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As a Research Fellow within the Neuro-Epigenetic Research Group I am interested in the regulation of signalling, epigenetic and genomic process which occur in the brain following stress. Our group is particularly interested in the function of the hippocampus under baseline conditions, and after stress, in regulating the HPA axis and facilitating adaptive responses towards stress resilience. Personally I am also very interested in understand how the extracellular matrix can influence adaptive learning processes.
In order to pursue these investigations we have developed novel advanced chromatin immunoprecipitation (ChIP) methods to understand protein-DNA interactions including sequential and tandem ChIP (Mifsud & Reul, PNAS, 2016). Other techniques used in our lab include immunohistochemistry, RNA extraction and analysis, quantitative PCR, RNAScope, western blotting, radioimmunoassays and ELISA.
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Mifsud, K. R., Kennedy, C. L. M., Salatino, S., Sharma, E., Price, E. M., Haque, S. N., Gialeli, A., Goss, H. M., Panchenko, P. E., Broxholme, J., Engledow, S., Lockstone, H., Cordero Llana, O. & Reul, J. M. H. M., 6 Aug 2021, In: Nature Communications. 12, 1, 4737.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile47 Downloads (Pure)
Haque, S., Mifsud, K. R., Price, E. & Reul, J. M. H. M., Jan 2021, Stress: Genetics, Epigenetics and Genomics. Amsterdam:Elsevier, p. 215-227
Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book
Unexpected effects of metyrapone on corticosteroid receptor interaction with the genome and subsequent gene transcription in the hippocampus of male ratsKennedy, C. LM., Carter, S. D., Mifsud, K. R. & Reul, J. M. H. M., Feb 2020, In: Journal of Neuroendocrinology. 32, 2, 12 p., e12820.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile3 Citations (Scopus)83 Downloads (Pure)