Professor Julian F R Paton

B.Sc.(Birm.), Ph.D.(Lond.)

  • BS8 1TD

19992021

Research output per year

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Personal profile

Research interests

Paton's group seeks to understand what changes within the central nervous system during the aetiology of neurogenic hypertension. Sympathetic nerve activity destined for the heart and arterioles is elevated prior to the onset of hypertension, which is suggestive of a causative role. In hypertension, cerebral vascular resistance is elevated causing brain hypoperfusion - a well known stimulant of sympathetic activity and hypertension. The microvasculature of the brainstem is also inflamed.

The hypothesis of elevated brainstem vascular resistance and inflammation as causative to hypertension is being explored in animal models and human patients. Transcriptomic analysis of brainstem genes altered in hypertension has led to exciting novel targets that are being validated with virally mediated transgenesis, stem cell transplantation, optogenetics and radio-telemetry in vivo.

The group's interest in mechanisms of central respiratory pattern generation has led to the observation that its modulation of sympathetic outflow is enhanced in hypertension. Additionally, data has shed light on plausible reasons for respiratory arrhythmias such as: sudden infant death and Rett syndromes. Data are being used to make mathematical models to assist in the further understanding of brainstem function as well as contributing to the Human Physiome project. A number of clinical translational studies driven by hypotheses gleaned from basic animal research are now underway in hypertensive patients.

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Projects

CResPace

Paton, J. F. R.

1/01/1731/12/21

Project: Research, Parent

Julian Paton CiC EBI application

Paton, J. F. R.

1/12/1631/07/17

Project: Research

Research Output

Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

Marina, N., Christie, I. N., Korsak, A., Doronin, M., Brazhe, A., Hosford, P. S., Wells, J. A., Sheikhbahaei, S., Humoud, I., Paton, J. F. R., Lythgoe, M. F., Semyanov, A., Kasparov, S. & Gourine, A. V., 9 Jan 2020, In : Nature Communications. 11, 1, 9 p., 131 (2020).

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 1 Citation (Scopus)
    50 Downloads (Pure)

    Efficacy of Electrical Baroreflex Activation Is Independent of Peripheral Chemoreceptor Modulation

    Heusser, K., Thöne, A., Lipp, A., Menne, J., Beige, J., Reuter, H., Hoffmann, F., Halbach, M., Eckert, S., Wallbach, M., Koziolek, M., Haarmann, H., Joyner, M. J., Paton, J. F. R., Diedrich, A., Haller, H., Jordan, J. & Tank, J., 1 Jan 2020, In : Hypertension (Dallas, Tex. : 1979). 75, 1, p. 257-264 8 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • Enhancing respiratory sinus arrhythmia increases cardiac output in rats with left ventricular dysfunction

    O'Callaghan, E. L., Lataro, R. M., Roloff, E. L., Chauhan, A. S., Salgado, H. C., Duncan, E., Nogaret, A. & Paton, J. F. R., 1 Feb 2020, In : Journal of Physiology. 598, 3, p. 455-471 17 p.

    Research output: Contribution to journalArticle (Academic Journal)

  • 1 Citation (Scopus)

    Thesis

    Blood pressure control during exercise in people with hypertension

    Author: Chant, B., 23 Jan 2019

    Supervisor: Paton, J. (Supervisor) & Hart, E. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Effect of Metabotropic Glutamate Receptor 5 Modulation on Blood Pressure and the Adaptive Immune System in Hypertension

    Author: Cruise, T., 23 Jan 2019

    Supervisor: Paton, J. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File

    Renal Denervation for Resistant Hypertension: Predictors of Procedural Response and Efficacy

    Author: Burchell, A., 23 Jan 2019

    Supervisor: Paton, J. (Supervisor) & Baumbach, A. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

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