 2, p. 47-59 13 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model

Colman, M. A., Varela, M., Hancox, J. C., Zhang, H. & Aslanidi, O. V., Mar 2014, In : EP-Europace. 16, 3, p. 416-23 8 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes

Bond, R. C., Choisy, S. C. M., Bryant, S. M., Hancox, J. C. & James, A. F., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 206-15 10 p.

Research output: Contribution to journalArticle (Academic Journal)

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8 Citations (Scopus)
325 Downloads (Pure)

In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation

Hancox, J. C., Kharche, S., El Harchi, A., Stott, J., Law, P. & Zhang, H., 15 Jan 2014, In : Journal of Electrocardiology. 47, 2, p. 158-165 8 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Inverstigating Stereoselectivity of Pharmacological Inhibition of Herg Channels

Zhang, Y. H., Harchi, A. E. I., Dempsey, C. E. & Hancox, J. C., 28 Jan 2014, In : Biophysical Journal. 106, 2, p. 139A-139A 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Modification of KCNH2-encoded cardiac potassium channels by KCNE1 polymorphism

Hancox, J. C., Du, C., El Harchi, A. & Zhang, H., 2014, In : Circulation Research. 78, 9, p. 2330

Research output: Contribution to journalArticle (Academic Journal)

Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy

Gysel, M., Crystal, A., Hancox, J. C., Methot, M. & Baranchuk, A., 2014, In : Case Reports in Cardiology. 2014, p. 213842

Research output: Contribution to journalArticle (Academic Journal)

Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports

Hasnain, M., Vieweg, W. V. R., Howland, R. H., Kogut, C., Breden Crouse, E. L., Koneru, J. N., Hancox, J. C., Digby, G. C., Baranchuk, A., Deshmukh, A. & Pandurangi, A. K., Jun 2014, In : Therapeutic Advances in Psychopharmacology. 4, 3, p. 130-8 9 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Quetiapine and the need for a thorough QT/QTc study

Hasnain, M., Vieweg, W. V. R., Howland, R. H., Kogut, C., Breden Crouse, E. L., Koneru, J. N., Hancox, J. C., Digby, G. C., Baranchuk, A., Deshmukh, A. & Pandurangi, A. K., Feb 2014, In : Journal of Clinical Psychopharmacology. 34, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)
Open Access
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29 Citations (Scopus)
434 Downloads (Pure)