Laura J Corbin

2024

Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised-controlled trial of individuals with type 2 diabetes

Bull, C. J., Hazelwood, E., Legge, D. N., Corbin, L. J., Richardson, T. G., Lee, M., Yarmolinsky, J., Smith-Byrne, K., Hughes, D. A., Johansson, M., Peters, U., Berndt, S. I., Brenner, H., Burnett-Hartman, A., Cheng, I., Kweon, S.-S., Le Marchand, L., Li, L., Newcomb, P. A. & Pearlman, R. & 9 others, McConnachie, A., Welsh, P., Taylor, R., Lean, M. E. J., Sattar, N., Murphy, N., Gunter, M., Timpson, N. J. & Vincent, E. E., 1 Feb 2024, In: EBioMedicine. 100, 13 p., 104977.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

Inflammation proteomics datasets in the ALSPAC cohort

Goulding, N. J., Goudswaard, L., Hughes, D. A., Corbin, L. J., Groom, A., Ring, S. M., Timpson, N. J., Fraser, A., Northstone, K. & Suderman, M. J., 19 Feb 2024, In: Wellcome Open Research. 7, 16 p., 277.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

2 Citations (Scopus)

40 Downloads (Pure)

New insights into understanding obesity: from measures to mechanisms

Timpson, N. J., Wade, K. H., Smith, M. L., Goudswaard, L. J., Sattar, N. A., Pournaras, D. J. & Corbin, L. J., 29 Mar 2024, In: BMJ Medicine. 3, 1

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)

Corbin, L. J., Hughes, D. A., Bull, C. J., Vincent, E. E., Smith, M. L., McConnachie, A., Messow, C.-M., Welsh, P., Taylor, R., Lean, M. E. J., Sattar, N. & Timpson, N. J., 1 Jan 2024, In: Diabetologia. 67, 1, p. 74-87 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

9 Citations (Scopus)

2023

Characterizing the Effect of Adiposity on Cardiometabolic Traits and the Circulating Proteome in Qatar Biobank

Goudswaard, L. J., Zaghlool, S., Thareja, G., Corbin, L. J., Hughes, D. A., Lee, M., Suhre, K. & Timpson, N. J., 17 Sept 2023.

Research output: Contribution to conference › Conference Poster › peer-review

Loci for insulin processing and secretion provide insight into type 2 diabetes risk

et al., 2 Feb 2023, In: American Journal of Human Genetics. 110, 2, p. 284-299 16 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

285 Downloads (Pure)

Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty

Duckett, K., Williamson, A., Kincaid, J., Rainbow, K., Lam, B., Corbin, L. J., Martin, H. C., Eberhardt, R. Y., Huang, Q. Q., Hurles, M., Brauner, R., Delaney, A., McElreavey, K., Hall, J., Hirschhorn, J. N., Palmert, M., Seminara, S., Banerjee, I., Perry, J. R. B. & Timpson, N. J. & 4 others, Clayton, P., Chan, Y.-M., Ong, K. K. & O'Rahilly, S., 20 Jun 2023, (E-pub ahead of print) In: Journal of Clinical Endocrinology and Metabolism. 108, 12, p. e1580-e1587 dgad373.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

5 Citations (Scopus)

Using trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome

Goudswaard, L. J., Smith, M. L., Hughes, D. A., Taylor, R., Lean, M. E. J., Sattar, N. A., Welsh, P., McConnachie, A., Blazeby, J., Rogers, C. A., Suhre, K., Zaghlool, S. B., Hers, I., Timpson, N. J. & Corbin, L. J., 29 Nov 2023, In: Scientific Reports. 13, 1, 21077.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

1 Citation (Scopus)

2022

A multivariant recall-by-genotype study of the metabolomic signature of BMI

Fang, S., Wade, K. H., Hughes, D. A., FitzGibbon, S. J., Yip, V. L., Timpson, N. J. & Corbin, L. J., 8 Jun 2022, In: Obesity. 30, 6, p. 1298-1310 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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7 Citations (Scopus)

200 Downloads (Pure)

Characterising the circulating proteome of adiposity through use of weight loss interventions and Mendelian randomisation

Goudswaard, L., Smith, M. L., Hughes, D. A., Sattar, N. A., Taylor, R., Lean, M. E. J., NIHR By-Band-Sleeve Trial Management Group, Blazeby, J., Hers, I., Corbin, L. J. & Timpson, N. J., 28 Oct 2022.

Research output: Contribution to conference › Conference Abstract › peer-review

Epigenetic regulation of F2RL3 associates with myocardial infarction and platelet function

Corbin, L. J., White, S. J., Taylor, A. E., Williams, C. M., Taylor, K., Van Den Bosch, M. T. J., Teasdale, J. E., Jones, M. L., Bond, M., Harper, M. T., Falk, L., Groom, A., Hazell, G. G. J., Paternoster, L., Munafo, M. R., Nordestgaard, B. G., Tybjaerg-Hansen, A., Bojesen, S. E., Relton, C. L. & Min, J. L. & 4 others, Davey Smith, G., Mumford, A. D., Poole, A. W. & Timpson, N. J., 4 Feb 2022, In: Circulation Research. 130, 3, p. 384-400 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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15 Citations (Scopus)

106 Downloads (Pure)

Evaluating the association of TRPA1 gene polymorphisms with pain sensitivity: a protocol for an adaptive recall by genotype study

Nickerson, A. P., Corbin, L. J., Timpson, N. J., Phillips, K., Pickering, A. E. & Dunham, J., 12 Jan 2022, In: BMC Medical Genomics. 15, 1, 12 p., 9.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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3 Citations (Scopus)

77 Downloads (Pure)

Higher body mass index raises immature platelet count: potential contribution to obesity-related thrombosis

Goudswaard, L. J., Corbin, L. J., Burley, K. L., Mumford, A., Akbari, P., Soranzo, N., Butterworth, A. S., Watkins, N. A., Pournaras, D. J., Harris, J., Timpson, N. J. & Hers, I., 24 Jan 2022, In: Platelets. 33, 6, p. 869-878 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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14 Citations (Scopus)

251 Downloads (Pure)

Long-term metabolomic effects of bariatric surgery

Smith, M. L., Goudswaard, L., Corbin, L. J., Timpson, N. J. & The By-Band-Sleeve Trial Management Group, Jun 2022, Metabolomics 2022.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

metaboprep: an R package for pre-analysis data description and processing

Hughes, D. A., Taylor, K., Mcbride, N. S., Lee, M., Mason, D., Lawlor, D. A., Timpson, N. J. & Corbin, L. J., 1 Apr 2022, In: Bioinformatics. 38, 7, p. 1980-1987 8 p.

Research output: Contribution to journal › Article (Academic Journal)

Open Access

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9 Citations (Scopus)

153 Downloads (Pure)

Systematic review and meta-analyses: What has the application of Mendelian randomization told us about the causal effect of adiposity on health outcomes?

Lee, M., Hatcher, C. A., McGuinness, L., Mcbride, N. S., Battram, T. M., Wan, W., Fang, S., Wade, K. H., Corbin, L. J. & Timpson, N. J., 21 Dec 2022, (Accepted/In press) In: Wellcome Open Research. 7, 308, 17 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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80 Downloads (Pure)

Using non-linear and stratified Mendelian randomisation to explore relationships between body mass index and the plasma proteome

Goudswaard, L., Hughes, D. A., Butterworth, A., Soranzo, N., Hers, I., Corbin, L. J. & Timpson, N. J., 2022.

Research output: Contribution to conference › Conference Abstract › peer-review

2021

Combining Mendelian Randomization and Randomized Control Trial Study Designs to Determine Effects of Adiposity on the Plasma Proteome

Goudswaard, L. J., Corbin, L. J., Hughes, D. A., Holmes, M. V., Sattar, N., Hers, I. & Timpson, N. J., 2021.

Research output: Contribution to conference › Conference Abstract

Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimates

Goudswaard, L. J., Bell, J. A., Hughes, D. A., Corbin, L. J., Walter, K., Davey Smith, G., Soranzo, N., Danesh, J., Di Angelantonio, E., Ouwehand, W. H., Watkins, N. A., Roberts, D., Butterworth , A. S., Hers, I. & Timpson, N. J., 1 Oct 2021, In: International Journal of Obesity. 45, p. 2221-2229 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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34 Citations (Scopus)

102 Downloads (Pure)

Investigation of the interplay between circulating lipids and IGF-I and relevance to breast cancer risk: an observational and mendelian randomization study

Tan, Y., Bull, C. J., Biernacka, K. M., Richardson, T. G., Sanderson, E. C. M., Corbin, L. J., Dudding, T., Perks, C. M., Holly, J. M. P. & Timpson, N. J., Dec 2021, In: Cancer Epidemiology, Biomarkers and Prevention. 30, 12, p. 2207-2216 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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10 Citations (Scopus)

97 Downloads (Pure)

Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort

Wade, K. H., Lam, B. Y. H., Melvin, A., Pan, W., Corbin, L. J., Hughes, D. A., Rainbow, K., Chen, J. H., Duckett, K., Liu, X., Mokrosińsk, J., Mörseburg, A., Neaves, S., Williamson, A., Zhang, C., Farooqi, I. S., Yeo, G. S. H., Timpson, N. J. & O'Rahilly, S., 27 May 2021, In: Nature Medicine. 27, 6, p. 1088-1096 9 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

76 Citations (Scopus)

220 Downloads (Pure)

Schizophrenia-associated variation at ZNF804A correlates with altered experience-dependent dynamics of sleep slow waves and spindles in healthy young adults

Bartsch, U., Corbin, L. J., Hellmich, C., Taylor, M., Easey, K., Durant, C. F., Marston, H. M., Timpson, N. J. & Jones, M. W., 10 Dec 2021, In: Sleep. 44, 12, zsab191.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

1 Citation (Scopus)

162 Downloads (Pure)

The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium

Guida, F., Tan, Y., Corbin, L. J., Bull, C. J., Vincent, E. E., Timpson, N. J. & Johansson, M., 20 Sept 2021, In: PLoS Medicine. 18, 9, 26 p., e1003786.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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21 Citations (Scopus)

92 Downloads (Pure)

The role of inflammatory cytokines as intermediates in the pathway from increased adiposity to disease

Kalaoja, M., Corbin, L. J., Tan, Y., Ahola-Olli, A. V., Havulinna, A. S., Santalahti, K., Pitkänen, N., Lehtimäki, T., Lyytikäinen, L. P., Raitoharju, E., Seppala, I., Kahonen, M., Ripatti, S., Palotie, A., Perola, M., Viikari, J., Jalkanen, S., Maksimow, M., Salomaa, V. & Salmi, M. & 3 others, Raitakari, O. T., Kettunen, J. & Timpson, N. J., 1 Feb 2021, In: Obesity. 29, 2, p. 428-437 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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37 Citations (Scopus)

151 Downloads (Pure)

The Trans-Ancestral Genomic Architecture of Glycemic Traits

Corbin, L. J., Timpson, N. J., Lawlor, D. A., Barroso, I. & et al., Jun 2021, In: Nature Genetics. 53, 6, p. 840-860 21 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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407 Citations (Scopus)

280 Downloads (Pure)

2020

An independent locus upstream of ASIP controls variation in the shade of the bay coat colour in horses

Corbin, L. J., Pope, J., Sanson, J., Antczak, D., Miller, D., Sadeghi, R. & Brooks, S., 30 May 2020, In: Genes. (2020) 11, 606, 13 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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18 Citations (Scopus)

125 Downloads (Pure)

Common variation at 16p11.2 is associated with glycosuria in pregnancy: Findings from a genome-wide association study in European women

Lee, M., McMahon, G., Karhunen, V., Wade, K. H., Corbin, L. J., Hughes, D. A., Davey Smith, G., Lawlor, D. A., Jarvelin, M.-R. & Timpson, N. J., 15 Jun 2020, In: Human Molecular Genetics. 29, 12, p. 9 2098 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

4 Citations (Scopus)

123 Downloads (Pure)

Metabolic characterisation of disturbances in the APOC3/triglyceride-rich lipoprotein pathway through sample-based recall by genotype

Corbin, L., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Ratcliffe, A., Jankevics, A., Weber, R. J. M., Groom, A., Dunn, W. B. & Timpson, N. J., 3 Jun 2020, In: Metabolomics. (2020) 16, 69, 12 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

4 Citations (Scopus)

101 Downloads (Pure)

2019

Apparent latent structure within the UK Biobank sample has implications for epidemiological analysis

Haworth, S., Mitchell, R., Corbin, L., Wade, K., Dudding, T., Budu-Aggrey, A., Carslake, D., Hemani, G., Paternoster, L., Davey Smith, G., Davies, N., Lawson, D. & Timpson, N., 1 Dec 2019, In: Nature Communications. 10, 1, 9 p., 333.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

193 Citations (Scopus)

482 Downloads (Pure)

Genetic architecture of human thinness compared to severe obesity

Riveros-Mckay, F., Mistry, V., Bounds, R., Hendricks, A., Keogh, J. M., Thomas, H., Henning, E., Corbin, L., Understanding Society Scientific Group, O'Rahilly, S., Zeggini, E., Wheeler, E., Barroso, I. & Sadaf Farooqi, I., 24 Jan 2019, In: PLoS Genetics. 15, 1, 25 p., e1007603.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

94 Citations (Scopus)

337 Downloads (Pure)

2018

Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference

Corbin, L. J., Tan, V. Y., Hughes, D. A., Wade, K. H., Paul, D. S., Tansey, K. E., Butcher, F., Dudbridge, F., Howson, J. M., Jallow, M. W., John, C., Kingston, N., Lindgren, C. M., O'Donavan, M., O'Rahilly, S., Owen, M. J., Palmer, C. N. A., Pearson, E. R., Scott, R. A. & Van Heel, D. A. & 11 others, Whittaker, J., Frayling, T., Tobin, M. D., Wain, L. V., Smith, G. D., Evans, D. M., Karpe, F., McCarthy, M. I., Danesh, J., Franks, P. W. & Timpson, N. J., 19 Feb 2018, In: Nature Communications. 9, 1, 11 p., 711.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

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47 Citations (Scopus)

340 Downloads (Pure)

2016

A reference panel of 64,976 haplotypes for genotype imputation

McCarthy, S., Das, S., Kretzschmar, W., Delaneau, O., Wood, A. R., Teumer, A., Kang, H. M., Fuchsberger, C., Danecek, P., Sharp, K., Luo, Y., Sidore, C., Kwong, A., Timpson, N., Koskinen, S., Vrieze, S., Scott, L. J., Zhang, H., Mahajan, A. & Veldink, J. & 31 others, Peters, U., Pato, C., van Duijn, C. M., Gillies, C. E., Gandin, I., Mezzavilla, M., Gilly, A., Cocca, M., Traglia, M., Angius, A., Barrett, J. C., Boomsma, D., Branham, K., Breen, G., Brummett, C. M., Busonero, F., Campbell, H., Chan, A., Chen, S., Chew, E., Collins, F. S., Corbin, L. J., Smith, G. D., Dedoussis, G., Dorr, M., Farmaki, A.-E., Ferrucci, L., Forer, L., Min, J. L., Soranzo, N. & Haplotype Reference Consortium, Oct 2016, In: Nature Genetics. 48, 10, p. 1279-1283 5 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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1931 Citations (Scopus)

446 Downloads (Pure)

BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization

Corbin, L. J., Richmond, R., Wade, K. H., Burgess, S., Bowden, J., Davey Smith, G. & Timpson, N., Oct 2016, In: Diabetes. 65, 10, p. 3002-3007 7 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

122 Citations (Scopus)

368 Downloads (Pure)

Body mass index: Has epidemiology started to break down causal contributions to health and disease?

Corbin, L. J. & Timpson, N. J., Aug 2016, In: Obesity. 24, 8, p. 1630-1638 9 p.

Research output: Contribution to journal › Review article (Academic Journal) › peer-review

Open Access

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18 Citations (Scopus)

302 Downloads (Pure)

2015

Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology

Hellmich, C., Durant, C. F., Timpson, N. J., Bartsch, U., Corbin, L. J. & Jones, M. W., 27 Oct 2015, In: BMC Medical Genetics. 16, 1, 8 p., 96.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

File

7 Citations (Scopus)

404 Downloads (Pure)

Using inactivating mutations to provide insight into drug action

Corbin, L. J. & Timpson, N. J., 28 Jan 2015, In: Genome Medicine. 7, 1, 3 p., 7.

Research output: Contribution to journal › Comment/debate (Academic Journal) › peer-review

Open Access

File

1 Citation (Scopus)

297 Downloads (Pure)

2014

Mis-matches between adiposity and glycaemic traits: A replicated genome-wide association study for metabolic disparity

Corbin, L. J., Burrows, K., Ring, S. M., Mangino, M. & Timpson, N. J., 2014.

Research output: Contribution to conference › Conference Poster › peer-review

The utility of low-density genotyping for imputation in the Thoroughbred horse

Corbin, L. J., Kranis, A., Blott, S. C., Swinburne, J. E., Vaudin, M., Bishop, S. C. & Woolliams, J. A., 4 Feb 2014, In: Genetics Selection Evolution. 46, 9, 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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28 Citations (Scopus)

294 Downloads (Pure)

2013

Advances in equine genomics

Corbin, L. J., Apr 2013, Advances in Animal Bioscience. 1 ed. Cambridge University Press, Vol. 4. p. 238 1 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

The application of genomic technologies to the horse

Corbin, L. J., 2013

Research output: Other contribution › PhD thesis (not Bristol)

2012

A genome-wide association study of osteochondritis dissecans in the Thoroughbred

Corbin, L. J., Blott, S. C., Swinburne, J. E., Sibbons, C., Fox-Clipsham, L. Y., Helwegen, M., Parkin, T. D. H., Newton, J. R., Bramlage, L. R., McIlwraith, C. W., Bishop, S. C., Woolliams, J. A. & Vaudin, M., Apr 2012, In: Mammalian Genome. 23, 3-4, p. 294-303 10 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Open Access

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36 Citations (Scopus)

536 Downloads (Pure)

A participatory approach to understanding the issues associated with establishing an equine biobank

Corbin, L. J., 17 Nov 2012.

Research output: Contribution to conference › Conference Poster › peer-review

Coalescence theory in livestock breeding

Woolliams, J. & Corbin, L., Aug 2012, In: Journal of Animal Breeding and Genetics. 129, 4, p. 255-256 2 p.

Research output: Contribution to journal › Editorial (Academic Journal) › peer-review

3 Citations (Scopus)

Could an equine biobank enable the UK horse industry to better exploit new genomic technologies?

Corbin, L. J., 2012, (Unpublished) British Equestrian Federation.

Research output: Book/Report › Confidential report for external body

Estimation of historical effective population size using linkage disequilibria with marker data

Corbin, L. J., Liu, A. Y. H., Bishop, S. C. & Woolliams, J. A., Aug 2012, In: Journal of Animal Breeding and Genetics. 129, 4, p. 257-70 14 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

115 Citations (Scopus)

25 Downloads (Pure)

The identification of SNPs with indeterminate positions using the Equine SNP50 BeadChip

Corbin, L. J., Blott, S. C., Swinburne, J. E., Vaudin, M., Bishop, S. C. & Woolliams, J. A., Jun 2012, In: Animal Genetics. 43, 3, p. 337-9 3 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

1 Citation (Scopus)

19 Downloads (Pure)

2011

A haplotype library for the horse

Corbin, L. J., Jul 2011, (Unpublished).

Research output: Contribution to conference › Conference Poster

2010

Characterisation of linkage disequilibrium and subsequent estimation of effective population size in Thoroughbred horses using SNP markers

Corbin, L. J., Blott, S. C., Swinburne, J. E., Vaudin, M., Bishop, S. C. & Woolliams, J. A., 2010, Advances in Animal Bioscience. 1 ed. Vol. 1. p. 58 1 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

Genomic prediction of risk for osteochondrosis in the Thoroughbred horse.

Corbin, L. J., Jan 2010.

Research output: Contribution to conference › Conference Poster › peer-review

Linkage disequilibrium and historical effective population size in the Thoroughbred horse

Corbin, L. J., Blott, S. C., Swinburne, J. E., Vaudin, M., Bishop, S. C. & Woolliams, J. A., Dec 2010, In: Animal Genetics. 41 Suppl 2, p. 8-15 8 p.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

82 Citations (Scopus)

47 Downloads (Pure)

Dr Laura J Corbin

Research output

Search results