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Research Output

2020

Agreement was moderate between data-based and opinion-based predictions of biases affecting randomized trials within meta-analyses

Turner, R. M., Rhodes, K. M., Jones, H. E., Higgins, J. P. T., Haskins, J., Whiting, P. F., Hróbjartsson, A., Caldwell, D. M., Morris, R. W., Reeves, B. C., Worthington, H., Boutron, I. & Savović, J., 1 Sep 2020, In : Journal of Clinical Epidemiology. 125, p. 16-25 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis

Sterne, J. A. C., Murthy, S., Diaz, J., Slutsky, A. S., Villar, J., Angus, D. C., Annane, D., Azevedo, L. C. P., Berwanger, O., B Cavalcanti, A., Dequin, P-F., Du, B., Emberson, J. R., Fisher, D., Giraudeau, B., Gordon, A. C., Granholm, A., Green, C., Haynes, R., Heming, N. & 18 others, Higgins, J. P. T., Horby, P., Juni, P., Landray, M. J., Le Gouge, A., Leclerc, M., Lim, W. S., R Machado, F., McArthur, C., Meziani, F., Møller, M. H., Perner, A., Petersen, M. W., Savović, J., Tomazini, B., C Veiga, V., Webb, S. & C Marshall, J., 2 Sep 2020, In : JAMA - Journal of the American Medical Association. 12 p.

Research output: Contribution to journalArticle (Academic Journal)

CINeMA: An approach for assessing confidence in the results of a network meta-analysis

Nikolakopoulou, A., Higgins, J. P. T., Papakonstantinou, T., Chaimani, A., Del Giovane, C., Egger, M. & Salanti, G., 3 Apr 2020, In : PLoS Medicine. 17, 4, 19 p., e1003082.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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33 Downloads (Pure)

CINeMA: Software for semi-automated assessment of the Confidence In the results of Network Meta-Analysis

Papakonstantinou, T., Nikolakopoulou, A., Higgins, J. P. T., Egger, M. & Salanti, G., Mar 2020, In : Campbell Systematic Reviews. 15 p., e1080.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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40 Downloads (Pure)

Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials

WHO COVID-19 Clinical Management and Characterization Working Group, 24 Aug 2020, In : Trials. 21, 1, p. 734

Research output: Contribution to journalArticle (Academic Journal)

COVID-19 in Older People: A Rapid Clinical Review

Lithander, F. E., Neumann, S., Tenison, E., Lloyd, K., Welsh, T. J., Rodrigues, J. C. L., Higgins, J. P. T., Scourfield, L., Christensen, H., Haunton, V. J. & Henderson, E., 1 Jul 2020, In : Age and Ageing. 49, 4, p. 501–515 15 p.

Research output: Contribution to journalArticle (Academic Journal)

Data extraction methods for systematic review (semi)automation: A living review protocol

Schmidt, L., Olorisade, K., McGuinness, L. A. & Higgins, J. P. T., 25 Mar 2020, In : F1000Research. 9, 8 p., 210.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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41 Downloads (Pure)

Impact of blinding on estimated treatment effects in randomised clinical trials: meta-epidemiological study

Moustgaard, H., Clayton, G. L., Jones, H. E., Boutron, I., Jørgensen, L., Laursen, D. LT., Paludan-Müller, P-M., Ravaud, P., Olsen, M. F., Paludan-Muller, A., Ravaud, P., Savović, J., Sterne, J. A. C., Higgins, J. P. T. & Hróbjartsson, A., 21 Jan 2020, In : BMJ. l6802.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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85 Downloads (Pure)

Methodological features of clinical pharmacokinetic–pharmacodynamic studies of antibacterials and antifungals: a systematic review

Mcaleenan, A., Ambrose, P. G., Bhavnani, S. M., Drusano, G. L., Hope, W. W., Mouton, J. W., Higgins, J. P. T. & Macgowan, A. P., 21 Feb 2020, In : Journal of Antimicrobial Chemotherapy. 16 p., dkaa005.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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109 Downloads (Pure)

The impact of the COVID-19 pandemic on self-harm and suicidal behaviour: protocol for a living systematic review

John, A., Eyles, E., McGuinness, L. A., Okolie, C., Olorisade, B. K., Schmidt, L., Webb, R. T., Arensman, E., Hawton, K., Kapur, N., Moran, P., O'Connor, R. C., O’Neill, S., Gunnell, D. & Higgins, J. P. T., 25 Jun 2020, In : F1000Research. 9, 10 p., 644.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Downloads (Pure)

The median and the mode as robust meta-analysis estimators in the presence of small-study effects and outliers

Hartwig, F. P., Davey Smith, G., Schmidt, A. F., Sterne, J. A. C., Higgins, J. P. T. & Bowden, J., 8 May 2020, In : Research Synthesis Methods. 11, 3, p. 397-412 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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44 Downloads (Pure)
2019

Adjusting trial results for biases in meta-analysis: combining data-based evidence on bias with detailed trial assessment

Rhodes, KM., Savović, J., Elbers, G., Jones, H., Higgins, J., Sterne, J., Welton, N. & Turner, RM., 4 Jul 2019, In : Journal of the Royal Statistical Society: Series A. 183, 1, p. 193-209 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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114 Downloads (Pure)

Altering the availability or proximity of food, alcohol, and tobacco products to change their selection and consumption

Hollands, G. J., Carter, P., Anwer, S., King, S. E., Jebb, S. A., Ogilvie, D., Shemilt, I., Higgins, J. P. T. & Marteau, T. M., 4 Sep 2019, In : Cochrane Database of Systematic Reviews. 9, p. CD012573 96 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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19 Downloads (Pure)

Design characteristics, risk of bias, and reporting of randomised controlled trials supporting European Medicines Agency approvals of cancer drugs, 2014-2016: Cross-sectional analysis

Naci, H., Davis, C., Savović, J., Higgins, J. P. T., Sterne, J., Gyawali, B., Romo-Sandoval, X., Handley, N. & Booth, C. M., 18 Sep 2019, In : BMJ. 366, 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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21 Citations (Scopus)
118 Downloads (Pure)

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma

McAleenan, A., Jones, H. E., Kernohan, A., Faulkner, C. L., Palmer, A., Dawson, S., Wragg, C., Jefferies, S., Brandner, S., Vale, L., Higgins, J. P. T. & Kurian, K. M., 1 Aug 2019, In : Cochrane Database of Systematic Reviews. 2019, 8, p. 1-25 27 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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16 Downloads (Pure)

Directly Acting Oral Anticoagulants for the Prevention of Stroke in Atrial Fibrillation in England and Wales: Cost-Effectiveness Model and Value of Information Analysis

Thom, H., Hollingworth, W., Sofat, R., Wang, Z., Fang, W., Bodalia, P. N., Bryden, P., Davies, P., Caldwell, D., Dias, S., Eaton, D., Higgins, J., Hingorani, A. D., Lopez-Lopez, J., Okoli, G., Richards, A., Salisbury, C., Savović, J., Stephens-Boal, A., Sterne, J. & 1 others, Welton, N., 17 Aug 2019, In : MDM Policy & Practice. 4, 2, 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
154 Downloads (Pure)
Open Access
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1 Citation (Scopus)
236 Downloads (Pure)

GRADE guidelines: 18. How ROBINS-I and other tools to assess risk of bias in nonrandomized studies should be used to rate the certainty of a body of evidence

GRADE Working Group, 1 Jul 2019, In : Journal of Clinical Epidemiology. 111, p. 105-114 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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63 Citations (Scopus)
290 Downloads (Pure)

Network meta-analysis of rare events using the Mantel-Haenszel method

Efthimiou, O., Rücker, G., Schwarzer, G., Higgins, J., Egger, M. & Salanti, G., 20 Jul 2019, In : Statistics in Medicine. 38, 16, p. 2992-3012 21 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
44 Downloads (Pure)

Prognostic value of test(S) for O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide

McAleenan, A., Howell, A., Kernohan, A., Faulkner, C. L., Dawson, S., Wragg, C., Jefferies, S., Brandner, S., Vale, L., Higgins, J. P. T. & Kurian, K. M., 30 Apr 2019, In : Cochrane Database of Systematic Reviews. 2019, 4, 18 p., CD013316.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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47 Downloads (Pure)

RoB 2: a revised tool for assessing risk of bias in randomised trials

Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H-Y., Corbett, M. S., Eldridge, S. M., Emberson, J. R., Hernán, M. A., Hopewell, S., Hróbjartsson, A., Junqueira, D. R., Juni, P., Kirkham, J. J., Lasserson, T., Li, T., McAleenan, A. & 8 others, Reeves, B. C., Shepperd, S., Shrier, I., Stewart, L. A., Tilling, K., White, I. R., Whiting, P. F. & Higgins, J. P. T., 28 Aug 2019, In : BMJ. 366, 8 p., l4898.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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408 Citations (Scopus)
336 Downloads (Pure)
Open Access
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1 Citation (Scopus)
39 Downloads (Pure)

Synthesising quantitative evidence in systematic reviews of complex health interventions

Higgins, J., Lopez-Lopez, J. A., Becker, B., Davies, S., Dawson, S., Grimshaw, J. M., McGuinness, L., Moore, T., Rehfuess, E. A., Thomas, J. & Caldwell, D., 25 Jan 2019, In : BMJ Global Health. 4, 15 p., e000858.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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249 Downloads (Pure)

Systematic reviews in health research

Tanner-Smith, E. E., Egger, M. & Higgins, J., 1 Sep 2019, In : Research Synthesis Methods. 10, 3, p. 310-311 2 p.

Research output: Contribution to journalEditorial (Academic Journal)

1 Citation (Scopus)

Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for Systematic Reviews of Interventions

Cumpston, M., Li, T., Page, M. J., Chandler, J., Welch, V. A., Higgins, J. P. & Thomas, J., 3 Oct 2019, In : Cochrane Database of Systematic Reviews. 10 (2019), 2 p., ED000142.

Research output: Contribution to journalArticle (Academic Journal)

2018

A comparison of heterogeneity variance estimators in simulated random-effects meta-analyses

Langan, D., Higgins, J. P. T., Jackson, D., Bowden, J., Veroniki, A. A., Kontopantelis, E., Viechtbauer, W. & Simmonds, M., 6 Sep 2018, In : Research Synthesis Methods. 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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42 Citations (Scopus)
138 Downloads (Pure)

Allowing for informative missingness in aggregate data meta-analysis with continuous or binary outcomes: Extensions to metamiss

Chaimani, A., Mavridis, D., Higgins, J., Salanti, G. & White, I. R., 14 Sep 2018, In : Stata Journal. 18, 3, p. 716-740 25 p., st0540.

Research output: Contribution to journalArticle (Academic Journal)

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156 Downloads (Pure)

Antidepressants might work for people with major depression: where do we go from here?

Cipriani, A., Salanti, G., Furukawa, T. A., Egger, M., Leucht, S., Ruhe, H. G., Turner, E. H., Atkinson, L. Z., Chaimani, A., Higgins, J. P. T., Ogawa, Y., Takeshima, N., Hayasaka, Y., Imai, H., Shinohara, K., Tajika, A., Ioannidis, J. P. A. & Geddes, J. R., 1 Jun 2018, In : Lancet Psychiatry. 5, 6, p. 461-463 3 p.

Research output: Contribution to journalComment/debate (Academic Journal)

8 Citations (Scopus)

A re-evaluation of fixed effect(s) meta-analysis

Rice, K., Higgins, J. P. T. & Lumley, T., 1 Jan 2018, In : Journal of the Royal Statistical Society: Series A. 181, 1, p. 205-227 23 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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47 Citations (Scopus)
525 Downloads (Pure)
Open Access
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4 Citations (Scopus)
189 Downloads (Pure)

Between-trial heterogeneity in meta-analyses may be partially explained by reported design characteristics

Rhodes, K. M., Turner, R. M., Savović, J., Jones, H., Mawdsley, D. & Higgins, J., Mar 2018, In : Journal of Clinical Epidemiology. 95, p. 45-54 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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8 Citations (Scopus)
288 Downloads (Pure)

B-type natriuretic peptide-guided therapy for heart failure (HF): a systematic review and meta-analysis of individual participant data (IPD) and aggregate data

Pufulete, M., Maishman, R., Dabner, L., Higgins, J., Rogers, C., Dayer, M., Macleod, J., Purdy, S., Hollingworth, W., Schou, M., Anguita-Sanchez, M., Karlström, P., Kleiner Shochat, M., McDonagh, T., Nightingale, A. & Reeves, B., 31 Jul 2018, In : Systematic Reviews. 7, 21 p., 112.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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11 Citations (Scopus)
296 Downloads (Pure)

Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis

Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., Leucht, S., Ruhe, H. G., Turner, E. H., Higgins, J., Egger, M., Takeshima, N., Hayasaka, Y., Imai, H., Shinohara, K., Tajika, A., Ioannidis, J. PA. & Geddes, J. R., 7 Apr 2018, In : Lancet. 391, 10128, p. 1357-1366 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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602 Citations (Scopus)
564 Downloads (Pure)

Dealing with effect size multiplicity in systematic reviews and meta-analyses

Lopez-Lopez, J. A., Page, M., Lipsey, M. & Higgins, J., Sep 2018, In : Research Synthesis Methods. 9, 3, p. 336-351 16 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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9 Citations (Scopus)
258 Downloads (Pure)

Doug Altman's legacy to Cochrane and evidence synthesis

Deeks, J. J., Hopewell, S., Moher, D., Higgins, J., Moons, K. G. M., Chandler, J. & Antes, G., 14 Sep 2018, In : Cochrane Database of Systematic Reviews. 8, ED000127, ED000127.

Research output: Contribution to journalArticle (Academic Journal)

Open Access

Impact of drinking water, sanitation and handwashing with soap on childhood diarrhoeal disease: updated meta-analysis and meta-regression

Wolf, J., Hunter, P. R., Freeman, M. C., Cumming, O., Clasen, T., Bartram, J., Higgins, J. P. T., Johnston, R., Medlicott, K., Boisson, S. & Prüss-Ustün, A., 1 May 2018, In : Tropical Medicine and International Health. 23, 5, p. 508-525 18 p.

Research output: Contribution to journalReview article (Academic Journal)

Open Access
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73 Citations (Scopus)
289 Downloads (Pure)

Impact of placebo arms on outcomes in antidepressant trials: systematic review and meta-regression analysis

Salanti, G., Chaimani, A., Furukawa, T. A., Higgins, J. P. T., Ogawa, Y., Cipriani, A. & Egger, M., 1 Oct 2018, In : International Journal of Epidemiology. 47, 5, p. 1454-1464 11 p., dyy076.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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13 Citations (Scopus)
180 Downloads (Pure)

Label-invariant models for the analysis of meta-epidemiological data

Rhodes, K. M., Mawdsley, D., Turner, R. M., Jones, H. E., Savović, J. & Higgins, J. P. T., 15 Jan 2018, In : Statistics in Medicine. 37, 1, p. 60-70 11 p., 7491.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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5 Citations (Scopus)
285 Downloads (Pure)

MELODI: Mining Enriched Literature Objects to Derive Intermediates

Elsworth, B., Dawe, K., Vincent, E., Langdon, R., Lynch, B., Martin, R., Relton, C., Higgins, J. & Gaunt, T., Apr 2018, In : International Journal of Epidemiology. 47, 2, p. 369–379 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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1 Citation (Scopus)
259 Downloads (Pure)

Methods to calculate uncertainty in the estimated overall effect size from a random-effects meta-analysis

Veroniki, A. A., Jackson, D., Bender, R., Kuss, O., Langan, D., Higgins, J. P. T., Knapp, G. & Salanti, G., 21 Aug 2018, In : Research Synthesis Methods.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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19 Citations (Scopus)
121 Downloads (Pure)

Pre‐emptive versus non pre‐emptive kidney transplantation for end‐stage kidney disease

Olarte Parra, C., Van de Bruaene, C., Weynants, L., Nagler, E. V., McAleenan, A., Elbers, R. G., Higgins, J. & Goetghebeur, E., 10 Dec 2018, In : Cochrane Database of Systematic Reviews. 12, 14 p., CD013073.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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104 Downloads (Pure)

Tools for assessing risk of reporting biases in studies and syntheses of studies: A systematic review

Page, M. J., McKenzie, J. E. & Higgins, J. P. T., Mar 2018, In : BMJ Open. 8, 3, 16 p., e019703.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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35 Citations (Scopus)
248 Downloads (Pure)
2017

Accounting for heterogeneity in meta-analysis using a multiplicative model—an empirical study

Mawdsley, D., Higgins, J., Sutton, A. J. & Abrams, K., Mar 2017, In : Research Synthesis Methods. 8, 1, p. 43–52 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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6 Citations (Scopus)
256 Downloads (Pure)

Additional considerations are required when preparing a protocol for a systematic review with multiple interventions

Chaimani, A., Caldwell, D., Li, T., Higgins, J. & Salanti, G., Mar 2017, In : Journal of Clinical Epidemiology. 83, p. 65–74 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
37 Citations (Scopus)
353 Downloads (Pure)

Altering the availability or proximity of food, alcohol and tobacco products to change their selection and consumption (Protocol)

Hollands, G. J., Carter, P., Shemilt, I., Marteau, T. M., Jebb, S., Higgins, J. & Ogilvie, D., 1 Mar 2017, In : Cochrane Database of Systematic Reviews. 2017, 3, 21 p., CD012573.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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16 Citations (Scopus)
341 Downloads (Pure)

Authors' response to comments from Nachman KE et al.

O'Connor, A. M., Auvermann, B. W., Dzikamunhenga, R. S., Glanville, J. M., Higgins, J. P. T., Kirychuk, S. P., Sargeant, J. M., Totton, S. C., Wood, H. & Von Essen, S. G., 23 Oct 2017, In : Systematic Reviews. 6, 1, 210.

Research output: Contribution to journalComment/debate (Academic Journal)

Open Access
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179 Downloads (Pure)

Authors' response to letter to the editor

Borenstein, M., Higgins, J. P. T., Hedges, L. V. & Rothstein, H. R., 1 Sep 2017, In : Research Synthesis Methods. 8, 3, 1 p.

Research output: Contribution to journalLetter (Academic Journal)

Open Access
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243 Downloads (Pure)

Basics of meta-analysis: I2 is not an absolute measure of heterogeneity

Borenstein, M., Higgins, J., Hedges, L. & Rothstein, H., Mar 2017, In : Research Synthesis Methods. 8, 1, p. 5-18 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
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326 Citations (Scopus)
1036 Downloads (Pure)