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As a Research Fellow within the Neuro-Epigenetic Research Group I am interested in the regulation of signalling, epigenetic and genomic process which occur in the brain following stress. Our group is particularly interested in the function of the hippocampus under baseline conditions, and after stress, in regulating the HPA axis and facilitating adaptive responses towards stress resilience. Personally I am also very interested in understand how the extracellular matrix can influence adaptive learning processes.
In order to pursue these investigations we have developed novel advanced chromatin immunoprecipitation (ChIP) methods to understand protein-DNA interactions including sequential and tandem ChIP (Mifsud & Reul, PNAS, 2016). Other techniques used in our lab include immunohistochemistry, RNA extraction and analysis, quantitative PCR, RNAScope, western blotting, radioimmunoassays and ELISA.
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Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brainKennedy, C. L. M., Price, E. M., Mifsud, K. R., Salatino, S., Sharma, E., Engledow, S., Broxholme, J., Goss, H. M. & Reul, J. M. H. M., 7 Mar 2023, In: Neurobiology of Stress. 23, 100532.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen Access
Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptorsMifsud, K. R., Kennedy, C. L. M., Salatino, S., Sharma, E., Price, E. M., Haque, S. N., Gialeli, A., Goss, H. M., Panchenko, P. E., Broxholme, J., Engledow, S., Lockstone, H., Cordero Llana, O. & Reul, J. M. H. M., 6 Aug 2021, In: Nature Communications. 12, 1, 4737.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile14 Citations (Scopus)101 Downloads (Pure)
Responding to Stress: Genomic and Nongenomic Actions of Corticosteroid Receptors in the BrainHaque, S., Mifsud, K. R., Price, E. & Reul, J. M. H. M., Jan 2021, Stress: Genetics, Epigenetics and Genomics. Amsterdam:Elsevier, p. 215-227
Research output: Chapter in Book/Report/Conference proceeding › Chapter in a book