Professor Jules C Hancox

DSc (Bristol), B.Sc.(Leeds), Ph.D.(St.And.)

  • BS8 1TD

20012020

Research output per year

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Research Output

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Article (Academic Journal)
2020

An update on the structure of hERG

Butler, A., Helliwell, M. V., Zhang, Y., Hancox, J. C. & Dempsey, C. E., 24 Jan 2020, In : Frontiers in Pharmacology. 10, 13 p., 1572.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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34 Downloads (Pure)
Open Access
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91 Downloads (Pure)

Inhibition of voltage-gated Na+ currents by eleclazine in rat atrial and ventricular myocytes

Caves, R. E., Carpenter, A., Choisy, S. C. M., Clennell, B., Cheng, H., McNiff, C., Mann, B., Milnes, J. T., Hancox, J. C. & James, A. F., 19 May 2020, (Accepted/In press) In : Heart Rhythm O2.

Research output: Contribution to journalArticle (Academic Journal)

Ion currents, action potentials and noradrenergic responses in rat pulmonary vein and left atrial cardiomyocytes

Bond, R. C., Choisy, S. C., Bryant, S. M., Hancox, J. C. & James, A. F., 13 May 2020, In : Physiological Reports. 8, 9, 16 p., e14432.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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13 Downloads (Pure)
Open Access
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39 Downloads (Pure)

Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide

Dawidowski, M., Król, M., Szulczyk, B., Chodkowski, A., Podsadni, P., Konopelski, P., Ufnal, M., Szuberski, P., Wróbel, M. Z., Zhang, Y., El Harchi, A., Hancox, J. C., Jarkovska, D., Mistrova, E., Sviglerova, J., Štengl, M., Popowicz, G. M. & Turło, J., 1 May 2020, In : Bioorganic chemistry. 98, 14 p., 103717.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Downloads (Pure)

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

El Harchi, A., Butler, A. S., Zhang, Y., Dempsey, C. E. & Hancox, J. C., 8 Mar 2020, In : Physiological Reports. 8, 5, 14 p., e14385.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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40 Downloads (Pure)
2019

Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome

Butler, A., Zhang, Y., Stuart, A. G., Dempsey, C. E. & Hancox, J. C., 20 Apr 2019, In : Heliyon. 5, 4, p. e01429 29 p., e01429.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
169 Downloads (Pure)

Identification of a proton sensor that regulates conductance and open time of single hERG channels

Wilson, S. L., Dempsey, C. E., Hancox, J. C. & Marrion, N. V., 27 Dec 2019, In : Scientific Reports. 9, 15 p., 19825 (2019).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
72 Downloads (Pure)

In silico Assessment of Pharmacotherapy for Human Atrial Patho-Electrophysiology Associated With hERG-Linked Short QT Syndrome

Whittaker, D. G., Hancox, J. C. & Zhang, H., 11 Jan 2019, In : Frontiers in Physiology. 9, 16 p., 1888.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
178 Downloads (Pure)

Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome

Cheng, H., Du, C., Zhang, Y., James, A., Dempsey, C., Abdala, A. P. & Hancox, J., 1 Oct 2019, In : Journal of Molecular and Cellular Cardiology. 135, p. 22-30 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
155 Downloads (Pure)

Rapid Characterization of hERG Channel Kinetics II: Temperature Dependence

Lei, C. L., Clerx, M., Beattie, K. A., Melgari, D., Hancox, J. C., Gavaghan, D. J., Polonchuk, L., Wang, K. & Mirams, G. R., 24 Dec 2019, In : Biophysical Journal. 117, 12, p. 2455-2470 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
34 Downloads (Pure)
Open Access
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1 Citation (Scopus)
54 Downloads (Pure)
2018

Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome

Butler, A., Zhang, Y., Stuart, A. G., Dempsey, C. E. & Hancox, J. C., Sep 2018, In : Physiological Reports. 6, 17, 14 p., e13845.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
205 Downloads (Pure)

A hERG mutation E1039X produced a synergistic lesion on I Ks together with KCNQ1-R174C mutation in a LQTS family with three compound mutations

Wu, J., Mizusawa, Y., Ohno, S., Ding, W. G., Higaki, T., Wang, Q., Kohjitani, H., Makiyama, T., Itoh, H., Toyoda, F., James, A. F., Hancox, J. C., Matsuura, H. & Horie, M., 15 Feb 2018, In : Scientific Reports. 8, 1, 12 p., 3129.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
239 Downloads (Pure)

A multicentre study of patients with Timothy syndrome

Walsh, M. A., Turner, C., Timothy, K. W., Seller, N., Hares, D. L., James, A. F., Hancox, J. C., Uzun, O., Boyce, D., Stuart, A. G., Brennan, P., Sarton, C., McGuire, K., Newbury-Ecob, R. A. & Mcleod, K., 1 Feb 2018, In : EP-Europace. 20, 2, p. 377-385 9 p., euw433.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
258 Downloads (Pure)
Open Access
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242 Downloads (Pure)

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

Whittaker, D. G., Colman, M. A., Ni, H., Hancox, J. C. & Zhang, H., 4 Oct 2018, In : Frontiers in Physiology. 9, 15 p., 1402.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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10 Citations (Scopus)
208 Downloads (Pure)

Investigation of hERG1b influence on hERG channel pharmacology at physiological temperature

Hancox, J., El Harchi, A., Melgari, D. & Zhang, H., 2018, In : Journal of Pharmacology and Pharmacotherapeutics. 9, 2, p. 92-103 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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202 Downloads (Pure)

Late Ca2+ Sparks and Ripples During the Systolic Ca2+ Transient in Heart Muscle Cells

Fowler, E., Kong, C., Hancox, J. & Cannell, M., 2018, In : Circulation Research. 122, p. 473-478 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
160 Downloads (Pure)

Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study

Wang, W., Zhang, S., Ni, H., Garratt, C. J., Boyett, M. R., Hancox, J. C. & Zhang, H., 30 Nov 2018, In : PLoS Computational Biology. 14, 11, 27 p., e1006594.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
220 Downloads (Pure)

Regulation of Kv4.3 and hERG potassium channels by KChIP2 isoforms and DPP6 and response to the dual K+ channel activator NS3623

Lainez Vicente, S., Doray, A., Hancox, J. & Cannell, M., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 120-130 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
311 Downloads (Pure)

Structural implications of hERG K+ channel block by a high affinity minimally-structured blocker

Helliwell, M. V., Zhang, Y., El Harchi, A., Du, C., Hancox, J. C. & Dempsey, C. E., 4 May 2018, In : Journal of Biological Chemistry. 293, 18, p. 7040-7057 38 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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13 Citations (Scopus)
199 Downloads (Pure)
2017

Atrial arrhythmogenicity of KCNJ2 mutations in short QT syndrome: Insights from virtual human atria

Whittaker, D. G., Ni, H., Harchi, A. E., Hancox, J. C. & Zhang, H., 13 Jun 2017, In : PLoS Computational Biology. 13, 6, 29 p., e1005593.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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17 Citations (Scopus)
222 Downloads (Pure)

Atrial-ventricular differences in rabbit cardiac voltage-gated Na+ currents: basis for atrial-selective block by ranolazine

Caves, R., Cheng, H., Choisy, S., Gadeberg, H., Bryant, S., Hancox, J. & James, A., 1 Nov 2017, In : Heart Rhythm. 14, 11, p. 1657-1664 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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3 Citations (Scopus)
241 Downloads (Pure)

Computational analysis of the mode of action of disopyramide and quinidine on hERG-linked short QT syndrome in human ventricles

Whittaker, D. G., Ni, H., Benson, A. P., Hancox, J. C. & Zhang, H., 4 Oct 2017, In : Frontiers in Physiology. 8, 15 p., 759.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
213 Downloads (Pure)

Development of Potent, Selective SRPK1 Inhibitors as Potential Topical Therapeutics for Neovascular Eye Disease

Batson, J., Toop, H. D., Redondo, C., Babaei-Jadidi, R., Chaikuad, A., Wearmouth, S. F., Gibbons, B., Allen, C., Tallant, C., Zhang, J., Du, C., Hancox, J. C., Hawtrey, T., Da Rocha, J., Griffith, R., Knapp, S., Bates, D. O. & Morris, J. C., 17 Mar 2017, In : ACS Chemical Biology. 12, 3, p. 825-832 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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28 Citations (Scopus)
389 Downloads (Pure)

Differential responses of rabbit ventricular and atrial transient outward current (Ito) to the Ito modulator NS5806

Cheng, H., Cannell, M. B. & Hancox, J. C., 7 Mar 2017, In : Physiological Reports. 5, 5, 16 p., e13172.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
179 Downloads (Pure)

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

Adeniran, I., Whittaker, D. G., El Harchi, A., Hancox, J. C. & Zhang, H., 16 Aug 2017, In : Scientific Reports. 7, 14 p., 8469.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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13 Citations (Scopus)
220 Downloads (Pure)

Long QT syndrome and left ventricular noncompaction in 4 family members across 2 generations with KCNQ1 mutation

Kharbanda, M., Hunter, A., Tennant, S., Curtis, S. L., Hancox, J. C. & Murday, V., 1 May 2017, In : European Journal of Medical Genetics. 60, 5, p. 233-238 6 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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4 Citations (Scopus)
245 Downloads (Pure)

Measuring kinetics and potency of hERG block for CiPA

Windley, M. J., Abi-Gerges, N., Fermini, B., Hancox, J. C., Vandenberg, J. I. & Hill, A. P., Sep 2017, In : Journal of Pharmacological and Toxicological Methods. 87, p. 99-107 9 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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22 Citations (Scopus)
248 Downloads (Pure)

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study

Bai, X., Wang, K., Yuan, Y., Li, Q., Dobrzynski, H., Boyett, M. R., Hancox, J. C. & Zhang, H., Sep 2017, In : Chaos. 27, 9, 10 p., 093934.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
218 Downloads (Pure)

Modulation of hERG potassium channels by a novel small molecule activator

Mitcheson, J. S. & Hancox, J. C., 22 Sep 2017, In : British Journal of Pharmacology. 174, 20, p. 3669-3671 3 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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169 Downloads (Pure)

Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure

Bond, R., Bryant, S., Watson, J., Hancox, J., Orchard, C. & James, A., Mar 2017, In : AJP - Heart and Circulatory Physiology. 312, 3, p. H384-H391 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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7 Citations (Scopus)
179 Downloads (Pure)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A., Abbracchio, M. P., Aldrich, R., Al-Hosaini, K. & 31 others, Arumugam, T. V., Attali, B., Bäck, M., Barnes, N. M., Bathgate, R., Beart, P. M., Becirovic, E., Bettler, B., Biel, M., Birdsall, N. J., Blaho, V., Boison, D., Bräuner-osborne, H., Bröer, S., Bryant, C., Burnstock, G., Calo, G., Catterall, W. A., Ceruti, S., Chan, S. L., Chandy, K. G., Chazot, P., Chiang, N., Chun, J. J., Chung, J. J., Clapham, D. E., Connor, M. A., Hancox, J. C., Lolait, S. J., Mcardle, C. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, p. S1-S16 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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156 Citations (Scopus)
239 Downloads (Pure)
2016

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm

Fermini, B., Hancox, J. C., Abi-Gerges, N., Bridgland-Taylor, M., Chaudhary, K. W., Colatsky, T., Correll, K., Crumb, W., Damiano, B., Erdemli, G., Gintant, G., Imredy, J., Koerner, J., Kramer, J., Levesque, P., Li, Z., Lindqvist, A., Obejero-Paz, C. A., Rampe, D., Sawada, K. & 2 others, Strauss, D. G. & Vandenberg, J. I., Jan 2016, In : Journal of Biomolecular Screening. 21, 1, p. 1-11 11 p.

Research output: Contribution to journalArticle (Academic Journal)

151 Citations (Scopus)

Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models

Varela, M., Colman, M. A., Hancox, J. C. & Aslanidi, O. V., 16 Dec 2016, In : PLoS Computational Biology. 12, 12, 22 p., e1005245.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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23 Citations (Scopus)
257 Downloads (Pure)

Characterization and influence of cardiac background sodium current in the atrioventricular node

Cheng, H., Li, J., James, A. F., Inada, S., Choisy, S. C. M., Orchard, C. H., Zhang, H., Boyett, M. R. & Hancox, J. C., Aug 2016, In : Journal of Molecular and Cellular Cardiology. 97, p. 114-124 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
270 Downloads (Pure)

Compound Heterozygous Triadin Mutation Causing Cardiac Arrest in Two Siblings

Walsh, M. A., Stuart, A. G., Schlecht, H., James, A. F., Hancox, J. C. & Newbury-Ecob, R. A., May 2016, In : Pacing and Clinical Electrophysiology. 39, 5, p. 497-501 5 p.

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century

Hill, A. P., Perry, M. D., Abi-Gerges, N., Couderc, J-P., Fermini, B., Hancox, J. C., Knollmann, B. C., Mirams, G. R., Skinner, J., Zareba, W. & Vandenberg, J. I., 1 Dec 2016, In : Journal of Physiology. 594, 23, p. 6893-6908 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
267 Downloads (Pure)

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

Zhang, Y. H., Colenso, C. K., Harchi, A. E., Cheng, H., Witchel, H. J., Dempsey, C. E. & Hancox, J. C., 1 Aug 2016, In : Biochemical Pharmacology. 113, p. 24-35 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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19 Citations (Scopus)
354 Downloads (Pure)

Multiple ion channel block by the cation channel inhibitor SKF-96365 in myocytes from the rabbit atrioventricular node

Cheng, H., Curtis, A. E., Fellingham, C. & Hancox, J. C., 10 Jun 2016, In : Physiological Reports. 4, 11, 10 p., e12819.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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2 Citations (Scopus)
262 Downloads (Pure)

Novel ion channel targets in atrial fibrillation

Hancox, J. C., James, A. F., Marrion, N. V., Zhang, H. & Thomas, D., Aug 2016, In : Expert Opinion on Therapeutic Targets. 20, 8, p. 947-958 12 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)
2015
28 Citations (Scopus)

A new algorithm to diagnose atrial ectopic origin from multi lead ECG systems--insights from 3D virtual human atria and torso

Alday, E. A. P., Colman, M. A., Langley, P., Butters, T. D., Higham, J., Workman, A. J., Hancox, J. C. & Zhang, H., Jan 2015, In : PLoS Computational Biology. 11, 1, p. e1004026

Research output: Contribution to journalArticle (Academic Journal)

17 Citations (Scopus)

Effects of candesartan, an angiotensin II receptor type I blocker, on atrial remodeling in spontaneously hypertensive rats

Choisy, S. C., Kim, S-J., Hancox, J. C., Jones, S. A. & James, A. F., 1 Jan 2015, In : Physiological Reports. 3, 1

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Effects of Persistent Atrial Fibrillation-Induced Electrical Remodeling on Atrial Electro-Mechanics - Insights from a 3D Model of the Human Atria

Adeniran, I., MacIver, D. H., Garratt, C. J., Ye, J., Hancox, J. C. & Zhang, H., 2015, In : PLoS ONE. 10, 11, p. e0142397

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange

Choisy, S. C., Cheng, H., Orchard, C. H., James, A. F. & Hancox, J. C., Nov 2015, In : Physiological Reports. 3, 11, 18 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
248 Downloads (Pure)

Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease

Avolio, E., Rodriguez-Arabaolaza, I., Spencer, H. L., Riu, F., Mangialardi, G., Slater, S. C., Rowlinson, J., Alvino, V. V., Idowu, O. O., Soyombo, S., Oikawa, A., Swim, M. M., Kong, C. H. T., Cheng, H., Jia, H., Ghorbel, M. T., Hancox, J. C., Orchard, C. H., Angelini, G., Emanueli, C. & 2 others, Caputo, M. & Madeddu, P., 2015, In : Journal of the American Heart Association. 4, 6

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

Melgari, D., Brack, K. E., Zhang, C., Zhang, Y., El Harchi, A., Mitcheson, J. S., Dempsey, C. E., Ng, G. A. & Hancox, J. C., 2015, In : Journal of the American Heart Association. 4, 4

Research output: Contribution to journalArticle (Academic Journal)

42 Citations (Scopus)
26 Downloads (Pure)