Dr Kevin A Wilkinson

MBioChem(Bath), PhD(Bristol)

  • BS8 1TD

20072020

Research output per year

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Research Output

  • 42 Article (Academic Journal)
  • 2 Review article (Academic Journal)
  • 1 Comment/debate (Academic Journal)
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Article (Academic Journal)
2020

Endocytosis, trafficking and exocytosis of intact full-length Botulinum neurotoxin type A in cultured rat neurons

Solabre Valois, L., Wilkinson, K. A., Nakamura, Y. & Henley, J. M., 20 Feb 2020, In : NeuroToxicology. 78 (2020), p. 80-87 8 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
33 Downloads (Pure)

Mechanisms and roles of mitochondrial localisation and dynamics in neuronal function

Seager, R. A., Lee, L. J., Henley, J. M. & Wilkinson, K. A., 1 Jun 2020, In : Neuronal Signaling. (2020) 4, 2, 28 p., NS20200008.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
15 Downloads (Pure)

Protein interactors and trafficking pathways that regulate the cannabinoid type 1 receptor (CB1R)

Fletcher-Jones, A. S., Hildick, K. L., Evans, A. J., Nakamura, Y., Henley, J. M. & Wilkinson, K. A., 12 Jun 2020, In : Frontiers in Molecular Neuroscience. 13, 19 p., 108.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
16 Downloads (Pure)

SUMOylation of synaptic and synapse-associated proteins: An update

Henley, J. M., Seager, R. A., Nakamura, Y., Talandyte, K., Dhandapani Nair, J. & Wilkinson, K. A., 15 Jun 2020, In : Journal of Neurochemistry. 17 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
37 Downloads (Pure)
2019

Developmental profiles of SUMOylation pathway proteins in rat cerebrum and cerebellum

Josa Prado, F., Luo, J., Rubin, P., Henley, J. & Wilkinson, K., 22 Feb 2019, In : PLoS ONE. 14, 2, 16 p., e0212857.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
210 Downloads (Pure)

Effects of amyloid-β on protein SUMOylation and mitochondrial dysfunction in primary cortical neurons

Guerra De Souza, A. C., Zanella, C. A., Carmichael, R., Henley, J., Wilkinson, K. & Cimarosti, H. I., 18 Jun 2019, (In preparation) In : BMC Neuroscience.

Research output: Contribution to journalArticle (Academic Journal)

Insulin-dependent GLUT4 trafcking is not regulated by protein SUMOylation in L6 myocytes

Carmichael, R. E., Wilkinson, K. & Craig, T., 24 Apr 2019, In : Scientific Reports. 9, 1, 9 p., 6477.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
121 Downloads (Pure)

Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff)

Lee, L., Seager, R., Nakamura, Y., Wilkinson, K. & Henley, J., 21 May 2019, In : PLoS ONE. 14, 5, 13 p., e0213116.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
171 Downloads (Pure)

Post-translational modifications of Parkinson's disease-related proteins: Phosphorylation, SUMOylation and Ubiquitination

Junqueira, S. C., Centeno, E. G. Z., Wilkinson, K. & Cimarosti, H. I., 1 Aug 2019, In : Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1865, 8, p. 2001-2007 7 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
121 Downloads (Pure)

Protective role of the deSUMOylating enzyme SENP3 in myocardial ischaemia-reperfusion injury

Rawlings, N., Lee, L., Seager, R., Wilkinson, K. & Henley, J., 21 Feb 2019, (Submitted) In : bioRxiv.

Research output: Contribution to journalArticle (Academic Journal)

File
118 Downloads (Pure)

Protective role of the deSUMOylating enzyme SENP3 in myocardial ischemia-reperfusion injury

Rawlings, N., Lee, L., Nakamura, Y., Wilkinson, K. & Henley, J., 11 Apr 2019, In : PLoS ONE. 14, 4, p. e0213331 17 p., e0213331.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
182 Downloads (Pure)

Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number

Binda, C., Nakamura, Y., Henley, J. & Wilkinson, K., 25 Jan 2019, In : Biochemical Journal. 476, 2, p. 293-306 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
53 Downloads (Pure)

The C-terminal Helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

Fletcher-Jones, A., Hildick, K., Evans, A., Nakamura, Y., Wilkinson, K. & Henley, J., 30 Apr 2019, In : eLife. 8, 26 p., e44252.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
2 Citations (Scopus)
162 Downloads (Pure)
2018

ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity

Gurung, S., Evans, A., Wilkinson, K. & Henley, J., Dec 2018, In : Journal of Cell Science. 131, 24, 11 p., jcs222273.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
1 Citation (Scopus)
88 Downloads (Pure)

MEF2A regulates mGluR-dependent AMPA receptor trafficking independently of Arc/Arg3.1

Carmichael, R. E., Wilkinson, K. A., Craig, T. J., Ashby, M. C. & Henley, J. M., 27 Mar 2018, In : Scientific Reports. 8, 8 p., 5263.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
196 Downloads (Pure)

The transcription factor MEF2A plays a key role in the differentiation/maturation of rat neural stem cells into neurons

Zhu, B., Carmichael, R., Solabre Valois, L., Wilkinson, K. & Henley, J., 7 Jun 2018, In : Biochemical and Biophysical Research Communications. 500, 3, p. 645-649 5 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
5 Citations (Scopus)
185 Downloads (Pure)
2017

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity

Evans, A. J., Gurung, S., Wilkinson, K. A., Stephens, D. J. & Henley, J. M., 20 Jun 2017, In : Cell Reports. 19, 12, p. 2613-2626 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
16 Citations (Scopus)
286 Downloads (Pure)

Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity

Luo, J., Henley, J., Gurung, S., Guo, C., Wilkinson, K. & Lee, L., 26 Jul 2017, In : Journal of Toxicological Sciences. 42, 5, p. 529-538 10 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
4 Citations (Scopus)
241 Downloads (Pure)

SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death

Guo, C., Wilkinson, K., Evans, A., Rubin, P. & Henley, J., 6 Mar 2017, In : Scientific Reports. 7, 11 p., 43811.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
23 Citations (Scopus)
334 Downloads (Pure)

SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis

Rocca, D., Wilkinson, K. & Henley, J., 13 Apr 2017, In : Scientific Reports. 7, 1, 12 p., 877.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
14 Citations (Scopus)
275 Downloads (Pure)
2016

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins

McMillan, K. J., Gallon, M. J., Jellett, A. P., Clairfeuille, T., Tilley, F. C., McGough, I., Danson, C. M., Heesom, K. J., Wilkinson, K. A., Collins, B. M. & Cullen, P. J., 15 Aug 2016, In : Journal of Cell Biology. 214, 4, p. 389-399 11 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
20 Citations (Scopus)
406 Downloads (Pure)

Synaptic AMPA receptor composition in development, plasticity and disease

Henley, J. & Wilkinson, K., Jun 2016, In : Nature Reviews Neuroscience. 17, 6, p. 337–350 14 p.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
149 Citations (Scopus)
649 Downloads (Pure)
2015

SUMOylation of Argonaute-2 regulates RNA interference activity

Josa-Prado, F., Henley, J. M. & Wilkinson, K. A., 4 Sep 2015, In : Biochemical and Biophysical Research Communications. 464, 4, p. 1066-71 6 p.

Research output: Contribution to journalArticle (Academic Journal)

9 Citations (Scopus)
2014

Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction

Henley, J. M., Craig, T. J. & Wilkinson, K. A., Oct 2014, In : Physiological Reviews. 94, 4, p. 1249-85 37 p.

Research output: Contribution to journalArticle (Academic Journal)

2013

In vivo characterization of the properties of SUM01-specific monobodies

Berndt, A., Wilkinson, K. A., Heimann, M. J., Bishop, P. & Henley, J. M., 15 Dec 2013, In : Biochemical Journal. 456, p. 385-395 11 p.

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Receptor trafficking and the regulation of synaptic plasticity by SUMO

Luo, J., Ashikaga, E., Rubin, P. P., Heimann, M. J., Hildick, K. L., Bishop, P., Girach, F., Josa-Prado, F., Tang, L. T. H., Carmichael, R. E., Henley, J. M. & Wilkinson, K. A., Dec 2013, In : Neuromolecular Medicine. 15, 4, p. 692-706 15 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

Guo, C., Hildick, K. L., Luo, J., Dearden, L., Wilkinson, K. A. & Henley, J. M., 29 May 2013, In : EMBO Journal. 32, 11, p. 1514-28 15 p.

Research output: Contribution to journalArticle (Academic Journal)

113 Citations (Scopus)

SUMOylation Is Required for Glycine-Induced Increases in AMPA Receptor Surface Expression (ChemLTP) in Hippocampal Neurons

Jaafari, N., Konopacki, F. A., Kantamneni, S., Rubin, P., Craig, T. J., Wilkinson, K. A. & Henley, J. M., 11 Jan 2013, In : PLoS ONE. 8, 1, 9 p., 52345.

Research output: Contribution to journalArticle (Academic Journal)

37 Citations (Scopus)
2012

Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones

Cimarosti, H., Ashikaga, E., Jaafari, N., Dearden, L., Rubin, P., Wilkinson, K. A. & Henley, JM., Jan 2012, In : Journal of Cerebral Blood Flow and Metabolism. 32, 1, p. 17 - 22 6 p.

Research output: Contribution to journalArticle (Academic Journal)

51 Citations (Scopus)

SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity

Chamberlain, S. E. L., Gonzalez, M. I., Wilkinson, K. A., Konopacki, F. A., Kantamneni, S., Henley, J. M. & Mellor, J. R., Jun 2012, In : Nature Neuroscience. 15, 6, p. 845-852 8 p.

Research output: Contribution to journalArticle (Academic Journal)

64 Citations (Scopus)
2011

Activity-dependent SUMOylation of the brain-specific scaffolding protein GISP

Kantamneni, S., Wilkinson, KA., Jaafari, N., Ashikaga, E., Rocca, D., Rubin, P., Jacobs, SC., Nishimune, A. & Henley, JM., Jun 2011, In : Biochemical and Biophysical Research Communications. 409 (4), p. 657 - 662 6 p.

Research output: Contribution to journalArticle (Academic Journal)

15 Citations (Scopus)

Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis

Konopacki, F. A., Jaafari, N., Rocca, D., Wilkinson, K. A., Chamberlain, S. E. L., Rubin, P., Kantamneni, S., Mellor, J. R. & Henley, JM., Dec 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 49, p. 19772 - 19777 6 p.

Research output: Contribution to journalArticle (Academic Journal)

48 Citations (Scopus)

Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation

Wilkinson, KA. & Henley, JM., Mar 2011, In : Neuroscience Letters. 491 (3), p. 181 - 186 6 p.

Research output: Contribution to journalArticle (Academic Journal)

12 Citations (Scopus)

Ubiquitin regulation of neuronal excitability

Kantamneni, S., Wilkinson, KA. & Henley, JM., Feb 2011, In : Nature Neuroscience. 14 (2), p. 126 - 128 3 p.

Research output: Contribution to journalArticle (Academic Journal)

7 Citations (Scopus)
2010

Mechanisms, regulation and cosequences of protein SUMOylation

Wilkinson, KA. & Henley, JM., Jun 2010, In : Biochemical Journal. 428 (2), p. 133 - 145 13 p.

Research output: Contribution to journalArticle (Academic Journal)

388 Citations (Scopus)

Targets and consequences of protein SUMOylation in neurons

Wilkinson, KA., Nakamura, Y. & Henley, JM., Sep 2010, In : Brain Research Reviews. 64 (1), p. 195 - 212 18 p.

Research output: Contribution to journalArticle (Academic Journal)

87 Citations (Scopus)
2009

GISP increases neurotransmitter receptor stability by down-regulating ESCRT-mediated lysosomal degradation

Kantamneni, S., Holman, DA., Wilkinson, KA., Nishimune, A. & Henley, JM., Mar 2009, In : Neuroscience Letters. 452(2), p. 106 - 110 5 p.

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Protein SUMOylation in neuropathological conditions

Anderson, D., Wilkinson, KA. & Henley, JM., Jun 2009, In : Drugs News and Perspectives. 22(5), p. 255 - 265 11 p.

Research output: Contribution to journalArticle (Academic Journal)

28 Citations (Scopus)
2008

Analysis of SUMO-1 modification of neuronal proteins containing consensus SUMOylation motifs

Wilkinson, KA., Nishimune, A. & Henley, JM., May 2008, In : Neuroscience Letters. 436 (2), p. 239 - 244 6 p.

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

GISP binding to TSG101 increases GABA(B) receptor stability by down-regulating ESCRT-mediated lysosomal degradation

Kantamneni, S., Holman, DA., Wilkinson, KA., Correa, SA., Feligioni, M., Ogden, S., Fraser, W., Nishimune, A. & Henley, JM., Jul 2008, In : Journal of Neurochemistry. 107(1), p. 86 - 95 10 p.

Research output: Contribution to journalArticle (Academic Journal)

21 Citations (Scopus)
2007

Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction

Martin, SAR., Wilkinson, KA., Nishimune, A. & Henley, JM., Dec 2007, In : Nature Reviews Neuroscience. 8 (12), p. 948 - 959 12 p.

Research output: Contribution to journalArticle (Academic Journal)

151 Citations (Scopus)