Projects per year
Virus-specific T cells constitute an essential line of defence during viral infection and both an impaired or exacerbated T cell response are detrimental to the host. We are interested in understanding how T cells contribute to protective immunity and/or immunopathology during viral infection, particularly in the context of dengue virus infection, and more recently in COVID-19. Understanding these mechanisms is critical for the development of effective vaccines and immunomodulatory therapeutics.
We collaborate with scientists and clinicians at the Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City in Vietnam, the National Centre for Infectious Diseases (NCID) in Singapore, Duke-NUS Medical School in Singapore and North Bristol NHS Trust in Bristol, UK.
Adjunct Assistant Professor, Duke-NUS Medical School
5 Jul 2019 → 31 Dec 2021
- T cells
- NK cells
- Dengue virus
- 1 Similar Profiles
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1/10/20 → 30/09/21
1/10/20 → 31/03/21
Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell FatesChng, M. H. Y., Lim, M. Q., Rouers, A., Becht, E., Lee, B., MacAry, P. A., Lye, D. C., Leo, Y. S., Chen, J., Fink, K., Rivino, L. & Newell, E. W., 17 Dec 2019, In: Immunity. 51, 6, p. 1119-1135.e5 23 p.
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile11 Citations (Scopus)43 Downloads (Pure)
Zimmer, C. L., Cornillet, M., Solà-Riera, C., Cheung, K. W., Ivarsson, M. A., Lim, M. Q., Marquardt, N., Leo, Y. S., Lye, D. C., Klingström, J., MacAry, P. A., Ljunggren, H. G., Rivino, L. & Björkström, N. K., 29 Aug 2019, In: Nature Communications. 10, 15 p., 3897 (2019).
Research output: Contribution to journal › Article (Academic Journal) › peer-reviewOpen AccessFile21 Citations (Scopus)120 Downloads (Pure)
Rivino, L., Kumaran, E. A., Thein, T-L., Too, C. T., Gan, V. C. H., Hanson, B. J., Wilder-Smith, A., Bertoletti, A., Gascoigne, N. R. J., Lye, D. C., Leo, Y. S., Akbar, A. N., Kemeny, D. M. & MacAry, P. A., 11 Mar 2015, In: Science Translational Medicine. 7, 278, 278ra35.
Research output: Contribution to journal › Article (Academic Journal) › peer-review55 Citations (Scopus)