Research output per year
Research output per year
BSc, MSc(Edin.), PhD
BS8 2BN
I am an Associate Professor in Genetic Epidemiology at the MRC Integrative Epidemiology Unit at the University of Bristol. My research is focused on the genetic aetiology of atopic dermatitis and related traits.
I am a leading member of the EAGLE eczema consortium, which brings together studies from around the world with eczema and genetic data in order to conduct large-scale research. Our aim is to identify genetic variants associated with eczema in order to improve understanding of the disease and inform therapeutic development. We have published two large genome-wide association studies for eczema, the largest of which (Paternoster et al., 2015, Nature Genetics) studied 21,000 cases and identified 10 novel risk loci for the disease, bringing the total number of established loci to 31 (24 in Europeans). I am also interested in sub-classes of atopic dermatitis and have worked with latent class analysis to determine longitudinal patterns of the disease throughout childhood and have keen interest in determining genetic risk factors for progression of the disease and response to treatment.
I work with a number of datasets:
- ALSPAC (The Avon Longitudinal Study of Parents and Children)
- UK Biobank
- EAGLE eczema consortium
Methods:
- Genome-wide association studies
- Target identification
- Mendelian Randomization for causal inference
- Genetics of disease progression
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to journal › Article (Academic Journal) › peer-review
Research output: Contribution to conference › Conference Abstract
Paternoster, L. (Principal Investigator)
1/10/12 → 1/10/16
Project: Research
Min, J. L. (Principal Investigator), Paternoster, L. (Principal Investigator) & Langan, S. M. (Principal Investigator)
Project: Research
Anderson, E. L. (Co-Principal Investigator), Davey Smith, G. (Co-Principal Investigator), Paternoster, L. (Co-Principal Investigator) & Tilling, K. M. (Co-Investigator)
1/11/20 → 30/11/22
Project: Research
Hartley, A. (Creator), Chong, A. (Creator), Mitchell, R. (Contributor) & Paternoster, L. (Contributor), University of Bristol, 16 Jan 2023
DOI: 10.5523/bris.2p0ih3u1cpxq12smf079dm1t5a, http://data.bris.ac.uk/data/dataset/2p0ih3u1cpxq12smf079dm1t5a
Dataset
Mitchell, R. (Creator), Elsworth, B. L. (Creator), Mitchell, R. (Creator), Raistrick, C. A. (Creator), Paternoster, L. (Creator), Hemani, G. (Creator) & Gaunt, T. R. (Creator), University of Bristol, 19 Feb 2019
DOI: 10.5523/bris.pnoat8cxo0u52p6ynfaekeigi, http://data.bris.ac.uk/data/dataset/pnoat8cxo0u52p6ynfaekeigi
Dataset
Mitchell, R. (Creator), Hemani, G. (Creator), Dudding, T. (Creator), Corbin, L. (Creator), Harrison, S. (Creator) & Paternoster, L. (Creator), University of Bristol, 22 Jan 2019
DOI: 10.5523/bris.1ovaau5sxunp2cv8rcy88688v, http://data.bris.ac.uk/data/dataset/1ovaau5sxunp2cv8rcy88688v
Dataset
Paternoster, L. (Editor)
Activity: Publication peer-review and editorial work types › Editorial activity
Paternoster, L. (Recipient)
Activity: Other activity types › Fellowship awarded competitively