Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

2008

Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs

McPate, MJW., Duncan, RS., Hancox, JC. & Witchel, HJ., 2008, In : British Journal of Pharmacology. 155, p. 957 - 966

Research output: Contribution to journalArticle (Academic Journal)

67 Citations (Scopus)

Refining insights into high-affinity drug binding to the human ether-à-go-go-related gene potassium channel

Hancox, JC. & James, AF., 2008, In : Molecular Pharmacology. 73, p. 1592 - 1595

Research output: Contribution to journalArticle (Academic Journal)

19 Citations (Scopus)

Regulation of cardiac Na+-Ca2+ exchanger activity by protein kinase phosphorylation--still a paradox?

Zhang, YH. & Hancox, JC., 2008, In : Cell Calcium. 45, p. 1 - 10

Research output: Contribution to journalArticle (Academic Journal)

Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study

Zhang, H., Kharche, S., Holden, AV. & Hancox, JC., 2008, In : Progress in Biophysics and Molecular Biology. 96, p. 112 - 132

Research output: Contribution to journalArticle (Academic Journal)

52 Citations (Scopus)

Spontaneous frequency of rabbit atrioventricular node myocytes depends on SR function

Ridley, JM., Cheng, H., Harrison, OJ., Jones, SK., Smith, GL., Hancox, JC. & Orchard, CH., 2008, In : Cell Calcium. 44, p. 580 - 591

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

Hancox, JC., McPate, MJW., El Harchi, A. & Zhang, YH., Aug 2008, In : Pharmacology and Therapeutics. 119, 2, p. 118 - 132 15 p.

Research output: Contribution to journalArticle (Academic Journal)

186 Citations (Scopus)

VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6

Hamdollah-Zadeh, AM., Glass, CA., Magnussen, AL., Hancox, JC. & Bates, DO., 2008, In : Mircrocirculation. 15, p. 605 - 614

Research output: Contribution to journalArticle (Academic Journal)

114 Citations (Scopus)
2007

Increased Susceptibility to Atrial Tachyarrhythmia in Spontaneously Hypertensive Rat Hearts

Choisy, SCM., Arberry, LA., Hancox, JC. & James, AF., Mar 2007, In : Hypertension. 49 (3), p. 498 - 505 8 p., HYP.0000257123.95372.ab.

Research output: Contribution to journalArticle (Academic Journal)

70 Citations (Scopus)

Recent advances in understanding sex differences in cardiac repolarization

James, AF., Choisy, SCM. & Hancox, JC., Jul 2007, In : Progress in Biophysics and Molecular Biology. 94 (3), p. 265 - 319 55 p.

Research output: Contribution to journalArticle (Academic Journal)

122 Citations (Scopus)
27 Citations (Scopus)
2006

A TRPC-like non-selective cation current activated by α1-adrenoceptors in rat mesenteric artery smooth muscle cells

Hill, AJ., Hinton, JM., Cheng, H., Gao, Z., Bates, DO., Hancox, JC., Langton, PD. & James, AF., Jul 2006, In : Cell Calcium. 40 (1), p. 29 - 40 12 p.

Research output: Contribution to journalArticle (Academic Journal)

46 Citations (Scopus)

Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel

Ridley, JM., Milnes, JT., Hancox, JC. & Witchel, HJ., Jan 2006, In : Journal of Molecular and Cellular Cardiology. 40 (1), p. 107 - 118 12 p.

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Disopyramide is an effective inhibitor of mutant HERG K+ channels involved in variant 1 short QT syndrome

McPate, MJW., Duncan, RS., Witchel, HJ. & Hancox, JC., Sep 2006, In : Journal of Molecular and Cellular Cardiology. 41 (3), p. 563 - 566 4 p.

Research output: Contribution to journalArticle (Academic Journal)

58 Citations (Scopus)

Erythromycin block of the HERG K,sup>+ channel: Accessability to F656 and Y652

Duncan, RS., Ridley, JM., Dempsey, CE., Leishman, DJ., Leaney, JL., Hancox, JC. & Witchel, HJ., 2006, In : Biochemical and Biophysical Research Communications. 341, p. 500 - 506 7 p.

Research output: Contribution to journalArticle (Academic Journal)

VEGF activates receptor-operated cation channels in human microvascular endothelial cells

Cheng, H., James, AF., Foster, RR., Hancox, JC. & Bates, DO., Aug 2006, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (8), p. 1768 - 1776 9 p.

Research output: Contribution to journalArticle (Academic Journal)

91 Citations (Scopus)
2004

Evidence for a novel K+ channel modulated by α1A-adrenoceptors in cardiac myocytes

Choisy, SCM., Hancox, JC., Arberry, LA., Reynolds, AM., Shattock, MJ. & James, AF., Sep 2004, In : Molecular Pharmacology. 66 (3), p. 735 - 748 14 p.

Research output: Contribution to journalArticle (Academic Journal)

14 Citations (Scopus)

Gender-related differences in ventricular myocyte repolarization in the guinea pig

James, AF., Arberry, LA. & Hancox, JC., May 2004, In : Basic Research in Cardiology. 99 (3), p. 183 - 192 10 p.

Research output: Contribution to journalArticle (Academic Journal)

41 Citations (Scopus)

Moderately elevated plasma homocysteine impairs functional endothelial recovery following denudation of mouse carotid arteries

Miller, AL., Witchel, HJ., Hancox, JC., Jackson, CL. & Jeremy, JY., 2004, In : Metabolism. p. 760 - 765

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)

Paradoxical effects of insulin on cardiac L-type calcium current and on contraction at physiological temperature

Pabbathi, VK., Suleiman, M-S. & Hancox, JC., Apr 2004, In : Diabetologia. 47 (4), p. 748 - 752 5 p.

Research output: Contribution to journalArticle (Academic Journal)

6 Citations (Scopus)

The low-potency, voltage-dependent HERG blocker propafenone-molecular determinants and drug trapping

Witchel, HJ., Dempsey, CE., Sessions, RB., Perry, M., Milnes, JT., Hancox, JC. & Mitcheson, JS., Nov 2004, In : Molecular Pharmacology. 66 (5), p. 1201 - 1212 12 p.

Research output: Contribution to journalArticle (Academic Journal)

103 Citations (Scopus)
2003

A novel, voltage-dependent nonselective cation current activated by insulin in guinea pig isolated ventricular myocytes

Zhang, YH. & Hancox, JC., Apr 2003, In : Circulation Research. 92 (7), p. 765 - 768 4 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)

Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652

Milnes, JT., Crociani, O., Arcangeli, A., Hancox, JC. & Witchel, HJ., Jul 2003, In : British Journal of Pharmacology. 139 (5), p. 887 - 898 12 p.

Research output: Contribution to journalArticle (Academic Journal)

164 Citations (Scopus)

Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine

Ridley, JM., Milnes, JT., Zhang, YH., Witchel, HJ. & Hancox, JC., Jun 2003, In : Journal of Physiology. 549 (3), p. 667 - 672 6 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Preferential closed channel blockade of HERG potassium currents by chemically synthesised BeKm-1 scorpion toxin

Milnes, JT., Dempsey, CE., Ridley, JM., Crociani, O., Arcangeli, A., Hancox, JC. & Witchel, HJ., Jul 2003, In : FEBS Letters. 547 (1-3), p. 20 - 26 7 p.

Research output: Contribution to journalArticle (Academic Journal)

62 Citations (Scopus)
2001

Anti-adrenergic effect of adenosine on Na+-Ca2+ exchange current recorded from guinea-pig ventricular myocytes

Zhang, YH., Hinde, AK. & Hancox, JC., May 2001, In : Cell Calcium. 29 (5), p. 347 - 358 12 p.

Research output: Contribution to journalArticle (Academic Journal)

25 Citations (Scopus)