Dr Kate M J de Mattos-Shipley

PhD(Bristol), BSc(Bristol)

  • BS8 1TQ

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Personal profile

Research interests

  • The detailed elucidation of fungal biosynthetic pathways, uncovering novel genes and their encoded chemistries.
  • The generation of novelty via biotransformations or pathway engineering.
  • Understanding fungal megasynthetases; in particular non-ribosomal peptide synthetases (NRPS), and how the megasynthetases and tailoring enzyme activities cooperate to generate diversity.
  • The application of comparative bioinformatics to fungal natural product research.
  • The development of molecular tools, such as heterologous expression systems, to aid both basic research and the various potential applications of fungal secondary metabolites.
  • The regulation of natural product biosynthesis, particularly as part of wider cellular stress responses. What this means for our understanding of fungal ecology and how it can be exploited.

Structured keywords and research groupings

  • BrisSynBio

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