Research output per year
Research output per year
Personal profile
Research interests
Mechanical loading is the primary functional influence on bone mass and architecture. This influence is exerted by bone cells responding to the strains engendered by functional loading within bone tissue. Increased strain-related stimulation results in increased bone formation and decreased stimulation in bone resorption. With age this strain-related regulation fails, bone mass declines and fracture incidence increases. The lifetime risk of a fragility fracture in women is 53.2% and men 20.7%.
Working within the Price lab, which investigates the mechanisms linking functional strain to bone (re)modelling by assessing the osteo-regulatory responses to short periods of dynamic load in mouse bones in vivo and in cell culture models ex vivo, I am currently investigating the failure of aged bone's response to mechanical loading and the role of this mechanism in age-related osteoporosis.
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Collaborations and top research areas from the last five years
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Research output
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The effect of flushing of the common bile duct on hepatobiliary markers and short-term outcome in dogs undergoing cholecystectomy for the management of gall bladder mucocele: A randomized controlled prospective study
Hernon, T., Friend, E. J., Chanoit, G. P. A., Black, V. & Meakin, L. B., 20 Mar 2023, (Accepted/In press) In: Veterinary Surgery.Research output: Contribution to journal › Article (Academic Journal) › peer-review
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Computed tomographic staging of dogs with anal sac adenocarcinoma
Sutton, D., Hernon, T., Hezzell, M. J., Meakin, L. B., Gould, S., Bradley, K. J. & Major, A. C., 17 Jan 2022, In: Journal of Small Animal Practice. 63, 1, p. 27-33 7 p.Research output: Contribution to journal › Article (Academic Journal) › peer-review
1 Citation (Scopus) -
Cortical Thickness Adaptive Response to Mechanical Loading Depends on Periosteal Position and Varies Linearly With Loading Magnitude
Miller, C. J., Trichilo, S., Pickering, E., Martelli, S., Delisser, P., Meakin, L. B. & Pivonka, P., 18 Jun 2021, In: Frontiers in Bioengineering and Biotechnology. 9, p. 671606 671606.Research output: Contribution to journal › Article (Academic Journal) › peer-review
Open AccessFile4 Citations (Scopus)31 Downloads (Pure)
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International Centre for Mechanical Sciences
Lee Meakin (Visiting lecturer)
24 Jun 2013 → 27 Jun 2013Activity: Visiting an external institution types › Visiting an external academic institution
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ECTS Annual Meeting
Lee Meakin (Participant)
18 May 2013 → 21 May 2013Activity: Participating in or organising an event types › Participation in conference
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ASBMR Annual Meeting
Lee Meakin (Participant)
12 Oct 2012 → 15 Oct 2012Activity: Participating in or organising an event types › Participation in conference
Thesis
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The effect of ageing on bone's adaptive response to mechanical loading
Author: Meakin, L. B., Jul 2013Supervisor: Price, J. (Supervisor) & Lanyon, L. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)