Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

Article (Academic Journal)

Erythromycin, QTc interval prolongation, and torsade de pointes: Case reports, major risk factors and illness severity

Hancox, J. C., Hasnain, M., Vieweg, W. V. R., Gysel, M., Methot, M. & Baranchuk, A., Apr 2014, In : Therapeutic advances in infectious disease. 2, 2, p. 47-59 13 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Erythromycin block of the HERG K,sup>+ channel: Accessability to F656 and Y652

Duncan, RS., Ridley, JM., Dempsey, CE., Leishman, DJ., Leaney, JL., Hancox, JC. & Witchel, HJ., 2006, In : Biochemical and Biophysical Research Communications. 341, p. 500 - 506 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Evidence for a novel K+ channel modulated by α1A-adrenoceptors in cardiac myocytes

Choisy, SCM., Hancox, JC., Arberry, LA., Reynolds, AM., Shattock, MJ. & James, AF., Sep 2004, In : Molecular Pharmacology. 66 (3), p. 735 - 748 14 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Evolution and pharmacological modulation of the arrhythmogenic wave dynamics in canine pulmonary vein model

Colman, M. A., Varela, M., Hancox, J. C., Zhang, H. & Aslanidi, O. V., Mar 2014, In : EP-Europace. 16, 3, p. 416-23 8 p.

Research output: Contribution to journalArticle (Academic Journal)

31 Citations (Scopus)

Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease

Avolio, E., Rodriguez-Arabaolaza, I., Spencer, H. L., Riu, F., Mangialardi, G., Slater, S. C., Rowlinson, J., Alvino, V. V., Idowu, O. O., Soyombo, S., Oikawa, A., Swim, M. M., Kong, C. H. T., Cheng, H., Jia, H., Ghorbel, M. T., Hancox, J. C., Orchard, C. H., Angelini, G., Emanueli, C. & 2 others, Caputo, M. & Madeddu, P., 2015, In : Journal of the American Heart Association. 4, 6

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

Butler, A., Zhang, Y., Stuart, A. G., Dempsey, C. E. & Hancox, J. C., 20 Apr 2019, In : Heliyon. 5, 4, p. e01429 29 p., e01429.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
175 Downloads (Pure)

Gender-related differences in ventricular myocyte repolarization in the guinea pig

James, AF., Arberry, LA. & Hancox, JC., May 2004, In : Basic Research in Cardiology. 99 (3), p. 183 - 192 10 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome

Mcpate, MJ., Zhang, H., Cordeiro, JM., Dempsey, CE., Witchel, HJ. & Hancox, JC., Aug 2009, In : Biochemical and Biophysical Research Communications. 386 (1), p. 111 - 117 7 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

Melgari, D., Brack, K. E., Zhang, C., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., 2015, In : Journal of the American Heart Association. 4, 4

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)
26 Downloads (Pure)

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes

Hancox, J. C., Melgari, D., Dempsey, C. E., Brack, K. E., Mitcheson, J. & Ng, G. A., Aug 2015, In : Therapeutic Advances in Drug Safety. 6, 4, p. 177-9 3 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

hERG potassium channel inhibition by ivabradine requires channel gating

Melgari, D., Brack, K. E., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., Oct 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 126-8 3 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation

Aslanidi, O. V., Colman, M. A., Varela, M., Zhao, J., Smaill, B. H., Hancox, J. C., Boyett, M. R. & Zhang, H., 6 Apr 2013, In : Interface Focus. 3, 2, p. 20120069

Research output: Contribution to journalArticle (Academic Journal)

30 Citations (Scopus)

High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943

Cheng, H., Zhang, Y., Du, C., Dempsey, CE. & Hancox, JC., Apr 2012, In : British Journal of Pharmacology. 165, 7, p. 2260 - 2273 14 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Whittaker, D. G., Colman, M. A., Ni, H., Hancox, J. C. & Zhang, H., 4 Oct 2018, In : Frontiers in Physiology. 9, 15 p., 1402.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
11 Citations (Scopus)
222 Downloads (Pure)

Identification of a proton sensor that regulates conductance and open time of single hERG channels

Wilson, S. L., Dempsey, C. E., Hancox, J. C. & Marrion, N. V., 27 Dec 2019, In : Scientific Reports. 9, 15 p., 19825 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
79 Downloads (Pure)

Increased Susceptibility to Atrial Tachyarrhythmia in Spontaneously Hypertensive Rat Hearts

Choisy, SCM., Arberry, LA., Hancox, JC. & James, AF., Mar 2007, In : Hypertension. 49 (3), p. 498 - 505 8 p., HYP.0000257123.95372.ab.

Research output: Contribution to journalArticle (Academic Journal)

70 Citations (Scopus)

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome

Adeniran, I., McPate, MJW., Witchel, HJ., Hancox, JC. & Zhang, H., Dec 2011, In : PLoS Computational Biology. 12, 7, p. e1002313

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
46 Citations (Scopus)
265 Downloads (Pure)

Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes

Bond, R. C., Choisy, S. C. M., Bryant, S. M., Hancox, J. C. & James, A. F., 1 Oct 2014, In : Cardiovascular Research. 104, 1, p. 206-15 10 p.

Research output: Contribution to journalArticle (Academic Journal)

File
8 Citations (Scopus)
331 Downloads (Pure)

Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine

Ridley, JM., Milnes, JT., Zhang, YH., Witchel, HJ. & Hancox, JC., Jun 2003, In : Journal of Physiology. 549 (3), p. 667 - 672 6 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits.

Cheng, H., Smith, G., Orchard, C. H., Hancox, J. C. & Burton, F., 2012, In : Experimental Physiology. 97, 10, p. 1131-1139

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca2+ ATPase

Cheng, H., Smith, GL., Hancox, JC. & Orchard, CH., Jan 2011, In : Cell Calcium. 49, 1, p. 56 - 65

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes

Caves, R. E., Carpenter, A., Choisy, S. C. M., Clennell, B., Cheng, H., McNiff, C., Mann, B., Milnes, J. T., Hancox, J. C. & James, A. F., 19 May 2020, (Accepted/In press) In : Heart Rhythm O2.

Research output: Contribution to journalArticle (Academic Journal)

Initiation and sustenance of reentry are promoted by two different mechanisms

Aslanidi, O. V. & Hancox, J. C., Jan 2015, In : Heart Rhythm. 12, 1, p. e2

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

Whittaker, D. G., Hancox, J. C. & Zhang, H., 11 Jan 2019, In : Frontiers in Physiology. 9, 16 p., 1888.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
186 Downloads (Pure)

In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation

Hancox, J. C., Kharche, S., El Harchi, A., Stott, J., Law, P. & Zhang, H., 15 Jan 2014, In : Journal of Electrocardiology. 47, 2, p. 158-165 8 p.

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Adeniran, I., Whittaker, D. G., El Harchi, A., Hancox, J. C. & Zhang, H., 16 Aug 2017, In : Scientific Reports. 7, 14 p., 8469.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
232 Downloads (Pure)

In silico investigation of the short QT syndrome, using human ventricle models incorporating electromechanical coupling

Adeniran, I., Hancox, J. C. & Zhang, H., 2013, In : Frontiers in Physiology. 4, p. 166

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Integration of Genetics into a Systems Model of Electrocardiographic Traits using HumanCVD BeadChip

Gaunt, T. R., Shah, S., Nelson, C. P., Drenos, F., Braund, P. S., Adeniran, I., Folkersen, L., Lawlor, D. A., Casas, J-P., Amuzu, A., Kivimaki, M., Whittaker, J., Eriksson, P., Zhang, H., Hancox, J. C., Tomaszewski, M., Burton, P. R., Tobin, M. D., Humphries, S. E., Talmud, P. J. & 5 others, Macfarlane, P. W., Hingorani, A. D., Samani, N. J., Kumari, M. & Day, I. N. M., Dec 2012, In : Circulation: Cardiovascular Genetics. 5, 6, p. 630-638

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)
Open Access
File
20 Citations (Scopus)
369 Downloads (Pure)
14 Citations (Scopus)

Inverstigating Stereoselectivity of Pharmacological Inhibition of Herg Channels

Zhang, Y. H., Harchi, A. E. I., Dempsey, C. E. & Hancox, J. C., 28 Jan 2014, In : Biophysical Journal. 106, 2, p. 139A-139A 1 p.

Research output: Contribution to journalArticle (Academic Journal)

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide

Milnes, JT., Witchel, HJ., Leaney, JL., Leishman, DJ. & Hancox, JC., Mar 2010, In : Journal of Pharmacological and Toxicological Methods. 61, 2, p. 178 - 191 14 p.

Research output: Contribution to journalArticle (Academic Journal)

56 Citations (Scopus)

Investigation of hERG1b influence on hERG channel pharmacology at physiological temperature

Hancox, J., El Harchi, A., Melgari, D. & Zhang, H., 2018, In : Journal of Pharmacology and Pharmacotherapeutics. 9, 2, p. 92-103 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
217 Downloads (Pure)

Ion currents, action potentials and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes

Bond, R. C., Choisy, S. C., Bryant, S. M., Hancox, J. C. & James, A. F., 13 May 2020, In : Physiological Reports. 8, 9, 16 p., e14432.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
22 Downloads (Pure)

Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells

Aslanidi, OV., Sleiman, RN., Boyett, M. R., Hancox, JC. & Zhang, H., 2010, In : Biophysical Journal. 98, p. 2420 - 2431

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

KCNE5 (KCNE1L) Variants Are Novel Modulator of Brugada Syndrome and Idiopathic Ventricular Fibrillation

Ohno, S., Zankov, DP., Ding, WG., Itoh, H., Makiyama, T., Doi, T., Shizuta, S., Hattori, T., Miyamoto, A., Naiki, N., Hancox, JC., Matsuura, H. & Horie, M., 2011, In : Circulation: Arrhythmia and Electrophysiology. 4, p. 352 - 361

Research output: Contribution to journalArticle (Academic Journal)

98 Citations (Scopus)

Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells

Fowler, E., Kong, C., Hancox, J. & Cannell, M., 2018, In : Circulation Research. 122, p. 473-478 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
166 Downloads (Pure)

Long QT syndrome and left ventricular noncompaction in 4 family members across 2 generations with KCNQ1 mutation

Kharbanda, M., Hunter, A., Tennant, S., Curtis, S. L., Hancox, J. C. & Murday, V., 1 May 2017, In : European Journal of Medical Genetics. 60, 5, p. 233-238 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
252 Downloads (Pure)

Measuring kinetics and potency of hERG block for CiPA

Windley, M. J., Abi-Gerges, N., Fermini, B., Hancox, J. C., Vandenberg, J. I. & Hill, A. P., Sep 2017, In : Journal of Pharmacological and Toxicological Methods. 87, p. 99-107 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
22 Citations (Scopus)
262 Downloads (Pure)

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study

Bai, X., Wang, K., Yuan, Y., Li, Q., Dobrzynski, H., Boyett, M. R., Hancox, J. C. & Zhang, H., Sep 2017, In : Chaos. 27, 9, 10 p., 093934.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
226 Downloads (Pure)

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study

Wang, W., Zhang, S., Ni, H., Garratt, C. J., Boyett, M. R., Hancox, J. C. & Zhang, H., 30 Nov 2018, In : PLoS Computational Biology. 14, 11, 27 p., e1006594.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
6 Citations (Scopus)
232 Downloads (Pure)

Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome

Butters, TD., Aslanidi, OV., Inada, S., Boyett, M. R., Hancox, JC., Lei, M. & Zhang, H., 9 Jul 2010, In : Circulation Research. 107, 1, p. 126 - 137

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem

Vieweg, W. V. R., Hasnain, M., Howland, R. H., Clausen, T., Koneru, J. N., Kogut, C., Crouse, E. L. B., Hancox, J. C., Fernandez, A. & Pandurangi, A. K., Aug 2013, In : Therapeutic Advances in Psychopharmacology. 3, 4, p. 219-32 14 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Methadone and torsade de pointes: how can we better understand the association?

Hasnain, M., Vieweg, W. V. R., Breden Crouse, E. L. & Hancox, J. C., Sep 2013, In : American Journal of Medicine. 126, 9, p. 757-8 2 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node

Zhang, H., Butters, T., Adeniran, I., Higham, J., Holden, A., Boyett, M. & Hancox, J. C., 2012, In : Frontiers in Physiology. 241.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Moderately elevated plasma homocysteine impairs functional endothelial recovery following denudation of mouse carotid arteries

Miller, AL., Witchel, HJ., Hancox, JC., Jackson, CL. & Jeremy, JY., 2004, In : Metabolism. p. 760 - 765

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)
13 Citations (Scopus)

Modification of KCNH2-encoded cardiac potassium channels by KCNE1 polymorphism

Hancox, J. C., Du, C., El Harchi, A. & Zhang, H., 2014, In : Circulation Research. 78, 9, p. 2330

Research output: Contribution to journalArticle (Academic Journal)

Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart

Choisy, S. C. M., Cheng, H., Smith, G., James, A. F. & Hancox, J. C., 29 Mar 2012, In : PLoS ONE. 7, 3, p. e33448

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Modulation by testosterone of an endogenous hERG potassium channel current

Ridley, JM., Shuba, YM., James, AF. & Hancox, JC., 2008, In : Journal of Physiology and Pharmacology. 59, p. 395 - 407

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)