Projects per year
Personal profile
Research interests
I am a Senior Lecturer in Genetic Epidemiology at the MRC Integrative Epidemiology Unit at the University of Bristol. My research is focused on the genetic aetiology of atopic dermatitis and related traits.
I am a leading member of the EAGLE eczema consortium, which brings together studies from around the world with eczema and genetic data in order to conduct large-scale research. Our aim is to identify genetic variants associated with eczema in order to improve understanding of the disease and inform therapeutic development. We have published two large genome-wide association studies for eczema, the largest of which (Paternoster et al., 2015, Nature Genetics) studied 21,000 cases and identified 10 novel risk loci for the disease, bringing the total number of established loci to 31 (24 in Europeans). I am also interested in sub-classes of atopic dermatitis and have worked with latent class analysis to determine longitudinal patterns of the disease throughout childhood and have keen interest in determining genetic risk factors for progression of the disease and response to treatment.
I work with a number of datasets:
- ALSPAC (The Avon Longitudinal Study of Parents and Children)
- UK Biobank
- EAGLE eczema consortium
- GOYA (Genomics of Obese Young Adults)
Methods:
- Genome-wide association studies
- Target identification
- Mendelian Randomization
- Genetics of Progression
Structured keywords and research groupings
- Bristol Population Health Science Institute
Keywords
- genetic epidemiology
- GWAS
- atopic disease
- disease progression
- Mendelian randomization
Fingerprint
- 1 Similar Profiles
Network
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Identifying causal risk factors for cognitive decline
Anderson, E. L., Davey Smith, G., Paternoster, L. & Tilling, K. M.
1/11/20 → 30/11/22
Project: Research
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Research output
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Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
Paternoster, L., Standl, M., Australian Asthma Genetics Consortium (AAGC) & The Genetics of Overweight Young Adults (GOYA) Consortium, Feb 2012, In: Nature Genetics. 44, 2, p. 187-192 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
242 Citations (Scopus) -
Epigenetic regulation of F2RL3 associates with myocardial infarction and platelet function
Corbin, L. J., White, S. J., Taylor, A. E., Williams, C. M., Taylor, K., Van Den Bosch, M. T. J., Teasdale, J. E., Jones, M. L., Bond, M., Harper, M. T., Falk, L., Groom, A., Hazell, G. G. J., Paternoster, L., Munafo, M. R., Nordestgaard, B. G., Tybjaerg-Hansen, A., Bojesen, S. E., Relton, C. L., Min, J. L. & 4 others, , 4 Feb 2022, In: Circulation Research. 130, 3, p. 384-400 17 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile24 Downloads (Pure) -
Imputation provides an opportunity to study filaggrin (FLG) null mutations in large population cohorts that lack bespoke genotyping
Paternoster, L., Budu-Aggrey, A. & Brown, S. J., 1 Feb 2022, In: Wellcome Open Research. 7, 9 p., 36.Research output: Contribution to journal › Article (Academic Journal)
Open AccessFile12 Downloads (Pure)
Datasets
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MRC IEU UK Biobank GWAS pipeline version 2
Mitchell, R. E. (Creator), Elsworth, B. L. (Creator), Mitchell, R. (Creator), Raistrick, C. A. (Creator), Paternoster, L. (Creator), Hemani, G. (Creator) & Gaunt, T. R. (Creator), University of Bristol, 19 Feb 2019
DOI: 10.5523/bris.pnoat8cxo0u52p6ynfaekeigi, http://data.bris.ac.uk/data/dataset/pnoat8cxo0u52p6ynfaekeigi
Dataset
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MRC IEU UK Biobank GWAS pipeline version 1
Mitchell, R. E. (Creator), Elsworth, B. (Creator), Raistrick, C. (Creator), Paternoster, L. (Creator), Hemani, G. (Creator) & Gaunt, T. R. (Creator), University of Bristol, 14 Dec 2017
DOI: 10.5523/bris.2fahpksont1zi26xosyamqo8rr, http://data.bris.ac.uk/data/dataset/2fahpksont1zi26xosyamqo8rr
Dataset
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EAGLE eczema consortium GWAS summary statistics
Paternoster, L. (Creator) & consortium, E. E. (Contributor), University of Bristol, 22 Feb 2016
DOI: 10.5523/bris.28uchsdpmub118uex26ylacqm, http://data.bris.ac.uk/data/dataset/28uchsdpmub118uex26ylacqm
Dataset
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European Journal of Clinical Investigation (Journal)
Lavinia Paternoster (Editor)
Nov 2013 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Population Health Oct 11 - The Genetic Epidemiology of Atopic Dermatitis.
Lavinia Paternoster (Recipient)
1 Oct 2012 → 1 Oct 2016Activity: Other activity types › Fellowship awarded competitively