Projects per year
Personal profile
Research interests
Virus-specific T cells constitute an essential line of defence during viral infection and both an impaired or exacerbated T cell response are detrimental to the host. We are interested in understanding how T cells contribute to protective immunity and/or immunopathology during viral infection, particularly in the context of dengue virus infection, and more recently in COVID-19. Understanding these mechanisms is critical for the development of effective vaccines and immunomodulatory therapeutics.
We collaborate with scientists and clinicians at the Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City in Vietnam, the National Centre for Infectious Diseases (NCID) in Singapore, Duke-NUS Medical School in Singapore and North Bristol NHS Trust in Bristol, UK.
External positions
Adjunct Assistant Professor, Duke-NUS Medical School
5 Jul 2019 → 31 Dec 2021
Keywords
- T cells
- NK cells
- Vaccines
- Dengue virus
- SARS-CoV-2
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Projects
- 5 Finished
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(CLOSED) 8049 CMM UK CIC Characterisation of COVID-19 long-term immunity (NCS_1) WP3
1/10/20 → 31/03/21
Project: Research
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UKCiC Characterization of COVID-19 long-term immunity (R101755-COA funding)
1/10/20 → 30/09/21
Project: Research
Research output
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Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates
Chng, M. H. Y., Lim, M. Q., Rouers, A., Becht, E., Lee, B., MacAry, P. A., Lye, D. C., Leo, Y. S., Chen, J., Fink, K., Rivino, L. & Newell, E. W., 17 Dec 2019, In: Immunity. 51, 6, p. 1119-1135.e5 23 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile17 Citations (Scopus)78 Downloads (Pure) -
NK cells are activated and primed for skin-homing during acute dengue virus infection in humans
Zimmer, C. L., Cornillet, M., Solà-Riera, C., Cheung, K. W., Ivarsson, M. A., Lim, M. Q., Marquardt, N., Leo, Y. S., Lye, D. C., Klingström, J., MacAry, P. A., Ljunggren, H. G., Rivino, L. & Björkström, N. K., 29 Aug 2019, In: Nature Communications. 10, 15 p., 3897 (2019).Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile31 Citations (Scopus)143 Downloads (Pure) -
Virus-specific T lymphocytes home to the skin during natural dengue infection
Rivino, L., Kumaran, E. A., Thein, T-L., Too, C. T., Gan, V. C. H., Hanson, B. J., Wilder-Smith, A., Bertoletti, A., Gascoigne, N. R. J., Lye, D. C., Leo, Y. S., Akbar, A. N., Kemeny, D. M. & MacAry, P. A., 11 Mar 2015, In: Science Translational Medicine. 7, 278, 278ra35.Research output: Contribution to journal › Article (Academic Journal) › peer-review
62 Citations (Scopus)