Projects per year
Personal profile
Research interests
As Director of the University of Bristol Proteomics Facility, I run a core research facility that provides a full range of bespoke proteomics services allowing the isolation, identification and quantitation of proteins of interest for researchers within the University of Bristol and to external academic and industrial clients.
The key services provided by the Facility are:
- Protein identification: we can identify the proteins present in anything from a single gel band up to a total cell lysate or tissue homogenate.
- Quantitative Proteomics (eg. TMT and SILAC) for the analysis of changes in protein levels between different samples or conditions.
- Phospho-Proteomics for the identification of phosphorylated proteins and the analysis of changes in phosphorylation between different samples or conditions.
- Interactome Analysis (eg. AP-MS) for the analysis of protein binding partners.
- Secretome analysis.
- Serum proteomics.
Keywords
- Proteomics
- Mass Spectrometry
- Protein Identification
- Protein Quantitation
- Protein Phosphorylation
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Projects
- 1 Finished
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Enabling advanced analytics for all users of the proteomics facility
Dowsey , A., Davidson, A. D., Heesom, K. J., Matthews, D. A. & Wuelfing, C.
1/01/18 → 8/06/21
Project: Research
Research output
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Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19
Goudswaard, L., Williams, C. M., Khalil, J. S., Burley, K. L., Hamilton, F. W., Arnold, D. T., Milne, A., Lewis, P., Heesom, K. J., Mundell, S. J., Davidson, A. D., Poole, A. W. & Hers, I., 19 Jan 2023, (Accepted/In press) In: Journal of Thrombosis and Haemostasis.Research output: Contribution to journal › Article (Academic Journal)
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Multiple interactions of the dynein-2 complex with the IFT-B complex are required for effective IFT
Hiyamizu, S., Qiu, H., Vuolo, L., Stevenson, N. L., Shak, C., Heesom, K. J., Hamada, Y., Tsurumi, Y., Chiba, S., Katoh, Y., Stephens, D. J. & Nakayama, K., 12 Jan 2023, (E-pub ahead of print) In: Journal of Cell Science.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Chemical degradation of BTK/TEC as a novel approach to inhibit platelet function
Trory, J. S., Munkacsi, A., Sledz, K., Goudswaard, L., Jackson, M. L., Heesom, K. J., Moore, S. F., Poole, A. W., Nabet, B., Aggarwal, V. K. & Hers, I., 7 Nov 2022, (E-pub ahead of print) In: Blood Advances.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access
Datasets
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A general role for MIA3/TANGO1 in secretory pathway organization and function
Stephens, D. J. (Creator), McCaughey, J. (Contributor), Mantell, J. M. (Contributor), Neal, C. (Contributor) & Heesom, K. J. (Contributor), University of Bristol, 20 Jul 2021
DOI: 10.5523/bris.xbao2ekjv5c124o2k0frhq7v6, http://data.bris.ac.uk/data/dataset/xbao2ekjv5c124o2k0frhq7v6
Dataset