Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

2013

Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels

Barman, P. P., Cheng, H., Hancox, J. C. & James, A. F., 1 Mar 2013, In : Biochemical and Biophysical Research Communications. 432, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle (Academic Journal)

ORM-10103: a significant advance in sodium-calcium exchanger pharmacology?

Terracciano, C. M. & Hancox, J. C., Oct 2013, In : British Journal of Pharmacology. 170, 4, p. 765-7 3 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Pro-arrhythmogenic Effects of Atrial Fibrillation Induced Electrical Remodelling- Insights from 3D Virtual Human Atria

Colman, M. A., Aslanidi, O. V., Kharche, S., Boyett, M. R., Garratt, C. J., Hancox, J. C. & Zhang, H., 3 Jun 2013, In : Journal of Physiology.

Research output: Contribution to journalArticle (Academic Journal)

83 Citations (Scopus)

Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports

Vieweg, W. V. R., Hasnain, M., Hancox, J. C., Baranchuk, A., Digby, G. C., Kogut, C., Crouse, E. L. B., Koneru, J. N., Deshmukh, A. & Pandurangi, A. K., Aug 2013, In : Psychopharmacology. 228, 4, p. 515-24 10 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Selective serotonin reuptake inhibitors and torsade de pointes: new concepts and new directions derived from a systematic review of case reports

Kogut, C., Crouse, E. B., Vieweg, W. V. R., Hasnain, M., Baranchuk, A., Digby, G. C., Koneru, J. N., Fernandez, A., Deshmukh, A., Hancox, J. C. & Pandurangi, A. K., Oct 2013, In : Therapeutic Advances in Drug Safety. 4, 5, p. 189-98 10 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias

Curtis, M. J., Hancox, J. C., Farkas, A., Wainwright, C. L., Stables, C. L., Saint, D. A., Clements-Jewery, H., Lambiase, P. D., Billman, G. E., Janse, M. J., Pugsley, M. K., Ng, G. A., Roden, D. M., Camm, A. J. & Walker, M. J. A., 12 Apr 2013, In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle (Academic Journal)

161 Citations (Scopus)

Topical anti-angiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative-AMD

Gammons, M. V., Federov, O., Ivison, D., Du, C., Clark, T. L., Hopkins, C., Hagiwara, M., Dick, A. D., Cox, R. J., Harper, S. J., Hancox, J. C., Knapp, S. & Bates, D. O., 25 Jul 2013, In : Investigative Ophthalmology and Visual Science.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)

Torsades de pointes following clarithromycin treatment

Gysel, M., Vieweg, W. V. R., Hasnain, M., Hancox, J. C., Kunanithy, V. & Baranchuk, A., Nov 2013, In : Expert Review of Cardiovascular Therapy. 11, 11, p. 1485-93 9 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
2012

Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel

El Harchi, A., Melgari, D., Zhang, Y. H., Zhang, H. & Hancox, J. C., 2012, In : PLoS ONE. 7, 12, p. e52451

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Activation of Glibenclamide-Sensitive ATP-Sensitive K+ Channels During β-Adrenergically Induced Metabolic Stress Produces a Substrate for Atrial Tachyarrhythmia

Kim, S. J., Zhang, H., Khaliulin, I., Choisy, S. C. M., Bond, R. C., Lin, H., El Haou, S., Milnes, J. T., Hancox, J. C., Suleiman, M. S. & James, A. F., 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 6, p. 1184-1192

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943

Cheng, H., Zhang, Y., Du, C., Dempsey, CE. & Hancox, JC., Apr 2012, In : British Journal of Pharmacology. 165, 7, p. 2260 - 2273 14 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Inhibition of sarcoplasmic reticulum Ca2+-ATPase decreases atrioventricular node-paced heart rate in rabbits.

Cheng, H., Smith, G., Orchard, C. H., Hancox, J. C. & Burton, F., 2012, In : Experimental Physiology. 97, 10, p. 1131-1139

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Integration of Genetics into a Systems Model of Electrocardiographic Traits using HumanCVD BeadChip

Gaunt, T. R., Shah, S., Nelson, C. P., Drenos, F., Braund, P. S., Adeniran, I., Folkersen, L., Lawlor, D. A., Casas, J-P., Amuzu, A., Kivimaki, M., Whittaker, J., Eriksson, P., Zhang, H., Hancox, J. C., Tomaszewski, M., Burton, P. R., Tobin, M. D., Humphries, S. E., Talmud, P. J. & 5 others, Macfarlane, P. W., Hingorani, A. D., Samani, N. J., Kumari, M. & Day, I. N. M., Dec 2012, In : Circulation: Cardiovascular Genetics. 5, 6, p. 630-638

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node

Zhang, H., Butters, T., Adeniran, I., Higham, J., Holden, A., Boyett, M. & Hancox, J. C., 2012, In : Frontiers in Physiology. 241.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart

Choisy, S. C. M., Cheng, H., Smith, G., James, A. F. & Hancox, J. C., 29 Mar 2012, In : PLoS ONE. 7, 3, p. e33448

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Molecular determinants of hERG potassium channel inhibition by disopyramide

El Harchi, A., Zhang, YH., Hussein, LK., Dempsey, CE. & Hancox, JC., Jan 2012, In : Journal of Molecular and Cellular Cardiology. 52, 1, p. 185 - 195 11 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

PALLAS: limiting indications for dronedarone treatment of atrial fibrillation?

Hancox, J. C. & Doggrell, S., 2012, In : Expert Opinion on Pharmacotherapy. 13, 6, p. 867-871

Research output: Contribution to journalReview article (Academic Journal)

1 Citation (Scopus)

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling

Adeniran, I., El Harchi, A., Hancox, J. C. & Zhang, H., 1 Apr 2012, In : Cardiovascular Research. 94, 1, p. 66-76

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling

Karche, S., Adeniran, I., Stott, J., Law, P., Boyett, M., Hancox, J. C. & Zhang, H., 2012, In : Journal of Physiology. 590, 18, p. 4501-4514

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)
2011

Atrial Remodeling and the Substrate for Atrial Fibrillation in Rat Hearts with Elevated Afterload

Kim, SJ., Choisy, SCM., Barman, P., Zhang, H., Hancox, JC., Jones, SA. & James, AF., Oct 2011, In : Circulation: Arrhythmia and Electrophysiology. 4, 5, p. 761 - 769 9 p.

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Cardiac ion channel current modulation by the CFTR inhibitor GlyH-101

Barman, P., Choisy, SCM., Gadeberg, HC., Hancox, JC. & James, AF., 2011, In : Biochemical and Biophysical Research Communications. 408, p. 12 - 17

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Cardiac ion channel modulation by the hypoglycaemic agent rosiglitazone

Hancox, JC., 2011, In : British Journal of Pharmacology. 163, p. 496 - 498

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform

Du, C., El Harchi, A., McPate, MJW., Orchard, CH. & Hancox, JC., 2011, In : Biochemical and Biophysical Research Communications. 405, p. 222 - 227

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Increased vulnerability of human ventricle to re-entrant excitation in hERG-linked variant 1 short QT syndrome

Adeniran, I., McPate, MJW., Witchel, HJ., Hancox, JC. & Zhang, H., Dec 2011, In : PLoS Computational Biology. 12, 7, p. e1002313

Research output: Contribution to journalArticle (Academic Journal)

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46 Citations (Scopus)
248 Downloads (Pure)

Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca2+ ATPase

Cheng, H., Smith, GL., Hancox, JC. & Orchard, CH., Jan 2011, In : Cell Calcium. 49, 1, p. 56 - 65

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

KCNE5 (KCNE1L) Variants Are Novel Modulator of Brugada Syndrome and Idiopathic Ventricular Fibrillation

Ohno, S., Zankov, DP., Ding, WG., Itoh, H., Makiyama, T., Doi, T., Shizuta, S., Hattori, T., Miyamoto, A., Naiki, N., Hancox, JC., Matsuura, H. & Horie, M., 2011, In : Circulation: Arrhythmia and Electrophysiology. 4, p. 352 - 361

Research output: Contribution to journalArticle (Academic Journal)

97 Citations (Scopus)

Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis

Du, C., El Harchi, A., Zhang, YH., Orchard, CH. & Hancox, JC., 2011, In : Journal of Cardiovascular Electrophysiology. p. in press

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

The hERG K(+) channel S4 domain L532P mutation: Characterization at 37°C

Zhang, YH., Colenso, CK., Sessions, RB., Dempsey, CE. & Hancox, JC., Oct 2011, In : Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808 (10), p. 2477 - 2487

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

The short QT syndrome

Hancox, JC., McPate, MJW., El Harchi, A., Duncan, RS., Dempsey, CE., Witchel, HJ., Adeniran, I. & Zhang, H., 2011, Heart Rate and Rhythm. T. (ed.). Springer-Verlag Berlin, p. 431 - 449 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

β-Adrenoceptor/PKA-stimulation, Na(+)-Ca(2+) exchange and PKA-activated Cl(-) currents in rabbit cardiomyocytes: A conundrum

Barman, P., Choisy, SCM., Hancox, JC. & James, AF., 2011, In : Cell Calcium. 49, p. 233 - 239

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
2010

Acidosis Impairs the Protective Role of hERG K(+) Channels Against Premature Stimulation

Du, C., Adeniran, I., Cheng, H., Zhang, YH., El Harchi, A., McPate, MJW., Zhang, H., Orchard, CH. & Hancox, JC., 2010, In : Journal of Cardiovascular Electrophysiology. 21, p. 1160 - 1169

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Action potential clamp and mefloquine sensitivity of recombinant 'I KS' channels incorporating the V307L KCNQ1 mutation

El Harchi, A., McPate, MJW., Zhang, YH. & Hancox, JC., 2010, In : Journal of Physiology and Pharmacology. 61, p. 123 - 131

Research output: Contribution to journalArticle (Academic Journal)

16 Citations (Scopus)

Characterization of recombinant hERG K(+) channel inhibition by the active metabolite of amiodarone desethyl-amiodarone

Zhang, YH., Cheng, H., Alexeenko, VA., Dempsey, CE. & Hancox, JC., 2010, In : Journal of Electrocardiology. 43, p. 440 - 448

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37 degrees C: Cisapride versus dofetilide

Milnes, JT., Witchel, HJ., Leaney, JL., Leishman, DJ. & Hancox, JC., Mar 2010, In : Journal of Pharmacological and Toxicological Methods. 61, 2, p. 178 - 191 14 p.

Research output: Contribution to journalArticle (Academic Journal)

54 Citations (Scopus)

Ionic mechanisms for electrical heterogeneity between rabbit Purkinje fiber and ventricular cells

Aslanidi, OV., Sleiman, RN., Boyett, M. R., Hancox, JC. & Zhang, H., 2010, In : Biophysical Journal. 98, p. 2420 - 2431

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome

Butters, TD., Aslanidi, OV., Inada, S., Boyett, M. R., Hancox, JC., Lei, M. & Zhang, H., 9 Jul 2010, In : Circulation Research. 107, 1, p. 126 - 137

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Perspective: does ranolazine have potential for the treatment of atrial fibrillation?

Hancox, JC. & Doggrell, SA., 2010, In : Expert Opinion on Investigational Drugs. 19, p. 1465 - 1474

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias

O'Leary, ME. & Hancox, JC., 2010, In : British Journal of Clinical Pharmacology. 69, p. 427 - 442

Research output: Contribution to journalArticle (Academic Journal)

49 Citations (Scopus)

Streptozotocin-induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node

Yuill, KH., Tosh, D. & Hancox, JC., 2010, In : Experimental Physiology. 95, p. 508 - 517

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
2009

Acidosis inhibits spontaneous activity and membrane currents in myocytes isolated from the rabbit atrioventricular node

Cheng, H., Smith, GL., Orchard, CH. & Hancox, JC., Jan 2009, In : Journal of Molecular and Cellular Cardiology. 46, 1, p. 75 - 85

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome

El Harchi, A., McPate, MJW., Zhang, YH., Zhang, H. & Hancox, JC., 2009, In : Journal of Molecular and Cellular Cardiology. 47, p. 743 - 747

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Comparative effects of the short QT N588K mutation at 37 degrees C on hERG K+ channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study

McPate, MJW., Zhang, H., Adeniran, I., Cordeiro, JM., Witchel, HJ. & Hancox, JC., 2009, In : Journal of Physiology and Pharmacology. 60, p. 23 - 41

Research output: Contribution to journalArticle (Academic Journal)

hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome

Mcpate, MJ., Zhang, H., Cordeiro, JM., Dempsey, CE., Witchel, HJ. & Hancox, JC., Aug 2009, In : Biochemical and Biophysical Research Communications. 386 (1), p. 111 - 117 7 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells

Inada, S., Hancox, JC., Zhang, H. & Boyett, M. R., 2009, In : Biophysical Journal. 97, p. 2117 - 2127

Research output: Contribution to journalArticle (Academic Journal)

55 Citations (Scopus)

Short QT interval linked to androgen misuse: wider significance and possible basis

Hancox, JC., Choisy, SCM. & James, AF., 2009, In : Annals of Noninvasive Electrocardiology. 14, p. 311 - 312

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)
2008

Atrial proarrhythmia due to increased inward rectifier current (I(K1)) arising from KCNJ2 mutation--a simulation study

Kharche, S., Garratt, CJ., Boyett, M. R., Inada, S., Holden, AV., Hancox, JC. & Zhang, H., 2008, In : Progress in Biophysics and Molecular Biology. 98, p. 186 - 197

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Computer three-dimensional reconstruction of the atrioventricular node

Li, J., Greener, I. D., Inada, S., Nikolski, V. P., Yamamoto, M., Hancox, JC., Zhang, H., Billeter, R., Efimov, I., Dobryznksi, H. & Boyett, M. R., 2008, In : Circulation Research. 102, p. 975 - 985

Research output: Contribution to journalArticle (Academic Journal)

74 Citations (Scopus)

Modulation by testosterone of an endogenous hERG potassium channel current

Ridley, JM., Shuba, YM., James, AF. & Hancox, JC., 2008, In : Journal of Physiology and Pharmacology. 59, p. 395 - 407

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)

Perception of validity of clinical and preclinical methods for assessment of torsades de pointes liability

Pugsley, MK., Hancox, JC. & Curtis, MJ., 2008, In : Pharmacology and Therapeutics. p. 115 - 117

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)