Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome

Butters, TD., Aslanidi, OV., Inada, S., Boyett, M. R., Hancox, JC., Lei, M. & Zhang, H., 9 Jul 2010, In : Circulation Research. 107, 1, p. 126 - 137

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Methadone, QTc interval prolongation and torsade de pointes: Case reports offer the best understanding of this problem

Vieweg, W. V. R., Hasnain, M., Howland, R. H., Clausen, T., Koneru, J. N., Kogut, C., Crouse, E. L. B., Hancox, J. C., Fernandez, A. & Pandurangi, A. K., Aug 2013, In : Therapeutic Advances in Psychopharmacology. 3, 4, p. 219-32 14 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Methadone and torsade de pointes: how can we better understand the association?

Hasnain, M., Vieweg, W. V. R., Breden Crouse, E. L. & Hancox, J. C., Sep 2013, In : American Journal of Medicine. 126, 9, p. 757-8 2 p.

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Modeling the Chronotropic Effect of Isoprenaline on Rabbit Sinoatrial Node

Zhang, H., Butters, T., Adeniran, I., Higham, J., Holden, A., Boyett, M. & Hancox, J. C., 2012, In : Frontiers in Physiology. 241.

Research output: Contribution to journalArticle (Academic Journal)

10 Citations (Scopus)

Moderately elevated plasma homocysteine impairs functional endothelial recovery following denudation of mouse carotid arteries

Miller, AL., Witchel, HJ., Hancox, JC., Jackson, CL. & Jeremy, JY., 2004, In : Metabolism. p. 760 - 765

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)
13 Citations (Scopus)

Modification of KCNH2-encoded cardiac potassium channels by KCNE1 polymorphism

Hancox, J. C., Du, C., El Harchi, A. & Zhang, H., 2014, In : Circulation Research. 78, 9, p. 2330

Research output: Contribution to journalArticle (Academic Journal)

Modulation by endothelin-1 of spontaneous activity and membrane currents of atrioventricular node myocytes from the rabbit heart

Choisy, S. C. M., Cheng, H., Smith, G., James, A. F. & Hancox, J. C., 29 Mar 2012, In : PLoS ONE. 7, 3, p. e33448

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Modulation by testosterone of an endogenous hERG potassium channel current

Ridley, JM., Shuba, YM., James, AF. & Hancox, JC., 2008, In : Journal of Physiology and Pharmacology. 59, p. 395 - 407

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)

Modulation of hERG potassium channels by a novel small molecule activator

Mitcheson, J. S. & Hancox, J. C., 22 Sep 2017, In : British Journal of Pharmacology. 174, 20, p. 3669-3671 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
174 Downloads (Pure)

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Melgari, D., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sep 2015, In : Journal of Molecular and Cellular Cardiology. 86, p. 42-53 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
27 Citations (Scopus)
266 Downloads (Pure)

Molecular determinants of hERG potassium channel inhibition by disopyramide

El Harchi, A., Zhang, YH., Hussein, LK., Dempsey, CE. & Hancox, JC., Jan 2012, In : Journal of Molecular and Cellular Cardiology. 52, 1, p. 185 - 195 11 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy

Gysel, M., Crystal, A., Hancox, J. C., Methot, M. & Baranchuk, A., 2014, In : Case Reports in Cardiology. 2014, p. 213842

Research output: Contribution to journalArticle (Academic Journal)

Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node

Cheng, H., Curtis, A. E., Fellingham, C. & Hancox, J. C., 10 Jun 2016, In : Physiological Reports. 4, 11, 10 p., e12819.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
265 Downloads (Pure)

Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels

Barman, P. P., Cheng, H., Hancox, J. C. & James, A. F., 1 Mar 2013, In : Biochemical and Biophysical Research Communications. 432, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Novel ion channel targets in atrial fibrillation

Hancox, J. C., James, A. F., Marrion, N. V., Zhang, H. & Thomas, D., Aug 2016, In : Expert Opinion on Therapeutic Targets. 20, 8, p. 947-958 12 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells

Inada, S., Hancox, JC., Zhang, H. & Boyett, M. R., 2009, In : Biophysical Journal. 97, p. 2117 - 2127

Research output: Contribution to journalArticle (Academic Journal)

57 Citations (Scopus)

ORM-10103: a significant advance in sodium-calcium exchanger pharmacology?

Terracciano, C. M. & Hancox, J. C., Oct 2013, In : British Journal of Pharmacology. 170, 4, p. 765-7 3 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

PALLAS: limiting indications for dronedarone treatment of atrial fibrillation?

Hancox, J. C. & Doggrell, S., 2012, In : Expert Opinion on Pharmacotherapy. 13, 6, p. 867-871

Research output: Contribution to journalReview article (Academic Journal)

1 Citation (Scopus)

Paradoxical effects of insulin on cardiac L-type calcium current and on contraction at physiological temperature

Pabbathi, VK., Suleiman, M-S. & Hancox, JC., Apr 2004, In : Diabetologia. 47 (4), p. 748 - 752 5 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Perception of validity of clinical and preclinical methods for assessment of torsades de pointes liability

Pugsley, MK., Hancox, JC. & Curtis, MJ., 2008, In : Pharmacology and Therapeutics. p. 115 - 117

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Perspective: does ranolazine have potential for the treatment of atrial fibrillation?

Hancox, JC. & Doggrell, SA., 2010, In : Expert Opinion on Investigational Drugs. 19, p. 1465 - 1474

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
26 Citations (Scopus)

Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

McPate, MJW., Duncan, RS., Hancox, JC. & Witchel, HJ., 2008, In : British Journal of Pharmacology. 155, p. 957 - 966

Research output: Contribution to journalArticle (Academic Journal)

67 Citations (Scopus)

Polyaromatic hydrocarbons in pollution: a heart-breaking matter

Marris, C. R., Kompella, S. N., Miller, M. R., Incardona, J. P., Brette, F., Hancox, J. C., Sørhus, E. & Shiels, H. A., 15 Jan 2020, In : Journal of Physiology. 598, 2, p. 227-247 21 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
3 Citations (Scopus)
97 Downloads (Pure)

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

Cheng, H., Du, C., Zhang, Y., James, A., Dempsey, C., Abdala, A. P. & Hancox, J., 1 Oct 2019, In : Journal of Molecular and Cellular Cardiology. 135, p. 22-30 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
168 Downloads (Pure)

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

Milnes, JT., Dempsey, CE., Ridley, JM., Crociani, O., Arcangeli, A., Hancox, JC. & Witchel, HJ., Jul 2003, In : FEBS Letters. 547 (1-3), p. 20 - 26 7 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)

Primary carnitine deficiency as a potential cause of short QT syndrome

Hancox, J., 27 Jul 2018, In : Cardiovascular Research and Medicine. 2, 1, p. 10-12 3 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
File
97 Downloads (Pure)

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling

Adeniran, I., El Harchi, A., Hancox, J. C. & Zhang, H., 1 Apr 2012, In : Cardiovascular Research. 94, 1, p. 66-76

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Pro-arrhythmogenic Effects of Atrial Fibrillation Induced Electrical Remodelling- Insights from 3D Virtual Human Atria

Colman, M. A., Aslanidi, O. V., Kharche, S., Boyett, M. R., Garratt, C. J., Hancox, J. C. & Zhang, H., 3 Jun 2013, In : Journal of Physiology.

Research output: Contribution to journalArticle (Academic Journal)

84 Citations (Scopus)

Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling

Karche, S., Adeniran, I., Stott, J., Law, P., Boyett, M., Hancox, J. C. & Zhang, H., 2012, In : Journal of Physiology. 590, 18, p. 4501-4514

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports

Hasnain, M., Vieweg, W. V. R., Howland, R. H., Kogut, C., Breden Crouse, E. L., Koneru, J. N., Hancox, J. C., Digby, G. C., Baranchuk, A., Deshmukh, A. & Pandurangi, A. K., Jun 2014, In : Therapeutic Advances in Psychopharmacology. 4, 3, p. 130-8 9 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Quetiapine and the need for a thorough QT/QTc study

Hasnain, M., Vieweg, W. V. R., Howland, R. H., Kogut, C., Breden Crouse, E. L., Koneru, J. N., Hancox, J. C., Digby, G. C., Baranchuk, A., Deshmukh, A. & Pandurangi, A. K., Feb 2014, In : Journal of Clinical Psychopharmacology. 34, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)
Open Access
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29 Citations (Scopus)
439 Downloads (Pure)

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

Lei, C. L., Clerx, M., Beattie, K. A., Melgari, D., Hancox, J. C., Gavaghan, D. J., Polonchuk, L., Wang, K. & Mirams, G. R., 24 Dec 2019, In : Biophysical Journal. 117, 12, p. 2455-2470 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
42 Downloads (Pure)

Rational prediction of pharmacological treatment options for a novel KCNH2-linked variant of the Short QT Syndrome

Hancox, J. & Stuart, G., Mar 2018, In : Annals of Circulation . 3, 1, p. 008-009 2 p.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
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182 Downloads (Pure)

Recent advances in understanding sex differences in cardiac repolarization

James, AF., Choisy, SCM. & Hancox, JC., Jul 2007, In : Progress in Biophysics and Molecular Biology. 94 (3), p. 265 - 319 55 p.

Research output: Contribution to journalArticle (Academic Journal)

123 Citations (Scopus)

Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure

Bond, R., Bryant, S., Watson, J., Hancox, J., Orchard, C. & James, A., Mar 2017, In : AJP - Heart and Circulatory Physiology. 312, 3, p. H384-H391 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
191 Downloads (Pure)

Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel

Hancox, JC. & James, AF., 2008, In : Molecular Pharmacology. 73, p. 1592 - 1595

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Regulation of cardiac Na+-Ca2+ exchanger activity by protein kinase phosphorylation--still a paradox?

Zhang, YH. & Hancox, JC., 2008, In : Cell Calcium. 45, p. 1 - 10

Research output: Contribution to journalArticle (Academic Journal)

Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623

Lainez Vicente, S., Doray, A., Hancox, J. & Cannell, M., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 120-130 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
330 Downloads (Pure)

Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study

Zhang, H., Kharche, S., Holden, AV. & Hancox, JC., 2008, In : Progress in Biophysics and Molecular Biology. 96, p. 112 - 132

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)

Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports

Vieweg, W. V. R., Hasnain, M., Hancox, J. C., Baranchuk, A., Digby, G. C., Kogut, C., Crouse, E. L. B., Koneru, J. N., Deshmukh, A. & Pandurangi, A. K., Aug 2013, In : Psychopharmacology. 228, 4, p. 515-24 10 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)
Open Access
File
1 Citation (Scopus)
62 Downloads (Pure)

Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias

O'Leary, ME. & Hancox, JC., 2010, In : British Journal of Clinical Pharmacology. 69, p. 427 - 442

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes

Hancock, J. M., Weatherall, K. L., Choisy, S. C., James, A. F., Hancox, J. C. & Marrion, N. V., May 2015, In : Heart Rhythm. 12, 5, p. 1003-15 13 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Selective serotonin reuptake inhibitors and torsade de pointes: new concepts and new directions derived from a systematic review of case reports

Kogut, C., Crouse, E. B., Vieweg, W. V. R., Hasnain, M., Baranchuk, A., Digby, G. C., Koneru, J. N., Fernandez, A., Deshmukh, A., Hancox, J. C. & Pandurangi, A. K., Oct 2013, In : Therapeutic Advances in Drug Safety. 4, 5, p. 189-98 10 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)
Open Access
File
41 Downloads (Pure)

Short QT interval linked to androgen misuse: wider significance and possible basis

Hancox, JC., Choisy, SCM. & James, AF., 2009, In : Annals of Noninvasive Electrocardiology. 14, p. 311 - 312

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Solifenacin linked QT interval prolongation and torsades de pointes

Bray, J. & Hancox, J., 10 Apr 2017, In : Therapeutic Advances in Drug Safety. 3 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
File
1 Citation (Scopus)
269 Downloads (Pure)