Projects per year
As Director of the University of Bristol Proteomics Facility, I run a core research facility that provides a full range of bespoke proteomics services allowing the isolation, identification and quantitation of proteins of interest for researchers within the University of Bristol and to external academic and industrial clients.
The key services provided by the Facility are:
- Protein identification: we can identify the proteins present in anything from a single gel band up to a total cell lysate or tissue homogenate.
- Quantitative Proteomics (eg. TMT and SILAC) for the analysis of changes in protein levels between different samples or conditions.
- Phospho-Proteomics for the identification of phosphorylated proteins and the analysis of changes in phosphorylation between different samples or conditions.
- Interactome Analysis (eg. AP-MS) for the analysis of protein binding partners.
- Secretome analysis.
- Serum proteomics.
A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancerNounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., Albanes, D., Baron, J. A., Hopper, J. L., Figueiredo, J. C., Newcomb, P. A., Lindor, N. M., Casey, G., Platz, E. A., Le Marchand, L., Ulrich, C. M., Li, C. I., van Duijnhoven, F. J. B., Gsur, A., Campbell, P. & 42 others, , 14 Dec 2020, In : Cancer Epidemiology, Biomarkers and Prevention.
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Lay, A. C., Barrington, A. F., Hurcombe, J. A., Ramnath, R. D., Graham, M., Lewis, P. A., Wilson, M. C., Heesom, K. J., Butler, M. J., Perrett, R. M., Neal, C. R., Herbert, E., Mountjoy, E., Atan, D., Nair, V., Ju, W., Nelson, R. G., Kretzler, M., Satchell, S. C., McArdle, C. A. & 2 others, , 19 Jun 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15862-15873 12 p., 202004651.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile25 Downloads (Pure)
Duggan, S., Laabei, M., Alnahari, A., O'Brien, E. T., Lacey, K., Bacon, L., Heesom, K. J., Fu, C-L., Otto, M., Skaar, E., McLoughlin, R. M. & Massey, R. C., 19 Aug 2020, In : Infection and Immunity. 20 p., e00162-20.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile26 Downloads (Pure)