Projects per year
Personal profile
Research interests
As Director of the University of Bristol Proteomics Facility, I run a core research facility that provides a full range of bespoke proteomics services allowing the isolation, identification and quantitation of proteins of interest for researchers within the University of Bristol and to external academic and industrial clients.
The key services provided by the Facility are:
- Protein identification: we can identify the proteins present in anything from a single gel band up to a total cell lysate or tissue homogenate.
- Quantitative Proteomics (eg. TMT and SILAC) for the analysis of changes in protein levels between different samples or conditions.
- Phospho-Proteomics for the identification of phosphorylated proteins and the analysis of changes in phosphorylation between different samples or conditions.
- Interactome Analysis (eg. AP-MS) for the analysis of protein binding partners.
- Secretome analysis.
- Serum proteomics.
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Projects
- 1 Active
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Enabling advanced analytics for all users of the proteomics facility
Dowsey , A., Davidson, A. D., Heesom, K. J., Matthews, D. A. & Wuelfing, C.
1/01/18 → 8/06/21
Project: Research
Research Output
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A combined proteomics and Mendelian randomization approach to investigate the effects of aspirin-targeted proteins on colorectal cancer
Nounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., Albanes, D., Baron, J. A., Hopper, J. L., Figueiredo, J. C., Newcomb, P. A., Lindor, N. M., Casey, G., Platz, E. A., Le Marchand, L., Ulrich, C. M., Li, C. I., van Duijnhoven, F. J. B., Gsur, A., Campbell, P. & 42 others, , 14 Dec 2020, In : Cancer Epidemiology, Biomarkers and Prevention.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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A role for NPY-NPY2R signaling in albuminuric kidney disease
Lay, A. C., Barrington, A. F., Hurcombe, J. A., Ramnath, R. D., Graham, M., Lewis, P. A., Wilson, M. C., Heesom, K. J., Butler, M. J., Perrett, R. M., Neal, C. R., Herbert, E., Mountjoy, E., Atan, D., Nair, V., Ju, W., Nelson, R. G., Kretzler, M., Satchell, S. C., McArdle, C. A. & 2 others, , 19 Jun 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 27, p. 15862-15873 12 p., 202004651.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile -
A small membrane stabilising protein critical to the pathogenicity of Staphylococcus aureus
Duggan, S., Laabei, M., Alnahari, A., O'Brien, E. T., Lacey, K., Bacon, L., Heesom, K. J., Fu, C-L., Otto, M., Skaar, E., McLoughlin, R. M. & Massey, R. C., 19 Aug 2020, In : Infection and Immunity. 20 p., e00162-20.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile