Professor Kathleen M Gillespie

Search results

• 2022

  Activated but functionally impaired memory Tregs are expanded in slow progressors to type 1 diabetes

  Boldison, J., Long, A. E., Aitken, R. J., Wilson, I. V., Hanna, S., Wong, F. S. & Gillespie, K. M., Feb 2022, In: Diabetologia. 65, 2, p. 343-355 13 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Type 1 Diabetes Mellitus 100%
  • Glucocorticoid-Induced TNFR-Related Protein 88%
  • Memory 81%
  • T-Lymphocytes 69%
  • Cluster Analysis 40%
  11 Downloads (Pure)
• 2021

  Adult-Onset Type 1 Diabetes: Current Understanding and Challenges

  Leslie, R. D., Evans-Molina, C., Freund-Brown, J., Buzzetti, R., Dabelea, D., Gillespie, K. M., Goland, R., Jones, A. G., Kacher, M., Phillips, L. S., Rolandsson, O., Wardian, J. L. & Dunne, J. L., Nov 2021, In: Diabetes Care. 44, 11, p. 2449-2456 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Type 1 Diabetes Mellitus 100%
  • Autoantibodies 51%
  • C-Peptide 42%
  • Comorbidity 29%
  • Immunogenetics 24%
  3 Citations (Scopus)

• Four decades of the Bart's Oxford study: Improved tests to predict type 1 diabetes

  Gillespie, K. M., Fareed, R. & Mortimer, G. L., 1 Dec 2021, In: Diabetic Medicine. 38, 12, 7 p., e14717.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Type 1 Diabetes Mellitus 100%
  • HLA Antigens 28%
  • Autoantibodies 25%
  • Zinc Transporter 8 24%
  • Class 8 Receptor-Like Protein Tyrosine Phosphatases 23%
  1 Citation (Scopus)

• The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147-receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease

  Avolio, E., Carrabba, M., Milligan, R., Kavanagh Williamson, M., Beltrami, A. P., Gupta, K., Elvers, K. T., Gamez, M., Foster, R. R., Gillespie, K. M., Hamilton, F. W., Arnold, D. T., Berger, I., Davidson, A. D., Hill, D. J., Caputo, M. & Madeddu, P. R., 22 Nov 2021, In: Clinical Science. 135, 24, p. 2667-2689 23 p., CS20210735.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Coronavirus Spike Glycoproteins 100%
  • Severe Acute Respiratory Syndrome 76%
  • Coronavirus 74%
  • Pericytes 72%
  • angiotensin converting enzyme 2 29%
  4 Citations (Scopus)

  1695 Downloads (Pure)

• Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2

  Goenka, A., Halliday, A., Gregorova, M., Milodowski, E. J., Thomas, A., Kavanagh Williamson, M., Baum, H. E., Oliver, E. H., Long, A. E., Knezevic, L., Gupta, K., Di Bartolo, N. D., Berger, I., Toye, A. M., Bernatoniene, J., Bailey, M., Gillespie, K. M., Davidson, A. D., Wooldridge, L., Rivino, L. & 1 others, Finn, A. H. R., 20 Jul 2021, In: Cell Reports Medicine. 2, 7, 13 p., 100327.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Antibody Formation 60%
  • Parents 12%
  • anti-IgA 11%
  • anti-IgG 9%
  5 Citations (Scopus)

  32 Downloads (Pure)
• 2020

  Islet autoantibody profiles associated with higher diabetes risk in Lithuanian compared with English schoolchildren

  Long, A. E., Caygill, C., Gillespie, K. M., Marčiulionytė, D. & Williams, A. J. K., 26 Sep 2020, (E-pub ahead of print) In: Clinical and Experimental Immunology. 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Autoantibodies 100%
  • England 21%
  • Autoimmunity 21%
  • Lithuania 20%
  • Protein Tyrosine Phosphatases 17%
  31 Downloads (Pure)

• Maternal micro-chimeric cells in the multiple sclerosis brain

  Snethen, H., Ye, J., Gillespie, K. M. & Scolding, N. J., May 2020, In: Multiple Sclerosis and Related Disorders. 40, 101925.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Multiple Sclerosis 100%
  • Mothers 72%
  • Brain 55%
  • Autoimmune Diseases 19%
  • Y Chromosome 13%

• Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype.

  Long, A. E., Gillespie, K. M., Williams, A. J. K. & Megson, C., 10 Mar 2020, In: Diabetologia. 63, p. 1174–1185 12 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • CD8 Antigens 100%
  • Autoantibodies 67%
  • Type 1 Diabetes Mellitus 64%
  • B-Lymphocytes 55%
  • T-Lymphocytes 44%
  7 Citations (Scopus)

  28 Downloads (Pure)
• 2019

  Gut microbiome analysis by post: Evaluation of the optimal method to collect stool samples from infants within a national cohort study

  Williams, G. M., Leary, S. D., Ajami, N. J., Chipper Keating, S., Petrosin, J. F., Hamilton-Shield, J. P. & Gillespie, K. M., 12 Jun 2019, In: PLoS ONE. 14, 6, 11 p., e0216557.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • cohort studies 100%
  • Gastrointestinal Microbiome 72%
  • microbiome 70%
  • Sampling 60%
  • digestive system 59%
  5 Citations (Scopus)

  164 Downloads (Pure)

• Maternal microchimerism in cord blood and risk of childhood-onset type 1 diabetes

  Tapia, G., Mortimer, G., Ye, J., Gillard, B. T., Chipper-Keating, S., Mårild, K., Viken, M. K., Lie, B. A., Joner, G., Skrivarhaug, T., Njølstad, P. R., Stordal, K., Gillespie, K. & Stene, L. C., 1 Aug 2019, In: Pediatric Diabetes. 20, p. 728-735 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Chimerism 100%
  • Fetal Blood 78%
  • Type 1 Diabetes Mellitus 71%
  • Mothers 50%
  • HLA Antigens 13%
  2 Citations (Scopus)

  27 Downloads (Pure)

• Trisomy 21 is a Cause of Permanent Neonatal Diabetes that is Autoimmune but not HLA Associated

  Johnson, M. B., De Franco, E., Greeley, S. A. W., Letourneau, L. R., Gillespie, K. M., Wakeling, M. N., Ellard, S., Flanagan, S. E., Patel, K. A. & Hattersley, A. T., 1 Jul 2019, In: Diabetes. 68, 7, p. 1525-1535 11 p., db190045.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Down Syndrome 100%
  • Type 1 Diabetes Mellitus 85%
  • Autoantibodies 8%
  • Cell Biology 8%
  • Mutation 5%
  14 Citations (Scopus)

  199 Downloads (Pure)
• 2018

  A novel LIPS assay for insulin autoantibodies

  Liberati, D., Wyatt, R. C., Brigatti, C., Marzinotto, I., Ferrari, M., Bazzigaluppi, E., Bosi, E., Gillard, B. T., Gillespie, K. M., Gorus, F., Weets, I., Balti, E., Piemonti, L., Achenbach, P., Williams, A. J. K. & Lampasona, V., 1 Mar 2018, In: Acta Diabetologica. 55, p. 263-270 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Luciferases 100%
  • Autoantibodies 98%
  • Insulin 72%
  • Type 1 Diabetes Mellitus 43%
  • Proinsulin 26%
  15 Citations (Scopus)

  406 Downloads (Pure)

• A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study

  Kozhakhmetova, A., Wyatt, R. C., Caygill, C., Williams, C. L., Long, A. E., Chandler, K., Aitken, R. J., Wenzlau, J. M., Davidson, H. W., Gillespie, K. M. & Williams, A. J. K., 1 Jun 2018, In: Clinical and Experimental Immunology. 192, 3, p. 251-258 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Iodide Peroxidase 100%
  • Autoimmunity 91%
  • Autoantibodies 86%
  • Type 1 Diabetes Mellitus 83%
  • Celiac Disease 69%
  21 Citations (Scopus)

  243 Downloads (Pure)

• Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study

  Long, A. E., Wilson, I. V., Becker, D. J., Libman, I. M., Arena, V. C., Wong, F. S., Steck, A. K., Rewers, M. J., Yu, L., Achenbach, P., Casas, R., Ludvigsson, J., Williams, A. J. K. & Gillespie, K. M., 12 Mar 2018, (E-pub ahead of print) In: Diabetologia. 61, 6, p. 1484-1490 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Autoantibodies 100%
  • Cohort Studies 73%
  • Sweden 42%
  • Autoimmunity 42%
  • HLA-DQ6 antigen 41%
  20 Citations (Scopus)

  247 Downloads (Pure)

• Identification of loci where DNA methylation potentially mediates genetic risk of type 1 diabetes

  Ye, J., Richardson, T. G., McArdle, W. L., Relton, C. L., Gillespie, K. M., Suderman, M. & Hemani, G., 1 Sep 2018, In: Journal of Autoimmunity. 93, p. 66-75 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • DNA Methylation 100%
  • Type 1 Diabetes Mellitus 90%
  • Single Nucleotide Polymorphism 36%
  • Cytosine 34%
  • Guanine 34%
  13 Citations (Scopus)

  283 Downloads (Pure)

• Plasma immunological markers in pregnancy and cord blood: a possible link between macrophage chemo-attractants and risk of childhood type 1 diabetes

  Vistnes, M., Tapia, G., Mårild, K., Midttun, Ø., Ueland, P. M., Viken, M. K., Magnus, P., Berg, J. P., Gillespie, K. M., Skrivarhaug, T., Njølstad, P. R., Joner, G., Størdal, K. & Stene, L. C., 1 Mar 2018, In: American Journal of Reproductive Immunology. 79, 3, 11 p., e12802.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Fetal Blood 100%
  • Type 1 Diabetes Mellitus 90%
  • Macrophages 71%
  • Pregnancy 61%
  • Interleukins 37%
  4 Citations (Scopus)

  318 Downloads (Pure)

• The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes

  Wyatt, R., Brigatti, C., Liberati, D., Grace, S., Gillard, B., Long, A., Marzinotto, I., Shoemark, D., Chandler, K., Achenbach, P., Gillespie, K., Piemonti, L., Lampasona, V. & Williams, A., 1 Jul 2018, In: Diabetic Medicine. 35, 7, p. 954-963 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Glutamate Decarboxylase 100%
  • Autoantibodies 74%
  • Type 1 Diabetes Mellitus 72%
  • Epitopes 69%
  • Amino Acids 56%
  4 Citations (Scopus)

  278 Downloads (Pure)

• What factors influence recruitment to a birth cohort of infants with Down's syndrome?

  Williams, G. M., Neville, P., Gillespie, K. M., Leary, S. D., Hamilton-Shield, J. P. & Searle, A. J., 1 Aug 2018, In: Archives of Disease in Childhood. 103, 8, p. 763-766 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Down Syndrome 100%
  • Parturition 66%
  • Parents 43%
  • Interviews 38%
  • Communication 28%
  3 Citations (Scopus)

  244 Downloads (Pure)
• 2017

  Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes

  Willcox, A., Richardson, S. J., Walker, L. S. K., Kent, S. C., Morgan, N. G. & Gillespie, K., Jul 2017, In: Diabetologia. 60, 7, p. 1294-1303 10 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Germinal Center 100%
  • Type 1 Diabetes Mellitus 75%
  • Lymph Nodes 60%
  • Follicular Dendritic Cells 40%
  • B-Lymphocytes 14%
  9 Citations (Scopus)

  350 Downloads (Pure)
• 2016

  Beta cell function and ongoing autoimmunity in long-standing, childhood onset type 1 diabetes.

  Williams, G., Long, A., Wilson, I., Aitken, R., Wyatt, R., McDonald, T. J., Wong, S., Hattersley, A. T., Williams, A., Bingley, P. & Gillespie, K., Dec 2016, In: Diabetologia. 59, 12, p. 2722-2726 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Autoimmunity 100%
  • C-Peptide 98%
  • Autoantibodies 78%
  • Type 1 Diabetes Mellitus 45%
  • Creatinine 40%
  24 Citations (Scopus)

  259 Downloads (Pure)
• 2015

  Attenuated humoral responses in HLA-A*24-positive individuals at risk of type 1 diabetes

  Ye, J., Long, A. E., Pearson, J. A., Taylor, H., Bingley, P. J., Williams, A. J. K. & Gillespie, K. M., Oct 2015, In: Diabetologia. 58, 10, p. 2284-7 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • HLA-A Antigens 100%
  • Type 1 Diabetes Mellitus 72%
  • Zinc Transporter 8 53%
  • Antigens 19%
  • Autoantibodies 18%
  5 Citations (Scopus)

• Fluorescence In Situ Hybridization with Concomitant Immunofluorescence in Human Pancreas

  Ye, J. & Gillespie, K. M., 13 Dec 2015, In: Methods in Molecular Biology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Fluorescence In Situ Hybridization 100%
  • Fluorescent Antibody Technique 84%
  • Pancreas 84%
  • Chimerism 41%
  • Constitution and Bylaws 40%
  2 Citations (Scopus)

• Laser capture and single cell genotyping from frozen tissue sections

  Kroneis, T., Ye, J. & Gillespie, K., 13 Dec 2015, In: Methods in Molecular Biology. 1433, p. 159-167 9 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Frozen Sections 100%
  • Lasers 73%
  • Microdissection 29%
  • Pancreas 29%
  • Amelogenin 16%
  1 Citation (Scopus)

• Reactivity to N-terminally truncated GAD65(96-585) identifies GAD autoantibodies that are more closely associated with diabetes progression in relatives of patients with type 1 diabetes: Autoantibodies to N-terminally truncated GAD discriminate diabetes risk

  Williams, A., Lampasona, V., Wyatt, R., Brigatti, C., Gillespie, K., Bingley, P. & Achenbach, P., Sep 2015, In: Diabetes. 64, 9, p. 3247-3252 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  File

  • GAD65 (96-585) 100%
  • Glutamate Decarboxylase 53%
  • Autoantibodies 40%
  • Type 1 Diabetes Mellitus 38%
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) 11%
  21 Citations (Scopus)

  212 Downloads (Pure)

• Type 1 Diabetes High-Risk HLA Class II Determination by Polymerase Chain Reaction Sequence-Specific Primers

  Aitken, R. J., Mortimer, G. L. & Gillespie, K. M., 13 Dec 2015, In: Methods in Molecular Biology.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Type 1 Diabetes Mellitus 100%
  • Polymerase Chain Reaction 66%
  • Chromosomes, Human, Pair 6 49%
  • DNA 41%
  • Genome-Wide Association Study 39%
  8 Citations (Scopus)
• 2014

  Early onset of diabetes in the proband is the major determinant of risk in HLA DR3-DQ2/DR4-DQ8 siblings

  Gillespie, K. M., Aitken, R. J., Wilson, I., Williams, A. J. K. & Bingley, P. J., 1 Mar 2014, In: Diabetes. 23 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • HLA-DR3 Antigen 100%
  • Siblings 61%
  • Autoimmunity 43%
  • Haplotypes 31%
  • Primary Prevention 11%
  12 Citations (Scopus)

• Maternal Microchimerism: Increased in the Insulin Positive Compartment of Type 1 Diabetes Pancreas but Not in Infiltrating Immune Cells or Replicating Islet Cells

  Ye, J., Vives-Pi, M. & Gillespie, K. M., 31 Jan 2014, In: PLoS ONE. 9, 9, 7 p., e86985.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • insulin-dependent diabetes mellitus 100%
  • Chimerism 85%
  • islets of Langerhans 82%
  • Effector 74%
  • Insulin Derivative 69%
  15 Citations (Scopus)

• Maternal microchimerism: Friend or foe in type 1 diabetes?

  Ye, J. & Gillespie, K., 2014, In: Chimerism.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  4 Citations (Scopus)
• 2013

  Early-Onset, Coexisting Autoimmunity and Decreased HLA-Mediated Susceptibility Are the Characteristics of Diabetes in Down Syndrome

  Aitken, R. J., Mehers, K. L., Williams, A. J. K., Brown, J. L., Bingley, P. J., Holl, R. W., Rohrer, T. P., Schober, E., Abdul-Rasoul, M. M., Hamilton-Shield, J. P. & Gillespie, K. M., May 2013, In: Diabetes Care. 36, 5, p. 1181-1185 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Down Syndrome 100%
  • Autoimmunity 93%
  • Type 1 Diabetes Mellitus 64%
  • Child 41%
  • HLA-DR3 Antigen 35%
  22 Citations (Scopus)

  255 Downloads (Pure)

• Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A *24 alleles at the onset of type 1 diabetes

  Long, A. E., Gillespie, K. M., Aitken, R. J., Goode, J. C., Bingley, P. J. & Williams, A. J. K., Jun 2013, In: Diabetic Medicine. 62, 6, p. 2067-2071

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  17 Citations (Scopus)

• Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells

  Zeng, L., Jarrett, C. E., Brown, K. W., Gillespie, K. M., Holly, J. M. P. & Perks, C. M., 15 Aug 2013, In: Experimental Cell Research. 319, 14, p. 2282-2295 14 p., 10.1016/j.yexcr.2013.06.011.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Decitabine 100%
  • Insulin-Like Growth Factor Binding Protein 3 97%
  • Estrogen Receptors 72%
  • Breast Neoplasms 49%
  • Transcription Factor AP-2 17%
  14 Citations (Scopus)
• 2012

  Maternal microchimerism in muscle biopsies from children with juvenile dermatomyositis

  Ye, J., Zyl, B., Varsani, H., Wedderburn, LR., Ramanan, AV. & Gillespie, KM., Jun 2012, In: Rheumatology. 51, 6, p. 987-991

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Chimerism 100%
  • Dermatomyositis 98%
  • Mothers 50%
  • Biopsy 48%
  • Muscles 48%
  14 Citations (Scopus)

• Rising Incidence of Type 1 Diabetes Is Associated With Altered Immunophenotype at Diagnosis

  Long, A. E., Gillespie, KM., Rokni, S., Bingley, PJ. & Williams, AJK., Mar 2012, In: Diabetes. 61, 3, p. 683 - 686 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Type 1 Diabetes Mellitus 100%
  • Autoimmunity 81%
  • Incidence 54%
  • Autoantibodies 51%
  • Zinc Transporter 8 49%
  43 Citations (Scopus)
• 2011

  An increased frequency of NK cell receptor and HLA-C group 1 combinations in early-onset type 1 diabetes

  Mehers, KL., Long, A. E., van der Slik, AR., Aitken, RJ., Nathwani, V., Wong, FS., Bain, S., Gill, G., Roep, BO., Bingley, PJ. & Gillespie, KM., Dec 2011, In: Diabetologia. 54, 12, p. 3062 - 3070

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  18 Citations (Scopus)
• 2010

  Microchimerism: covert genetics?

  Ye, J., Berendine, VZ., Hellmich, C. & Gillespie, K. M., Dec 2010, In: International Journal of Molecular Epidemiology and Genetics. 1, 4, p. 350-357 8 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  Open Access

  File

  • Chimerism 100%
  • Genetic Predisposition to Disease 32%
  • Disease Resistance 21%
  • Allogeneic Cells 17%
  • Autoimmunity 15%
  5 Citations (Scopus)

  75 Downloads (Pure)

• Molecular Genetics of Type 1 Diabetes

  Ye, J., Mehers, KL. & Gillespie, KM., Sep 2010, In: Encyclopedia of Life Sciences. p. 1 - 6 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

• Organ-specific autoantibodies but not anti-cyclic citrullinated peptides are a feature of autoimmunity in Down's syndrome

  Fisher, BA., Charles, P., Lundberg, K., Gillespie, KM., Newton, RW. & Venables, PJ., May 2010, In: Annals of the Rheumatic Diseases. 69(5), p. 939 - 940 2 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  6 Citations (Scopus)

• Why are levels of maternal microchimerism higher in type 1 diabetes pancreas?

  Vanzyl, B., Planas, R., Ye, J., Foulis, A., de Krijger, RR., Vives-Pi, N. V. & Gillespie, KM., Oct 2010, In: Chimerism. 1, 2, p. 45 - 50 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Chimerism 100%
  • Insulin Derivative 81%
  • Type 1 Diabetes Mellitus 71%
  • Pancreas 68%
  • Mothers 50%
  19 Citations (Scopus)
• 2009

  Microchimerism in type 1 diabetes

  vanZyl, B. & Gillespie, KM., Apr 2009, In: Current diabetes reports. 9(2), p. 125 - 129 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Chimerism 100%
  • Type 1 Diabetes Mellitus 71%
  • Mothers 50%
  • Maternal Inheritance 14%
  • Islets of Langerhans 11%
  3 Citations (Scopus)

• Vascular Endothelial Growth Factor (VEGF) isoform expression and activity in human and murine lung injury

  Medford, A. R. L., Douglas, SK., Godinho, SIH., Uppington, KM., Armstrong, L., Gillespie, K. M., Van Zyl, B., Tetley, TD., Ibrahim, NBN. & Millar, AB., 2009, In: Respiratory Research. 10(1), p. 27 - 38 27 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Lung Injury 100%
  • Human Activities 95%
  • Vascular Endothelial Growth Factor A 81%
  • Protein Isoforms 76%
  • RNA Isoforms 32%
  39 Citations (Scopus)
• 2008

  Autoantibodies to islet antigen-2 are associated with HLA-DRB1*07 and DRB1*09 haplotypes as well as DRB1*04 at onset of type 1 diabetes: the possible role of HLA-DQA in autoimmunity to IA-2

  Williams, AJK., Aitken, RJ., Chandler, MA-M., Gillespie, KM., Lampasona, V. & Bingley, PJ., Aug 2008, In: Diabetologia. 51 (8), p. 1444 - 1448 5 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • HLA-DRB1*07 antigen 100%
  • HLA-DQA1 antigen 82%
  • Autoimmunity 52%
  • Haplotypes 50%
  • Autoantibodies 49%
  27 Citations (Scopus)

• The genetic basis of type 1 diabetes

  Mehers, KL. & Gillespie, KM., Dec 2008, In: British Medical Bulletin. 88(1), p. 115 - 129 15 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Type 1 Diabetes Mellitus 100%
  • Genetic Predisposition to Disease 48%
  • Genes 25%
  • DNA Copy Number Variations 24%
  • Chromosomes, Human, Pair 6 21%
  53 Citations (Scopus)
• 2007

  An association analysis of the HLA gene region in Latent Autoimmune Diabetes in Adults

  Desai, M., Zeggini, E., Horton, VA., Owen, KR., Hattersley, AT., Levy, JC., Walker, M., Gillespie, KM., Bingley, PJ., Hitman, GA., Holman, RR., McCarthy, MI. & Clark, A., Jan 2007, In: Diabetologia. 50 (1), p. 68 - 73 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Latent Autoimmune Diabetes in Adults 100%
  • HLA-DQB1 antigen 61%
  • Type 1 Diabetes Mellitus 46%
  • Odds Ratio 39%
  • HLA-DRB1 Chains 34%
  61 Citations (Scopus)

• Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet β cell microchimerism

  Nelson, JL., Gillespie, KM., Lambert, NC., Stevens, AM., Loubiere, LS., Rutledge, JC., Leiserling, WM., Erickson, TD., Yan, Z., Mullarkey, ME., Boespflug, ND., Bingley, PJ. & Gale, EAM., 30 Jan 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104 (5), p. 1637 - 1642 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  136 Citations (Scopus)

• Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes:a meta-analysis

  Thomas, G., Valdes, AM., Noble, JA., Kockum, I., Grote, MN., Najman, J., Erlich, HA., Cucca, F., Pugliese, A., Steenkiste, A., Dorman, JS., Caillat-Zucman, S., Hermann, R., Ilonen, J., Lambert, AP., Bingley, PJ., Gillespie, KM., Lernmark, A., Sanjeevi, CB., Ronningen, KS. & 32 others, Undlien, DE., Thorsby, E., Petrone, A., Buzzetti, R., Koeleman, BP., Roep, BO., Saruhan-Direskeneli, G., Uyar, FA., Gunoz, H., Gorodezky, C., Alaez, C., Boehm, BO., Mlynarski, W., Ikegami, H., Berrino, M., Fasano, ME., Dametto, E., Israel, S., Brautbar, C., Santiago-Cortes, A., Frazer de Llado, T., She, JX., Bugawan, TL., Rotter, JI., Raffel, L., Zeidler, A., Leyva-Cobian, F., Chan, SH., Castano, L., Pociot, F., Nerup, J. & Hawkins, BR., Aug 2007, In: Tissue Antigens. 70 (2), p. 110 - 127 18 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Haplotypes 100%
  • Type 1 Diabetes Mellitus 95%
  • Protective 88%
  • Meta-Analysis 79%
  • Genotype 76%
• 2006

  HLA genotyping supports a nonautoimmune etiology in patients diagnosed with diabetes under the age of 6 months

  Edghill, EL., Dix, RJ., Flanagan, SE., Bingley, PJ., Hattersley, AT., Ellard, S. & Gillespie, KM., Jun 2006, In: Diabetes. 55 (6), p. 1895 - 1898 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  93 Citations (Scopus)

• Islet autoimmunity in children with Down's syndrome

  Gillespie, KM., Dix, RJ., Williams, AJK., Newton, RW., Robinson, ZF., Bingley, PJ., Gale, EAM. & Shield, JPH., Nov 2006, In: Diabetes. 55 (11), p. 3185 - 3188 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  40 Citations (Scopus)

• Type 1 diabetes: Pathogenesis and prevention

  Gillespie, KM., Jul 2006, In: CMAJ: Canadian Medical Association Journal. 175, 2, p. 165-170 6 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  • Type 1 Diabetes Mellitus 100%
  • Islets of Langerhans 56%
  • Insulin 38%
  • Autoantibodies 25%
  • Pancreas 23%
  158 Citations (Scopus)
• 2005

  Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry

  Li-Sucholeiki, XC., Mitchell, AT., Arnold, K., Glassner, BJ., Thompson, T., Murthy, JV., Berk, L., Lange, C., Leong-Morgenthaler, PM., MacDougall, D., Munro, J., Cannon, D., Mistry, T., Miller, A., Deka, C., Karger, B., Gillespie, KM., Ekstrom, PO., Todd, JA. & Thilly, WG., 2005, In: Mutation Research. 570, p. 267 - 280 14 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review

  15 Citations (Scopus)

• Is puberty an accelerator of Type 1 diabetes in IL6-174CC females?

  Gillespie, KM., Nolsøe, R., Betin, VMS., Kristiansen, OP., Bingley, PJ., Mandrup-Poulsen, T. & Gale, EAM., Apr 2005, In: Diabetes. 54 (4), p. 1245 - 1248 4 p.

  Research output: Contribution to journal › Article (Academic Journal) › peer-review
  23 Citations (Scopus)