Professor Julian P Hamilton-Shield

M.B.,Ch.B., M.D.(Bristol), M.R.C.P., FRCPCH

  • BS2 8AE

20002020

Research output per year

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Research Output

  • 125 Article (Academic Journal)
  • 9 Conference Contribution (Conference Proceeding)
  • 2 Letter (Academic Journal)
  • 2 Review article (Academic Journal)

Mosaic paternal uniparental isodisomy and an ABCC8 gene mutation in a patient with permanent neonatal diabetes and hemihypertrophy

Shield, JPH., 2008, In : Diabetes. 57, p. 255 - 258

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Use of accelerometers in a large field-based study of children: protocols, design issues, and effects on precision

Mattocks, CG., Ness, A., Leary, SD., Tilling, K., Blair, SN., Hamilton-Shield, J. P., Deere, KC., Saunders, JE., Kirkby, JM., Davey Smith, G., Wells, J., Wareham, N., Reilly, J. & Riddoch, CJ., 2008, In : Journal of Physical Activity and Health. Suppl 1, p. S98 - S111 3 p.

Research output: Contribution to journalArticle (Academic Journal)

254 Citations (Scopus)
2007

Clinical measures of adiposity and percentage fat loss: which measure most accurately reflects fat loss and what should we aim for?

Hunt, LP., Ford, AL., Sabin, M., Crowne, E. & Shield, JPH., 2007, In : Archives of Disease in Childhood. 92, p. 399 - 403 4 p.

Research output: Contribution to journalArticle (Academic Journal)

45 Citations (Scopus)

Depot-specific effects of fatty acids on lipid accumulation in children's adipocytes

Sabin, M., Crowne, E., Stewart, CEH., Hunt, LP., Welsh, G., Turner, SJ., Grohmann, M., Holly, JMP. & Shield, JP., Jul 2007, In : Biochemical and Biophysical Research Communications. 361 (2), p. 356 - 361 6 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Fasting nonesterified fatty acid profiles in childhood and their relationship with adiposity, insulin sensitivity, and lipid levels

Sabin, M., De Hora, M., Holly, JMP., Hunt, LP., Ford, AL., Williams, SR., Baker, J., Retallick, CJ., Crowne, EC. & Shield, JPH., Dec 2007, In : Pediatrics. 120 (6), p. 1426 - 1433 8 p.

Research output: Contribution to journalArticle (Academic Journal)

43 Citations (Scopus)

Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid

Sabin, M., Stewart, CEH., Crowne, E., Turner, SJ., Hunt, LP., Welsh, G., Grohmann, M., Holly, JMP. & Shield, JPH., Apr 2007, In : Journal of Cellular Physiology. 211 (1), p. 244 - 252 9 p.

Research output: Contribution to journalArticle (Academic Journal)

56 Citations (Scopus)

Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene

Pearson, E., Boj, SF., Steele, AM., Barrett, TG., Stals, K., Shield, JPH., Ellard, SE., Ferrer, J. & Hattersley, AT., Apr 2007, In : PLoS Medicine. 4 (4) e118, p. 0760 - 0769 10 p.

Research output: Contribution to journalArticle (Academic Journal)

264 Citations (Scopus)

Mutations in ATP-Sensitive K+ Channel Genes Cause Transient Neonatal Diabetes and Permanent Diabetes in Childhood or Adulthood

Flanagan, SE., Patch, AM., Mackay, DJ., Edghill, EL., Gloyn, AL., Robinson, D., Shield, JPH., Temple, IK., Ellard, SE. & Hattersley, AT., Jul 2007, In : Diabetes. 56 (7), p. 1930 - 1937 8 p.

Research output: Contribution to journalArticle (Academic Journal)

236 Citations (Scopus)

Overview of neonatal diabetes

Hamilton-Shield, J. P., 2007, In : Endocr Dev. 12, p. 12-23 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Rising incidence of type 2 diabetes in children in the United Kingdom

Haines, L., Chong, WK., Lynn, R., Barrett, TG. & Shield, JPH., May 2007, In : Diabetes Care. 30 (5), p. 1097 - 1101 5 p.

Research output: Contribution to journalArticle (Academic Journal)

170 Citations (Scopus)
2006

Adipogenesis and IGF-I

Holly, JMP., Sabin, M., Perks, CM. & Shield, JPH., Mar 2006, In : Metabolic Syndrome and Related Disorders. 4 (1), p. 43 - 50 8 p.

Research output: Contribution to journalArticle (Academic Journal)

24 Citations (Scopus)

A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus

Mackay, DM., Boonen, SE., Clayton-Smith, J., Goodship, J., Hahnemann, JM., Kant, SG., Njolsted, P., Robin, NH., Robinson, DO., Siebert, R., Shield, JPH., White, HE. & Temple, IK., Sep 2006, In : Human Genetics. 120 (2), p. 262 - 269 8 p.

Research output: Contribution to journalArticle (Academic Journal)

126 Citations (Scopus)

Characterisation of morbidity in a UK, hospital-based, obesity clinic

Sabin, M., Ford, AL., Holly, J. M. P., Hunt, L., Crowne, E. & Shield, JPH., 2006, In : Archives of Disease in Childhood. 91, 2, p. 126 - 130 5 p.

Research output: Contribution to journalArticle (Academic Journal)

36 Citations (Scopus)

Islet autoimmunity in children with Down's syndrome

Gillespie, KM., Dix, RJ., Williams, AJK., Newton, RW., Robinson, ZF., Bingley, PJ., Gale, EAM. & Shield, JPH., Nov 2006, In : Diabetes. 55 (11), p. 3185 - 3188 4 p.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)

Mature subcutaneous and visceral adipocyte concentrations of adiponectin are highly correlated in prepubertal children and inversely related to body mass index standard deviation score

Sabin, M. A., Holly, J. M. P., Hamilton-Shield, J. P., Turner, S. J., Grohmann, M. J., Stewart-Paton, C. E. H. & Crowne, E. C., 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 1, p. 332 - 335 4 p.

Research output: Contribution to journalArticle (Academic Journal)

22 Citations (Scopus)

Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations

Shield, JPH., 2006, In : New England Journal of Medicine. 355, p. 467 - 477

Research output: Contribution to journalArticle (Academic Journal)

679 Citations (Scopus)
2005

Bone marrow transplantation correcting beta-galactosidase activity does not influence neurological outcome in juvenile GM1-gangliosidosis

Hamilton-Shield, JP., Stone, J. & Steward, CG., 2005, In : Journal of Inherited Metabolic Disease. 28, p. 797 - 798 2 p.

Research output: Contribution to journalArticle (Academic Journal)

Isolation and validation of human prepubertal skeletal muscle cells: maturation and metabolic effects of IGF-I, IGFBP-3 and TNFalpha

Grohmann, M., Foulstone, E. J., Welsh, G., Holly, JMP., Hamilton-Shield, J. P., Crowne, E. & Stewart, CE., Oct 2005, In : Journal of Physiology. 568 , 1, p. 229 - 242 14 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)

Physical activity patterns in non-obese and obese children assessed using minute-by-minute accelerometry

Page, AS., Cooper, AR., Stamatakis, E., Foster, LJ., Crowne, EC., Sabin, MA. & Shield, JPH., Sep 2005, In : International Journal of Obesity. 29 (9), p. 1070 - 1076 7 p.

Research output: Contribution to journalArticle (Academic Journal)

110 Citations (Scopus)

Site-specific differences of insulin action in adipose tissue derived from normal prepubertal children

Grohmann, M., Stewart, CE., Welsh, G., Hunt, L. P., Tavare, J. M., Holly, JMP., Hamilton-Shield, J. P., Sabin, M. A. & Crowne, E. C., 15 Aug 2005, In : Experimental Cell Research. 308, 2, p. 469 - 478 10 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)
2004

Activating Mutations in the Gene Encoding the ATP-Sensitive Potassium-Channel Subunit Kir6.2 and Permanent Neonatal Diabetes

Gloyn, AL., Pearson, ER., Antcliff, JF., Proks, P., Bruining, GJ., Slingerland, AS., Howard, N., Srinivasan, S., Silva, JMCL., Molnes, J., Edghill, EL., Frayling, TM., Temple, IK., Mackay, D., Shield, JPH., Sumnik, Z., van Rhijn, A., Wales, JKH., Clark, P., Gorman, S. & 5 others, Aisenberg, J., Ellard, S., Njølstad, PR., Ashcroft, FM. & Hattersley, AT., 29 Apr 2004, In : New England Journal of Medicine. 350 (18), p. 1838 - 1849 12 p.

Research output: Contribution to journalArticle (Academic Journal)

Characterisation of a physiologically relevant model to investigate the differentiation of children's subcutaneous and visceral adipose tissue and the influences of TNFalpha and IGF-I

Grohmann, M., Holly, JMP., Hamilton-Shield, J. P., Crowne, E. & Stewart, CE., 2004, In : Journal of Lipid Research. 46, p. 93 - 103 10 p.

Research output: Contribution to journalArticle (Academic Journal)

β-cell dysfunction in classic transient neonatal diabetes is characterized by impaired insulin response to glucose but normal response to glucagon

Valerio, G., Franzese, A., Salerno, M., Muzzi, G., Cecere, G., Temple, KI. & Shield, JP., Oct 2004, In : Diabetes Care. 27 (10), p. 2405 - 2408 4 p.

Research output: Contribution to journalArticle (Academic Journal)

26 Citations (Scopus)
2003

Cardiovascular risk factors in obese children and their association with insulin resistance

Sabin, M. A., Crowne, EC. & Hamilton-Shield, JP., 2003, 22nd Joint Meeting of the British Endocrine Societies. Vol. 5. p. 92 - 92 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Outpatient-based Paediatric Obesity intervention clinic - simple advice and support are associated with significant redeuctions in weight in the first year

Sabin, MA., Crowne, EC. & Hamilton-Shield, J. P., 2003, 7th Spring Meeting of the Royal College of Paediatrics and Child Health. Suppl 1 ed. Vol. 88. p. 198 - 198 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Subcutaneous and visceral preadipocytes from pre-pubertal children show site-specific differences in insulin action

Grohmann, M. J., Sabin, M. A., Holly, J. M. P., Hamilton-Shield, JP., Crowne, EC. & Stewart, CEH., 2003, 22nd Joint Meeting of the British Endocrine Societies. Vol. 5. p. 95 - 95 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Transient neonatal carnitine deficiency: a potential cause of neonatal collapse or sudden death

Morris, AP., Stone, J., Stuart, G., Fleming, PJ. & Hamilton-Shield, JP., 2003, In : Archives of Disease in Childhood. 88 (1), p. 70 - 70 1 p.

Research output: Contribution to journalArticle (Academic Journal)

2002

A respiratory chain disorder presenting as developemental delay and hypoglycaemia with adrenal insufficiency

Sabin, MA., Crowne, EC., Heales, S., Hargreaves, IP., Land, J., Sharples, P. & Hamilton-Shield, JP., 2002, European Society of Paediatric Endocrinology. Vol. 58. p. 149 - 149 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

A Respiratory Chain Disorder Presenting as Developmental Delay and Hypoglycaemia with Adrenal Insufficiency

Sabin, MA., Crowne, EC., Heales, S., Hargreaves, IP., Land, J., Sharples, PM. & Hamilton-Shield, J. P., 2002, 41st Annual Meeting of the European Society for Paediatric Endocrinology. Vol. 58 (S2). p. 149 - 149 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Childhood obesity and type II diabetes

Sabin, MA., Crowne, EC. & Hamilton-Shield, J. P., 2002, In : Nursing Times. 98, p. 49 - 50 19.

Research output: Contribution to journalArticle (Academic Journal)

Mitochondrial inheritance of maternal, familial short stature with diabetes mellitus

Sabin, M. A., Crowne, E. C., Poulton, J. & Hamilton-Shield, JP., 2002, British Endocrine Society - Endocrine abstracts. Vol. 3. p. 21 - 21 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

Neonatal diabetes Mellitus, a disorder of imprinting

Temple, IK. & Hamilton-Shield, JP., 2002, In : Journal of Medical Genetics. 39, p. 872 - 875

Research output: Contribution to journalArticle (Academic Journal)

Symptomatic adrenal insufficiency presenting with hypoglycaemia in asthmatic children receiving high-dose fluticasone propionate

Drake, A., Howells, R., Hamilton-Shield, JP., Prendeville, A., Ward, P. & Crowne, E., 2002, In : BMJ. 324, p. 1081 - 1083

Research output: Contribution to journalArticle (Academic Journal)

122 Citations (Scopus)

Thyrotoxicosis related to iodine toxicity in paediatric burn patient

Robertson, P., Fraser, J., Hamilton-Shield, JP. & Weir, P., 2002, In : Intensive Care Medicine. 28, p. 1369 - 1369 1 p.

Research output: Contribution to journalArticle (Academic Journal)

3 Citations (Scopus)

Understanding neonatal diabetes

Hamilton-Shield, JP., 2002, In : Journal of Pediatrics. 141, p. 462 - 463

Research output: Contribution to journalArticle (Academic Journal)

2 Citations (Scopus)
2001

Mitochondrial inheritance of maternal, familial short stature with diabetes mellitus

Sabin, MA., Crowne, E. C., Poulton, J. & Hamilton-Shield, J. P., 2001, 21st Joint Meeting of the British Endocrine Societies. Vol. 3. p. 21 - 21 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference Contribution (Conference Proceeding)

2000

Deliberate sulphonylurea poisoning mimicking hyperinsulinaemia of infancy

Owen, L., Hamilton-Shield, J. P. & Ellis, M. E., May 2000, In : Archives of Disease in Childhood. 82, 5, p. 392-393 2 p.

Research output: Contribution to journalArticle (Academic Journal)

18 Citations (Scopus)