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Dr Lee B Meakin

MA(Cantab.), MRes(RVC), PhD(Bris), VetMB, MRCVS

  • BS40 5DU

20112020

Research output per year

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Personal profile

Research interests

Mechanical loading is the primary functional influence on bone mass and architecture. This influence is exerted by bone cells responding to the strains engendered by functional loading within bone tissue. Increased strain-related stimulation results in increased bone formation and decreased stimulation in bone resorption. With age this strain-related regulation fails, bone mass declines and fracture incidence increases. The lifetime risk of a fragility fracture in women is 53.2% and men 20.7%.

Working within the Price lab, which investigates the mechanisms linking functional strain to bone (re)modelling by assessing the osteo-regulatory responses to short periods of dynamic load in mouse bones in vivo and in cell culture models ex vivo, I am currently investigating the failure of aged bone's response to mechanical loading and the role of this mechanism in age-related osteoporosis.

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Research Output

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice

Galea, G. L., Delisser, P. J., Meakin, L., Price, J. S. & Windahl, S. H., 1 Apr 2020, In : Bone. 133, 9 p., 115255.

Research output: Contribution to journalArticle (Academic Journal)

Open Access
File
  • 37 Downloads (Pure)

    Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2

    Galea, G. L., Paradise, C. R., Meakin, L. B., Camilleri, E. T., Taipaleenmaki, H., Stein, G. S., Lanyon, L. E., Price, J. S., van Wijnen, A. J. & Dudakovic, A., 16 Jan 2020, In : Gene: X. 5, 9 p., 100027.

    Research output: Contribution to journalArticle (Academic Journal)

    Open Access
    File
  • 32 Downloads (Pure)

    Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results

    Main, R. P., Shefelbine, S. J., Meakin, L. B., Silva, M. J., van der Meulen, M. C. H. & Willie, B. M., 1 Feb 2020, In : Journal of Orthopaedic Research. 38, 2, p. 233-252 20 p.

    Research output: Contribution to journalReview article (Academic Journal)

  • 3 Citations (Scopus)

    Activities

    • 2 Participation in conference
    • 1 Visiting an external academic institution

    ECTS Annual Meeting

    Lee Meakin (Participant)

    18 May 201321 May 2013

    Activity: Participating in or organising an event typesParticipation in conference

    International Centre for Mechanical Sciences

    Lee Meakin (Visiting lecturer)

    24 Jun 201327 Jun 2013

    Activity: Visiting an external institution typesVisiting an external academic institution

    ASBMR Annual Meeting

    Lee Meakin (Participant)

    12 Oct 201215 Oct 2012

    Activity: Participating in or organising an event typesParticipation in conference

    Thesis

    The effect of ageing on bone's adaptive response to mechanical loading

    Author: Meakin, L. B., Jul 2013

    Supervisor: Price, J. (Supervisor) & Lanyon, L. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy (PhD)