Professor Karim T A Malik

Search results

• 2025

  Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse

  Edmonds, A., Balourdas, D.-I., Marsh, G. P., Felix, R., Brasher, B., Cooper, J., Graber-Feesl, C., Kollareddy, M., Malik, K., Stewart, H., Chevassut, T. J. T., Lineham, E., Morley, S., Fedorov, O., Bennett, J., Rajasekaran, M. B., Ojeda, S., Harrison, D. A., Ott, C. J. & Joerger, A. C. & 2 others, Maple, H. J. & Spencer, J., 8 May 2025, In: Journal of Medicinal Chemistry. 68, 9, p. 9638-9660 23 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • EP300 100%
  • BRD4 100%
  • Ubiquitination 40%
  • Protein Catabolism 20%
  • Ternary Complex 20%
• 2024

  Identifying targetable metabolic dependencies across colorectal cancer progression

  Legge, D. N., Collard, T. J., Stanko, E., Hoskin, A. J., Holt, A. K., Bull, C. J., Kollareddy, M., Bellamy, J., Groves, S., Ma, E. H., Hazelwood, E., Qualtrough, D., Amulic, B., Malik, K., Williams, A. C., Jones, N. & Vincent, E. E., 1 Dec 2024, In: Molecular metabolism. 90, p. 1-18 18 p., 102037.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Asparagine 100%
  • Asparagine Synthetase 60%
  • Aspartate Ammonia Ligase 50%
  • Metabolic Pathway 40%
  • Glutamine 20%
  4 Citations (Scopus)

  3 Downloads (Pure)

• Spliceosomal vulnerability of MYCN-amplified neuroblastoma is contingent on PRMT5-mediated regulation of epitranscriptomic and metabolomic pathways

  Bojko, J., Kollareddy, M., Szemes, M., Bellamy, J. S., Poon, E., Moukachar, A., Legge, D. N., Vincent, E. E., Jones, N., Malik, S., Greenhough, A., Paterson, A. R., Park, J. H., Gallacher, K., Chesler, L. & Malik, K. T. A., 1 Nov 2024, In: Cancer Letters. 604, 18 p., 217263.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  • Glutaminase 100%
  • Intron Retention 25%
  • m6A Methylation 25%
  1 Citation (Scopus)
• 2021

  The epithelial splicing regulator ESRP2 is epigenetically repressed by DNA hypermethylation in Wilms tumour and acts as a tumour suppressor

  Legge, D. N., Moriarty, W. F., Lee, D. A., Szemes, M., Zahed, A., Panousopoulos, L., Chung, W. Y., Aghabi, Y., Barratt, J., Williams, R., Pritchard-Jones, K., Malik, K. T. A., Oltean, S. & Brown, K. W., 28 Sept 2021, In: Molecular Oncology. 18 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Wilms' Tumor 100%
  • Regulator Protein 100%
  • DNA Methylation 100%
  • Tumor Suppressor Protein 100%
  • Wilms Tumor Cell Line 100%
  4 Citations (Scopus)

  142 Downloads (Pure)

• Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms' tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities

  Szemes, M., Melegh, Z. B., Bellamy, J. S., Greenhough, A., Catchpoole, D. & Malik, K. T. A., 6 Feb 2021, In: Cancers. 13, 4, p. 1-21 21 p., 656.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File
  7 Citations (Scopus)

  132 Downloads (Pure)
• 2020

  A Wnt-BMP4 Signaling Axis Induces MSX and NOTCH Proteins and Promotes Growth Suppression and Differentiation in Neuroblastoma

  Szemes, M., Bellamy, J., Melegh, Z., Greenhough, A., Kollareddy, M., Catchpoole, D. & Malik, K., 23 Mar 2020, In: Cells. 9, 3, 18 p., 783.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Growth Inhibition 100%
  • Ganglioneuroblastoma 100%
  • Bone Morphogenetic Protein 4 100%
  • Neuroblastoma 100%
  • Neoplasm 33%
  10 Citations (Scopus)

  170 Downloads (Pure)

• Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma

  Bellamy, J., Szemes, M., Melegh, Z., Dallosso, A., Kollareddy, M., Catchpoole, D. & Malik, K., 27 May 2020, In: Frontiers in Oncology. 10, 14 p., 818.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Small Molecule 100%
  • Epigenetics 100%
  • Histone Methyltransferase 100%
  • Ganglioneuroblastoma 100%
  • Tumor Suppressor Gene 50%
  16 Citations (Scopus)

  147 Downloads (Pure)

• PRMT1 promotes neuroblastoma cell survival through ATF5

  Hua, Z.-Y., Hansen, J. N., He, M., Dai, S.-K., Choi, Y., Fulton, M. D., Lloyd, S. M., Szemes, M., Sen, J., Ding, H.-F., Angelastro, J. M., Fei, X., Li, H.-P., Wu, C.-R., Yang, S.-Y., Malik, K., Bao, X., George Zheng, Y., Liu, C.-M. & Schor, N. F. & 2 others, Li, Z.-J. & Li, X.-G., 15 May 2020, In: Oncogenesis. 9, 12 p., 50.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cell Survival 100%
  • Neuroblastoma Cell 100%
  • Factor V 100%
  • PRMT1 100%
  • Activating Transcription Factor 100%
  30 Citations (Scopus)

  114 Downloads (Pure)
• 2019

  Epigenetic deregulation of GATA3 in neuroblastoma is associated with increased GATA3 protein expression and with poor outcomes

  Almutairi, B., Charlet, J., Dallosso, A. R., Szemes, M., Etchevers, H. C., Malik, K. T. A. & Brown, K. W., 12 Dec 2019, In: Scientific Reports. 9, 12 p., 18934 (2019).

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Protein Expression 100%
  • Ganglioneuroblastoma 100%
  • Transcription Factor GATA 3 100%
  • Epigenetics 100%
  • GATA3 100%
  20 Citations (Scopus)

  128 Downloads (Pure)

• Outcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction

  Drake, T. M., Lee, M. J., Sayers, A. E., Abercrombie, J., Acheson, A., Alderson, D., Anderson, I., Bradburn, M., Davies, M., Hamady, Z., Hind, D., Hollyman, M., Hare, S., Lee, E., Northover, J., Lewis, C., Marriott, P. J., Maynard, N., McFall, M. & Muragananthan, A. & 506 others, Murray, D., Singh, P., Tierney, G., Verjee, A., Walsh, C., Wild, J. R., Wilson, T., Abbott, S., Abdulaal, Y., Afshar, S., Akhtar, M., Anderson, D., Appleton, S., Bandyopadhyay, D., Bashir, G., Behar, N., Bhandari, S., Branagan, G., Boulton, R., Borg, C., Bouras, G., Boyle, J., Brewer, H., Brown, L., Briggs, C., Cartmell, M., Chan, S., Chandratreya, N., Conaghan, P., Cornish, J., Cotton, D., Coyne, P., Crozier, J., Cook, T., Cunha, P., Curtis, N., Day, A., Dayal, S., Dennis, R., Dent, P., Dowson, H., Fallaize, R., Farag, S., El Farran, M., Faulkner, G., Giordano, P., Grey, T., Halahakoon, V., Hannay, J., Harikrishnan, A., Holtham, S., Hawkin, P., Hall, C., Hancock, L., Hartley, J., Howse, F., Kallam, R., Kakaniaris, G., Kelly, S., Lockwood, S., Leinhardt, D., Levy, B., Lal, R., Lazim, T., Lund, J., Lunevicius, R., Mathur, P., Maude, K., McArthur, D., McIlroy, B., Miles, A., Moug, S., Mondragon-Pritchard, M., Messenger, D., Mullan, M., Myers, A., Muhammad, K., Mason, C., Sarveswaran, J., Shatkar, V., Singh, B., Skelly, B., Subramonia, S., Swinscoe, M., Thava, B., Thorn, C., Panagiotopoulos, S., Patel, P., Phillips, J., Peristerakis, I., Qureshi, A., Saunders, M., Shah, P., Sheel, A., Siddiqui, S., Skaife, P., Smart, N., Smith, I., Stevenson, L., Stylianides, N., Steinke, J., Stubbs, B., Thompson, R., Varcada, M., Vimalachandran, D., Virlos, I., Watfah, J., Watson, N., Walker, M., Ventham, N., West, H., Wilson, J., Wijeyekoon, S., Ah-Chuen, J., Ahmed, T., Akram, F., Aldred, E., Ali, A., Aly, M., Amajuoyi, A., Amin, V., Andreou, A., Ansari, A., Ardley, R., Arshad, F., Ashour, O., Asour, A., Ayoub, F., Azeem, H., Azhar, B., Baillie, C., Barker, J., Barkham, B., Baron, R., Barrie, J., Barry-Yarrow, E., Battersby, N., Bazoua, G., Berger, C., Bhasin, S., Biggs, S., Bisset, C., Blencowe, N., Boddy, A., Boereboom, C., Bogdan, M., Bogle, R., Bohra, P., Bolkan, H., Boyer, M., Broadhurst, J., Brown, E., Brown, J., Burns, K., Butcher, K., Capper, C., Cash, T., Chapman, J., Chapman, S., Charalabopoulos, A., Cheek, C., Chok, S., Choong, W., Chowdhury, J., Coe, P., Conn, G., Cook, N., Cooper, S., Cox, C., Crook, R., Cuffolo, G., da Silva, L., Das, B., Davenport, M., Davies, J., Davies, T., Dean, S., Demetriou, G., Dengu, F., Dent, H., Di Benedetto, G., Dindyal, S., Donnelly, E., Douka, E., Downham, C., Edent, H., Edgerton, K., El-Sharif, M., Elamin, O., Elsaid, N., Evans, J., Evans, M., Ewe, R., Ewing, A., Ferguson, H., Fisher, O., Fletcher, J., Forouzanfar, A., Foster, A., Fox, R., Francis, N., Fretwell, V., Fung, D., Gammeri, E., Garnham, J., Geraghty, A., Gilbert, A., Gill, M., Gillespie, M., Glasbey, J., Golder, A., Green, N., Groundwater, E., Grove, T., Habib, H., Haddow, J., Halkias, C., Hampson, A., Hanna, T., Harries, R., Harvey, K., Hawkins, J., Healy, R., Heartshorne, R., Heller, S., Hendra, L., Herrod, P., Heywood, N., Hicks, G., Ng, P., Hope, C., Hopley, P., Hossain, T., Hossaini, S., Hubbard, T., Humphreys, A., Ikram, H., Ioannis, M., Iqbal, M., Jatania, J., Jenkinson, P., Jokhan, S., Jones, A., Jones, C., Jones, L., Joshi, H., Joshi, K., Joy, M., Jull, P., Kane, E., Kanitkar, R., Kauser, S., Kazmi, F., Kedrzycki, M., Kendall, J., Khan, M., King, G., Kisiel, A., Kitsis, C., Kolawole, I., Kosasih, S., Kosti, A., Kotb, A., Lau, A., Lafaurie, G., Lazzaro, A., Lefroy, R., Lennon, H., Leong, K., Lim, E., Lim, J., Lindley, S., Liu, D., Lloyd, P., Locker, D., Lowe, C., Lunt, A., Lutfi, S., Luther, A., Luwemba, S., Mahankali-Rao, P., Mai, D., Majid, S., Malik, A., Manu, N., Mapara, R., Martin, C., Martin, J., Massey, L., Mathias, J., McCain, S., McCluney, S., McNair, A., Mekhail, P., Merchant, J., Merker, L., Mir, S., Mistry, P., Miu, V., Moat, M., Mohamed, E., Mohamed, I., Moore, N., Moretti, L., Morris, H., Morrison, T., Moss, J., Mountford, D., Moynihan, R., Muldoon-Smith, D., Mulholland, J., Murgitroyd, E., Murugaiyan, K., Mykoniatis, I., Nana, G., Nash, T., Nassar, A., Newton, R., Nguyen, K., Nicholas, F., Noor, M., Nowers, J., Nugent, C., Nunn, A., O'Callaghan, J., O'Hara, R., O'Neill, A., Olivier, J., Osei-Bordom, D., Osgood, L., Panchasara, B., Parks, R., Patel, H., Pawelec, K., Payne, C., Pearson, K., Perin, G., Petronio, B., Phelan, L., Pisaneschi, C., Ponchietti, L., Powell, A., Powell-Chandler, A., Pranesh, N., Proctor, V., Qureshi, N., Rahman, M., Rai, Z., Ramcharan, S., Rangarajan, K., Rashid, M., Reader, H., Rehman, A., Rehan, S., Rengifo, C., Richardson, N., Robinson, A., Robinson, D., Rossi, B., Rutherford, F., Sadien, I., Saghir, T., Sahnan, K., Salahia, G., Scott, B., Scott, K., Seager, A., Seal, S., Sezen, E., Shaban, F., Shahmohammadi, M., Shamsiddinova, A., Shankar, S., Sharpe, A., Shields, T., Shinkwin, M., Shurmer, J., Siddika, A., Simson, R., Singh, S., Sivaraj, J., Skinner, A., Smart, C., Smith, F., Smith, R., Sreedhar, A., Stewart-Parker, E., Stott, M., Symons, N., Taj, T., Tam, J., Tan, K., Tani, S., Tao, D., Thippeswamy, K., Thomas, C., Thompson, E., Thompson-Reil, C., Tongo, F., Toth, G., Turnbull, A., Turnbull, J., Wade, T., Wafi, A., Waite, K., Walker, N., Walker, T., Walsh, U., Wardle, S., Warner, R., Watt, J., Wayman, J., Weegenaar, C., West, M., Whyler, M., Whitehurst, L., Wiggans, M., Williams, G., Williams, R., Williamson, A., Williamson, J., Winter, A., Wolpert, L., Wong, J., van Boxel, G., Yeap, E., Zaman, S., Zappa, B., Zosimas, D., Anderson, O., Athem, A., Athersmith, M., Badenoch, T., Barker, S., Bellam, S., Boam, T., Boland, M., Blake, L., Brown, O., Butler, M., Byrne, B., Campbell, L., Chow, M., Da Costa, K., Cutting, J., Deputy, M., Devoto, L., Doody, P., Ekpete, N., Eljaafari, M., Exarchou, K., Faoury, M., Farinella, E., Gill, C., Goh, M., Gregoir, T., Growcott, S., Gunasekaran, S., Harris, G., Heard, R., Hobson, B., Iqbal, N., Jain, R., Kang, P., Khan, M., Korambayil, S., Kouris, S., Kshatriya, K., Kumar, S., Lee, K., Mahroof, S., Malik, K., Mann, K., Mansour, S., Martin, R., McKay, S., McKinley, N., McWhirter, D., Mellor, K., Mishra, A., Mockford, K., Morrison-Jones, V., Ng, C., Nunn, R., O'Neill, S., Oke, O., Obeid, N., Patel, R., Patel, S., Plunkett-Reed, K., Pouzi, M., Pywell, S., Richards, E., Sinclair, P., Slim, N., Spence, G., Swinkin, M., Tahir, W., Takacs, K., Tanner, N., Taylor, M., Valero, C., Venn, M., Venza, M., Yeong, T. & Fearnhead, N. S., 2019, In: European Journal of Surgical Oncology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  12 Citations (Scopus)

• Wnt Signaling Is a Major Determinant of Neuroblastoma Cell Lineages

  Szemes, M., Greenhough, A. & Malik, K., 16 Apr 2019, In: Frontiers in Molecular Neuroscience. 12, 14 p., 90.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cell Lineage 100%
  • Neuroblastoma Cell 100%
  • Neural Crest 100%
  • Wnt Signaling 100%
  • Gene Regulatory Network 75%
  21 Citations (Scopus)

  239 Downloads (Pure)
• 2018

  Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis

  Greenhough, A., Bagley, C., Heesom, K., Gurevich, D., Gay, D., Bond, M., Collard, T., Paraskeva, C., Martin, P., Sansom, O. J., Malik, K. & Williams, A., 1 Nov 2018, In: EMBO Molecular Medicine. 10, 11, 13 p., e8699.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cancer Cell 100%
  • Transcription 33%
  • Gene Signature 33%
  • Genetic Approach 33%
  • Proteomics 33%
  70 Citations (Scopus)

  453 Downloads (Pure)

• Wnt signalling drives context-dependent differentiation or proliferation in neuroblastoma

  Szemes, M., Greenhough, A., Melegh, Z., Malik, S., Yuksel, A., Catchpoole, D., Gallacher, K., Kollareddy, M., Park, J. H. & Malik, K., 1 Apr 2018, In: Neoplasia. 20, 4, p. 335-350 16 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Drive 100%
  • Ganglioneuroblastoma 100%
  • Wnt Signaling 100%
  • Wnt Signaling Pathway 100%
  • Signal Transduction 40%
  34 Citations (Scopus)

  410 Downloads (Pure)
• 2017

  Genome-wide DNA methylation analysis identifies MEGF10 as a novel epigenetically repressed candidate tumour suppressor gene in neuroblastoma

  Charlet, J., Tomari, A., Dallosso, A. R., Szemes, M., Kaselova, M., Curry, T. J., Almutairi, B., Etchevers, H., McConville, C., Malik, K. & Brown, K., 1 Apr 2017, In: Molecular Carcinogenesis. 56, 4, p. 1290–1301 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Tumor Suppressor Gene 100%
  • DNA Methylation 100%
  • Ganglioneuroblastoma 100%
  • Methylation 66%
  • Tumor Suppressor Protein 33%
  22 Citations (Scopus)

  387 Downloads (Pure)

• Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma

  Williams, M. J., Singleton, W. G. B., Lowis, S. P., Malik, K. & Kurian, K. M., 28 Mar 2017, In: Frontiers in Oncology. 7, 13 p., 45.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Ganglioglioma 100%
  • Pediatrics 100%
  • Histone Modification 100%
  • Histone Deacetylase 100%
  • Lysine 100%
  50 Citations (Scopus)

  592 Downloads (Pure)

• The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis

  Kollareddy, M., Sherrard, A., Park, J. H., Szemes, M., Gallacher, K., Melegh, Z., Oltean, S., Michaelis, M., Cinatl Jr., J., Kaidi, A. & Malik, K., 10 Sept 2017, In: Cancer Letters. 403, p. 74-85 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Vincristine 100%
  • Neuroblastoma Cell 100%
  • Ganglioneuroblastoma 100%
  • Drug Resistance 100%
  • Neuroblastoma 100%
  29 Citations (Scopus)

  646 Downloads (Pure)
• 2015

  Glycogen synthase kinase-3 controls IL-10 expression in CD4⁺ effector T-cell subsets through epigenetic modification of the IL-10 promoter

  Hill, E. V., Ng, T. H., Burton, B. R., Oakley, C. M., Malik, K. & Wraith, D. C., Apr 2015, In: European Journal of Immunology. 45, 4, p. 1103-1115 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Glycogen Synthase Kinase 3 100%
  • Epigenetic Modification 100%
  • T Cell 100%
  • Promoter Region 100%
  • CD4 100%
  53 Citations (Scopus)

  325 Downloads (Pure)

• LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

  Vieira, G. C., Sankarakuttalam, C., Melegh, Z., Greenhough, A., Malik, S., Szemes, M., Park, J. H., Kaidi, A., Zhou, L., Catchpoole, D., Morgan, R., Bates, D. O., Gabb, P. D. & Malik, K., 24 Nov 2015, In: Oncotarget. 6, 37, p. 40053-40067 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Mitogens 11%
  69 Citations (Scopus)

  307 Downloads (Pure)

• Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells

  Park, J. H., Szemes, M., Vieira, G. C. C., Melegh, Z. B., Malik, S., Heesom, K. J., Von Wallwitz-Freitas, L., Greenhough, A., Brown, K. W., Zheng, Y. G., Catchpoole, D., Deery, M. J. & Malik, K. T. A., 1 Mar 2015, In: Molecular Oncology. 9, 3, p. 617-27 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Cell Line 100%
  • Gene Amplification 100%
  • Neuroblastoma Cell 100%
  • Neuroblastoma Cell Line 100%
  • Oncoprotein 100%
  43 Citations (Scopus)

  404 Downloads (Pure)
• 2014

  MYCN is recruited to the RASSF1A promoter but is not critical for DNA hypermethylation in neuroblastoma

  Charlet, J., Szemes, M., Malik, K. T. A. & Brown, K. W., May 2014, In: Molecular Carcinogenesis. 53, 5, p. 413-420 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • DNA Methylation 100%
  • Promoter Region 100%
  • DNA Methyltransferase 60%
  • Tumor Suppressor Gene 40%
  • Immunoprecipitation 20%
  7 Citations (Scopus)
• 2013

  Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk

  Petherick, K. J., Williams, A. C., Lane, J. D., Ordóñez-Morán, P., Huelsken, J., Collard, T. J., Smartt, H. J., Batson, J., Malik, K., Paraskeva, C. & Greenhough, A., 4 Jun 2013, In: EMBO Journal. 32, 13, p. 1903 - 1916 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Catenin 100%
  • Autophagy 100%
  • Signal Transduction 7%
  • Transcription 7%
  • Homeostasis 7%
  267 Citations (Scopus)

• Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A

  Szemes, M., Dallosso, A. R., Melegh, Z. B., Curry, T. J., Li, Y., Rivers, C. A., Uney, J. B., Magdefrau, A.-S., Schwiderski, K., Park, J., Brown, K. W., Shandilya, J., Roberts, S. G. E. & Malik, K. T. A., 1 Jan 2013, In: Human Molecular Genetics. 22, 1, p. 74-83

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Epigenetics 100%
  • Wilms' Tumor 100%
  • DNA Methyltransferase 100%
  • Promoter Region 21%
  • Gene Promoter 14%
  32 Citations (Scopus)
• 2012

  Characterization of 17.94, a novel anaplastic Wilms' tumor cell line

  Brown, K. W., Charles, A., Dallosso, A., White, G., Charlet, J., Standen, G. R. & Malik, K., Jun 2012, In: Cancer Genetics. 205, 6, p. 319-26 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Wilms' Tumor 100%
  • Wilms Tumor Cell Line 100%
  • Cell Line 100%
  • Nerve Cell Adhesion Molecule 66%
  • Neural Cell Adhesion Molecule 66%
  15 Citations (Scopus)

• Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways

  Dallosso, A., Oster, B., Greenhough, A., Thorsen, K., Curry, T., Owen, C., Hancock, A., Szemes, M., Paraskeva, C., Frank, M., Andersen, C. & Malik, K., 4 Oct 2012, In: Oncogene. 31, 40, p. 4409-4419 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Carcinogenesis 100%
  • Carcinoma 100%
  • Adenoma 100%
  • Cadherin 100%
  • Methylation 100%
  69 Citations (Scopus)
• 2010

  A novel Wilms Tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway

  Kim, M., Yoon, S., Bollig, F., Kitagaki, J., Hur, W., Whye, N., Wu, Y., Rivera, M., Park, J., Kim, H., Malik, K., Bell, D., Englert, C., Perantoni, A. & Lee, S., 7 May 2010, In: Journal of Biological Chemistry. 285, 19, p. 14585 - 14593 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Signal Transduction 100%
  • Dishevelled 100%
  • Wilms' Tumor 100%
  • Catenin 75%
  • WT1 62%
  92 Citations (Scopus)
• 2009

  Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in wilms' tumor

  Dallosso, A., Hancock, A., Szemes, M., Moorwood, K., Chilukamarri, L., Tsai, H.-H., Sarkar, A., Vuononvirta, R., Jones, C., Pritchard-Jones, K., Royer-Pokora, B., Lee, S., Owen, C., Malik, S., Feng, Y., Frank, M., Ward, A., Brown, K., Malik, K. & Barasch, J., Nov 2009, In: PLoS Genetics. 5, 11, 13 p., e1000745.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Epigenetics 100%
  • Protocadherin 100%
  • Wilms' Tumor 100%
  • Gene Cluster 100%
  • Catenin 42%
  132 Citations (Scopus)
• 2008

  Frequency and timing of loss of imprinting at 11p13 and 11p15 in Wilms' tumor development

  Brown, K., Power, F., Moore, B., Charles, A. & Malik, K., Jul 2008, In: Molecular Cancer Research. 6, p. 1114 - 1123 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Wilms' Tumor 100%
  • Methylation 100%
  • WT1 80%
  • Heterozygosity 80%
  • Epigenetics 40%
  18 Citations (Scopus)
• 2007

  A CTCF-binding silencer regulates the imprinted genes AWT1 and WT1-AS and exhibits sequential epigenetic defects during Wilms' tumourigenesis

  Hancock, A., Brown, K., Moorwood, K., Moon, H., Holmgren, C., Mardikar, S., Dallosso, A., Klenova, E., Loukinov, D., Ohlsson, R., Lobanenkov, V. & Malik, K., Feb 2007, In: Human Molecular Genetics. 16 (3), p. 343 - 354 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  37 Citations (Scopus)

• Alternately spliced WT1 antisense transcripts interact with WT1 sense RNA and show epigenetic and splicing defects in cancer

  Dallosso, A., Hancock, A., Malik, S., Salpekar, A., King-Underwood, L., Pritchard-Jones, K., Peters, J., Moorwood, K., Ward, A., Malik, K. & Brown, K., Dec 2007, In: RNA. 13 (12), p. 2287 - 2299 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • RNA 100%
  • WT1 100%
  • Epigenetics 100%
  • Antisense 100%
  • Splicing Defect 100%
  71 Citations (Scopus)

• Hypomethylation and Aberrant Expression of the Glioma Pathogenesis-Related 1 Gene in Wilms Tumors

  Chilukamarri, L., Hancock, A., Malik, S., Zabkiewicz, J., Baker, J., Greenhough, A., Dallosso, A., Hui-Ming Huang, T., Royer-Pokora, B., Brown, K. & Malik, K., Nov 2007, In: Neoplasia. 9 (11), p. 970 - 978 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Epigenomics 11%
  41 Citations (Scopus)

• Identification of Novel Wilms' Tumor Suppressor Gene Target Genes Implicated in Kidney Development

  Kim, H.-S., Kim, M., Hancock, A., Harper, J., Park, J., Poy, G., Perantoni, A., Cam, M., Malik, K. & Lee, S., Jun 2007, In: Journal of Biological Chemistry. 282 (22), p. 16278 - 16287 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Wilms' Tumor 100%
  • Tumor Suppressor Gene 100%
  • Kidney Development 100%
  • Epidermal Growth Factor 100%
  • WT1 100%
  52 Citations (Scopus)
• 2006

  Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells

  H-Zadeh, A., Collard, T., Malik, K., Hicks, D., Paraskeva, C. & Williams, A., Nov 2006, In: International Journal of Oncology. 29 (5), p. 1279 - 1286 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Carcinoma Cell 100%
  • Somatomedin 100%
  • Amino Terminal Sequence 100%
  • Protein Binding 100%
  • Insulin-Like Growth Factor Binding Proteins 100%
  20 Citations (Scopus)
• 2004

  Genomic imprinting at the WT1 gene involves a novel coding transcript (AWT1) that shows deregulation in Wilms' tumours

  Dallosso, A., Hancock, A., Brown, K., Williams, A., Jackson, S. & Malik, K., Dec 2004, In: Human Molecular Genetics. 13 (4), p. 405 - 415 11 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  69 Citations (Scopus)
• 2003

  The parathyroid hormone-responsive B1 gene is interrupted by a t(1;7)(q42;p15) breakpoint associated with Wilms' tumour

  Vernon, E., Malik, K., Reynolds, P., Powlesland, R., Dallosso, A., Jackson, S., Henthorn, K., Green, E. & Brown, K., Mar 2003, In: Oncogene. 22 (9), p. 1371 - 1380 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  29 Citations (Scopus)