Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

2014

Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration

Melgari, D., Du, C., El Harchi, A., Zhang, Y. & Hancox, J. C., 1 Oct 2014, In : Physiological Reports. 2, 10

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)
31 Downloads (Pure)

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues

Alexandrou, A. J., Milnes, J. T., Sun, S. Z., Fermini, B., Kim, S. C., Jenkinson, S., Leishman, D. J., Witchel, H. J., Hancox, J. C. & Leaney, J. L., Aug 2014, In : Journal of Physiology and Pharmacology. 65, 4, p. 511-523 13 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Towards limiting QT interval prolongation and arrhythmia risk in citalopram use

Zhang, Y., Baranchuk, A. & Hancox, J. C., 2014, In : Cardiol Young. 21, 5, p. 454-457 4 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Voltage sensor gating charge transfer in a HERG potassium channel model

Colenso, C. K., Cao, Y., Sessions, R. B., Hancox, J. C. & Dempsey, C. E., 18 Nov 2014, In : Biophysical Journal. 107, 10, p. L25-8

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
2015
28 Citations (Scopus)

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems--insights from 3D virtual human atria and torso

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., Hancox, J. C. & Zhang, H., Jan 2015, In : PLoS Computational Biology. 11, 1, p. e1004026

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

Choisy, S. C., Kim, S-J., Hancox, J. C., Jones, S. A. & James, A. F., 1 Jan 2015, In : Physiological Reports. 3, 1

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria

Adeniran, I., MacIver, D. H., Garratt, C. J., Ye, J., Hancox, J. C. & Zhang, H., 2015, In : PLoS ONE. 10, 11, p. e0142397

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange

Choisy, S. C., Cheng, H., Orchard, C. H., James, A. F. & Hancox, J. C., Nov 2015, In : Physiological Reports. 3, 11, 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
256 Downloads (Pure)

Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease

Avolio, E., Rodriguez-Arabaolaza, I., Spencer, H. L., Riu, F., Mangialardi, G., Slater, S. C., Rowlinson, J., Alvino, V. V., Idowu, O. O., Soyombo, S., Oikawa, A., Swim, M. M., Kong, C. H. T., Cheng, H., Jia, H., Ghorbel, M. T., Hancox, J. C., Orchard, C. H., Angelini, G., Emanueli, C. & 2 others, Caputo, M. & Madeddu, P., 2015, In : Journal of the American Heart Association. 4, 6

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

Melgari, D., Brack, K. E., Zhang, C., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., 2015, In : Journal of the American Heart Association. 4, 4

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)
26 Downloads (Pure)

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes

Hancox, J. C., Melgari, D., Dempsey, C. E., Brack, K. E., Mitcheson, J. & Ng, G. A., Aug 2015, In : Therapeutic Advances in Drug Safety. 6, 4, p. 177-9 3 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

hERG potassium channel inhibition by ivabradine requires channel gating

Melgari, D., Brack, K. E., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., Oct 2015, In : Journal of Molecular and Cellular Cardiology. 87, p. 126-8 3 p.

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)

Initiation and sustenance of reentry are promoted by two different mechanisms

Aslanidi, O. V. & Hancox, J. C., Jan 2015, In : Heart Rhythm. 12, 1, p. e2

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Melgari, D., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sep 2015, In : Journal of Molecular and Cellular Cardiology. 86, p. 42-53 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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27 Citations (Scopus)
266 Downloads (Pure)

Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes

Hancock, J. M., Weatherall, K. L., Choisy, S. C., James, A. F., Hancox, J. C. & Marrion, N. V., May 2015, In : Heart Rhythm. 12, 5, p. 1003-15 13 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

To the Editor--Altered in vivo systolic function in the short QT syndrome anticipated in silico

Hancox, J. C., Adeniran, I., Whittaker, D. G. & Zhang, H., Sep 2015, In : Heart Rhythm. 12, 9, p. e115

Research output: Contribution to journalArticle (Academic Journal)

1 Citation (Scopus)
2016

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., Gintant, G., Imredy, J., Koerner, J., Kramer, J., Levesque, P., Li, Z., Lindqvist, A., Obejero-Paz, C. A., Rampe, D., Sawada, K. & 2 others, Strauss, D. G. & Vandenberg, J. I., Jan 2016, In : Journal of Biomolecular Screening. 21, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle (Academic Journal)

154 Citations (Scopus)

Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

Varela, M., Colman, M. A., Hancox, J. C. & Aslanidi, O. V., 16 Dec 2016, In : PLoS Computational Biology. 12, 12, 22 p., e1005245.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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25 Citations (Scopus)
276 Downloads (Pure)

Characterization and influence of cardiac background sodium current in the atrioventricular node

Cheng, H., Li, J., James, A. F., Inada, S., Choisy, S. C. M., Orchard, C. H., Zhang, H., Boyett, M. R. & Hancox, J. C., Aug 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 114-124 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
280 Downloads (Pure)

Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings

Walsh, M. A., Stuart, A. G., Schlecht, H., James, A. F., Hancox, J. C. & Newbury-Ecob, R. A., May 2016, In : Pacing and Clinical Electrophysiology. 39, 5, p. 497-501 5 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

Hill, A. P., Perry, M. D., Abi-Gerges, N., Couderc, J-P., Fermini, B., Hancox, J. C., Knollmann, B. C., Mirams, G. R., Skinner, J., Zareba, W. & Vandenberg, J. I., 1 Dec 2016, In : Journal of Physiology. 594, 23, p. 6893-6908 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
274 Downloads (Pure)
Open Access
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20 Citations (Scopus)
369 Downloads (Pure)

Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node

Cheng, H., Curtis, A. E., Fellingham, C. & Hancox, J. C., 10 Jun 2016, In : Physiological Reports. 4, 11, 10 p., e12819.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
265 Downloads (Pure)

Novel ion channel targets in atrial fibrillation

Hancox, J. C., James, A. F., Marrion, N. V., Zhang, H. & Thomas, D., Aug 2016, In : Expert Opinion on Therapeutic Targets. 20, 8, p. 947-958 12 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)
2017

A basis for human QT interval prolongation and arrhythmia risk in type 2 diabetes?

Hancox, J. C., 2 Sep 2017, In : Experimental Physiology. 102, 11, p. 1395-1396 2 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
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1 Citation (Scopus)
208 Downloads (Pure)

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Whittaker, D. G., Ni, H., Harchi, A. E., Hancox, J. C. & Zhang, H., 13 Jun 2017, In : PLoS Computational Biology. 13, 6, 29 p., e1005593.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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18 Citations (Scopus)
234 Downloads (Pure)

Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: basis for atrial-selective block by ranolazine

Caves, R., Cheng, H., Choisy, S., Gadeberg, H., Bryant, S., Hancox, J. & James, A., 1 Nov 2017, In : Heart Rhythm. 14, 11, p. 1657-1664 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
248 Downloads (Pure)

Atrial-Ventricular Differences in Voltage-Gated Na+ Currents of Rabbit Cardiomyocytes

Caves, R. E., Cheng, H., Choisy, S. C., Gadeberg, H. C., Bryant, S. M., Hancox, J. C. & James, A. F., 3 Feb 2017, p. 243a. 1 p.

Research output: Contribution to conferenceConference Abstract

Open Access
File
282 Downloads (Pure)

Cardiac background sodium current: Elusive but important

Cheng, H., James, A. F., Boyett, M. R. & Hancox, J. C., 2 Jan 2017, In : Channels. 11, 1, p. 3-4 2 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
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235 Downloads (Pure)

Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles

Whittaker, D. G., Ni, H., Benson, A. P., Hancox, J. C. & Zhang, H., 4 Oct 2017, In : Frontiers in Physiology. 8, 15 p., 759.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
220 Downloads (Pure)

Could ivabradine be a new treatment for the short QT syndrome?

Hancox, J. C., Sep 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, 9, p. 907-908 2 p.

Research output: Contribution to journalEditorial (Academic Journal)

Open Access
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1 Citation (Scopus)
186 Downloads (Pure)

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Batson, J., Toop, H. D., Redondo, C., Babaei-Jadidi, R., Chaikuad, A., Wearmouth, S. F., Gibbons, B., Allen, C., Tallant, C., Zhang, J., Du, C., Hancox, J. C., Hawtrey, T., Da Rocha, J., Griffith, R., Knapp, S., Bates, D. O. & Morris, J. C., 17 Mar 2017, In : ACS Chemical Biology. 12, 3, p. 825-832 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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28 Citations (Scopus)
411 Downloads (Pure)

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

Cheng, H., Cannell, M. B. & Hancox, J. C., 7 Mar 2017, In : Physiological Reports. 5, 5, 16 p., e13172.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
184 Downloads (Pure)

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Adeniran, I., Whittaker, D. G., El Harchi, A., Hancox, J. C. & Zhang, H., 16 Aug 2017, In : Scientific Reports. 7, 14 p., 8469.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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14 Citations (Scopus)
232 Downloads (Pure)

Long QT syndrome and left ventricular noncompaction in 4 family members across 2 generations with KCNQ1 mutation

Kharbanda, M., Hunter, A., Tennant, S., Curtis, S. L., Hancox, J. C. & Murday, V., 1 May 2017, In : European Journal of Medical Genetics. 60, 5, p. 233-238 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
252 Downloads (Pure)

Measuring kinetics and potency of hERG block for CiPA

Windley, M. J., Abi-Gerges, N., Fermini, B., Hancox, J. C., Vandenberg, J. I. & Hill, A. P., Sep 2017, In : Journal of Pharmacological and Toxicological Methods. 87, p. 99-107 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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22 Citations (Scopus)
262 Downloads (Pure)

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study

Bai, X., Wang, K., Yuan, Y., Li, Q., Dobrzynski, H., Boyett, M. R., Hancox, J. C. & Zhang, H., Sep 2017, In : Chaos. 27, 9, 10 p., 093934.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
226 Downloads (Pure)

Modulation of hERG potassium channels by a novel small molecule activator

Mitcheson, J. S. & Hancox, J. C., 22 Sep 2017, In : British Journal of Pharmacology. 174, 20, p. 3669-3671 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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174 Downloads (Pure)

Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure

Bond, R., Bryant, S., Watson, J., Hancox, J., Orchard, C. & James, A., Mar 2017, In : AJP - Heart and Circulatory Physiology. 312, 3, p. H384-H391 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
191 Downloads (Pure)

Solifenacin linked QT interval prolongation and torsades de pointes

Bray, J. & Hancox, J., 10 Apr 2017, In : Therapeutic Advances in Drug Safety. 3 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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1 Citation (Scopus)
269 Downloads (Pure)

The basis for low-affinity hERG potassium channel block by sotalol

Zhang, Y., Dempsey, C. & Hancox, J., 27 Sep 2017, In : Journal of Pharmacology and Pharmacotherapeutics. 8, 3, p. 130-131 2 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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1 Citation (Scopus)
58 Downloads (Pure)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K. & 31 others, Arumugam, T. V., Attali, B., Bäck, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M., Birdsall, N. J., Blaho, V., Boison, D., Bräuner-osborne, H., Bröer, S., Bryant, C., Burnstock, G., Calo, G., Catterall, W. A., Ceruti, S., Chan, S. L., Chandy, K. G., Chazot, P., Chiang, N., Chun, J. J., Chung, J. J., Clapham, D. E., Connor, M. A., Hancox, J. C., Lolait, S. J., Mcardle, C. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, p. S1-S16 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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162 Citations (Scopus)
256 Downloads (Pure)

The Effects of Extracellular Protons on the hERG Potassium Channel

Wilson, S. L., Marrion, N. V. & Hancox, J. C., 3 Feb 2017, p. 410a. 1 p.

Research output: Contribution to conferenceConference Abstract

Open Access
File
252 Downloads (Pure)
2018

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

Butler, A., Zhang, Y., Stuart, A. G., Dempsey, C. E. & Hancox, J. C., Sep 2018, In : Physiological Reports. 6, 17, 14 p., e13845.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
213 Downloads (Pure)

A hERG mutation E1039X produced a synergistic lesion on I Ks together with KCNQ1-R174C mutation in a LQTS family with three compound mutations

Wu, J., Mizusawa, Y., Ohno, S., Ding, W. G., Higaki, T., Wang, Q., Kohjitani, H., Makiyama, T., Itoh, H., Toyoda, F., James, A. F., Hancox, J. C., Matsuura, H. & Horie, M., 15 Feb 2018, In : Scientific Reports. 8, 1, 12 p., 3129.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
249 Downloads (Pure)

A multicentre study of patients with Timothy syndrome

Walsh, M. A., Turner, C., Timothy, K. W., Seller, N., Hares, D. L., James, A. F., Hancox, J. C., Uzun, O., Boyce, D., Stuart, A. G., Brennan, P., Sarton, C., McGuire, K., Newbury-Ecob, R. A. & Mcleod, K., 1 Feb 2018, In : EP-Europace. 20, 2, p. 377-385 9 p., euw433.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
269 Downloads (Pure)
Open Access
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249 Downloads (Pure)

Emerging therapeutic targets in the short QT syndrome

Hancox, J. C., Whittaker, D. G., Du, C., Stuart, A. G. & Zhang, H., May 2018, In : Expert Opinion on Therapeutic Targets. 22, 5, p. 439-451 13 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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15 Citations (Scopus)
199 Downloads (Pure)

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Whittaker, D. G., Colman, M. A., Ni, H., Hancox, J. C. & Zhang, H., 4 Oct 2018, In : Frontiers in Physiology. 9, 15 p., 1402.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
222 Downloads (Pure)