Personal profile
Research interests
I am a genetic epidemiologist working in the MRC Integrative Epidemiology Unit at the University of Bristol. My research is focused on the genetic aetiology of skin conditions.
I have led the EAGLE eczema consortium in several genome-wide association studies for eczema. I am also interested in subtypes of disease and have undertaken genetic studies of disease progression, severity and longitudinal trajectories. I now co-lead the Skin Genetics Consortium (skingeneticsconsortium.org) which leverages population scale genomic datasets to understand the genetic mechanisms underlying skin diseases and traits.
Key interests:
- Genome-wide association studies (GWAS)
- Target identification
- Mendelian Randomization for causal inference
- Genetics of disease progression
- Eczema and other skin conditions
Research Groups and Themes
- Bristol Population Health Science Institute
Keywords
- genetic epidemiology
- GWAS
- eczema
- disease progression
- Mendelian randomization
- skin conditions
- Dermatology
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Collaborations and top research areas from the last five years
Research output
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Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
Paternoster, L., Standl, M., Australian Asthma Genetics Consortium (AAGC) & The Genetics of Overweight Young Adults (GOYA) Consortium, Feb 2012, In: Nature Genetics. 44, 2, p. 187-192 6 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
308 Citations (Scopus) -
Statistical Methods for Understanding Trajectories in Genetic Epidemiology
Wang, G., Paternoster, L. & Warrington, N., 25 Mar 2026, (E-pub ahead of print) In: Annual Review of Biomedical Data Science. 24 p.Research output: Contribution to journal › Review article (Academic Journal) › peer-review
Open AccessFile12 Downloads (Pure) -
Childhood Allergy and Anxiety/Depression in Early Adulthood: a longitudinal study in the ALSPAC birth cohort
Fairweather, S., Hammerton, G. L., Paternoster, L., Gilbody, S., Jones, H. J. & Khandaker, G., 1 Feb 2025, In: Brain, Behavior, and Immunity. 124, p. 226-236 11 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open Access1 Citation (Scopus)
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MRC Population Health Scientist Fellowship
Paternoster, L. (Principal Investigator)
1/10/12 → 1/10/16
Project: Research
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Leveraging multi-omics approaches to identify and predict subtypes of atopic dermatitis
Min, J. L. (Principal Investigator), Paternoster, L. (Principal Investigator) & Langan, S. M. (Principal Investigator)
Project: Research
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Identifying causal risk factors for cognitive decline
Anderson, E. L. (Co-Principal Investigator), Davey Smith, G. (Co-Principal Investigator), Paternoster, L. (Co-Principal Investigator) & Tilling, K. M. (Co-Investigator)
1/11/20 → 30/11/22
Project: Research
Datasets
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Age and Sex GWAS in Myocardial Infarction Cases
Hartley, A. (Creator), Chong, A. (Creator), Mitchell, R. (Contributor) & Paternoster, L. (Contributor), University of Bristol, 16 Jan 2023
DOI: 10.5523/bris.2p0ih3u1cpxq12smf079dm1t5a, http://data.bris.ac.uk/data/dataset/2p0ih3u1cpxq12smf079dm1t5a
Dataset
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MRC IEU UK Biobank GWAS pipeline version 2
Mitchell, R. (Creator), Elsworth, B. L. (Creator), Mitchell, R. (Creator), Raistrick, C. A. (Creator), Paternoster, L. (Creator), Hemani, G. (Creator) & Gaunt, T. R. (Creator), University of Bristol, 19 Feb 2019
DOI: 10.5523/bris.pnoat8cxo0u52p6ynfaekeigi, http://data.bris.ac.uk/data/dataset/pnoat8cxo0u52p6ynfaekeigi
Dataset
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UK Biobank Genetic Data: MRC-IEU Quality Control, version 2
Mitchell, R. (Creator), Hemani, G. (Creator), Dudding, T. (Creator), Corbin, L. (Creator), Harrison, S. (Creator) & Paternoster, L. (Creator), University of Bristol, 22 Jan 2019
DOI: 10.5523/bris.1ovaau5sxunp2cv8rcy88688v, http://data.bris.ac.uk/data/dataset/1ovaau5sxunp2cv8rcy88688v
Dataset
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European Journal of Clinical Investigation (Journal)
Paternoster, L. (Editor)
Nov 2013 → …Activity: Publication peer-review and editorial work types › Editorial activity
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Population Health Oct 11 - The Genetic Epidemiology of Atopic Dermatitis.
Paternoster, L. (Recipient)
1 Oct 2012 → 1 Oct 2016Activity: Other activity types › Fellowship awarded competitively