20082020

Research output per year

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Personal profile

Research interests

I am a Senior Lecturer in Genetic Epidemiology at the MRC Integrative Epidemiology Unit at the University of Bristol. My research is focused on the genetic aetiology of atopic dermatitis and related traits.

I am a leading member of the EAGLE eczema consortium, which brings together studies from around the world with eczema and genetic data in order to conduct large-scale research. Our aim is to identify genetic variants associated with eczema in order to improve understanding of the disease and inform therapeutic development. We have published two large genome-wide association studies for eczema, the largest of which (Paternoster et al., 2015, Nature Genetics) studied 21,000 cases and identified 10 novel risk loci for the disease, bringing the total number of established loci to 31 (24 in Europeans). I am also interested in sub-classes of atopic dermatitis and have worked with latent class analysis to determine longitudinal patterns of the disease throughout childhood and have keen interest in determining genetic risk factors for progression of the disease and response to treatment.

I work with a number of datasets:

- ALSPAC (The Avon Longitudinal Study of Parents and Children)

- UK Biobank

- EAGLE eczema consortium

- GOYA (Genomics of Obese Young Adults)


Methods:

- Genome-wide association studies

- Target identification

- Mendelian Randomization

- Genetics of Progression

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Projects

MRC IEU Studentship - Emily Jamieson

Paternoster, L.

2/10/171/10/21

Project: Research

Research Output

  • 101 Article (Academic Journal)
  • 4 Letter (Academic Journal)
  • 2 Review article (Academic Journal)
  • 1 Comment/debate (Academic Journal)

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

Paternoster, L., Standl, M., Australian Asthma Genetics Consortium (AAGC) & The Genetics of Overweight Young Adults (GOYA) Consortium, Feb 2012, In : Nature Genetics. 44, 2, p. 187-192 6 p.

Research output: Contribution to journalArticle (Academic Journal)

  • 206 Citations (Scopus)

    Age-of-onset information helps identify 76 genetic variants associated with allergic disease

    Ferreira, M. A. R., Granell, R., Brumpton, B. M., Paternoster, L. & al., E., 20 Mar 2020, (Accepted/In press) In : PLoS Genetics.

    Research output: Contribution to journalArticle (Academic Journal)

  • Assessment of a causal relationship between body mass index and atopic dermatitis

    Budu-Aggrey, A., Watkins, S. H., Brumpton, B. M., Løset, M., Tyrrell, J., Modalsli, E. H., Vie, G. Å., Palmer, T., Fritsche, L. G., Nielsen, J. B., Romundstad, P. R., Davey Smith, G., Åsvold, B. O., Paternoster, L. & Brown, S. J., 17 Apr 2020, In : Journal of Allergy and Clinical Immunology. 3 p.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 5 Downloads (Pure)

    Activities

    • 1 Editorial activity
    • 1 Fellowship awarded competitively

    European Journal of Clinical Investigation (Journal)

    Lavinia Paternoster (Editor)

    Nov 2013 → …

    Activity: Publication peer-review and editorial work typesEditorial activity

    Population Health Oct 11 - The Genetic Epidemiology of Atopic Dermatitis.

    Lavinia Paternoster (Recipient)

    1 Oct 20121 Oct 2016

    Activity: Other activity typesFellowship awarded competitively

    Supervised Work

    An Epigenome-Wide Association Study of Eczema

    Author: Berryman, K., 7 May 2019

    Supervisor: Paternoster, L. (Supervisor), Elliott, H. (Supervisor) & Relton, C. (Supervisor)

    Student thesis: Master's ThesisMaster of Science (MSc)

    File

    Describing the development of hip shape in adolescence, and environmental and genetic influences on this process, in ALSPAC offspring

    Author: Frysz, M., 19 Mar 2019

    Supervisor: Paternoster, L. (Supervisor) & Tobias, J. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)

    File