Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

Article (Academic Journal)

Modulation of hERG potassium channels by a novel small molecule activator

Mitcheson, J. S. & Hancox, J. C., 22 Sep 2017, In : British Journal of Pharmacology. 174, 20, p. 3669-3671 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
174 Downloads (Pure)

Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

Melgari, D., Zhang, Y. H., El Harchi, A., Dempsey, C. E. & Hancox, J. C., Sep 2015, In : Journal of Molecular and Cellular Cardiology. 86, p. 42-53 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
27 Citations (Scopus)
266 Downloads (Pure)

Molecular determinants of hERG potassium channel inhibition by disopyramide

El Harchi, A., Zhang, YH., Hussein, LK., Dempsey, CE. & Hancox, JC., Jan 2012, In : Journal of Molecular and Cellular Cardiology. 52, 1, p. 185 - 195 11 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Multifactorial QT Interval Prolongation and Takotsubo Cardiomyopathy

Gysel, M., Crystal, A., Hancox, J. C., Methot, M. & Baranchuk, A., 2014, In : Case Reports in Cardiology. 2014, p. 213842

Research output: Contribution to journalArticle (Academic Journal)

Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node

Cheng, H., Curtis, A. E., Fellingham, C. & Hancox, J. C., 10 Jun 2016, In : Physiological Reports. 4, 11, 10 p., e12819.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
266 Downloads (Pure)

Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels

Barman, P. P., Cheng, H., Hancox, J. C. & James, A. F., 1 Mar 2013, In : Biochemical and Biophysical Research Communications. 432, 1, p. 46-51 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Novel ion channel targets in atrial fibrillation

Hancox, J. C., James, A. F., Marrion, N. V., Zhang, H. & Thomas, D., Aug 2016, In : Expert Opinion on Therapeutic Targets. 20, 8, p. 947-958 12 p.

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

One-dimensional mathematical model of the atrioventricular node including atrio-nodal, nodal, and nodal-his cells

Inada, S., Hancox, JC., Zhang, H. & Boyett, M. R., 2009, In : Biophysical Journal. 97, p. 2117 - 2127

Research output: Contribution to journalArticle (Academic Journal)

57 Citations (Scopus)

ORM-10103: a significant advance in sodium-calcium exchanger pharmacology?

Terracciano, C. M. & Hancox, J. C., Oct 2013, In : British Journal of Pharmacology. 170, 4, p. 765-7 3 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Paradoxical effects of insulin on cardiac L-type calcium current and on contraction at physiological temperature

Pabbathi, VK., Suleiman, M-S. & Hancox, JC., Apr 2004, In : Diabetologia. 47 (4), p. 748 - 752 5 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

Perception of validity of clinical and preclinical methods for assessment of torsades de pointes liability

Pugsley, MK., Hancox, JC. & Curtis, MJ., 2008, In : Pharmacology and Therapeutics. p. 115 - 117

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Perspective: does ranolazine have potential for the treatment of atrial fibrillation?

Hancox, JC. & Doggrell, SA., 2010, In : Expert Opinion on Investigational Drugs. 19, p. 1465 - 1474

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
26 Citations (Scopus)

Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

McPate, MJW., Duncan, RS., Hancox, JC. & Witchel, HJ., 2008, In : British Journal of Pharmacology. 155, p. 957 - 966

Research output: Contribution to journalArticle (Academic Journal)

67 Citations (Scopus)

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

Cheng, H., Du, C., Zhang, Y., James, A., Dempsey, C., Abdala, A. P. & Hancox, J., 1 Oct 2019, In : Journal of Molecular and Cellular Cardiology. 135, p. 22-30 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
168 Downloads (Pure)

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

Milnes, JT., Dempsey, CE., Ridley, JM., Crociani, O., Arcangeli, A., Hancox, JC. & Witchel, HJ., Jul 2003, In : FEBS Letters. 547 (1-3), p. 20 - 26 7 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)

Proarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling

Adeniran, I., El Harchi, A., Hancox, J. C. & Zhang, H., 1 Apr 2012, In : Cardiovascular Research. 94, 1, p. 66-76

Research output: Contribution to journalArticle (Academic Journal)

40 Citations (Scopus)

Pro-arrhythmogenic Effects of Atrial Fibrillation Induced Electrical Remodelling- Insights from 3D Virtual Human Atria

Colman, M. A., Aslanidi, O. V., Kharche, S., Boyett, M. R., Garratt, C. J., Hancox, J. C. & Zhang, H., 3 Jun 2013, In : Journal of Physiology.

Research output: Contribution to journalArticle (Academic Journal)

84 Citations (Scopus)

Pro-arrhythmogenic effects of the S140G KCNQ1 mutation in human atrial fibrillation - insights from modelling

Karche, S., Adeniran, I., Stott, J., Law, P., Boyett, M., Hancox, J. C. & Zhang, H., 2012, In : Journal of Physiology. 590, 18, p. 4501-4514

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports

Hasnain, M., Vieweg, W. V. R., Howland, R. H., Kogut, C., Breden Crouse, E. L., Koneru, J. N., Hancox, J. C., Digby, G. C., Baranchuk, A., Deshmukh, A. & Pandurangi, A. K., Jun 2014, In : Therapeutic Advances in Psychopharmacology. 4, 3, p. 130-8 9 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)

Quetiapine and the need for a thorough QT/QTc study

Hasnain, M., Vieweg, W. V. R., Howland, R. H., Kogut, C., Breden Crouse, E. L., Koneru, J. N., Hancox, J. C., Digby, G. C., Baranchuk, A., Deshmukh, A. & Pandurangi, A. K., Feb 2014, In : Journal of Clinical Psychopharmacology. 34, 1, p. 3-6 4 p.

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)
Open Access
File
29 Citations (Scopus)
439 Downloads (Pure)

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

Lei, C. L., Clerx, M., Beattie, K. A., Melgari, D., Hancox, J. C., Gavaghan, D. J., Polonchuk, L., Wang, K. & Mirams, G. R., 24 Dec 2019, In : Biophysical Journal. 117, 12, p. 2455-2470 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
8 Citations (Scopus)
42 Downloads (Pure)

Recent advances in understanding sex differences in cardiac repolarization

James, AF., Choisy, SCM. & Hancox, JC., Jul 2007, In : Progress in Biophysics and Molecular Biology. 94 (3), p. 265 - 319 55 p.

Research output: Contribution to journalArticle (Academic Journal)

123 Citations (Scopus)

Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure

Bond, R., Bryant, S., Watson, J., Hancox, J., Orchard, C. & James, A., Mar 2017, In : AJP - Heart and Circulatory Physiology. 312, 3, p. H384-H391 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
7 Citations (Scopus)
191 Downloads (Pure)

Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel

Hancox, JC. & James, AF., 2008, In : Molecular Pharmacology. 73, p. 1592 - 1595

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Regulation of cardiac Na+-Ca2+ exchanger activity by protein kinase phosphorylation--still a paradox?

Zhang, YH. & Hancox, JC., 2008, In : Cell Calcium. 45, p. 1 - 10

Research output: Contribution to journalArticle (Academic Journal)

Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623

Lainez Vicente, S., Doray, A., Hancox, J. & Cannell, M., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 120-130 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
330 Downloads (Pure)

Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study

Zhang, H., Kharche, S., Holden, AV. & Hancox, JC., 2008, In : Progress in Biophysics and Molecular Biology. 96, p. 112 - 132

Research output: Contribution to journalArticle (Academic Journal)

53 Citations (Scopus)

Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports

Vieweg, W. V. R., Hasnain, M., Hancox, J. C., Baranchuk, A., Digby, G. C., Kogut, C., Crouse, E. L. B., Koneru, J. N., Deshmukh, A. & Pandurangi, A. K., Aug 2013, In : Psychopharmacology. 228, 4, p. 515-24 10 p.

Research output: Contribution to journalArticle (Academic Journal)

29 Citations (Scopus)
Open Access
File
1 Citation (Scopus)
62 Downloads (Pure)

Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias

O'Leary, ME. & Hancox, JC., 2010, In : British Journal of Clinical Pharmacology. 69, p. 427 - 442

Research output: Contribution to journalArticle (Academic Journal)

50 Citations (Scopus)

Selective activation of heteromeric SK channels contributes to action potential repolarization in mouse atrial myocytes

Hancock, J. M., Weatherall, K. L., Choisy, S. C., James, A. F., Hancox, J. C. & Marrion, N. V., May 2015, In : Heart Rhythm. 12, 5, p. 1003-15 13 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Selective serotonin reuptake inhibitors and torsade de pointes: new concepts and new directions derived from a systematic review of case reports

Kogut, C., Crouse, E. B., Vieweg, W. V. R., Hasnain, M., Baranchuk, A., Digby, G. C., Koneru, J. N., Fernandez, A., Deshmukh, A., Hancox, J. C. & Pandurangi, A. K., Oct 2013, In : Therapeutic Advances in Drug Safety. 4, 5, p. 189-98 10 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)
Open Access
File
41 Downloads (Pure)

Short QT interval linked to androgen misuse: wider significance and possible basis

Hancox, JC., Choisy, SCM. & James, AF., 2009, In : Annals of Noninvasive Electrocardiology. 14, p. 311 - 312

Research output: Contribution to journalArticle (Academic Journal)

4 Citations (Scopus)

Spontaneous frequency of rabbit atrioventricular node myocytes depends on SR function

Ridley, JM., Cheng, H., Harrison, OJ., Jones, SK., Smith, GL., Hancox, JC. & Orchard, CH., 2008, In : Cell Calcium. 44, p. 580 - 591

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Streptozotocin-induced diabetes modulates action potentials and ion channel currents from the rat atrioventricular node

Yuill, KH., Tosh, D. & Hancox, JC., 2010, In : Experimental Physiology. 95, p. 508 - 517

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)

Structural implications of hERG K+ channel block by a high affinity minimally-structured blocker

Helliwell, M. V., Zhang, Y., El Harchi, A., Du, C., Hancox, J. C. & Dempsey, C. E., 4 May 2018, In : Journal of Biological Chemistry. 293, 18, p. 7040-7057 38 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
13 Citations (Scopus)
208 Downloads (Pure)

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide

Dawidowski, M., Król, M., Szulczyk, B., Chodkowski, A., Podsadni, P., Konopelski, P., Ufnal, M., Szuberski, P., Wróbel, M. Z., Zhang, Y., El Harchi, A., Hancox, J. C., Jarkovska, D., Mistrova, E., Sviglerova, J., Štengl, M., Popowicz, G. M. & Turło, J., 1 May 2020, In : Bioorganic chemistry. 98, 14 p., 103717.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
19 Downloads (Pure)

Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration

Melgari, D., Du, C., El Harchi, A., Zhang, Y. & Hancox, J. C., 1 Oct 2014, In : Physiological Reports. 2, 10

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)
31 Downloads (Pure)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K. & 31 others, Arumugam, T. V., Attali, B., Bäck, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M., Birdsall, N. J., Blaho, V., Boison, D., Bräuner-osborne, H., Bröer, S., Bryant, C., Burnstock, G., Calo, G., Catterall, W. A., Ceruti, S., Chan, S. L., Chandy, K. G., Chazot, P., Chiang, N., Chun, J. J., Chung, J. J., Clapham, D. E., Connor, M. A., Hancox, J. C., Lolait, S. J., Mcardle, C. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, p. S1-S16 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
162 Citations (Scopus)
257 Downloads (Pure)

The hERG K(+) channel S4 domain L532P mutation: Characterization at 37°C

Zhang, YH., Colenso, CK., Sessions, RB., Dempsey, CE. & Hancox, JC., Oct 2011, In : Biochimica et Biophysica Acta (BBA) - Biomembranes. 1808 (10), p. 2477 - 2487

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

Hancox, JC., McPate, MJW., El Harchi, A. & Zhang, YH., Aug 2008, In : Pharmacology and Therapeutics. 119, 2, p. 118 - 132 15 p.

Research output: Contribution to journalArticle (Academic Journal)

188 Citations (Scopus)

The human ether-a'-go-go related gene (hERG) K+ channel blockade by the investigative selective-serotonin reuptake inhibitor CONA-437: limited dependence on S6 aromatic residues

Alexandrou, A. J., Milnes, J. T., Sun, S. Z., Fermini, B., Kim, S. C., Jenkinson, S., Leishman, D. J., Witchel, H. J., Hancox, J. C. & Leaney, J. L., Aug 2014, In : Journal of Physiology and Pharmacology. 65, 4, p. 511-523 13 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias

Curtis, M. J., Hancox, J. C., Farkas, A., Wainwright, C. L., Stables, C. L., Saint, D. A., Clements-Jewery, H., Lambiase, P. D., Billman, G. E., Janse, M. J., Pugsley, M. K., Ng, G. A., Roden, D. M., Camm, A. J. & Walker, M. J. A., 12 Apr 2013, In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle (Academic Journal)

167 Citations (Scopus)

The low-potency, voltage-dependent HERG blocker propafenone-molecular determinants and drug trapping

Witchel, HJ., Dempsey, CE., Sessions, RB., Perry, M., Milnes, JT., Hancox, JC. & Mitcheson, JS., Nov 2004, In : Molecular Pharmacology. 66 (5), p. 1201 - 1212 12 p.

Research output: Contribution to journalArticle (Academic Journal)

103 Citations (Scopus)

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

El Harchi, A., Butler, A. S., Zhang, Y., Dempsey, C. E. & Hancox, J. C., 8 Mar 2020, In : Physiological Reports. 8, 5, 14 p., e14385.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
54 Downloads (Pure)
27 Citations (Scopus)

Topical anti-angiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative-AMD

Gammons, M. V., Federov, O., Ivison, D., Du, C., Clark, T. L., Hopkins, C., Hagiwara, M., Dick, A. D., Cox, R. J., Harper, S. J., Hancox, J. C., Knapp, S. & Bates, D. O., 25 Jul 2013, In : Investigative Ophthalmology and Visual Science.

Research output: Contribution to journalArticle (Academic Journal)

33 Citations (Scopus)